clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Encephalitis D004660 15 associated lipids
Encephalomyelitis, Acute Disseminated D004673 1 associated lipids
Endometriosis D004715 29 associated lipids
Enterocolitis, Pseudomembranous D004761 8 associated lipids
Ergotism D004881 4 associated lipids
Erythema Nodosum D004893 5 associated lipids
Esophagitis, Peptic D004942 4 associated lipids
Euthyroid Sick Syndromes D005067 1 associated lipids
Exanthema D005076 11 associated lipids
Fever D005334 35 associated lipids
Fibrosis D005355 23 associated lipids
Fistula D005402 8 associated lipids
Foot Diseases D005534 4 associated lipids
Fractures, Open D005597 3 associated lipids
Fusobacterium Infections D005674 3 associated lipids
Gastritis D005756 27 associated lipids
Gastritis, Atrophic D005757 4 associated lipids
Gastritis, Hypertrophic D005758 1 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Giardiasis D005873 3 associated lipids
Glossitis, Benign Migratory D005929 1 associated lipids
Granuloma, Plasma Cell D006104 1 associated lipids
Hand Dermatoses D006229 5 associated lipids
Hearing Disorders D006311 10 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Heart Failure D006333 36 associated lipids
Hemolysis D006461 131 associated lipids
Hemophilia A D006467 10 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hernia, Hiatal D006551 3 associated lipids
HIV Seropositivity D006679 15 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperemesis Gravidarum D006939 2 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hypoproteinemia D007019 1 associated lipids
Immunoproliferative Small Intestinal Disease D007161 2 associated lipids
Infant, Premature, Diseases D007235 7 associated lipids
Influenza, Human D007251 11 associated lipids
Insulin Resistance D007333 99 associated lipids
Iris Diseases D007499 2 associated lipids
Iritis D007500 2 associated lipids
Ischemia D007511 18 associated lipids
Keratoconjunctivitis D007637 3 associated lipids
Klebsiella Infections D007710 7 associated lipids
Obstetric Labor, Premature D007752 9 associated lipids
Legionnaires' Disease D007877 4 associated lipids
Leishmaniasis, Visceral D007898 13 associated lipids
Leprosy D007918 8 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Per page 10 20 50 100 | Total 7636
Authors Title Published Journal PubMed Link
Heifets LB et al. Clarithromycin minimal inhibitory and bactericidal concentrations against Mycobacterium avium. 1992 Am. Rev. Respir. Dis. pmid:1532486
Guay DR and Craft JC Comparative safety and efficacy of clarithromycin and ampicillin in the treatment of out-patients with acute bacterial exacerbation of chronic bronchitis. 1992 J. Intern. Med. pmid:1532615
Chonmaitree T et al. Effect of viral respiratory tract infection on outcome of acute otitis media. 1992 J. Pediatr. pmid:1534364
Neu HC New macrolide antibiotics: azithromycin and clarithromycin. 1992 Ann. Intern. Med. pmid:1310839
Chu SY et al. Absolute bioavailability of clarithromycin after oral administration in humans. 1992 Antimicrob. Agents Chemother. pmid:1387301
Yajko DM et al. Comparison of the intracellular activities of clarithromycin and erythromycin against Mycobacterium avium complex strains in J774 cells and in alveolar macrophages from human immunodeficiency virus type 1-infected individuals. 1992 Antimicrob. Agents Chemother. pmid:1387302
Calzolari E et al. The efficacy of clarythromycin (A-56268, TE-031) in the treatment of genital chlamydial infection. 1992 Drugs Exp Clin Res pmid:1306155
Klemens SP et al. Activity of clarithromycin against Mycobacterium avium complex infection in beige mice. 1992 Antimicrob. Agents Chemother. pmid:1336945
Ji B et al. Bactericidal activities of single or multiple doses of various combinations of new antileprosy drugs and/or rifampin against M. leprae in mice. 1992 Int. J. Lepr. Other Mycobact. Dis. pmid:1338596
Yajko DM In vitro activity of antimicrobial agents against the Mycobacterium avium complex inside macrophages from HIV1-infected individuals: the link to clinical response to treatment? 1992 Res. Microbiol. pmid:1455069
Omura S et al. [Research and development of clarithromycin]. 1992 Yakugaku Zasshi pmid:1469609
Chu SY et al. Clarithromycin pharmacokinetics in healthy young and elderly volunteers. 1992 J Clin Pharmacol pmid:1474166
Gelber RH et al. Clarithromycin at very low levels and on intermittent administration inhibits the growth of M. leprae in mice. 1992 Int. J. Lepr. Other Mycobact. Dis. pmid:1474290
Rehg JE Anti-cryptosporidial activity of macrolides in immunosuppressed rats. 1991 Nov-Dec J. Protozool. pmid:1667930
Hughes WT Macrolide-antifol synergism in anti-Pneumocystis carinii therapeutics. 1991 Nov-Dec J. Protozool. pmid:1818149
De Punzio C et al. Isolation of Chlamydia trachomatis during IVF-ET. 1991 Jul-Aug Acta Eur. Fertil. pmid:1844324
Cogo R et al. [Dynamics of sIgA concentration in bronchial secretions in patients with COBP treated with clarithromycin]. 1991 Jan-Dec G Ital Chemioter pmid:1365564
Clarithro- and azithromycin--better erythromycins? 1991 Drug Ther Bull pmid:1665125
Perronne C et al. Activities of sparfloxacin, azithromycin, temafloxacin, and rifapentine compared with that of clarithromycin against multiplication of Mycobacterium avium complex within human macrophages. 1991 Antimicrob. Agents Chemother. pmid:1656860
Truffot-Pernot C et al. Effect of pH on the in vitro potency of clarithromycin against Mycobacterium avium complex. 1991 Antimicrob. Agents Chemother. pmid:1834015