clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Huang J et al. | Randomised controlled trial: sequential vs. standard triple therapy for Helicobacter pylori infection in Chinese children-a multicentre, open-labelled study. | 2013 | Aliment. Pharmacol. Ther. | pmid:24117692 |
Yoon H et al. | Meta-analysis: is sequential therapy superior to standard triple therapy for Helicobacter pylori infection in Asian adults? | 2013 | J. Gastroenterol. Hepatol. | pmid:24118110 |
Calza P et al. | Fate of selected pharmaceuticals in river waters. | 2013 | Environ Sci Pollut Res Int | pmid:22851223 |
Laving A et al. | Effectiveness of sequential v. standard triple therapy for treatment of Helicobacter pylori infection in children in Nairobi, Kenya. | 2013 | S. Afr. Med. J. | pmid:24300630 |
Cecchini MP et al. | Might Helicobacter pylori infection be associated with distortion on taste perception? | 2013 | Med. Hypotheses | pmid:23845559 |
Delgado JS et al. | Granulomatous gastritis and Helicobacter pylori infection. | 2013 | Isr. Med. Assoc. J. | pmid:23882902 |
Ang TL et al. | Is there still a role for empiric first-line triple therapy using proton pump inhibitor, amoxicillin and clarithromycin for Helicobacter pylori infection in Singapore? Results of a time trend analysis. | 2013 | J Dig Dis | pmid:23253473 |
Kazama I and Maruyama Y | Differential effects of clarithromycin and azithromycin on delayed rectifier K(+)-channel currents in murine thymocytes. | 2013 | Pharm Biol | pmid:23527897 |
Sardarian H et al. | Comparison of hybrid and sequential therapies for Helicobacter pylori eradication in Iran: a prospective randomized trial. | 2013 | Helicobacter | pmid:23121338 |
Goh IX et al. | Cytochrome P450 drug interactions with statin therapy. | 2013 | Singapore Med J | pmid:23546024 |
Maggi P et al. | Fatal fulminant hepatitis following administration of clarithromycin in a patient chronically treated with antipsycotic drugs. | 2013 | Immunopharmacol Immunotoxicol | pmid:22804484 |
Hong SK et al. | First case of Mycobacterium longobardum infection. | 2013 | Ann Lab Med | pmid:24003427 |
Faraji F et al. | The effect of Helicobacter pylori eradication on migraine: a randomized, double blind, controlled trial. | 2012 Nov-Dec | Pain Physician | pmid:23159967 |
Eremenko AA et al. | [Effect of clarithromycin on the systemic inflammatory response syndrome severity in patients after myocardial revascularization surgery]. | 2012 May-Jun | Anesteziol Reanimatol | pmid:22993930 |
Singh V et al. | Vesicular palmoplantar pityriasis rosea. | 2012 Mar-Apr | Skinmed | pmid:22545332 |
Gutiérrez-Castrellón P et al. | Efficacy and safety of clarithromycin in pediatric patients with upper respiratory infections: a systematic review with meta-analysis. | 2012 Mar-Apr | Rev. Invest. Clin. | pmid:22991774 |
Rajendiran S et al. | Increased protein carbonylation and decreased antioxidant status in anemic H. pylori infected patients: effect of treatment. | 2012 Jul-Aug | Saudi J Gastroenterol | pmid:22824768 |
De Sanctis V et al. | Anti-Helicobacter pylori therapy in primary MALT lymphoma of rectum. | 2012 Jul-Aug | Tumori | pmid:23052174 |
Figueroa M et al. | [Antimicrobial susceptibility of Helicobacter pylori with chronic gastritis]. | 2012 Jan-Mar | Biomedica | pmid:23235785 |
de Lalibera IB et al. | Meningoencephalitis associated with Mycoplasma pneumoniae. | 2012 Jan-Mar | Einstein (Sao Paulo) | pmid:23045836 |
Dhillon GS et al. | Clarithromycin for prevention of bronchiolitis obliterans syndrome in lung allograft recipients. | 2012 Jan-Feb | Clin Transplant | pmid:21352378 |
Onsun N et al. | Impact of Helicobacter pylori infection on severity of psoriasis and response to treatment. | 2012 Jan-Feb | Eur J Dermatol | pmid:22063790 |
Montero-Tinnirello J et al. | [Pulmonary hemorrhage due to leptospirosis]. | 2012 Jan-Feb | Med Intensiva | pmid:21592620 |
Dai WQ et al. | The eradicating Helicobacter pylori infection in duodenal ulcer patients by three short-term triple therapies in China: a multicenter clinical comparative study. | 2012 Jan-Feb | Hepatogastroenterology | pmid:22260837 |
Walkey AJ and Wiener RS | Macrolide antibiotics and survival in patients with acute lung injury. | 2012 | Chest | pmid:22116799 |
Reva I et al. | Virulence genotypes and drug resistance of Helicobacter pylori from Vladivostok, Russia: another feature in the Far East. | 2012 | Microbiol. Immunol. | pmid:22211953 |
Park SJ et al. | Fulminant and Fatal Multiple Organ Failure in a 12-Year-Old Boy With Mycoplasma pneumoniae Infection. | 2012 | Allergy Asthma Immunol Res | pmid:22211173 |
Falkinham JO et al. | Antibacterial activities of dendritic amphiphiles against nontuberculous mycobacteria. | 2012 | Tuberculosis (Edinb) | pmid:22209468 |
Cuadrado-LavÃn A et al. | Levofloxacin versus clarithromycin in a 10 day triple therapy regimen for first-line Helicobacter pylori eradication: a single-blind randomized clinical trial. | 2012 | J. Antimicrob. Chemother. | pmid:22687889 |
Nseir W et al. | Randomised clinical trial: simvastatin as adjuvant therapy improves significantly the Helicobacter pylori eradication rate--a placebo-controlled study. | 2012 | Aliment. Pharmacol. Ther. | pmid:22646167 |
Zaater MF et al. | Determination and stability assessment of clarithromycin in human plasma using RP-LC with electrochemical detection. | 2012 | J Chromatogr Sci | pmid:22647394 |
Choi HS et al. | Comparison of sequential and 7-, 10-, 14-d triple therapy for Helicobacter pylori infection. | 2012 | World J. Gastroenterol. | pmid:22654429 |
Gisbert JP and Calvet X | Review article: rifabutin in the treatment of refractory Helicobacter pylori infection. | 2012 | Aliment. Pharmacol. Ther. | pmid:22129228 |
Nujić K et al. | Valosin containing protein (VCP) interacts with macrolide antibiotics without mediating their anti-inflammatory activities. | 2012 | Eur. J. Pharmacol. | pmid:22209877 |
Hiramatsu M et al. | Risk factors that affect the surgical outcome in the management of focal bronchiectasis in a developed country. | 2012 | Ann. Thorac. Surg. | pmid:22119119 |
Chan A et al. | A case of wrist tenosynovitis caused by Mycobacterium kansasii in a renal transplant recipient. | 2012 | Transpl Infect Dis | pmid:22822725 |
Koh WJ et al. | Therapeutic drug monitoring in the treatment of Mycobacterium avium complex lung disease. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:22878282 |
Maurer FP et al. | Acquisition of clarithromycin resistance mutations in the 23S rRNA gene of Mycobacterium abscessus in the presence of inducible erm(41). | 2012 | J. Antimicrob. Chemother. | pmid:22833642 |
Kanazu T et al. | Investigation of drug-drug interaction via mechanism-based inhibition of cytochrome P450 3A by macrolides in dexamethasone-treated female rats. | 2012 | Biopharm Drug Dispos | pmid:22447511 |
Togami K et al. | Transport characteristics of clarithromycin, azithromycin and telithromycin, antibiotics applied for treatment of respiratory infections, in Calu-3 cell monolayers as model lung epithelial cells. | 2012 | Pharmazie | pmid:22764569 |
Fujioka T et al. | A large-scale nationwide multicenter prospective observational study of triple therapy using rabeprazole, amoxicillin, and clarithromycin for Helicobacter pylori eradication in Japan. | 2012 | J. Gastroenterol. | pmid:22065160 |
Park HG et al. | Randomised clinical trial: a comparative study of 10-day sequential therapy with 7-day standard triple therapy for Helicobacter pylori infection in naïve patients. | 2012 | Aliment. Pharmacol. Ther. | pmid:22066530 |
Liang J et al. | Helicobacter pylori eradication with ecabet sodium, omeprazole, amoxicillin, and clarithromycin versus bismuth, omeprazole, amoxicillin, and clarithromycin quadruple therapy: a randomized, open-label, phase IV trial. | 2012 | Helicobacter | pmid:23066868 |
Erol E et al. | Antibiotic susceptibility patterns of Crossiella equi and Amycolatopsis species causing nocardioform placentitis in horses. | 2012 | J. Vet. Diagn. Invest. | pmid:23051830 |
Dalkmann P et al. | Accumulation of pharmaceuticals, Enterococcus, and resistance genes in soils irrigated with wastewater for zero to 100 years in central Mexico. | 2012 | PLoS ONE | pmid:23049795 |
Kurugol Z et al. | Severe Hemolytic Anemia Associated with Mild Pneumonia Caused by Mycoplasma pneumonia. | 2012 | Case Rep Med | pmid:23049568 |
Deng ZH et al. | Influence of Helicobacter pylori infection on ghrelin levels in children. | 2012 | World J. Gastroenterol. | pmid:23049220 |
Malfertheiner P et al. | Helicobacter pylori: clinical management. | 2012 | Curr. Opin. Gastroenterol. | pmid:23010682 |
Saracino IM et al. | High prevalence of primary antibiotic resistance in Helicobacter pylori isolates in Italy. | 2012 | J Gastrointestin Liver Dis | pmid:23256118 |
Spyridaki A et al. | Effect of clarithromycin in inflammatory markers of patients with ventilator-associated pneumonia and sepsis caused by Gram-negative bacteria: results from a randomized clinical study. | 2012 | Antimicrob. Agents Chemother. | pmid:22564837 |
Cajigas-Pezo D et al. | [Swelling of right knee in an immunologically compromised patient]. | 2012 | Enferm. Infecc. Microbiol. Clin. | pmid:22521279 |
McCallum GB et al. | Antibiotics for persistent cough or wheeze following acute bronchiolitis in children. | 2012 | Cochrane Database Syst Rev | pmid:23235681 |
Boyanova L et al. | Numerous risk factors for Helicobacter pylori antibiotic resistance revealed by extended anamnesis: a Bulgarian study. | 2012 | J. Med. Microbiol. | pmid:21873378 |
Kotsaki A and Giamarellos-Bourboulis EJ | Emerging drugs for the treatment of sepsis. | 2012 | Expert Opin Emerg Drugs | pmid:22780561 |
Fiorini G et al. | Newer agents for Helicobacter pylori eradication. | 2012 | Clin Exp Gastroenterol | pmid:22767998 |
Whittemore KR and Cohen M | Imaging and review of a large pre-auricular pilomatrixoma in a child. | 2012 | World J Radiol | pmid:22761984 |
Kudo T et al. | Comparison of lafutidine and rabeprazole in 7-day second-line amoxicillin- and metronidazole-containing triple therapy for Helicobacter pylori: a pilot study. | 2012 | Helicobacter | pmid:22759327 |
Roccarina D et al. | Different Antibiotic No Culture Eradicating (DANCE) strategy: an easy way to manage H. pylori eradication. | 2012 | Dig Liver Dis | pmid:22743557 |
Tursi A et al. | Efficacy and tolerability of a third-line, levofloxacin-based, 10-day sequential therapy in curing resistant Helicobacter pylori infection. | 2012 | J Gastrointestin Liver Dis | pmid:22720300 |
Birteksöz-Tan AS and Zeybek Z | Postantibiotic effect of various antibiotics on Legionella pneumophila strains isolated from water systems. | 2012 | Folia Microbiol. (Praha) | pmid:22627604 |
Chang WJ et al. | Successful salvage treatment of steroid-refractory bronchiolar COP with low-dose macrolides. | 2012 | Pathol. Int. | pmid:22243785 |
Burt HJ et al. | Progress curve mechanistic modeling approach for assessing time-dependent inhibition of CYP3A4. | 2012 | Drug Metab. Dispos. | pmid:22621802 |
Lismond A et al. | Antimicrobial susceptibility of Streptococcus pneumoniae isolates from vaccinated and non-vaccinated patients with a clinically confirmed diagnosis of community-acquired pneumonia in Belgium. | 2012 | Int. J. Antimicrob. Agents | pmid:22245497 |
Bermudez LE et al. | Identification of (+)-erythro-mefloquine as an active enantiomer with greater efficacy than mefloquine against Mycobacterium avium infection in mice. | 2012 | Antimicrob. Agents Chemother. | pmid:22615290 |
Agarwal E et al. | Efficacy of local drug delivery of 0.5% clarithromycin gel as an adjunct to non-surgical periodontal therapy in the treatment of current smokers with chronic periodontitis: a randomized controlled clinical trial. | 2012 | J. Periodontol. | pmid:22248223 |
Khan A et al. | Antibiotic resistance and cagA gene correlation: a looming crisis of Helicobacter pylori. | 2012 | World J. Gastroenterol. | pmid:22611319 |
Szałek E et al. | Sunitinib in combination with clarithromycin or azithromycin - is there a risk of interaction or not? | 2012 | Pharmacol Rep | pmid:23406766 |
Takeshima F et al. | Successful management of cap polyposis with eradication of Helicobacter pylori relapsing 15 years after remission on steroid therapy. | 2012 | Intern. Med. | pmid:22333383 |
Lawal TO et al. | Combination studies of Eucalyptus torelliana F. Muell. leaf extracts and clarithromycin on Helicobacter pylori. | 2012 | Phytother Res | pmid:22318891 |
Slater CM and Ford AC | Treatment of Helicobacter pylori in Latin America. | 2012 | Lancet | pmid:22305216 |
Gatta L et al. | Treatment of Helicobacter pylori in Latin America. | 2012 | Lancet | pmid:22305217 |
Dicicco M et al. | Efficacy of clarithromycin on biofilm formation of methicillin-resistant Staphylococcus pseudintermedius. | 2012 | BMC Vet. Res. | pmid:23171620 |
Alfakry H et al. | The association of serum neutrophil markers and acute coronary syndrome. | 2012 | Scand. J. Immunol. | pmid:22537345 |
Shaifali I et al. | Antibiotic susceptibility patterns of urinary pathogens in female outpatients. | 2012 | N Am J Med Sci | pmid:22536558 |
Gisbert JP | Rescue Therapy for Helicobacter pylori Infection 2012. | 2012 | Gastroenterol Res Pract | pmid:22536225 |
Lee RP et al. | Mycobacterium chelonae infection after total knee arthroplasty: a case report. | 2012 | J Orthop Surg (Hong Kong) | pmid:22535831 |
Fakheri H et al. | A comparison between sequential therapy and a modified bismuth-based quadruple therapy for Helicobacter pylori eradication in Iran: a randomized clinical trial. | 2012 | Helicobacter | pmid:22221615 |
Georgopoulos S et al. | Evaluation of a four-drug, three-antibiotic, nonbismuth-containing "concomitant" therapy as first-line Helicobacter pylori eradication regimen in Greece. | 2012 | Helicobacter | pmid:22221616 |
Senhorinho GN et al. | Occurrence and antimicrobial susceptibility of Porphyromonas spp. and Fusobacterium spp. in dogs with and without periodontitis. | 2012 | Anaerobe | pmid:22609780 |
Komatsu S et al. | Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells. | 2012 | Int. J. Oncol. | pmid:22200786 |
Matsuzaki J et al. | Efficacy of sitafloxacin-based rescue therapy for Helicobacter pylori after failures of first- and second-line therapies. | 2012 | Antimicrob. Agents Chemother. | pmid:22203601 |
Adrjanowicz K et al. | Molecular dynamics in supercooled liquid and glassy states of antibiotics: azithromycin, clarithromycin and roxithromycin studied by dielectric spectroscopy. Advantages given by the amorphous state. | 2012 | Mol. Pharm. | pmid:22540343 |
Kobashi Y et al. | Relationship between clinical efficacy for pulmonary MAC and drug-sensitivity test for isolated MAC in a recent 6-year period. | 2012 | J. Infect. Chemother. | pmid:22205543 |
Lin Z and Will Y | Evaluation of drugs with specific organ toxicities in organ-specific cell lines. | 2012 | Toxicol. Sci. | pmid:22166485 |
Onoe H et al. | Buruli ulcer accompanied by pain in a Japanese patient. | 2012 | J. Dermatol. | pmid:22168180 |
Lulitanond A et al. | Prevalence of β-lactamase-negative ampicillin-resistant haemophilus influenzae isolated from patients of a teaching hospital in Thailand. | 2012 | Jpn. J. Infect. Dis. | pmid:22446118 |
Liang Y et al. | Epidemiological and molecular characteristics of clinical isolates of Streptococcus pyogenes collected between 2005 and 2008 from Chinese children. | 2012 | J. Med. Microbiol. | pmid:22442290 |
Gomez-Abreo D et al. | [Chronic necrotizing pulmonary aspergillosis following an infection by Mycobacterium malmoense]. | 2012 | Rev Mal Respir | pmid:22440310 |
Lee JH et al. | A nanohybrid system for taste masking of sildenafil. | 2012 | Int J Nanomedicine | pmid:22619517 |
Molina-Infante J et al. | Nonbismuth quadruple (concomitant) therapy: empirical and tailored efficacy versus standard triple therapy for clarithromycin-susceptible Helicobacter pylori and versus sequential therapy for clarithromycin-resistant strains. | 2012 | Helicobacter | pmid:22759326 |
Kongchayanun C et al. | Pilot studies to identify the optimum duration of concomitant Helicobacter pylori eradication therapy in Thailand. | 2012 | Helicobacter | pmid:22759328 |
Song JY et al. | Case series of mycobacterium abscessus infections associated with a trigger point injection and epidural block at a rural clinic. | 2012 | Epidemiol Health | pmid:22323979 |
Nguyen TV et al. | Eradication of Helicobacter pylori in children in Vietnam in relation to antibiotic resistance. | 2012 | Helicobacter | pmid:22759333 |
Hirata Y et al. | Sitafloxacin resistance in Helicobacter pylori isolates and sitafloxacin-based triple therapy as a third-line regimen in Japan. | 2012 | Int. J. Antimicrob. Agents | pmid:22321702 |
NiziÄ T et al. | Solitary erythema migrans in children: comparison of treatment with clarithromycin and amoxicillin. | 2012 | Wien. Klin. Wochenschr. | pmid:22760494 |
Yokota S et al. | Clarithromycin suppresses human respiratory syncytial virus infection-induced Streptococcus pneumoniae adhesion and cytokine production in a pulmonary epithelial cell line. | 2012 | Mediators Inflamm. | pmid:22761540 |
Brown-Elliott BA et al. | Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria. | 2012 | Clin. Microbiol. Rev. | pmid:22763637 |
Pereyre S et al. | Clonal spread of Mycoplasma pneumoniae in primary school, Bordeaux, France. | 2012 | Emerging Infect. Dis. | pmid:22305177 |
Butler CC et al. | Effectiveness of multifaceted educational programme to reduce antibiotic dispensing in primary care: practice based randomised controlled trial. | 2012 | BMJ | pmid:22302780 |
Correia M et al. | Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization. | 2012 | PLoS ONE | pmid:22529974 |