MeSH term | MeSH ID | Detail |
---|---|---|
Lung Neoplasms | D008175 | 171 associated lipids |
Body Weight | D001835 | 333 associated lipids |
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Bartnof HS | OIs and cancers. | 1999 | BETA | pmid:11367262 |
Moreau P et al. | Lack of efficacy of clarithromycin in advanced multiple myeloma. Intergroupe Français du Myélome (IFM) | 1999 | Leukemia | pmid:10086745 |
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Horgen L et al. | Postantibiotic effects of rifampin, amikacin, clarithromycin and ethambutol used alone or in various two-, three- and four-drug combinations against Mycobacterium avium. | 1999 | FEMS Immunol. Med. Microbiol. | pmid:10030545 |
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Murakami K and Kimoto M | [Antibiotic-resistant H. pylori strains in the last ten years in Japan]. | 1999 | Nippon Rinsho | pmid:10036940 |
Maeda S and Yoshida H | [Detection of Helicobacter pylori 23S rRNA gene mutation associated with clarithromycin resistance and its clinical applicability]. | 1999 | Nippon Rinsho | pmid:10036941 |
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Mégraud F | Resistance of Helicobacter pylori to antibiotics: the main limitation of current proton-pump inhibitor triple therapy. | 1999 | Eur J Gastroenterol Hepatol | pmid:10503821 |
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Geiderman JM | Central nervous system disturbances following clarithromycin ingestion. | 1999 | Clin. Infect. Dis. | pmid:10476775 |
Midolo PD et al. | In vitro synergy between ranitidine bismuth citrate and tetracycline or clarithromycin against resistant strains of Helicobacter pylori. | 1999 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:10614963 |
Suleymanlar I et al. | Response to triple treatment with omeprazole, amoxicillin, and clarithromycin for Helicobacter pylori infections in continuous ambulatory peritoneal dialysis patients. | 1999 | Adv Perit Dial | pmid:10682076 |
Sassa K et al. | Therapeutic effect of clarithromycin on a transplanted tumor in rats. | 1999 | Antimicrob. Agents Chemother. | pmid:9869567 |
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Sato K et al. | [MICs and MBCs of levofloxacin, clarithromycin, and KRM-1648 for Mycobacterium tuberculosis and M. avium complex residing in MONO-MAC-6 human macrophage-like cell and A-549 human type II alveolar epithelial cell lines]. | 1999 | Kekkaku | pmid:10481412 |
Kiyota K et al. | Comparison of 1-week and 2-week triple therapy with omeprazole, amoxicillin, and clarithromycin in peptic ulcer patients with Helicobacter pylori infection: results of a randomized controlled trial. | 1999 | J. Gastroenterol. | pmid:10616771 |
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Aoyama N et al. | Sufficient effect of 1-week omeprazole and amoxicillin dual treatment for Helicobacter pylori eradication in cytochrome P450 2C19 poor metabolizers. | 1999 | J. Gastroenterol. | pmid:10616772 |
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Gotoda T et al. | Endoscopic and histological reversibility of gastric adenoma after eradication of Helicobacter pylori. | 1999 | J. Gastroenterol. | pmid:10616774 |
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Gisbert JP et al. | Seven-day 'rescue' therapy after Helicobacter pylori treatment failure: omeprazole, bismuth, tetracycline and metronidazole vs. ranitidine bismuth citrate, tetracycline and metronidazole. | 1999 | Aliment. Pharmacol. Ther. | pmid:10540045 |
Hammett DC and Evans MF | Functional (non-ulcer) dyspepsia and Helicobacter pylori infection. To treat or not to treat? | 1999 | Can Fam Physician | pmid:10540692 |
Madsen LG et al. | Ménétrier's disease and Helicobacter pylori: normalization of gastrointestinal protein loss after eradication therapy. | 1999 | Dig. Dis. Sci. | pmid:10573379 |
Semret M et al. | Mycobacterium ulcerans infection (Buruli ulcer): first reported case in a traveler. | 1999 | Am. J. Trop. Med. Hyg. | pmid:10586895 |
Chérin P et al. | Macrophagic myofasciitis: improvement with antibiotic therapy. | 1999 | J. Rheumatol. | pmid:10529163 |
Nasu T et al. | [In vitro antibacterial activity of faropenem, a novel oral penem antibiotic, against enterohemorrhagic Escherichia coli O157 strains]. | 1999 | Jpn J Antibiot | pmid:10587879 |
Moola S et al. | A multicenter study of grepafloxacin and clarithromycin in the treatment of patients with community-acquired pneumonia. | 1999 | Chest | pmid:10531162 |
Langan CE et al. | Randomized, double-blind study of short-course (5 day) grepafloxacin versus 10 day clarithromycin in patients with acute bacterial exacerbations of chronic bronchitis. | 1999 | J. Antimicrob. Chemother. | pmid:10588313 |
Unal M et al. | Ocular toxicity of intravitreal clarithromycin. | 1999 | Retina (Philadelphia, Pa.) | pmid:10546942 |
Rodvold KA | Clinical pharmacokinetics of clarithromycin. | 1999 | Clin Pharmacokinet | pmid:10589373 |
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Adamsson I et al. | Comparative effects of omeprazole, amoxycillin plus metronidazole versus omeprazole, clarithromycin plus metronidazole on the oral, gastric and intestinal microflora in Helicobacter pylori-infected patients. | 1999 | J. Antimicrob. Chemother. | pmid:10552979 |
Cirioni O et al. | In-vitro activity of rifabutin and albendazole singly and in combination with other clinically used antimicrobial agents against Pneumocystis carinii. | 1999 | J. Antimicrob. Chemother. | pmid:10552982 |
Blackington E | The gastric demon. An update on Helicobacter pylori infection. | 1999 | Adv Nurse Pract | pmid:10745720 |
Owen RJ et al. | Effect of clarithromycin and omeprazole therapy on the diversity and stability of genotypes of Helicobacter pylori from duodenal ulcer patients. | 1999 | Microb. Drug Resist. | pmid:10432275 |
Johnson MM et al. | Effect of carbon dioxide on testing of susceptibilities of respiratory tract pathogens to macrolide and azalide antimicrobial agents. | 1999 | Antimicrob. Agents Chemother. | pmid:10428903 |
Baena DÃez JM et al. | [Are 5 days of omeprazole plus 2 antibiotics enough for eradication of H. pylori? Comments on sample size]. | 1999 | Rev Clin Esp | pmid:10432821 |
Schmitt H et al. | Successful treatment of pulmonary Mycobacterium xenopi infection in a natural killer cell-deficient patient with clarithromycin, rifabutin, and sparfloxacin. | 1999 | Clin. Infect. Dis. | pmid:10433574 |
Credito KL et al. | Activity of telithromycin (HMR 3647) against anaerobic bacteria compared to those of eight other agents by time-kill methodology. | 1999 | Antimicrob. Agents Chemother. | pmid:10428930 |
Cohn DL et al. | A prospective randomized trial of four three-drug regimens in the treatment of disseminated Mycobacterium avium complex disease in AIDS patients: excess mortality associated with high-dose clarithromycin. Terry Beirn Community Programs for Clinical Research on AIDS. | 1999 | Clin. Infect. Dis. | pmid:10433575 |
Lipsky BA et al. | Treating acute bacterial exacerbations of chronic bronchitis in patients unresponsive to previous therapy: sparfloxacin versus clarithromycin. | 1999 | Clin Ther | pmid:10440620 |
Shimada N et al. | [A case of acute renal failure with rhabdomyolysis caused by the interaction of theophylline and clarithromycin]. | 1999 | Nihon Jinzo Gakkai Shi | pmid:10441997 |
Champney WS and Tober CL | Molecular investigation of the postantibiotic effects of clarithromycin and erythromycin on Staphylococcus aureus cells. | 1999 | Antimicrob. Agents Chemother. | pmid:10348746 |
Williams SL et al. | Development of a firefly luciferase-based assay for determining antimicrobial susceptibility of Mycobacterium avium subsp. paratuberculosis. | 1999 | J. Clin. Microbiol. | pmid:9889208 |
Savarino V et al. | Optimal duration of therapy combining ranitidine bismuth citrate with clarithromycin and metronidazole in the eradication of Helicobacter pylori infection. | 1999 | Aliment. Pharmacol. Ther. | pmid:9892878 |
Gooch WM et al. | Loracarbef versus clarithromycin in children with acute otitis media with effusion. | 1999 | Clin Ther | pmid:10363736 |
Woods GL et al. | Multisite reproducibility of results obtained by the broth microdilution method for susceptibility testing of Mycobacterium abscessus, Mycobacterium chelonae, and Mycobacterium fortuitum. | 1999 | J. Clin. Microbiol. | pmid:10325306 |
Moshkowitz M et al. | The efficacy of omeprazole-based short-term triple therapy in Helicobacter pylori-positive older patients with dyspepsia. | 1999 | J Am Geriatr Soc | pmid:10366173 |
Wimsatt JH et al. | Clarithromycin pharmacokinetics in the desert tortoise (Gopherus agassizii). | 1999 | J. Zoo Wildl. Med. | pmid:10367642 |
Iida H et al. | Hypoglycemia induced by interaction between clarithromycin and disopyramide. | 1999 | Jpn Heart J | pmid:10370402 |
Le Gars L et al. | Polyarthralgia-arthritis syndrome induced by low doses of rifabutin. | 1999 | J. Rheumatol. | pmid:10332992 |
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Goddard AF et al. | Randomized controlled comparison of nitroimidazoles for the eradication of Helicobacter pylori and relief of ulcer-associated and non-ulcer dyspepsia. | 1999 | Aliment. Pharmacol. Ther. | pmid:10233187 |
Champney WS and Tober CL | Superiority of 11,12 carbonate macrolide antibiotics as inhibitors of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells. | 1999 | Curr. Microbiol. | pmid:10341075 |
Pilotto A et al. | The effect of antibiotic resistance on the outcome of three 1-week triple therapies against Helicobacter pylori. | 1999 | Aliment. Pharmacol. Ther. | pmid:10233191 |
McConnell SA and Amsden GW | Review and comparison of advanced-generation macrolides clarithromycin and dirithromycin. | 1999 | Pharmacotherapy | pmid:10212011 |
Hayashi Y et al. | Torsades de pointes ventricular tachycardia induced by clarithromycin and disopyramide in the presence of hypokalemia. | 1999 | Pacing Clin Electrophysiol | pmid:10234723 |
Vakil N and Cutler A | Ten-day triple therapy with ranitidine bismuth citrate, amoxicillin, and clarithromycin in eradicating Helicobacter pylori. | 1999 | Am. J. Gastroenterol. | pmid:10235192 |
Dubois J and St-Pierre C | In vitro activity of gatifloxacin, compared with ciprofloxacin, clarithromycin, erythromycin, and rifampin, against Legionella species. | 1999 | Diagn. Microbiol. Infect. Dis. | pmid:10212753 |
Abdul Aal GM et al. | Resolution of gastritis induced by Helicobacter pylori 4-5 weeks after successful eradication of infection using a triple therapy regimen of pantoprazole, amoxycillin and clarithromycin for one week. | 1999 | Digestion | pmid:10343145 |
Alvarez-Elcoro S and Enzler MJ | The macrolides: erythromycin, clarithromycin, and azithromycin. | 1999 | Mayo Clin. Proc. | pmid:10377939 |
Behrens R et al. | Dual versus triple therapy of Helicobacter pylori infection: results of a multicentre trial. | 1999 | Arch. Dis. Child. | pmid:10373140 |
Masa K et al. | Effect of clarithromycin and other macrolides on the sulfoxidation and 5-hydroxylation of lansoprazole in dogs. | 1999 | Biol. Pharm. Bull. | pmid:10375172 |
Bamford JT et al. | Effect of treatment of Helicobacter pylori infection on rosacea. | 1999 | Arch Dermatol | pmid:10376693 |
Delle Cave M et al. | Seven days of ranitidine bismuth citrate plus two antimicrobials for Helicobacter pylori eradication. | 1999 | Ital J Gastroenterol Hepatol | pmid:10379492 |
Schubert ML | H. pylori and nonulcer dyspepsia: not guilty as charged. | 1999 | Gastroenterology | pmid:10381939 |
Yonemochi E et al. | Physicochemical properties of amorphous clarithromycin obtained by grinding and spray drying. | 1999 | Eur J Pharm Sci | pmid:9971917 |
Realdi G et al. | Pretreatment antibiotic resistance in Helicobacter pylori infection: results of three randomized controlled studies. | 1999 | Helicobacter | pmid:10382124 |
Piquette RK | Torsade de pointes induced by cisapride/clarithromycin interaction. | 1999 | Ann Pharmacother | pmid:9972380 |
Schwartz HI et al. | Twice-daily versus thrice-daily clarithromycin in combination with ranitidine bismuth citrate in the eradication of Helicobacter pylori. | 1999 | Helicobacter | pmid:10382126 |
Mera R et al. | Eradication of Helicobacter pylori infection with proton pump-based triple therapy in patients in whom bismuth-based triple therapy failed. | 1999 | J. Clin. Gastroenterol. | pmid:10405232 |
Sato K and Tomioka H | Antimicrobial activities of benzoxazinorifamycin (KRM-1648) and clarithromycin against Mycobacterium avium-intracellulare complex within murine peritoneal macrophages, human macrophage-like cells and human alveolar epithelial cells. | 1999 | J. Antimicrob. Chemother. | pmid:10223590 |
Desta Z et al. | Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6). | 1999 | Clin. Pharmacol. Ther. | pmid:9951426 |
Fish DN and Abraham E | Pharmacokinetics of a clarithromycin suspension administered via nasogastric tube to seriously ill patients. | 1999 | Antimicrob. Agents Chemother. | pmid:10223952 |
Gisbert JP et al. | [Antral biopsy is sufficient to confirm Helicobacter pylori eradication with the "new" one-week long triple treatments]. | 1999 | Med Clin (Barc) | pmid:10227015 |
Zhou Q et al. | CYP2C19 genotypes and omeprazole metabolism after single and repeated dosing when combined with clarithromycin. | 1999 | Eur. J. Clin. Pharmacol. | pmid:10206083 |
Tirén U et al. | Helicobacter pylori gastritis in children: efficacy of 2 weeks of treatment with clarithromycin, amoxicillin and omeprazole. | 1999 | Acta Paediatr. | pmid:10102149 |
Kamochi H et al. | Clarithromycin associated with torsades de pointes. | 1999 | Jpn. Circ. J. | pmid:10943628 |
Carbon C and Poole MD | The role of newer macrolides in the treatment of community-acquired respiratory tract infection. A review of experimental and clinical data. | 1999 | J Chemother | pmid:10326741 |
Laine L et al. | Once-daily therapy for H. pylori infection: a randomized comparison of four regimens. | 1999 | Am. J. Gastroenterol. | pmid:10201465 |
Khan AA et al. | Effect of clarithromycin and azithromycin on production of cytokines by human monocytes. | 1999 | Int. J. Antimicrob. Agents | pmid:10221415 |
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Horgan SE et al. | Use of a low nutrient culture medium for the identification of bacteria causing severe ocular infection. | 1999 | J. Med. Microbiol. | pmid:10403423 |
Woo PC et al. | Clarithromycin attenuates the inflammatory response induced by surgical trauma in a guinea pig model. | 1999 | Pharmacol. Res. | pmid:10051377 |
Kistler A et al. | Therapeutic dilemma: crescentic mesangiocapillary glomerulonephritis type 1 in a patient on antituberculous therapy with rifampicin. | 1999 | Nephrol. Dial. Transplant. | pmid:10052525 |
Garey KW et al. | Lack of effect of zafirlukast on the pharmacokinetics of azithromycin, clarithromycin, and 14-hydroxyclarithromycin in healthy volunteers. | 1999 | Antimicrob. Agents Chemother. | pmid:10223928 |
Yan JJ et al. | Disseminated Mycobacterium genavense infection in a patient with acquired immunodeficiency syndrome: first case report in Taiwan. | 1999 | J. Formos. Med. Assoc. | pmid:10063276 |
Bergman KL et al. | Antimicrobial activities and postantibiotic effects of clarithromycin, 14-hydroxy-clarithromycin, and azithromycin in epithelial cell lining fluid against clinical isolates of haemophilus influenzae and Streptococcus pneumoniae. | 1999 | Antimicrob. Agents Chemother. | pmid:10223956 |