clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Arthritis D001168 41 associated lipids
Surgical Wound Infection D013530 7 associated lipids
Abscess D000038 13 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Gastritis D005756 27 associated lipids
Heart Failure D006333 36 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Rodent Diseases D012376 4 associated lipids
Osteomyelitis D010019 10 associated lipids
Pancreatitis D010195 10 associated lipids
Skin Ulcer D012883 6 associated lipids
Cysts D003560 4 associated lipids
Urination Disorders D014555 9 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Abnormalities, Drug-Induced D000014 10 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


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Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Authors Title Published Journal PubMed Link
Struillou L et al. Activities of roxithromycin against Mycobacterium avium infections in human macrophages and C57BL/6 mice. 1995 Antimicrob. Agents Chemother. pmid:7785988
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Truffot-Pernot C et al. Clarithromycin is inactive against Mycobacterium tuberculosis. 1995 Antimicrob. Agents Chemother. pmid:8593032
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Ford A et al. Clarithromycin-induced digoxin toxicity in a patient with AIDS. 1995 Clin. Infect. Dis. pmid:8645810
Gidoh M and Saito H [Present status of studies on antileprosy drugs]. 1995 Nihon Rai Gakkai Zasshi pmid:8582877
Gioulekas J and Hall A Uveitis associated with rifabutin therapy. 1995 Aust N Z J Ophthalmol pmid:11980079
Reid R et al. Pneumococcal meningitis during therapy of otitis media with clarithromycin. 1995 Pediatr. Infect. Dis. J. pmid:8786899
Van Asselt GJ et al. Susceptibility of Streptococcus pyogenes to azithromycin, clarithromycin, erythromycin and roxithromycin in vitro. 1995 J. Med. Microbiol. pmid:7563004
Parasakthi N and Goh KL Primary and acquired resistance to clarithromycin among Helicobacter pylori strains in Malaysia. 1995 Am. J. Gastroenterol. pmid:7872306
Kadayifçi A et al. Low dose clarithromycin plus omeprazole eradicates Helicobacter pylori in duodenal ulcer disease. 1995 Am. J. Gastroenterol. pmid:7872307
Clarithromycin for MAC. 1995 AIDS Patient Care pmid:11361361
Wallace RJ et al. Reduced serum levels of clarithromycin in patients treated with multidrug regimens including rifampin or rifabutin for Mycobacterium avium-M. intracellulare infection. 1995 J. Infect. Dis. pmid:7876634
Moorthy RS and Rao NA Atypical mycobacterial wound infection after blepharoplasty. 1995 Br J Ophthalmol pmid:7880802
Yoshizawa A et al. [Legionella pneumonia diagnosed by urinary antigen detection]. 1995 Nihon Kyobu Shikkan Gakkai Zasshi pmid:7791279
Claussen DW The most commonly prescribed medications in the United States: Part 3. 1995 Jul-Aug Gastroenterol Nurs pmid:7654815
Hashisaki GT Update on macrolide antibiotics. 1995 May-Jun Am J Otolaryngol pmid:7661309
Kees F et al. Serum and cellular pharmacokinetics of clarithromycin 500 mg q.d. and 250 mg b.i.d. in volunteers. 1995 May-Jun Infection pmid:7499006
Sternon J et al. Azithromycin compared with clarithromycin in the treatment of adult patients with acute purulent tracheobronchitis: a cost of illness study. 1995 Nov-Dec J. Int. Med. Res. pmid:8746608
Stein GE et al. A preliminary study of clarithromycin versus doxycycline in the treatment of nongonococcal urethritis and mucopurulent cervicitis. 1995 Nov-Dec Pharmacotherapy pmid:8602379
Dalston MO et al. [Clarithromycin combined with pyrimethamine in cerebral toxoplasmosis--a report of 2 cases]. 1995 Oct-Dec Rev. Soc. Bras. Med. Trop. pmid:8668843
Pinzani V et al. [Occurrence of anterior uveitis in a HIV patient treated with rifabutin, ethambutol, clarithromycin]. 1995 Sep-Oct Therapie pmid:8571297
Lowe SH et al. Uveitis during treatment of disseminated Mycobacterium avium-intracellulare complex infection with the combination of rifabutin, clarithromycin and ethambutol. 1996 Neth J Med pmid:8710040
Vasquez A et al. Metronidazole and clarithromycin resistance in Helicobacter pylori determined by measuring MICs of antimicrobial agents in color indicator egg yolk agar in a miniwell format. The Gastrointestinal Physiology Working Group of Universidad Peruana Cayetano Heredia and the Johns Hopkins University. 1996 J. Clin. Microbiol. pmid:8727909
Darouiche RO et al. Recurrent disseminated infection with Mycobacterium avium complex identified in tissues by molecular analysis. 1996 Clin. Infect. Dis. pmid:8729215
Gillum JG et al. Effect of clarithromycin on the pharmacokinetics of 2',3'-dideoxyinosine in patients who are seropositive for human immunodeficiency virus. 1996 Clin. Infect. Dis. pmid:8729217
Apseloff G et al. Severe neutropenia caused by recommended prophylactic doses of rifabutin. 1996 Lancet pmid:8782773
Pankuch GA et al. MIC and time-kill study of antipneumococcal activities of RPR 106972 (a new oral streptogramin), RP 59500 (quinupristin-dalfopristin), pyostacine (RP 7293), penicillin G, cefotaxime, erythromycin, and clarithromycin against 10 penicillin-susceptible and -resistant pneumococci. 1996 Antimicrob. Agents Chemother. pmid:8878583
Tateda K et al. Direct evidence for antipseudomonal activity of macrolides: exposure-dependent bactericidal activity and inhibition of protein synthesis by erythromycin, clarithromycin, and azithromycin. 1996 Antimicrob. Agents Chemother. pmid:8891128
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Tomioka H et al. [Preclinical study of therapeutic agents used against Mycobacterium avium complex infections--with special reference to new macrolides and new quinolones]. 1996 Kekkaku pmid:8999135
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Rana KZ et al. Clarithromycin does not affect phosphorylation of zidovudine in vitro. 1996 Antimicrob. Agents Chemother. pmid:8843311
Flamm RK et al. Kill kinetics of antimicrobial agents against Helicobacter pylori. 1996 J. Antimicrob. Chemother. pmid:8937967
Bermudez LE et al. Effect of ethambutol on emergence of clarithromycin-resistant Mycobacterium avium complex in the beige mouse model. 1996 J. Infect. Dis. pmid:8940212
Nagashima R et al. Regression of duodenal mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori. 1996 Gastroenterology pmid:8942749
McLinn S and Williams D Incidence of antibiotic-resistant Streptococcus pneumoniae and beta-lactamase-positive Haemophilus influenzae in clinical isolates from patients with otitis media. 1996 Pediatr. Infect. Dis. J. pmid:8878239
Wenisch C et al. Effect of single oral dose of azithromycin, clarithromycin, and roxithromycin on polymorphonuclear leukocyte function assessed ex vivo by flow cytometry. 1996 Antimicrob. Agents Chemother. pmid:8878577
Pierce M et al. A randomized trial of clarithromycin as prophylaxis against disseminated Mycobacterium avium complex infection in patients with advanced acquired immunodeficiency syndrome. 1996 N. Engl. J. Med. pmid:8663871
Rastogi N et al. In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain in human macrophages. 1996 Curr. Microbiol. pmid:8672093
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Bachelez H et al. Disseminated varioliform pustular eruption due to Mycobacterium avium intracellulare in an HIV-infected patient. 1996 Br. J. Dermatol. pmid:8733397
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New data suggest antibiotic clarithromycin is effective in prolonging life of AIDS patients. 1996 AIDS Patient Care STDS pmid:11361575
Clarithromycin and MAC. 1996 AIDS Patient Care STDS pmid:11361673
Harris AW et al. Lansoprazole, clarithromycin and metronidazole for seven days in Helicobacter pylori infection. 1996 Aliment. Pharmacol. Ther. pmid:8971302
Moshkowitz M et al. One week triple therapy with omeprazole, clarithromycin and tinidazole for Helicobacter pylori: differing efficacy in previously treated and untreated patients. 1996 Aliment. Pharmacol. Ther. pmid:8971304
Laine L et al. Randomized comparison of differing periods of twice-a-day triple therapy for the eradication of Helicobacter pylori. 1996 Aliment. Pharmacol. Ther. pmid:8971306
Patel KB et al. Comparison of bronchopulmonary pharmacokinetics of clarithromycin and azithromycin. 1996 Antimicrob. Agents Chemother. pmid:8891147