| MeSH term | MeSH ID | Detail |
|---|---|---|
| Bacterial Infections | D001424 | 21 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Stomach Diseases | D013272 | 7 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Leishmaniasis, Visceral | D007898 | 13 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with clarithromycin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (5)
- Drug Metab. Dispos. (1)
- FEMS Immunol. Med. Microbiol. (1)
- Others (5)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fontana C et al. | Detection of clarithromycin-resistant Helicobacter pylori in stool samples. | 2003 | J. Clin. Microbiol. | pmid:12904368 |
| Laine L | Is it time for quadruple therapy to be first line? | 2003 | Can. J. Gastroenterol. | pmid:12905979 |
| Miyazaki M et al. | Macrolide antibiotics inhibit prostaglandin E2 synthesis and mRNA expression of prostaglandin synthetic enzymes in human leukocytes. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12907132 |
| Drummond MF et al. | An economic evaluation of sequential i.v./po moxifloxacin therapy compared to i.v./po co-amoxiclav with or without clarithromycin in the treatment of community-acquired pneumonia. | 2003 | Chest | pmid:12907538 |
| Godoy AP et al. | Analysis of antimicrobial susceptibility and virulence factors in Helicobacter pylori clinical isolates. | 2003 | BMC Gastroenterol | pmid:12911839 |
| Miyashita N et al. | In vitro activity of cethromycin, a novel antibacterial ketolide, against Chlamydia pneumoniae. | 2003 | J. Antimicrob. Chemother. | pmid:12917246 |
| Walsh F et al. | High-level telithromycin resistance in laboratory-generated mutants of Streptococcus pneumoniae. | 2003 | J. Antimicrob. Chemother. | pmid:12917252 |
| Clarkson JE et al. | Interventions for preventing oral mucositis for patients with cancer receiving treatment. | 2003 | Cochrane Database Syst Rev | pmid:12917895 |
| Mauriello JA | Atypical mycobacterial infection of the periocular region after periocular and facial surgery. | 2003 | Ophthalmic Plast Reconstr Surg | pmid:12918551 |
| Baron BW et al. | Thrombotic thrombocytopenic purpura after cephalosporin administration: a possible relationship. | 2003 | Transfusion | pmid:12919436 |
| Holzer MP et al. | [Diagnosis and treatment of mycobacterial keratitis following LASIK. Case report and review of the literature]. | 2003 | Ophthalmologe | pmid:12920556 |
| Isomoto H et al. | A case of mucosa-associated lymphoid tissue lymphoma of the ampulla of Vater: successful treatment with radiation therapy. | 2003 | Eur J Gastroenterol Hepatol | pmid:12923379 |
| Shimokata K | Treatment of pulmonary disease caused by Mycobacterium avium complex. | 2003 | Intern. Med. | pmid:12924480 |
| Kobashi Y and Matsushima T | The effect of combined therapy according to the guidelines for the treatment of Mycobacterium avium complex pulmonary disease. | 2003 | Intern. Med. | pmid:12924489 |
| Jones ME et al. | In vitro susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis: a European multicenter study during 2000-2001. | 2003 | Clin. Microbiol. Infect. | pmid:12925097 |
| Loffeld RJ and Fijen CA | Antibiotic resistance of Helicobacter pylori: a cross-sectional study in consecutive patients, and relation to ethnicity. | 2003 | Clin. Microbiol. Infect. | pmid:12925098 |
| Bozdogan B et al. | Activity of telithromycin and seven other agents against 1034 pediatric Streptococcus pneumoniae isolates from ten central and eastern European centers. | 2003 | Clin. Microbiol. Infect. | pmid:12925106 |
| Ioannidou S et al. | In vitro activity of telithromycin (HMR 3647) against Greek Streptococcus pyogenes and Streptococcus pneumoniae clinical isolates with different macrolide susceptibilities. | 2003 | Clin. Microbiol. Infect. | pmid:12925112 |
| Bozdogan B et al. | Activity of telithromycin compared with seven other agents against 1039 Streptococcus pyogenes pediatric isolates from ten centers in central and eastern Europe. | 2003 | Clin. Microbiol. Infect. | pmid:12925122 |
| Ohsaki Y et al. | Alterations in penicillin binding protein gene of Streptococcus pneumoniae and their correlation with susceptibility patterns. | 2003 | Int. J. Antimicrob. Agents | pmid:12927954 |
| Sifrim D et al. | Comparison of the effects of midecamycin acetate and clarithromycin on gastrointestinal motility in man. | 1992 | Drugs Exp Clin Res | pmid:1292916 |
| Toy BR and Frank PJ | Outbreak of Mycobacterium abscessus infection after soft tissue augmentation. | 2003 | Dermatol Surg | pmid:12930343 |
| Parr DG et al. | Panniculitis secondary to extravasation of clarithromycin in a patient with alpha 1-antitrypsin deficiency (phenotype PiZ). | 2003 | Br. J. Dermatol. | pmid:12932253 |
| Kindergarten-based outbreak of perianal group A streptococcal infection. | 2003 | Arch. Dis. Child. | pmid:12937107 | |
| Ebrahimi-Dariani N et al. | The efficacy of furazolidone-based quadruple therapy for eradication of Helicobacter pylori infection in Iranian patients resistant to metronidazole-based quadruple therapy. | 2003 | Med. Sci. Monit. | pmid:12942042 |
| Gordon KA et al. | Comparison of Streptococcus pneumoniae and Haemophilus influenzae susceptibilities from community-acquired respiratory tract infections and hospitalized patients with pneumonia: five-year results for the SENTRY Antimicrobial Surveillance Program. | 2003 | Diagn. Microbiol. Infect. Dis. | pmid:12944021 |
| Forslöw U et al. | Early chemotherapy for non-tuberculous mycobacterial infections in patients with cystic fibrosis. | 2003 | Acta Paediatr. | pmid:12948065 |
| Uthaisaengsook W | Low dose, one-week triple therapy (lanzoprazole, amoxycillin, clarithromycin) for eradication of Helicobacter pylori infection. | 2003 | J Med Assoc Thai | pmid:12948252 |
| Sagir A et al. | Inhibition of cytochrome P450 3A: relevant drug interactions in gastroenterology. | 2003 | Digestion | pmid:12949438 |
| Nakamura M et al. | Gastric juice, gastric tissue and blood antibiotic concentrations following omeprazole, amoxicillin and clarithromycin triple therapy. | 2003 | Helicobacter | pmid:12950601 |
| Miehlke S et al. | A prospective, randomized study of quadruple therapy and high-dose dual therapy for treatment of Helicobacter pylori resistant to both metronidazole and clarithromycin. | 2003 | Helicobacter | pmid:12950604 |
| Baier RJ et al. | Failure of erythromycin to eliminate airway colonization with ureaplasma urealyticum in very low birth weight infants. | 2003 | BMC Pediatr | pmid:12956892 |
| Zhang L et al. | P-glycoprotein restricted transport of nimodipine across blood-brain barrier. | 2003 | Acta Pharmacol. Sin. | pmid:12956939 |
| Abeyama K et al. | Antibiotic cyclic AMP signaling by "primed" leukocytes confers anti-inflammatory cytoprotection. | 2003 | J. Leukoc. Biol. | pmid:12960287 |
| Andrzejewska E et al. | Characterization of Helicobacter pylori strainsisolated before and after therapy. | 2003 | Med. Sci. Monit. | pmid:12960930 |
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| Gamova NA | [Drug sensitivity of Ureaplasma urealyticum, persisting in patients with chronic inflammatory diseases of the urogenital tract]. | 2003 Jul-Aug | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:12966887 |
| Johnson DM et al. | Susceptibility trends of haemophilus influenzae and Moraxella catarrhalis against orally administered antimicrobial agents: five-year report from the SENTRY Antimicrobial Surveillance Program. | 2003 | Diagn. Microbiol. Infect. Dis. | pmid:12967753 |
| Malfertheiner P et al. | Helicobacter pylori eradication is beneficial in the treatment of functional dyspepsia. | 2003 | Aliment. Pharmacol. Ther. | pmid:12969088 |
| Nista EC et al. | Levofloxacin-based triple therapy vs. quadruple therapy in second-line Helicobacter pylori treatment: a randomized trial. | 2003 | Aliment. Pharmacol. Ther. | pmid:12969089 |
| Hassan C et al. | Sequential treatment for Helicobacter pylori eradication in duodenal ulcer patients: improving the cost of pharmacotherapy. | 2003 | Aliment. Pharmacol. Ther. | pmid:12969091 |
| Lohitnavy O et al. | Average bioequivalence of generic clarithromycin tablets in healthy Thai male volunteers. | 2003 | Biopharm Drug Dispos | pmid:12973819 |
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| McCarthy DM et al. | Impact of cotherapy with some proton pump inhibitors on medical claims among HMO patients already using other common drugs also cleared by cytochrome P450. | 2003 Sep-Oct | Am J Ther | pmid:12975717 |
| Calzolari E et al. | The efficacy of clarythromycin (A-56268, TE-031) in the treatment of genital chlamydial infection. | 1992 | Drugs Exp Clin Res | pmid:1306155 |
| Bale MJ et al. | MIC quality control guidelines for Haemophilus susceptibility tests using cefdinir (FK482), cefepime, cefetamet, cefpirome, ceftibuten, fleroxacin, temafloxacin, clarithromycin, RP59500, and trospectomycin. | 1992 | J. Clin. Microbiol. | pmid:1310329 |
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| Brown BA et al. | Activities of four macrolides, including clarithromycin, against Mycobacterium fortuitum, Mycobacterium chelonae, and M. chelonae-like organisms. | 1992 | Antimicrob. Agents Chemother. | pmid:1317144 |
| Bahal N and Nahata MC | The new macrolide antibiotics: azithromycin, clarithromycin, dirithromycin, and roxithromycin. | 1992 | Ann Pharmacother | pmid:1318761 |
| Hammerschlag MR et al. | In vitro activities of azithromycin, clarithromycin, L-ofloxacin, and other antibiotics against Chlamydia pneumoniae. | 1992 | Antimicrob. Agents Chemother. | pmid:1324650 |
| Paulsen P et al. | Influence of azithromycin and other macrolides on the intracellular killing of Staphylococcus aureus by human polymorphonuclear leucocytes of healthy donors and a patient with Chédiak-Higashi syndrome. | 1992 | Chemotherapy | pmid:1324831 |
| Cynamon MH and Klemens SP | Activity of azithromycin against Mycobacterium avium infection in beige mice. | 1992 | Antimicrob. Agents Chemother. | pmid:1329622 |
| Cohen Y et al. | Activities of WIN-57273, minocycline, clarithromycin, and 14-hydroxy-clarithromycin against Mycobacterium avium complex in human macrophages. | 1992 | Antimicrob. Agents Chemother. | pmid:1332586 |
| Klemens SP et al. | Activity of clarithromycin against Mycobacterium avium complex infection in beige mice. | 1992 | Antimicrob. Agents Chemother. | pmid:1336945 |
| Ji B et al. | Bactericidal activities of single or multiple doses of various combinations of new antileprosy drugs and/or rifampin against M. leprae in mice. | 1992 | Int. J. Lepr. Other Mycobact. Dis. | pmid:1338596 |
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| Chapelsky MC et al. | Renal tubular enzyme effects of clarithromycin in comparison with gentamicin and placebo in volunteers. | 1992 Jul-Aug | Drug Saf | pmid:1355971 |
| Takeda H et al. | [A study to clarify the mechanism of the usefulness of the macrolides--the influence of clarithromycin to biofilm with P. aeruginosa]. | 1992 | Kansenshogaku Zasshi | pmid:1363435 |
| Cogo R et al. | [Dynamics of sIgA concentration in bronchial secretions in patients with COBP treated with clarithromycin]. | 1991 Jan-Dec | G Ital Chemioter | pmid:1365564 |
| Nalepa P et al. | Short-course therapy of acute bacterial exacerbation of chronic bronchitis: a double-blind, randomized, multicenter comparison of extended-release versus immediate-release clarithromycin. | 2003 | Curr Med Res Opin | pmid:13678478 |
| Takker U et al. | Comparison of 5 days of extended-release clarithromycin versus 10 days of penicillin V for the treatment of streptococcal pharyngitis/tonsillitis: results of a multicenter, double-blind, randomized study in adolescent and adult patients. | 2003 | Curr Med Res Opin | pmid:13678479 |
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