clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Tenosynovitis D013717 3 associated lipids
Splenic Diseases D013158 5 associated lipids
Hernia, Hiatal D006551 3 associated lipids
Chlamydial Pneumonia D061387 2 associated lipids
Leprosy, Lepromatous D015440 2 associated lipids
Gastritis, Hypertrophic D005758 1 associated lipids
Hypoproteinemia D007019 1 associated lipids
Cutaneous Fistula D017577 1 associated lipids
Tuberculosis, Ocular D014392 1 associated lipids
Euthyroid Sick Syndromes D005067 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Authors Title Published Journal PubMed Link
Pamuk ON et al. Are Turkish Helicobacter pylori strains gaining resistance against clarithromycin? 2000 Am. J. Gastroenterol. pmid:10926000
Hammerschlag MR Treatment of Chlamydia pneumoniae. 2000 Int. J. Antimicrob. Agents pmid:10926449
Nagaya T et al. A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndrome. 2000 J. Clin. Invest. pmid:10930442
Van Oijen AH et al. Review article: treatment of Helicobacter pylori infection with ranitidine bismuth citrate- or proton pump inhibitor-based triple therapies. 2000 Aliment. Pharmacol. Ther. pmid:10930892
Hurenkamp GJ et al. Equally high efficacy of 4, 7 and 10-day triple therapies to eradicate Helicobacter pylori infection in patients with ulcer disease. 2000 Aliment. Pharmacol. Ther. pmid:10930901
Lai KC et al. Ulcer-healing drugs are required after eradication of Helicobacter pylori in patients with gastric ulcer but not duodenal ulcer haemorrhage. 2000 Aliment. Pharmacol. Ther. pmid:10930902
Pilotto A et al. Pantoprazole versus one-week Helicobacter pylori eradication therapy for the prevention of acute NSAID-related gastroduodenal damage in elderly subjects. 2000 Aliment. Pharmacol. Ther. pmid:10930903
Kihira K et al. Rabeprazole, amoxycillin and low- or high-dose clarithromycin for cure of Helicobacter pylori infection. 2000 Aliment. Pharmacol. Ther. pmid:10930904
Kamada T et al. Cetraxate, a mucosal protective agent, combined with omeprazole, amoxycillin, and clarithromycin increases the eradication rate of helicobacter pylori in smokers. 2000 Aliment. Pharmacol. Ther. pmid:10930905
Savarino V et al. OAM for cure of Helicobacter pylori infection. 2000 Aliment. Pharmacol. Ther. pmid:10930908
Yamashita H et al. When can complete regression of low-grade gastric lymphoma of mucosa-associated lymphoid tissue be predicted after helicobacter pylori eradication? 2000 Histopathology pmid:10931236
Gücüyener K et al. Methyl-prednisolone in neurologic complications of Mycoplasma pneumonia. 2000 Indian J Pediatr pmid:10932970
Theron AJ et al. Investigation of the anti-inflammatory and membrane-stabilizing potential of spiramycin in vitro. 2000 J. Antimicrob. Chemother. pmid:10933651
Kihara Y and Otsuki M Interaction of gliclazide and rifampicin. 2000 Diabetes Care pmid:10937528
Morlet-Barla N et al. [Severe hypoglycemia and recurrence caused by disopyramide-clarithromycin interaction]. 2000 Jul 8-15 Presse Med pmid:10938688
Narita N "Multi-effect" macrolides. 2000 Intern. Med. pmid:10939528
Shivkumar K Images in cardiovascular medicine. Labile repolarization from "cell to bedside". 2000 Circulation pmid:10942753
Kamochi H et al. Clarithromycin associated with torsades de pointes. 1999 Jpn. Circ. J. pmid:10943628
Daudén E et al. Helicobacter pylori and idiopathic chronic urticaria. 2000 Int. J. Dermatol. pmid:10944090
Sato K and Ebe T [A study on the effect of combined chemotherapy on Mycobacterium avium complex pulmonary disease]. 2000 Kekkaku pmid:10944891
Katz VL et al. Mycobacterium chelonae sepsis associated with long-term use of an intravenous catheter for treatment of hyperemesis gravidarum. A case report. 2000 J Reprod Med pmid:10948471
Mayhew BS et al. An in vitro model for predicting in vivo inhibition of cytochrome P450 3A4 by metabolic intermediate complex formation. 2000 Drug Metab. Dispos. pmid:10950845
Boxenbaum H Human in vivo competitive inhibition of P450 substrates: increased plasma concentrations as a function of hepatic extraction ratio and percent inhibition. 1999 Sep-Dec J Pharm Pharm Sci pmid:10953254
Gomollón F et al. [Cost-effectiveness analysis of 2 strategies of Helicobacter pylori eradication: results of a prospective and randomized study in primary care]. 2000 Med Clin (Barc) pmid:10953829
Piqué JM [Helicobacter pylori eradication in gastroduodenal ulcer: good, fine and not expensive]. 2000 Med Clin (Barc) pmid:10953833
Fujiue Y et al. [Results of antimicrobial susceptibilities of strains clinically isolated at 8 institutions in Hiroshima City to major oral antimicrobial drugs, mainly new quinolone drugs. Hiroshima Levofloxacin Susceptibility Surveillance Group]. 2000 Jpn J Antibiot pmid:10955237
Hatipoglu ON and Tasan Y A comparative efficacy and safety study of clarithromycin, roxithromycin and erythromycin stearate in mild pneumonia. 2000 Yonsei Med. J. pmid:10957888
Dupas JL et al. [Acid suppression therapy is not required after one-week anti-Helicobacter pylori triple therapy for duodenal ulcer healing]. 2000 Jun-Jul Gastroenterol. Clin. Biol. pmid:10962387
McCarty JM Clarithromycin in the management of community-acquired pneumonia. 2000 Clin Ther pmid:10963284
Scaglione F et al. In vitro comparative dynamics of modified-release clarithromycin and of azithromycin. 2000 Sep-Oct Chemotherapy pmid:10965100
Castellote J and Porta F [Combination of ranitidine and bismuth citrate plus 2 antibiotics in the eradication of Helicobacter pylori]. 2000 Med Clin (Barc) pmid:10965489
Ozkan Y et al. Clarithromycin targeting to lung: characterization, size distribution and in vivo evaluation of the human serum albumin microspheres. 2000 Farmaco pmid:10966162
Katsura Y et al. Anti-Helicobacter pylori agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives. 2000 J. Med. Chem. pmid:10966750
Heep M et al. Secondary resistance among 554 isolates of Helicobacter pylori after failure of therapy. 2000 Eur. J. Clin. Microbiol. Infect. Dis. pmid:10968325
Beyer G et al. Impact of moxifloxacin versus clarithromycin on normal oropharyngeal microflora. 2000 Eur. J. Clin. Microbiol. Infect. Dis. pmid:10968328
Gisbert JP et al. Helicobacter pylori eradication: proton pump inhibitor vs. ranitidine bismuth citrate plus two antibiotics for 1 week-a meta-analysis of efficacy. 2000 Aliment. Pharmacol. Ther. pmid:10971230
Frevel M et al. Eradication of Helicobacter pylori with pantoprazole and two antibiotics: a comparison of two short-term regimens. 2000 Aliment. Pharmacol. Ther. pmid:10971231
Colin AA Eradication of mycobacterium abscessus in a chronically infected patient with cystic fibrosis. 2000 Pediatr. Pulmonol. pmid:10973047
Cattoli G et al. Helicobacter acinonychis eradication leading to the resolution of gastric lesions in tigers. 2000 Vet. Rec. pmid:10975334
Scuderi G et al. Helicobacter pylori: use of a stool antigen detection test and a six-day triple therapy. 2000 Jan-Feb Dig Liver Dis pmid:10975761
Buzás György M et al. [Lansoprazole versus ranitidine bismuth citrate containing triple regimens for Helicobacter pylori eradication in patients with duodenal ulcer]. 2000 Orv Hetil pmid:10976194
Sohn YT et al. Polymorphism of clarithromycin. 2000 Arch. Pharm. Res. pmid:10976587
Bosne-David S et al. Intrinsic resistance of Mycobacterium tuberculosis to clarithromycin is effectively reversed by subinhibitory concentrations of cell wall inhibitors. 2000 J. Antimicrob. Chemother. pmid:10980165
Denis A et al. Beta-keto-ester chemistry and ketolides. Synthesis and antibacterial activity of 2-halogeno, 2-methyl and 2,3 enol-ether ketolides. 2000 Bioorg. Med. Chem. Lett. pmid:10987440
Komine M and Tamaki K An open trial of oral macrolide treatment for psoriasis vulgaris. 2000 J. Dermatol. pmid:10989574
Hentschel E [Treatment of Helicobacter pylori infections]. 2000 Acta Med. Austriaca pmid:10989677
Bermudez LE et al. Clarithromycin-resistant mycobacterium avium is still susceptible to treatment with clarithromycin and is virulent in mice. 2000 Antimicrob. Agents Chemother. pmid:10991834
Ohtani H et al. Comparative pharmacodynamic analysis of Q-T interval prolongation induced by the macrolides clarithromycin, roxithromycin, and azithromycin in rats. 2000 Antimicrob. Agents Chemother. pmid:10991836
Rastogi N et al. In vitro activities of the ketolides telithromycin (HMR 3647) and HMR 3004 compared to those of clarithromycin against slowly growing mycobacteria at pHs 6.8 and 7.4. 2000 Antimicrob. Agents Chemother. pmid:10991870
Cynamon MH et al. Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model. 2000 Antimicrob. Agents Chemother. pmid:10991883