| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arthritis, Infectious | D001170 | 8 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Bacteriuria | D001437 | 7 associated lipids |
| Barrett Esophagus | D001471 | 3 associated lipids |
| Bartonella Infections | D001474 | 3 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Boutonneuse Fever | D001907 | 5 associated lipids |
| Bradycardia | D001919 | 13 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with clarithromycin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Douthwaite S et al. | Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA. | 2000 | Mol. Microbiol. | pmid:10760175 |
| Najib MM et al. | Cost-effectiveness of sparfloxacin compared with other oral antimicrobials in outpatient treatment of community-acquired pneumonia. | 2000 | Pharmacotherapy | pmid:10772376 |
| Van Oijen AH et al. | Review article: treatment of Helicobacter pylori infection with ranitidine bismuth citrate- or proton pump inhibitor-based triple therapies. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930892 |
| Hurenkamp GJ et al. | Equally high efficacy of 4, 7 and 10-day triple therapies to eradicate Helicobacter pylori infection in patients with ulcer disease. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930901 |
| Lai KC et al. | Ulcer-healing drugs are required after eradication of Helicobacter pylori in patients with gastric ulcer but not duodenal ulcer haemorrhage. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930902 |
| Pilotto A et al. | Pantoprazole versus one-week Helicobacter pylori eradication therapy for the prevention of acute NSAID-related gastroduodenal damage in elderly subjects. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930903 |
| Kihira K et al. | Rabeprazole, amoxycillin and low- or high-dose clarithromycin for cure of Helicobacter pylori infection. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930904 |
| Kamada T et al. | Cetraxate, a mucosal protective agent, combined with omeprazole, amoxycillin, and clarithromycin increases the eradication rate of helicobacter pylori in smokers. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930905 |
| Savarino V et al. | OAM for cure of Helicobacter pylori infection. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930908 |
| Amayasu H et al. | Clarithromycin suppresses bronchial hyperresponsiveness associated with eosinophilic inflammation in patients with asthma. | 2000 | Ann. Allergy Asthma Immunol. | pmid:10875487 |
| Maggiolo F et al. | In-vitro activity of moxifloxacin combined with other antibacterials against methicillin-resistant Staphylococcus aureus. | 2000 | J Chemother | pmid:10877512 |
| Hammerschlag MR and Roblin PM | Microbiologic efficacy of moxifloxacin for the treatment of community-acquired pneumonia due to Chlamydia pneumoniae. | 2000 | Int. J. Antimicrob. Agents | pmid:10854812 |
| Hirschl AM et al. | In vitro activities of linezolid alone and in combination with amoxicillin, clarithromycin, and metronidazole against Helicobacter pylori. | 2000 | Antimicrob. Agents Chemother. | pmid:10858365 |
| Lamouliatte H et al. | [Treatment of Helicobacter pylori infection with lansoprazole 30 mg or 60 mg combined with two antibiotics for duodenal ulcers]. | 2000 | Gastroenterol. Clin. Biol. | pmid:10891736 |
| Ives TJ et al. | In vitro susceptibilities of Rickettsia and Bartonella spp. to 14-hydroxy-clarithromycin as determined by immunofluorescent antibody analysis of infected vero cell monolayers. | 2000 | J. Antimicrob. Chemother. | pmid:10702548 |
| Schweeger I et al. | Successful eradication of Helicobacter pylori as determined by ((13))C-urea breath test does not alter fibrinogen and acute phase response markers. | 2000 | Thromb. Res. | pmid:10704650 |
| Parola D et al. | [Efficacy and safety of clarithromycin in the treatment of community-acquired pneumonia]. | 2000 | Recenti Prog Med | pmid:10705778 |
| Fonquernie L et al. | [Pseudotumoral abdominal granuloma concomitant with immune reconstitution after antiretroviral treatment]. | 2000 | Presse Med | pmid:10705894 |
| Raderer M et al. | Regression of colonic low grade B cell lymphoma of the mucosa associated lymphoid tissue type after eradication of Helicobacter pylori. | 2000 | Gut | pmid:10601069 |
| Tran JQ et al. | Comparison of the abilities of grepafloxacin and clarithromycin to eradicate potential bacterial pathogens from the sputa of patients with chronic bronchitis: influence of pharmacokinetic and pharmacodynamic variables. | 2000 | J. Antimicrob. Chemother. | pmid:10719007 |
| Numazaki K et al. | Therapeutic effect of clarithromycin for respiratory-tract infections in children caused by Chlamydia pneumoniae. Research Group of Sapporo for Pediatric Chlamydial Infections. | 2000 | Int. J. Antimicrob. Agents | pmid:10724028 |
| Gomollón F et al. | [Does eliminating Helicobacter pylori mean the healing of the duodenal ulcer? The results of a prospective study in Spain]. | 2000 | Gastroenterol Hepatol | pmid:10726384 |
| Fernández-Roblas R et al. | In vitro susceptibilities of rapidly growing mycobacteria to telithromycin (HMR 3647) and seven other antimicrobials. | 2000 | Antimicrob. Agents Chemother. | pmid:10602744 |
| Jung R et al. | Postantibiotic effects and bactericidal activities of clarithromycin-14-hydroxy-clarithromycin, versus those of amoxicillin-clavulanate, against anaerobes. | 2000 | Antimicrob. Agents Chemother. | pmid:10681358 |
| Abe S et al. | Interleukin-8 gene repression by clarithromycin is mediated by the activator protein-1 binding site in human bronchial epithelial cells. | 2000 | Am. J. Respir. Cell Mol. Biol. | pmid:10615065 |
| Sugimoto M et al. | Prevention of hemorrhage from intradiverticular ulcer in the duodenum by Helicobacter pylori eradication. | 2000 | Am. J. Gastroenterol. | pmid:10685780 |
| Zuckerman JM | The newer macrolides: azithromycin and clarithromycin. | 2000 | Infect. Dis. Clin. North Am. | pmid:10829265 |
| Bortolotti M et al. | Effect of clarithromycin on esophageal motility. | 2000 | Dis. Esophagus | pmid:11206638 |
| Hoshiya S et al. | Relationship between eradication therapy and clarithromycin-resistant Helicobacter pylori in Japan. | 2000 | J. Gastroenterol. | pmid:10632534 |
| Fujioka T | Clarithromycin resistance in Helicobacter pylori: implications for therapy. | 2000 | J. Gastroenterol. | pmid:10632546 |
| Iakovlev VP et al. | [Macrolide antibiotic clarithromycin (Klabax) in treatment of community-acquired respiratory tract infections]. | 2000 | Antibiot. Khimioter. | pmid:11210297 |
| Bardhan KD et al. | Triple therapy for Helicobacter pylori eradication: a comparison of pantoprazole once versus twice daily. | 2000 | Aliment. Pharmacol. Ther. | pmid:10632646 |
| Sazykin IuO et al. | [Clarithromycin and tumor chemotherapy]. | 2000 | Antibiot. Khimioter. | pmid:11210301 |
| Cammarota G et al. | Five-day regimens containing ranitidine bismuth citrate plus high-dose clarithromycin and either amoxycillin or tinidazole for Helicobacter pylori infection. | 2000 | Aliment. Pharmacol. Ther. | pmid:10632648 |
| Gasbarrini A et al. | Efficacy of a multistep strategy for Helicobacter pylori eradication. | 2000 | Aliment. Pharmacol. Ther. | pmid:10632649 |
| Chan FK et al. | Salvage therapies after failure of Helicobacter pylori eradication with ranitidine bismuth citrate-based therapies. | 2000 | Aliment. Pharmacol. Ther. | pmid:10632651 |
| Rhee CS et al. | Effects of clarithromycin on rheological properties of nasal mucus in patients with chronic sinusitis. | 2000 | Ann. Otol. Rhinol. Laryngol. | pmid:10823478 |
| Sato K et al. | Antimicrobial activities of levofloxacin, clarithromycin, and KRM-1648 against Mycobacterium tuberculosis and Mycobacterium avium complex replicating within Mono Mac 6 human macrophage and A-549 type II alveolar cell lines. | 2000 | Int. J. Antimicrob. Agents | pmid:11185410 |
| Paton R et al. | Susceptibility testing of Haemophilus influenzae to clarithromycin. | 2000 | J. Antimicrob. Chemother. | pmid:10747833 |
| Fujimura S et al. | Clarithromycin-susceptible Helicobacter pylori with mutation in 23S rRNA gene by PCR-RFLP method. | 2000 | J. Gastroenterol. | pmid:10777165 |
| Abisheganaden JA et al. | Effect of clarithromycin on experimental rhinovirus-16 colds: a randomized, double-blind, controlled trial. | 2000 | Am. J. Med. | pmid:10781777 |
| Kaushik SP and Vu C | Helicobacter pylori eradication with lansoprazole, amoxycillin and clarithromycin: testing an ideal regimen in a multicultural south east Asian population and examining factors potentially influencing eradication. | 2000 | Aust N Z J Med | pmid:10833116 |
| Waites K et al. | Use of clindamycin disks To detect macrolide resistance mediated by ermB and mefE in Streptococcus pneumoniae isolates from adults and children. | 2000 | J. Clin. Microbiol. | pmid:10790089 |
| Ianaro A et al. | Anti-inflammatory activity of macrolide antibiotics. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10604943 |
| Calvet X et al. | A meta-analysis of short versus long therapy with a proton pump inhibitor, clarithromycin and either metronidazole or amoxycillin for treating Helicobacter pylori infection. | 2000 | Aliment. Pharmacol. Ther. | pmid:10792124 |
| Shimizu T et al. | Successful treatment using clarithromycin for a cutaneous lesion caused by Mycobacterium szulgai. | 2000 | Br. J. Dermatol. | pmid:10792258 |
| Vernet Vernet M et al. | [Analysis of indications and diagnosis of the gastroscopies requested by primary care physicians]. | 2000 | Aten Primaria | pmid:10795440 |
| Shashidhar H et al. | A prospective trial of lansoprazole triple therapy for pediatric Helicobacter pylori infection. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:10749411 |
| Joosen EA et al. | Costs and benefits of a test-and-treat strategy in Helicobacter pylori-infected subjects: a prospective intervention study in general practice. | 2000 | Eur J Gastroenterol Hepatol | pmid:10750653 |
| Woo PC et al. | Clarithromycin attenuates cyclophosphamide-induced mucositis in mice. | 2000 | Pharmacol. Res. | pmid:10753551 |
| Frank F et al. | Helicobacter pylori infection in recurrent abdominal pain. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:11045841 |
| Giannini E et al. | Influence of Helicobacter pylori eradication therapy on 13C aminopyrine breath test: comparison among omeprazole-, lansoprazole-, or pantoprazole-containing regimens. | 2000 | Am. J. Gastroenterol. | pmid:11051345 |
| Herr H and You CH | Relationship between Helicobacter pylori and rosacea: it may be a myth. | 2000 | J. Korean Med. Sci. | pmid:11068993 |
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| Canducci F et al. | A lyophilized and inactivated culture of Lactobacillus acidophilus increases Helicobacter pylori eradication rates. | 2000 | Aliment. Pharmacol. Ther. | pmid:11121911 |
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| Bañuls J et al. | Mycobacterium chelonae infection resistant to clarithromycin in a patient with dermatomyositis. | 2000 | Br. J. Dermatol. | pmid:11122063 |
| Krebs T et al. | Mycobacterium genavense infection in a patient with long-standing chronic lymphocytic leukaemia. | 2000 | J. Intern. Med. | pmid:11086646 |
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| Rea TH | Trials of daily, long-term minocycline and rifampin or clarithromycin and rifampin in the treatment of borderline lepromatous and lepromatous leprosy. | 2000 | Int. J. Lepr. Other Mycobact. Dis. | pmid:11036492 |
| Bhasin DK et al. | Drug resistance in Helicobacter pylori infection. | 2000 | Indian J Gastroenterol | pmid:11060974 |
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| Badyal DK and Garg SK | Effect of clarithromycin on the pharmacokinetics of carbamazepine in rhesus monkeys. | 2000 | Methods Find Exp Clin Pharmacol | pmid:11196346 |
| Drinkard CR et al. | Postmarketing surveillance of medications and pregnancy outcomes: clarithromycin and birth malformations. | 2000 | Pharmacoepidemiol Drug Saf | pmid:11338912 |
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| Alter P et al. | [Impediment of cellular immune response under treatment with ticlopidine in a patient with Staphylococcus aureus endocarditis]. | 2000 | Z Kardiol | pmid:11013974 |
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| Mayhew BS et al. | An in vitro model for predicting in vivo inhibition of cytochrome P450 3A4 by metabolic intermediate complex formation. | 2000 | Drug Metab. Dispos. | pmid:10950845 |
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| Brophy DF et al. | Pharmacokinetic interaction between amprenavir and clarithromycin in healthy male volunteers. | 2000 | Antimicrob. Agents Chemother. | pmid:10722500 |
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| Bortolotti M et al. | Dose-related stimulatory effect of clarithromycin on interdigestive gastroduodenal motility. | 2000 | Digestion | pmid:10899723 |
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| Miwi H et al. | Comparison of the efficacy of 400mg and 800mg of clarithromycin used with lansoprazole and amoxicillin in eradication regimens for Helicobacter pylori infection in a Japanese population. | 2000 | J. Gastroenterol. | pmid:10905362 |
| Pilotto A et al. | Incidence of secondary Helicobacter pylori resistance to antibiotics in treatment failures after 1-week proton pump inhibitor-based triple therapies: a prospective study. | 2000 | Dig Liver Dis | pmid:11142574 |
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