clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Korres DS et al. | Multifocal spinal and extra-spinal Mycobacterium chelonae osteomyelitis in a renal transplant recipient. | 2007 | Transpl Infect Dis | pmid:17313477 |
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Bhaloo S and Prasad GV | Severe reduction in tacrolimus levels with rifampin despite multiple cytochrome P450 inhibitors: a case report. | 2003 | Transplant. Proc. | pmid:14611983 |
Lasmar EP et al. | Mucosa-associated lymphoid tissue gastric lymphoma regression in a renal transplant patient after conversion of the immunosuppression to sirolimus: a case report. | 2009 | Transplant. Proc. | pmid:19376398 |
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Gómez G et al. | Acute tacrolimus nephrotoxicity in renal transplant patients treated with clarithromycin. | 1999 | Transplant. Proc. | pmid:10500563 |
Tokgöz B et al. | Effects of azithromycin on cyclosporine-induced gingival hyperplasia in renal transplant patients. | 2004 | Transplant. Proc. | pmid:15621128 |
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Ferrari SL et al. | The interaction between clarithromycin and cyclosporine in kidney transplant recipients. | 1994 | Transplantation | pmid:7940695 |
Torpiano P and Pace D | Clinically-diagnosed Mediterranean Spotted Fever in Malta. | Travel Med Infect Dis | pmid:29462726 | |
Swanson RN et al. | Once-daily azithromycin for 3 days compared with clarithromycin for 10 days for acute exacerbation of chronic bronchitis: a multicenter, double-blind, randomized study. | 2005 | Treat Respir Med | pmid:15725048 |
Banerjee D et al. | The effect of oral clarithromycin on bronchial airway inflammation in moderate-to-severe stable COPD: a randomized controlled trial. | 2004 | Treat Respir Med | pmid:15174894 |
Aukema AA and Fokkens WJ | Chronic rhinosinusitis: management for optimal outcomes. | 2004 | Treat Respir Med | pmid:15182211 |
Ambrose PG | Antimicrobial susceptibility breakpoints: PK-PD and susceptibility breakpoints. | 2005 | Treat Respir Med | pmid:15846151 |
McCormack PL and Keating GM | Spotlight on amoxicillin/clavulanic acid 2000 mg/125 mg extended release (XR) in respiratory tract infections in adults. | 2005 | Treat Respir Med | pmid:16137193 |
Böttger EC | Resistance to drugs targeting protein synthesis in mycobacteria. | 1994 | Trends Microbiol. | pmid:7850212 |
Montoya CJ et al. | Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial. | 2009 | Trials | pmid:19538732 |
Lee H et al. | Concomitant, sequential, and 7-day triple therapy in first-line treatment of Helicobacter pylori infection in Korea: study protocol for a randomized controlled trial. | 2017 | Trials | pmid:29149904 |
Chang AB et al. | Randomized placebo-controlled trial on azithromycin to reduce the morbidity of bronchiolitis in Indigenous Australian infants: rationale and protocol. | 2011 | Trials | pmid:21492416 |
Neuhann HF et al. | Efficacy of different antibiotic regimens for eradication treatment of Helicobacter pylori infection in peptic ulcer disease in Tanzanian patients. | 2003 | Trop Doct | pmid:14620428 |
Amarapurkar D et al. | Helicobacter pylori eradication: efficacy of conventional therapy in India. | 2004 | Trop Doct | pmid:15117141 |
Aminian K et al. | A randomized trial comparing four Helicobacter pylori eradication regimens: standard triple therapy, ciprofloxacin based triple therapy, quadruple and sequential therapy. | 2010 Oct-Dec | Trop Gastroenterol | pmid:21568147 |
Lubell Y et al. | Susceptibility of bacterial isolates from community-acquired infections in sub-Saharan Africa and Asia to macrolide antibiotics. | 2011 | Trop. Med. Int. Health | pmid:21740488 |
Ndip RN et al. | Helicobacter pylori isolates recovered from gastric biopsies of patients with gastro-duodenal pathologies in Cameroon: current status of antibiogram. | 2008 | Trop. Med. Int. Health | pmid:18384477 |
Jamal MA et al. | Molecular basis of clarithromycin-resistance in Mycobacterium avium intracellulare complex. | 2000 | Tuber. Lung Dis. | pmid:10897378 |
Lazard T et al. | Chloroquine does not enhance the activity of clarithromycin against multiplication of Mycobacterium avium within human macrophages. | 1994 | Tuber. Lung Dis. | pmid:7949074 |
Saito H et al. | Therapeutic effect of KRM-1648 with various antimicrobials against Mycobacterium avium complex infection in mice. | 1995 | Tuber. Lung Dis. | pmid:7718848 |
Sanchez T et al. | Quantitation of mycobacteria in blood specimens from patients with AIDS. | 1994 | Tuber. Lung Dis. | pmid:7841433 |
Heifets LB | Clarithromycin against Mycobacterium avium complex infections. | 1996 | Tuber. Lung Dis. | pmid:8733409 |
Falkinham JO et al. | Antibacterial activities of dendritic amphiphiles against nontuberculous mycobacteria. | 2012 | Tuberculosis (Edinb) | pmid:22209468 |
Clarithromycin. | 2008 | Tuberculosis (Edinb) | pmid:18486039 | |
Howard ST | Recent progress towards understanding genetic variation in the Mycobacterium abscessus complex. | 2013 | Tuberculosis (Edinb) | pmid:24388643 |
De Sanctis V et al. | Anti-Helicobacter pylori therapy in primary MALT lymphoma of rectum. | 2012 Jul-Aug | Tumori | pmid:23052174 |
Miyamoto S et al. | Analysis of Helicobacter pylori genotypes in clinical gastric wash samples. | 2016 | Tumour Biol. | pmid:26825980 |
Oikawa R et al. | Enrichment of Helicobacter pylori mutant strains after eradication therapy analyzed by gastric wash-based quantitative pyrosequencing. | 2017 | Tumour Biol. | pmid:28990461 |
Mrad SM et al. | [Children Helicobacter pylori infection: antibiogram results]. | 2005 | Tunis Med | pmid:16370209 |
Chelly I et al. | [Gastric MALT lymphoma: anatomo-clinical data and outcome of early stage H. pylori-associated gastric MALT-lymphoma resistant to treatment]. | 2011 | Tunis Med | pmid:22198892 |
Loghmari H et al. | Clarithromycin versus metronidazole in first-line Helicobacter pylori eradication. Prospective randomized study of 85 Tunisian adults. | 2012 | Tunis Med | pmid:22311445 |
Aydin A et al. | The efficacy of two-week therapy with ranitidine bismuth citrate, amoxicillin and clarithromycin on Helicobacter pylori eradication in clarithromycinresistant and- sensitive cases. | 2005 | Turk J Gastroenterol | pmid:16547848 |