| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hyperemesis Gravidarum | D006939 | 2 associated lipids |
| Empyema, Pleural | D016724 | 2 associated lipids |
| Mastoiditis | D008417 | 2 associated lipids |
| Pityriasis Rosea | D017515 | 3 associated lipids |
| Duodenogastric Reflux | D004383 | 2 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Scrub Typhus | D012612 | 3 associated lipids |
| Tuberculosis, Avian | D014379 | 2 associated lipids |
| Typhoid Fever | D014435 | 2 associated lipids |
| Central Nervous System Protozoal Infections | D020808 | 3 associated lipids |
clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with clarithromycin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (5)
- Drug Metab. Dispos. (1)
- FEMS Immunol. Med. Microbiol. (1)
- Others (5)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| AvÅŸar E et al. | A multicenter, randomized, prospective study of 14-day ranitidine bismuth citrate- vs. lansoprazole-based triple therapy for the eradication of Helicobacter pylori in dyspeptic patients. | 2013 | Turk J Gastroenterol | pmid:24254262 |
| Smiley R et al. | Comparative proteomics analysis of sarcosine insoluble outer membrane proteins from clarithromycin resistant and sensitive strains of Helicobacter pylori. | 2013 | J. Microbiol. | pmid:24173641 |
| Ma Y et al. | Characteristics and evaluation of an injectable clarithromycin lipid-based complex in vitro and in vivo. | 2013 | Drug Deliv | pmid:24032596 |
| Patel AM et al. | Statin toxicity from macrolide antibiotic coprescription: a population-based cohort study. | 2013 | Ann. Intern. Med. | pmid:23778904 |
| Boyanova L et al. | Characterization of oral Helicobacter pylori strain by 4 methods. | 2013 | Diagn. Microbiol. Infect. Dis. | pmid:24075629 |
| Morakul B et al. | Precipitation-lyophilization-homogenization (PLH) for preparation of clarithromycin nanocrystals: influencing factors on physicochemical properties and stability. | 2013 | Int J Pharm | pmid:24076396 |
| Siamas K and Khachemoune A | Mycobacteria infection in an immunocompetent patient with no risk factors: evaluation and management of non-healing majocchi granuloma-type nodule. | 2013 | Dermatol. Online J. | pmid:24021439 |
| Xu Y et al. | Synthesis and antibacterial activity of novel modified 5-O-mycaminose 14-membered ketolides. | 2013 | Eur J Med Chem | pmid:24021890 |
| Ranganathan D et al. | Mycobacterium fortuitum peritonitis in a patient receiving continuous ambulatory peritoneal dialysis. | 2013 | Saudi J Kidney Dis Transpl | pmid:24029271 |
| Krashias G et al. | Prevalence of Helicobacter pylori cagA and vacA genes in Cypriot patients. | 2013 | J Infect Dev Ctries | pmid:24042099 |
| Lally L and Mannion L | The potential for antimicrobials to adversely affect mental state. | 2013 | BMJ Case Rep | pmid:23833088 |
| Nguyen L and Taylor-Gjevre RM | An emerging role for clarithromycin in adult-onset still disease? | 2013 | J Clin Rheumatol | pmid:24048102 |
| Murai A et al. | Mastitis caused by Mycobacterium kansasii infection in a dog. | 2013 | Vet Clin Pathol | pmid:23808608 |
| Trespalacios AA et al. | Phenotypic and genotypic analysis of clarithromycin-resistant Helicobacter pylori from Bogotá D.C., Colombia. | 2013 | J. Microbiol. | pmid:23990295 |
| Lee YC et al. | The benefit of mass eradication of Helicobacter pylori infection: a community-based study of gastric cancer prevention. | 2013 | Gut | pmid:22698649 |
| Saviola G et al. | Clarithromycin in rheumatoid arthritis: the addition to methotrexate and low-dose methylprednisolone induces a significant additive value--a 24-month single-blind pilot study. | 2013 | Rheumatol. Int. | pmid:23864141 |
| Amado-RodrÃguez L et al. | Anti-inflammatory effects of clarithromycin in ventilator-induced lung injury. | 2013 | Respir. Res. | pmid:23663489 |
| Pereira JM et al. | Interplay of degradation, dissolution and stabilization of clarithromycin and its amorphous solid dispersions. | 2013 | Mol. Pharm. | pmid:24116899 |
| Huang J et al. | Randomised controlled trial: sequential vs. standard triple therapy for Helicobacter pylori infection in Chinese children-a multicentre, open-labelled study. | 2013 | Aliment. Pharmacol. Ther. | pmid:24117692 |
| Wang S et al. | A supra-monolayer nanopattern for organic nanoparticle array deposition. | 2013 | ACS Appl Mater Interfaces | pmid:23480527 |
| Khamraev AA et al. | [State of mucosal barrier of the stomach after Helicobacter pylori eradication and ulcer healing in patients with duodenal ulcer disease]. | 2013 | Eksp Klin Gastroenterol | pmid:24933985 |
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| Raghunatha K and George JP | Periodontal tissue and serum concentration of clarithromycin after systemic administration in patients affected by chronic periodontitis. | 2013 | J. Periodontol. | pmid:23451987 |
| Liang X et al. | Efficacy of bismuth-containing quadruple therapies for clarithromycin-, metronidazole-, and fluoroquinolone-resistant Helicobacter pylori infections in a prospective study. | 2013 | Clin. Gastroenterol. Hepatol. | pmid:23376004 |
| Calza P et al. | Fate of selected pharmaceuticals in river waters. | 2013 | Environ Sci Pollut Res Int | pmid:22851223 |
| Naserpour Farivar T et al. | Prevalence of clarithromycin-resistant Helicobacter pylori in patients with chronic tonsillitis by allele-specific Scorpion real-time polymerase chain reaction assay. | 2013 | Laryngoscope | pmid:23404672 |
| Koh WJ et al. | Treatment of refractory Mycobacterium avium complex lung disease with a moxifloxacin-containing regimen. | 2013 | Antimicrob. Agents Chemother. | pmid:23478956 |
| Mikamo H et al. | [Infection and host reaction]. | 2013 | Jpn J Antibiot | pmid:24649796 |
| Komatsu S et al. | Combined treatment with SAHA, bortezomib, and clarithromycin for concomitant targeting of aggresome formation and intracellular proteolytic pathways enhances ER stress-mediated cell death in breast cancer cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23792097 |
| Zhen-Hua Z et al. | Characterization of 23S rRNA gene mutation in primary and secondary clarithromycin-resistant Helicobacter pylori strains from East China. | 2013 | Turk J Gastroenterol | pmid:23794337 |
| Evdokimova AG et al. | [New approaches to therapy of Helicobacterpylori infection (by the materials of the Maastricht Consensus-IV, Florence, 2010)]. | 2013 | Antibiot. Khimioter. | pmid:24640139 |
| Onal IK et al. | What is the impact of Helicobacter pylori density on the success of eradication therapy: a clinico-histopathological study. | 2013 | Clin Res Hepatol Gastroenterol | pmid:23796974 |
| de Zeeuw J et al. | Serum levels of neopterin during antimicrobial treatment for Mycobacterium ulcerans infection. | 2013 | Am. J. Trop. Med. Hyg. | pmid:23836576 |
| Janković B et al. | Consolidation trend design based on Young's modulus of clarithromycin single crystals. | 2013 | Int J Pharm | pmid:23872226 |
| Shinahara W et al. | Immunomodulator clarithromycin enhances mucosal and systemic immune responses and reduces re-infection rate in pediatric patients with influenza treated with antiviral neuraminidase inhibitors: a retrospective analysis. | 2013 | PLoS ONE | pmid:23875018 |
| Friedman ND et al. | Mycobacterium ulcerans disease: experience with primary oral medical therapy in an Australian cohort. | 2013 | PLoS Negl Trop Dis | pmid:23875050 |
| Suzuki RB et al. | Low Helicobacter pylori primary resistance to clarithromycin in gastric biopsy specimens from dyspeptic patients of a city in the interior of São Paulo, Brazil. | 2013 | BMC Gastroenterol | pmid:24305035 |
| Yano K et al. | Clinical outcome of the chronic flexor tenosynovitis in the hand caused by non-tuberculous mycobacterium treated by extensive tenosynovectomy and drugs. | 2013 | J Plast Surg Hand Surg | pmid:23875916 |
| Trifan A et al. | Pseudomembranous colitis associated with a triple therapy for Helicobacter pylori eradication. | 2013 | World J. Gastroenterol. | pmid:24259981 |
| Laving A et al. | Effectiveness of sequential v. standard triple therapy for treatment of Helicobacter pylori infection in children in Nairobi, Kenya. | 2013 | S. Afr. Med. J. | pmid:24300630 |
| Venerito M et al. | Meta-analysis of bismuth quadruple therapy versus clarithromycin triple therapy for empiric primary treatment of Helicobacter pylori infection. | 2013 | Digestion | pmid:23880479 |
| Bustamante-Rengifo JA et al. | In vitro effect of amoxicillin and clarithromycin on the 3' region of cagA gene in Helicobacter pylori isolates. | 2013 | World J. Gastroenterol. | pmid:24106405 |
| Kim SG et al. | [Guidelines for the diagnosis and treatment of Helicobacter pylori infection in Korea, 2013 revised edition]. | 2013 | Korean J Gastroenterol | pmid:23954956 |
| Yoshida S et al. | Further isolation of Mycobacterium abscessus subsp. abscessus and subsp. bolletii in different regions of Japan and susceptibility of these isolates to antimicrobial agents. | 2013 | Int. J. Antimicrob. Agents | pmid:23850022 |
| Ohe M and Hashino S | Successful treatment of recurrent follicular B-cell lymphoma with clarithromycin, prednisolone, and cyclophosphamide. | 2013 | Korean J. Intern. Med. | pmid:23682236 |
| Sadeghifard N et al. | Survey in Iran of clarithromycin resistance in Helicobacter pylori isolates by PCR-RFLP. | 2013 | Southeast Asian J. Trop. Med. Public Health | pmid:23682442 |
| Serelis J et al. | Granulomatous infection of the hand and wrist due to Azospirillum spp. | 2013 | Diagn. Microbiol. Infect. Dis. | pmid:23685031 |
| Cerqueira L et al. | Validation of a fluorescence in situ hybridization method using peptide nucleic acid probes for detection of Helicobacter pylori clarithromycin resistance in gastric biopsy specimens. | 2013 | J. Clin. Microbiol. | pmid:23596234 |
| Gibbins NE et al. | Time to reconsider guidelines on clarithromycin in chronic rhinosinusitis? | 2013 | BMJ | pmid:23635541 |
| Pilcer G et al. | Carrier-free combination for dry powder inhalation of antibiotics in the treatment of lung infections in cystic fibrosis. | 2013 | Int J Pharm | pmid:23643509 |
| Rimbara E et al. | Helicobacter cinaedi and Helicobacter fennelliae transmission in a hospital from 2008 to 2012. | 2013 | J. Clin. Microbiol. | pmid:23658263 |
| Bismuth + metronidazole + tetracycline. Why risk adding bismuth? | 2013 | Prescrire Int | pmid:23662315 | |
| Zhuo FL et al. | Clinical isolates of Mycobacterium abscessus in Guangzhou area most possibly from the environmental infection showed variable susceptibility. | 2013 | Chin. Med. J. | pmid:23673103 |
| Seck A et al. | Primary antibiotic resistance and associated mechanisms in Helicobacter pylori isolates from Senegalese patients. | 2013 | Ann. Clin. Microbiol. Antimicrob. | pmid:23298145 |
| Rossi A et al. | BiRd (clarithromycin, lenalidomide, dexamethasone): an update on long-term lenalidomide therapy in previously untreated patients with multiple myeloma. | 2013 | Blood | pmid:23299315 |
| Andersen JT et al. | Clarithromycin in early pregnancy and the risk of miscarriage and malformation: a register based nationwide cohort study. | 2013 | PLoS ONE | pmid:23301061 |
| James GD et al. | Use of long-term antibiotic treatment in COPD patients in the UK: a retrospective cohort study. | 2013 | Prim Care Respir J | pmid:23839240 |
| Liu X et al. | Clarithromycin-loaded liposomes offering high drug loading and less irritation. | 2013 | Int J Pharm | pmid:23337631 |
| Shinde DD et al. | Different effects of clopidogrel and clarithromycin on the enantioselective pharmacokinetics of sibutramine and its active metabolites in healthy subjects. | 2013 | J Clin Pharmacol | pmid:23381968 |
| Singh RP et al. | Antimicrobial prophylaxis in open reduction and internal fixation of compound mandibular fractures: a collaborative regional audit of outcome. | 2013 | Br J Oral Maxillofac Surg | pmid:23369782 |
| Prasertpetmanee S et al. | Improved efficacy of proton pump inhibitor - amoxicillin - clarithromycin triple therapy for Helicobacter pylori eradication in low clarithromycin resistance areas or for tailored therapy. | 2013 | Helicobacter | pmid:23356886 |
| Nakamura Y et al. | Optimal duration of macrolide treatment for chronic sinusitis after endoscopic sinus surgery. | 2013 | Auris Nasus Larynx | pmid:23107100 |
| Kazama I and Maruyama Y | Differential effects of clarithromycin and azithromycin on delayed rectifier K(+)-channel currents in murine thymocytes. | 2013 | Pharm Biol | pmid:23527897 |
| Sardarian H et al. | Comparison of hybrid and sequential therapies for Helicobacter pylori eradication in Iran: a prospective randomized trial. | 2013 | Helicobacter | pmid:23121338 |
| Sarkeshikian SS et al. | Azithromycin based triple therapy versus standard clarithromycin based triple therapy in eradication of Helicobacter pylori infection in Iran: a randomized controlled clinical trial. | 2013 | Turk J Gastroenterol | pmid:23794338 |
| Uthman MM et al. | Interventions for the prevention of mycobacterium avium complex in adults and children with HIV. | 2013 | Cochrane Database Syst Rev | pmid:23633339 |
| Kim MS et al. | Long-term follow-up Helicobacter pylori reinfection rate and its associated factors in Korea. | 2013 | Helicobacter | pmid:23066652 |
| Xiong LJ et al. | Detection of clarithromycin-resistant Helicobacter pylori by stool PCR in children: a comprehensive review of literature. | 2013 | Helicobacter | pmid:23067446 |
| Kupcinskas L et al. | Evolution of Helicobacter pylori susceptibility to antibiotics during a 10-year period in Lithuania. | 2013 | APMIS | pmid:23078193 |
| Wu Y et al. | Overexpression of YKL-40 predicts plaque instability in carotid atherosclerosis with CagA-positive Helicobacter pylori infection. | 2013 | PLoS ONE | pmid:23573226 |
| Koh WJ et al. | Reply: drug concentration monitoring in Mycobacterium avium lung disease: problems with methods and conclusions. | 2013 | Am. J. Respir. Crit. Care Med. | pmid:23577353 |
| Schmitt BH et al. | PCR detection of clarithromycin-susceptible and -resistant Helicobacter pylori from formalin-fixed, paraffin-embedded gastric biopsies. | 2013 | Mod. Pathol. | pmid:23579617 |
| Lai J et al. | Epithelioid histiocytic infiltrate caused by Mycobacterium scrofulaceum infection: a potential mimic of various neoplastic entities. | 2013 | Am J Dermatopathol | pmid:22935892 |
| Boyanova L et al. | Living in Sofia is associated with a risk for antibiotic resistance in Helicobacter pylori: a Bulgarian study. | 2013 | Folia Microbiol. (Praha) | pmid:23580173 |
| Bradbeer L et al. | Childhood headache and H. pylori--a possible association. | 2013 | Aust Fam Physician | pmid:23529524 |
| Yula E et al. | Detection of primary clarithromycin resistance of Helicobacter pylori and association between cagA (+) status and clinical outcome. | 2013 | Folia Microbiol. (Praha) | pmid:22956464 |
| Zhou L et al. | Cutaneous Mycobacterium intracellulare infection in an immuno-competent person. | 2013 | Acta Derm. Venereol. | pmid:23532357 |
| Tsuji D et al. | Retrospective analysis of severe neutropenia in patients receiving concomitant administration of docetaxel and clarithromycin. | 2013 | Chemotherapy | pmid:25011542 |
| Marin AC et al. | A review of rescue regimens after clarithromycin-containing triple therapy failure (for Helicobacter pylori eradication). | 2013 | Expert Opin Pharmacother | pmid:23537368 |
| Phunpruch S et al. | A role for 16S rRNA dimethyltransferase (ksgA) in intrinsic clarithromycin resistance in Mycobacterium tuberculosis. | 2013 | Int. J. Antimicrob. Agents | pmid:23541074 |
| Alhajlan M et al. | Efficacy and safety of liposomal clarithromycin and its effect on Pseudomonas aeruginosa virulence factors. | 2013 | Antimicrob. Agents Chemother. | pmid:23545534 |
| Georgopoulos S et al. | Nonbismuth quadruple "concomitant" therapy versus standard triple therapy, both of the duration of 10 days, for first-line H. pylori eradication: a randomized trial. | 2013 | J. Clin. Gastroenterol. | pmid:22858517 |
| Zullo A et al. | Concomitant, sequential, and hybrid therapy for H. pylori eradication: a pilot study. | 2013 | Clin Res Hepatol Gastroenterol | pmid:23747131 |
| Markert C et al. | Interaction of ambrisentan with clarithromycin and its modulation by polymorphic SLCO1B1. | 2013 | Eur. J. Clin. Pharmacol. | pmid:23748747 |
| Nishizawa T et al. | Delay of second-line eradication therapy for Helicobacter pylori can increase eradication failure. | 2013 | J. Gastroenterol. Hepatol. | pmid:23701705 |
| Lands LC and Stanojevic S | Oral non-steroidal anti-inflammatory drug therapy for lung disease in cystic fibrosis. | 2013 | Cochrane Database Syst Rev | pmid:23765216 |
| Kwon HJ et al. | Life-threatening scrub typhus with hemophagocytosis and acute respiratory distress syndrome in an infant. | 2013 | J. Trop. Pediatr. | pmid:22735791 |
| Liu MK et al. | Randomized trial comparing rabeprazole- versus lansoprazole-based Helicobacter pylori eradication regimens. | 2013 | Kaohsiung J. Med. Sci. | pmid:23768702 |
| Li XM et al. | Telithromycin versus clarithromycin for the treatment of community-acquired respiratory tract infections: a meta-analysis of randomized controlled trials. | 2013 | Chin. Med. J. | pmid:23769580 |
| Asaoka D et al. | Trends of second-line eradication therapy for Helicobacter pylori in Japan: a multicenter study in the Tokyo metropolitan area. | 2013 | Helicobacter | pmid:23773231 |
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| Quinney SK et al. | Rate of onset of inhibition of gut-wall and hepatic CYP3A by clarithromycin. | 2013 | Eur. J. Clin. Pharmacol. | pmid:22777148 |
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| Georgopoulos SD et al. | Clinical evaluation of a ten-day regimen with esomeprazole, metronidazole, amoxicillin, and clarithromycin for the eradication of Helicobacter pylori in a high clarithromycin resistance area. | 2013 | Helicobacter | pmid:23714140 |
| Koh WJ et al. | Successful treatment of Mycobacterium massiliense lung disease with oral antibiotics only. | 2013 | Antimicrob. Agents Chemother. | pmid:23183432 |
| Cerqueira RM et al. | Cumulative Helicobacter pylori eradication therapy in obese patients undergoing gastric bypass surgery. | 2013 | Obes Surg | pmid:23054570 |
| Zendedel A et al. | Antibiotic resistance of Helicobacter pylori in Mashhad, Iran. | 2013 | J Pak Med Assoc | pmid:23914633 |
| Haider M et al. | Post-operative sinus formation due to Mycobacterium abscessus: a case report. | 2013 | Indian J Tuberc | pmid:24000496 |
| Moriya S et al. | Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells. | 2013 | Int. J. Oncol. | pmid:23546223 |
| Akiyoshi T et al. | Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants. | 2013 | Drug Metab. Pharmacokinet. | pmid:23514827 |