clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Hyperemesis Gravidarum D006939 2 associated lipids
Typhoid Fever D014435 2 associated lipids
Chromoblastomycosis D002862 2 associated lipids
Leprosy, Paucibacillary D056005 2 associated lipids
Diphtheria D004165 2 associated lipids
Soft Tissue Infections D018461 2 associated lipids
Empyema, Pleural D016724 2 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Mastoiditis D008417 2 associated lipids
Periodontal Abscess D010508 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Authors Title Published Journal PubMed Link
De Wit S et al. Acquired resistance to clarithromycin as combined therapy in Mycobacterium avium intracellulare infection. 1993 Lancet pmid:8093299
Maurin M and Raoult D In vitro susceptibilities of spotted fever group rickettsiae and Coxiella burnetti to clarithromycin. 1993 Antimicrob. Agents Chemother. pmid:8109928
Parish LC Clarithromycin in the treatment of skin and skin structure infections: two multicenter clinical studies. Clarithromycin Study Group. 1993 Int. J. Dermatol. pmid:8340194
Clarithromycin effectively treats infection in AIDS patients. 1993 Oncology (Williston Park, N.Y.) pmid:8512782
Humphreys JE et al. A clarithromycin sensitivity survey in the United Kingdom using Stokes' method. 1993 J. Antimicrob. Chemother. pmid:8226438
Scaglione F et al. Immunostimulation by clarithromycin in healthy volunteers and chronic bronchitis patients. 1993 J Chemother pmid:8229150
Andrews J and Wise R Disk susceptibility testing for clarithromycin. 1993 Eur. J. Clin. Microbiol. Infect. Dis. pmid:8187799
Luger SW Clarithromycin vs penicillin. 1993 J Fam Pract pmid:8482930
MacGowan AR et al. Synergy testing of macrolide combinations using the chequerboard technique. 1993 J. Antimicrob. Chemother. pmid:8144439
Ximenes E et al. [Ciprofloxacin, clarithromycin, rifampin: in vitro bactericidal activity of double and triple drug combinations against strains of atypical mycobacteria]. 1993 Pathol. Biol. pmid:8233629
Peterson WL et al. Clarithromycin as monotherapy for eradication of Helicobacter pylori: a randomized, double-blind trial. 1993 Am. J. Gastroenterol. pmid:8237933
Romand S et al. In vitro and in vivo activities of the hydroxynaphthoquinone atovaquone alone or combined with pyrimethamine, sulfadiazine, clarithromycin, or minocycline against Toxoplasma gondii. 1993 Antimicrob. Agents Chemother. pmid:8285620
Yasuda H et al. Interaction between biofilms formed by Pseudomonas aeruginosa and clarithromycin. 1993 Antimicrob. Agents Chemother. pmid:8239580
Schmidt T et al. Clarithromycin lacks bactericidal activity in cerebrospinal fluid in experimental pneumococcal meningitis. 1993 J. Antimicrob. Chemother. pmid:8288505
Dautzenberg B et al. Clarithromycin and other antimicrobial agents in the treatment of disseminated Mycobacterium avium infections in patients with acquired immunodeficiency syndrome. 1993 Arch. Intern. Med. pmid:8427539
Walker LL et al. Clarithromycin is bactericidal against strains of Mycobacterium leprae resistant and susceptible to dapsone and rifampin. 1993 Int. J. Lepr. Other Mycobact. Dis. pmid:8326182
Lazard T et al. Clarithromycin, minocycline, and rifabutin treatments before and after infection of C57BL/6 mice with Mycobacterium avium. 1993 Antimicrob. Agents Chemother. pmid:8215285
Pialoux G et al. Combination antibiotic treatment with clarithromycin for human immunodeficiency virus-associated Rhodococcus equi infection. 1993 Clin. Infect. Dis. pmid:8218702
Clinical Perspectives on Clarithromycin in Pediatric Infections. Symposium proceedings. February 19-20, 1993. 1993 Pediatr. Infect. Dis. J. pmid:7905199
Fraschini F et al. Clarithromycin clinical pharmacokinetics. 1993 Clin Pharmacokinet pmid:8222460
Neu HC and Chick TW Efficacy and safety of clarithromycin compared to cefixime as outpatient treatment of lower respiratory tract infections. 1993 Chest pmid:8222794
Kodama R et al. [Eradication therapy of Helicobacter pylori in gastroduodenal ulcer and its long-term course]. 1993 Nippon Rinsho pmid:8283646
Ji B et al. Powerful bactericidal activities of clarithromycin and minocycline against Mycobacterium leprae in lepromatous leprosy. 1993 J. Infect. Dis. pmid:8257487
Scaglione F et al. The postantibiotic effect of clarithromycin and its major human metabolite, 14-hydroxy clarithromycin. 1993 J. Antimicrob. Chemother. pmid:8262876
Guay DR and Craft JC Overview of the pharmacology of clarithromycin suspension in children and a comparison with that in adults. 1993 Pediatr. Infect. Dis. J. pmid:8295810
Roig J et al. Treatment of Legionnaires' disease. Current recommendations. 1993 Drugs pmid:7691508
Nasu M [Helicobacter pylori infections]. 1993 Nippon Naika Gakkai Zasshi pmid:8315343
Braga PC and Piatti G Sub-lethal concentrations of clarithromycin interfere with the expression of Staphylococcus aureus adhesiveness to human cells. 1993 J Chemother pmid:8371124
Macklin JL et al. A single-blind, randomised, comparative study of clarithromycin and amoxycillin suspensions in the treatment of children with lower respiratory tract infections. 1993 J Chemother pmid:8371127
Ragnaud JM et al. [Cerebral toxoplasmosis in AIDS. 73 cases. Clinical Epidemiology Group on AIDS in Aquitania]. 1993 Presse Med pmid:8378280
Hoffner SE et al. Susceptibility of Mycobacterium malmoense to antibacterial drugs and drug combinations. 1993 Antimicrob. Agents Chemother. pmid:8392308
Gevaudan MJ et al. In-vitro evaluation of clarithromycin, temafloxacin, and ethambutol in combination against Mycobacterium avium complex. 1993 J. Antimicrob. Chemother. pmid:8392998
Wallace RJ et al. Clinical trial of clarithromycin for cutaneous (disseminated) infection due to Mycobacterium chelonae. 1993 Ann. Intern. Med. pmid:8357113
Wettengel R et al. Clarithromycin versus cefaclor for the treatment of mild-to-moderate acute bacterial bronchitis. 1993 J. Antimicrob. Chemother. pmid:8360133
Nakashio S et al. [Antimicrobial activity of clarithromycin and its effect on bacterial adherence to medical material]. 1993 Jpn J Antibiot pmid:8360978
Lonks JR and Medeiros AA High rate of erythromycin and clarithromycin resistance among Streptococcus pneumoniae isolates from blood cultures from Providence, R.I. 1993 Antimicrob. Agents Chemother. pmid:8239578
Mor N and Heifets L MICs and MBCs of clarithromycin against Mycobacterium avium within human macrophages. 1993 Antimicrob. Agents Chemother. pmid:8431006
Tomioka H et al. In vitro antimicrobial activity of benzoxazinorifamycin, KRM-1648, against Mycobacterium avium complex, determined by the radiometric method. 1993 Antimicrob. Agents Chemother. pmid:8431020
Chu SY et al. Effect of moderate or severe hepatic impairment on clarithromycin pharmacokinetics. 1993 J Clin Pharmacol pmid:8331208
Graham DY et al. Clarithromycin for the eradication of Helicobacter pylori. 1993 J. Clin. Gastroenterol. pmid:8331260
Esvant H et al. [Primary prophylaxis of cerebral toxoplasmosis in AIDS with clarithromycin]. 1993 Presse Med pmid:8337221
Lederer J et al. Clarithromycin treatment of posttraumatic Mycobacterium fortuitum wound infection. 1993 Pediatr. Infect. Dis. J. pmid:8414785
Guay DR et al. Overview of the tolerability profile of clarithromycin in preclinical and clinical trials. 1993 Drug Saf pmid:8504017
Dever LL et al. Comparative in vitro activities of clarithromycin, azithromycin, and erythromycin against Borrelia burgdorferi. 1993 Antimicrob. Agents Chemother. pmid:8215288
Mazzei T et al. Chemistry and mode of action of macrolides. 1993 J. Antimicrob. Chemother. pmid:7683018
Lazard T et al. Efficacy of granulocyte colony-stimulating factor and RU-40555 in combination with clarithromycin against Mycobacterium avium complex infection in C57BL/6 mice. 1993 Antimicrob. Agents Chemother. pmid:7684213
Emori M et al. Therapeutic efficacy of the benzoxazinorifamycin KRM-1648 against experimental Mycobacterium avium infection induced in rabbits. 1993 Antimicrob. Agents Chemother. pmid:7684214
Fass RJ Erythromycin, clarithromycin, and azithromycin: use of frequency distribution curves, scattergrams, and regression analyses to compare in vitro activities and describe cross-resistance. 1993 Antimicrob. Agents Chemother. pmid:8257127
Dempsey CL et al. Drug usage evaluation: clarithromycin as sequential therapy. 1993 Hosp Formul pmid:10130382
Watanabe Y et al. Chemical modification of erythromycins. XII. A facile synthesis of clarithromycin (6-O-methylerythromycin A) via 2'-silylethers of erythromycin A derivatives. 1993 J. Antibiot. pmid:8360112