clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with clarithromycin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (2)
- J. Antimicrob. Chemother. (1)
- Clin. Diagn. Lab. Immunol. (1)
- Others (2)
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ednie LM et al. | Comparative antianaerobic activities of the ketolides HMR 3647 (RU 66647) and HMR 3004 (RU 64004). | 1997 | Antimicrob. Agents Chemother. | pmid:9303406 |
| Visalli MA et al. | Susceptibility of penicillin-susceptible and -resistant pneumococci to dirithromycin compared with susceptibilities to erythromycin, azithromycin, clarithromycin, roxithromycin, and clindamycin. | 1997 | Antimicrob. Agents Chemother. | pmid:9303375 |
| Versalovic J et al. | Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance. | 1997 | J. Antimicrob. Chemother. | pmid:9301997 |
| López-Brea M et al. | Evolution of resistance to metronidazole and clarithromycin in Helicobacter pylori clinical isolates from Spain. | 1997 | J. Antimicrob. Chemother. | pmid:9301996 |
| Stone GG et al. | PCR-RFLP typing of ureC from Helicobacter pylori isolated from gastric biopsies during a European multi-country clinical trial. | 1997 | J. Antimicrob. Chemother. | pmid:9301991 |
| Irie Y et al. | Antibiotic MICs and short time-killing against Helicobacter pylori: therapeutic potential of kanamycin. | 1997 | J. Antimicrob. Chemother. | pmid:9301989 |
| Bardhan KD et al. | Ranitidine bismuth citrate with clarithromycin for the treatment of duodenal ulcer. | 1997 | Gut | pmid:9301496 |
| Laberge P and Martineau P | Clarithromycin-induced digoxin intoxication. | 1997 | Ann Pharmacother | pmid:9296239 |
| Recker MW and Kier KL | Potential interaction between clarithromycin and warfarin. | 1997 | Ann Pharmacother | pmid:9296238 |
| Visalli MA et al. | Susceptibility of twenty penicillin-susceptible and -resistant pneumococci to levofloxacin, ciprofloxacin, ofloxacin, erythromycin, azithromycin, and clarithromycin by MIC and time-kill. | 1997 | Diagn. Microbiol. Infect. Dis. | pmid:9294703 |
| Akaki T et al. | [In vivo activities of benzoxazinorifamycin KRM-1648, clarithromycin, and levofloxacin, or combination of KRM-1648 with diclofenac sodium against Mycobacterium avium infection induced in mice]. | 1997 | Kekkaku | pmid:9293712 |
| Kearsley NL et al. | Comparison of clarithromycin suspension and amoxycillin syrup for the treatment of children with pharyngitis and/or tonsillitis. | 1997 Apr-May | Br J Clin Pract | pmid:9293051 |
| Sekkarie MA | Torsades de pointes in two chronic renal failure patients treated with cisapride and clarithromycin. | 1997 | Am. J. Kidney Dis. | pmid:9292575 |
| Kobler E et al. | [Effectiveness of short-term triple therapy for healing Helicobacter pylori infection in ulcer disease]. | 1997 | Schweiz Med Wochenschr Suppl | pmid:9289833 |
| Tan WC et al. | Helicobacter pylori eradication--comparison of three drug regimens and symptomatic assessment in duodenitis and antral gastritis. | 1997 | Int. J. Clin. Pract. | pmid:9287260 |
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| Hirakawa T | [Diagnosis and treatment of Helicobacter pylori]. | 1997 | Nippon Ika Daigaku Zasshi | pmid:9283206 |
| Lam SK et al. | Does treatment of Helicobacter pylori with antibiotics alone heal duodenal ulcer? A randomised double blind placebo controlled study. | 1997 | Gut | pmid:9274470 |
| Current European concepts in the management of Helicobacter pylori infection. The Maastricht Consensus Report. European Helicobacter Pylori Study Group. | 1997 | Gut | pmid:9274464 | |
| Marone P et al. | Rapid drug susceptibility of Mycobacterium avium complex using a fluorescence quenching method. | 1997 | J Chemother | pmid:9269603 |
| Uemura N et al. | Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer. | 1997 | Cancer Epidemiol. Biomarkers Prev. | pmid:9264278 |
| Sato K et al. | [Anti-Mycobacterium avium complex activities of KRM-1648, clarithromycin and levofloxacin in 7HSF medium at peak or average blood concentrations after their oral administration of clinical dosages]. | 1997 | Kekkaku | pmid:9259129 |
| Shibata K et al. | Bactericidal effect of ecabet sodium on clarithromycin- and metronidazole-resistant clinical isolates of Helicobacter pylori. | 1997 | Jpn J Antibiot | pmid:9258741 |
| Polis MA et al. | Clarithromycin lowers plasma zidovudine levels in persons with human immunodeficiency virus infection. | 1997 | Antimicrob. Agents Chemother. | pmid:9257746 |
| Rouse MS et al. | Efficacy of azithromycin or clarithromycin for prophylaxis of viridans group streptococcus experimental endocarditis. | 1997 | Antimicrob. Agents Chemother. | pmid:9257739 |
| Böttger EC et al. | Prophylaxis of mycobacterial infection and acquired drug resistance. | 1997 | J. Antimicrob. Chemother. | pmid:9249224 |
| Fuursted K | Evaluation of the post-antibiotic effect of six anti-mycobacterial agents against Mycobacterium avium by the Bactec radiometric method. | 1997 | J. Antimicrob. Chemother. | pmid:9249202 |
| Gisbert JP et al. | Unhealed duodenal ulcers despite Helicobacter pylori eradication. | 1997 | Scand. J. Gastroenterol. | pmid:9246702 |
| Saluja A et al. | A surgical wound infection due to Mycobacterium chelonae successfully treated with clarithromycin. | 1997 | Dermatol Surg | pmid:9236871 |
| Sano M et al. | [A clinical study on combination therapy of antimicrobial agents for complicated urinary tract infection--with special reference to combination with clarithromycin]. | 1997 | Nippon Hinyokika Gakkai Zasshi | pmid:9234616 |
| Hoffman JS | Pharmacological therapy of Helicobacter pylori infection. | 1997 | Semin. Gastrointest. Dis. | pmid:9232728 |
| Matsumoto T et al. | Regression of mucosa-associated lymphoid-tissue lymphoma of rectum after eradication of Helicobacter pylori. | 1997 | Lancet | pmid:9228971 |
| Svoboda P et al. | Pantoprazole-based dual and triple therapy for the eradication of Helicobacter pylori infection: a randomized controlled trial. | 1997 May-Jun | Hepatogastroenterology | pmid:9222709 |
| Gisbert JP et al. | [What is the current role of clarithromycin in the eradication of Helicobacter pylori?]. | 1997 | Rev Esp Enferm Dig | pmid:9221019 |
| Nawarskas JJ et al. | Digoxin toxicity secondary to clarithromycin therapy. | 1997 Jul-Aug | Ann Pharmacother | pmid:9220047 |
| Grunden JW and Fisher KA | Lovastatin-induced rhabdomyolysis possibly associated with clarithromycin and azithromycin. | 1997 Jul-Aug | Ann Pharmacother | pmid:9220046 |
| Hoppe JE and Tschirner T | Comparison of Etest and agar dilution for testing the activity of three macrolides against Bordetella parapertussis. | 1997 | Diagn. Microbiol. Infect. Dis. | pmid:9218920 |
| O'Brien B et al. | Cost effectiveness of alternative Helicobacter pylori eradication strategies in the management of duodenal ulcer. | 1997 May-Jun | Can. J. Gastroenterol. | pmid:9218858 |
| Best LM et al. | Helicobacter pylori: primary susceptibility to clarithromycin in vitro in Nova Scotia. | 1997 May-Jun | Can. J. Gastroenterol. | pmid:9218854 |
| Lim AG et al. | Helicobacter pylori eradication using a 7-day regimen of low-dose clarithromycin, lansoprazole and amoxycillin. | 1997 | Aliment. Pharmacol. Ther. | pmid:9218079 |
| Chimura T | [Measurement of antibody titers to chlamydial infection and effects of levofloxacin in cystic cervicitis and chlamydial infection]. | 1997 | Jpn J Antibiot | pmid:9212369 |
| Meyer JM et al. | In vitro synergy testing of clarithromycin and 14-hydroxyclarithromycin with amoxicillin or bismuth subsalicylate against Helicobacter pylori. | 1997 | Antimicrob. Agents Chemother. | pmid:9210696 |
| Mikasa K et al. | Significant survival benefit to patients with advanced non-small-cell lung cancer from treatment with clarithromycin. | 1997 Jul-Aug | Chemotherapy | pmid:9209786 |
| Kim MJ et al. | Serum 13C-bicarbonate assay for the diagnosis of gastric Helicobacter pylori infection and response to treatment. | 1997 | Gastroenterology | pmid:9207259 |
| Verhaegen J et al. | Impredictable susceptibility for cephalosporins in penicillin resistant Streptococcus pneumoniae. | 1997 | Acta Clin Belg | pmid:9204588 |
| Götz JM et al. | Treatment of Helicobacter pylori infection favourably affects gastric mucosal superoxide dismutases. | 1997 | Gut | pmid:9203935 |
| Kato S et al. | Omeprazole-based dual and triple regimens for Helicobacter pylori eradication in children. | 1997 | Pediatrics | pmid:9200377 |
| Marignani M et al. | Reversal of long-standing iron deficiency anaemia after eradication of Helicobacter pylori infection. | 1997 | Scand. J. Gastroenterol. | pmid:9200297 |
| Fréhel C et al. | The phagosomal environment protects virulent Mycobacterium avium from killing and destruction by clarithromycin. | 1997 | Infect. Immun. | pmid:9199452 |
| Lo WC et al. | Clarithromycin in the combination therapy for the eradication of Helicobacter pylori in peptic ulcer disease. | 1997 | Zhonghua Yi Xue Za Zhi (Taipei) | pmid:9198292 |
| Rubin BK et al. | Effect of clarithromycin on nasal mucus properties in healthy subjects and in patients with purulent rhinitis. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9196110 |
| Gabl M et al. | Flexor tenosynovitis in the hand caused by Mycobacterium malmoense: a case report. | 1997 | J Hand Surg Am | pmid:9195437 |
| Villanueva A et al. | Report on an outbreak of postinjection abscesses due to Mycobacterium abscessus, including management with surgery and clarithromycin therapy and comparison of strains by random amplified polymorphic DNA polymerase chain reaction. | 1997 | Clin. Infect. Dis. | pmid:9195073 |
| Griffith DE | Nontuberculous mycobacteria. | 1997 | Curr Opin Pulm Med | pmid:9193860 |
| Katari SR et al. | Clinical features of acute reversible tacrolimus (FK 506) nephrotoxicity in kidney transplant recipients. | 1997 | Clin Transplant | pmid:9193849 |
| Waites K et al. | In vitro activities of oral antimicrobial agents against penicillin-resistant Streptococcus pneumoniae: implications for outpatient treatment. | 1997 | South. Med. J. | pmid:9191739 |
| Ebell MH et al. | Evaluation of the dyspeptic patient: a cost-utility study. | 1997 | J Fam Pract | pmid:9191627 |
| Damianos AJ and McGarrity TJ | Treatment strategies for Helicobacter pylori infection. | 1997 | Am Fam Physician | pmid:9191460 |
| Gisbert JP et al. | [One-week treatment with omeprazole, clarithromycin and amoxicillin: high efficacy in the eradication of Helicobacter pylori and cicatrization of duodenal ulcer]. | 1997 | Med Clin (Barc) | pmid:9190436 |
| Kadayifçi A et al. | Clarithromycin-induced fever in a patient with Helicobacter pylori gastritis. | 1997 | Ann Pharmacother | pmid:9184727 |
| Pellegrin I et al. | Activity of rifabutin, clarithromycin, ethambutol, sparfloxacin and amikacin, alone and in combination, against Mycobacterium avium complex in human macrophages. | 1996 | J. Antimicrob. Chemother. | pmid:9182107 |
| Langtry HD and Brogden RN | Clarithromycin. A review of its efficacy in the treatment of respiratory tract infections in immunocompetent patients. | 1997 | Drugs | pmid:9179528 |
| Nakao K et al. | Relation of lactoferrin levels in gastric mucosa with Helicobacter pylori infection and with the degree of gastric inflammation. | 1997 | Am. J. Gastroenterol. | pmid:9177520 |
| Veldhuyzen van Zanten SJ et al. | Helicobacter pylori: new developments and treatments. | 1997 | CMAJ | pmid:9176424 |
| Rodvold KA et al. | Intrapulmonary steady-state concentrations of clarithromycin and azithromycin in healthy adult volunteers. | 1997 | Antimicrob. Agents Chemother. | pmid:9174209 |
| Tillenburg B et al. | [Helicobacter pylori: pretherapeutic resistance status in Germany (Ruhr area)]. | 1997 | Z Gastroenterol | pmid:9173687 |
| Alfandari S et al. | Isolated cutaneous Mycobacterium avium complex infection in AIDS. | 1997 | Int. J. Dermatol. | pmid:9169332 |
| OÄŸuz O et al. | Conjunctival involvement in familial chronic benign pemphigus (Hailey-Hailey disease). | 1997 | Int. J. Dermatol. | pmid:9169328 |
| Walsh D et al. | One week treatment for Helicobacter pylori infection. | 1997 | Arch. Dis. Child. | pmid:9166031 |
| Nilius AM et al. | Variability in susceptibilities of Haemophilus influenzae to clarithromycin and azithromycin due to medium pH. | 1997 | J. Clin. Microbiol. | pmid:9163435 |
| Peloquin CA and Berning SE | Advice on treatment of Mycobacterium avium complex infection. | 1997 | Am J Health Syst Pharm | pmid:9161632 |
| Misiewicz JJ | Management of Helicobacter pylori-related disorders. | 1997 | Eur J Gastroenterol Hepatol | pmid:9160212 |
| Garrison MW et al. | Influence of pH on the antimicrobial activity of clarithromycin and 14-hydroxyclarithromycin against Haemophilus influenzae using an in vitro pharmacodynamic model. | 1997 | Diagn. Microbiol. Infect. Dis. | pmid:9154410 |
| Rodrigues AD et al. | Oxidative metabolism of clarithromycin in the presence of human liver microsomes. Major role for the cytochrome P4503A (CYP3A) subfamily. | 1997 | Drug Metab. Dispos. | pmid:9152603 |
| Chaisson RE et al. | Clarithromycin and ethambutol with or without clofazimine for the treatment of bacteremic Mycobacterium avium complex disease in patients with HIV infection. | 1997 | AIDS | pmid:9147422 |
| Peterson WL | The role of antisecretory drugs in the treatment of Helicobacter pylori infection. | 1997 | Aliment. Pharmacol. Ther. | pmid:9146787 |
| Spinzi G et al. | Randomized study comparing omeprazole plus amoxycillin versus omeprazole plus clarithromycin for eradication of Helicobacter pylori. | 1997 | Aliment. Pharmacol. Ther. | pmid:9146769 |
| Lounis N et al. | Comparative activities of amikacin against Mycobacterium avium complex in nude and beige mice. | 1997 | Antimicrob. Agents Chemother. | pmid:9145892 |
| Collins L and Franzblau SG | Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium. | 1997 | Antimicrob. Agents Chemother. | pmid:9145860 |
| Khan AA et al. | Activity of trovafloxacin in combination with other drugs for treatment of acute murine toxoplasmosis. | 1997 | Antimicrob. Agents Chemother. | pmid:9145840 |
| Plemmons RM et al. | Osteomyelitis due to Mycobacterium haemophilum in a cardiac transplant patient: case report and analysis of interactions among clarithromycin, rifampin, and cyclosporine. | 1997 | Clin. Infect. Dis. | pmid:9142810 |
| Guillemet C et al. | [Clarithromycin-digoxin: an unrecognized interaction in some patients]. | 1997 | Presse Med | pmid:9137381 |
| Spicer ST et al. | The mechanism of cyclosporine toxicity induced by clarithromycin. | 1997 | Br J Clin Pharmacol | pmid:9131953 |
| [Management of atypical Mycobacterium infections in AIDS-patients]. | 1996 | Internist (Berl) | pmid:9131082 | |
| Stone GG et al. | PCR-RFLP typing of ureC from Helicobacter pylori isolated in Argentina from gastric biopsies before and after treatment with clarithromycin. | 1997 | Epidemiol. Infect. | pmid:9129588 |
| Lazzaroni M et al. | Triple therapy with ranitidine or lansoprazole in the treatment of Helicobacter pylori-associated duodenal ulcer. | 1997 | Am. J. Gastroenterol. | pmid:9128316 |
| Hultén K et al. | New pharmacokinetic in vitro model for studies of antibiotic activity against intracellular microorganisms. | 1996 | Antimicrob. Agents Chemother. | pmid:9124830 |
| Cadranel JF et al. | [Acute symptomatic cytolytic hepatitis probably related to clarithromycin]. | 1996 | Gastroenterol. Clin. Biol. | pmid:9119179 |
| Rodrigo Sáez L et al. | [The efficacy of using a short course of 6-day duration (OCA-6) in the treatment to eradicate Helicobacter pylori infection. Omeprazole, clarithromycin, amoxicillin]. | 1997 | Rev Esp Enferm Dig | pmid:9115827 |
| Tarlow MJ et al. | Future indications for macrolides. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109159 |
| Block SL | Causative pathogens, antibiotic resistance and therapeutic considerations in acute otitis media. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109158 |
| Tarlow MJ | Macrolides in the management of streptococcal pharyngitis/tonsillitis. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109157 |
| Nightingale CH | Pharmacokinetics and pharmacodynamics of newer macrolides. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109156 |
| McCracken GH | Microbiologic activity of the newer macrolide antibiotics. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109155 |
| Klein JO | History of macrolide use in pediatrics. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109154 |
| Arguedas A et al. | Comparative trial of 3 days of azithromycin versus 10 days of clarithromycin in the treatment of children with acute otitis media with effusion. | 1997 | J Chemother | pmid:9106017 |
| Fietta A et al. | Requirements for intracellular accumulation and release of clarithromycin and azithromycin by human phagocytes. | 1997 | J Chemother | pmid:9106014 |
| Fietta A et al. | Inhibition of intracellular growth of Staphylococcus aureus by exposure of infected human monocytes to clarithromycin and azithromycin. | 1997 | J Chemother | pmid:9106013 |
| Szczebara F et al. | Evaluation of rapid molecular methods for detection of clarithromycin resistance in Helicobacter pylori. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9105846 |
| Kato A | [Effect of erythromycin and clarithromycin on ion transport across dissected canine tracheal epithelium]. | 1997 | Nippon Jibiinkoka Gakkai Kaiho | pmid:9103848 |