MeSH term | MeSH ID | Detail |
---|---|---|
Lung Neoplasms | D008175 | 171 associated lipids |
Body Weight | D001835 | 333 associated lipids |
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Irie Y et al. | Antibiotic MICs and short time-killing against Helicobacter pylori: therapeutic potential of kanamycin. | 1997 | J. Antimicrob. Chemother. | pmid:9301989 |
Stone GG et al. | PCR-RFLP typing of ureC from Helicobacter pylori isolated from gastric biopsies during a European multi-country clinical trial. | 1997 | J. Antimicrob. Chemother. | pmid:9301991 |
López-Brea M et al. | Evolution of resistance to metronidazole and clarithromycin in Helicobacter pylori clinical isolates from Spain. | 1997 | J. Antimicrob. Chemother. | pmid:9301996 |
Versalovic J et al. | Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance. | 1997 | J. Antimicrob. Chemother. | pmid:9301997 |
Hoffman JS | Pharmacological therapy of Helicobacter pylori infection. | 1997 | Semin. Gastrointest. Dis. | pmid:9232728 |
Sano M et al. | [A clinical study on combination therapy of antimicrobial agents for complicated urinary tract infection--with special reference to combination with clarithromycin]. | 1997 | Nippon Hinyokika Gakkai Zasshi | pmid:9234616 |
Saluja A et al. | A surgical wound infection due to Mycobacterium chelonae successfully treated with clarithromycin. | 1997 | Dermatol Surg | pmid:9236871 |
Gisbert JP et al. | [One-week treatment with omeprazole, clarithromycin and amoxicillin: high efficacy in the eradication of Helicobacter pylori and cicatrization of duodenal ulcer]. | 1997 | Med Clin (Barc) | pmid:9190436 |
Damianos AJ and McGarrity TJ | Treatment strategies for Helicobacter pylori infection. | 1997 | Am Fam Physician | pmid:9191460 |
Rodvold KA et al. | Intrapulmonary steady-state concentrations of clarithromycin and azithromycin in healthy adult volunteers. | 1997 | Antimicrob. Agents Chemother. | pmid:9174209 |
Katari SR et al. | Clinical features of acute reversible tacrolimus (FK 506) nephrotoxicity in kidney transplant recipients. | 1997 | Clin Transplant | pmid:9193849 |
Waites K et al. | In vitro activities of oral antimicrobial agents against penicillin-resistant Streptococcus pneumoniae: implications for outpatient treatment. | 1997 | South. Med. J. | pmid:9191739 |
Hoogkamp-Korstanje JA et al. | Multicentre in-vitro evaluation of the susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis to ciprofloxacin, clarithromycin, co-amoxiclav and sparfloxacin. | 1997 | J. Antimicrob. Chemother. | pmid:9096192 |
Fujii K et al. | Multiple primary Mycobacterium avium infection of the skin. | 1997 | Int. J. Dermatol. | pmid:9071619 |
Stone GG et al. | PCR-RFLP typing of ureC from Helicobacter pylori isolated in Argentina from gastric biopsies before and after treatment with clarithromycin. | 1997 | Epidemiol. Infect. | pmid:9129588 |
Spicer ST et al. | The mechanism of cyclosporine toxicity induced by clarithromycin. | 1997 | Br J Clin Pharmacol | pmid:9131953 |
Guillemet C et al. | [Clarithromycin-digoxin: an unrecognized interaction in some patients]. | 1997 | Presse Med | pmid:9137381 |
Rodrigues AD et al. | Oxidative metabolism of clarithromycin in the presence of human liver microsomes. Major role for the cytochrome P4503A (CYP3A) subfamily. | 1997 | Drug Metab. Dispos. | pmid:9152603 |
Garrison MW et al. | Influence of pH on the antimicrobial activity of clarithromycin and 14-hydroxyclarithromycin against Haemophilus influenzae using an in vitro pharmacodynamic model. | 1997 | Diagn. Microbiol. Infect. Dis. | pmid:9154410 |
Nightingale CH | Pharmacokinetics and pharmacodynamics of newer macrolides. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109156 |
Block SL | Causative pathogens, antibiotic resistance and therapeutic considerations in acute otitis media. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109158 |
Tarlow MJ et al. | Future indications for macrolides. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109159 |
Rodrigo Sáez L et al. | [The efficacy of using a short course of 6-day duration (OCA-6) in the treatment to eradicate Helicobacter pylori infection. Omeprazole, clarithromycin, amoxicillin]. | 1997 | Rev Esp Enferm Dig | pmid:9115827 |
Yanagihara K et al. | Effect of clarithromycin on lymphocytes in chronic respiratory Pseudomonas aeruginosa infection. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9001333 |
Gan VN et al. | Penetration of clarithromycin into middle ear fluid of children with acute otitis media. | 1997 | Pediatr. Infect. Dis. J. | pmid:9002099 |
Shortridge VD et al. | Molecular typing of Helicobacter pylori isolates from a multicenter U.S. clinical trial by ureC restriction fragment length polymorphism. | 1997 | J. Clin. Microbiol. | pmid:9003618 |
Fischbach W et al. | Regression of immunoproliferative small intestinal disease after eradication of Helicobacter pylori. | 1997 | Lancet | pmid:8988128 |
Tonai A et al. | [Clarithromycin suppression of DNA synthesis by rat nasal mucosal cells enhanced by endotoxin instillation]. | 1997 | Jpn J Antibiot | pmid:9678983 |
Martin SJ et al. | In vitro activity of clarithromycin alone and in combination with ciprofloxacin or levofloxacin against Legionella spp.: enhanced effect by the addition of the metabolite 14-hydroxy clarithromycin. | 1997 | Diagn. Microbiol. Infect. Dis. | pmid:9401809 |
Sander P et al. | The role of ribosomal RNAs in macrolide resistance. | 1997 | Mol. Microbiol. | pmid:9402018 |
Brancato R et al. | Mycobacterium chelonae keratitis after excimer laser photorefractive keratectomy. | 1997 | Arch. Ophthalmol. | pmid:9338681 |
Jingu K et al. | [A case of fluminant Mycoplasma pneumonia and bronchiolitis managed by artificial respiration]. | 1997 | Nippon Naika Gakkai Zasshi | pmid:9340346 |
Szántó D et al. | [Could Helicobacter pylori cause reactive arthro-osteitis?]. | 1997 | Orv Hetil | pmid:9340585 |
Yamamoto M et al. | [The clinical study of clarithromycin for pulmonary Mycobacterium avium-intracellulare complex infection]. | 1997 | Kekkaku | pmid:9038009 |
Rodrigues AD and Wong SL | Application of human liver microsomes in metabolism-based drug-drug interactions: in vitro-in vivo correlations and the Abbott Laboratories experience. | 1997 | Adv. Pharmacol. | pmid:9342173 |
Hoppe JE and Tschirner T | Comparison of Etest and agar dilution for testing the activity of three macrolides against Bordetella parapertussis. | 1997 | Diagn. Microbiol. Infect. Dis. | pmid:9218920 |
Yasui N et al. | Carbamazepine toxicity induced by clarithromycin coadministration in psychiatric patients. | 1997 | Int Clin Psychopharmacol | pmid:9347384 |
May T et al. | Comparison of combination therapy regimens for treatment of human immunodeficiency virus-infected patients with disseminated bacteremia due to Mycobacterium avium. ANRS Trial 033 Curavium Group. Agence Nationale de Recherche sur le Sida. | 1997 | Clin. Infect. Dis. | pmid:9314450 |
Dohil R et al. | Effective 2-wk therapy for Helicobacter pylori disease in children. | 1997 | Am. J. Gastroenterol. | pmid:9040199 |
Wright DH | Regression of mucosa-associated lymphoid-tissue lymphoma after eradication of Helicobacter pylori. | 1997 | Lancet | pmid:9314895 |
Lerang F et al. | Highly effective twice-daily triple therapies for Helicobacter pylori infection and peptic ulcer disease: does in vitro metronidazole resistance have any clinical relevance? | 1997 | Am. J. Gastroenterol. | pmid:9040200 |
Picardeau M et al. | Use of different molecular typing techniques for bacteriological follow-up in a clinical trial with AIDS patients with Mycobacterium avium bacteremia. | 1997 | J. Clin. Microbiol. | pmid:9316897 |
Chey WD et al. | Bismuth subsalicylate instead of metronidazole with lansoprazole and clarithromycin for Helicobacter pylori infection: a randomized trial. | 1997 | Am. J. Gastroenterol. | pmid:9317068 |
Brown BA et al. | Clarithromycin-associated digoxin toxicity in the elderly. | 1997 | Clin. Infect. Dis. | pmid:8994761 |
de'Clari F | Ciprofloxacin was the culprit--not itraconazole. | 1997 | Clin. Infect. Dis. | pmid:8994764 |
Raasveld MH et al. | Cat-scratch disease mimicking pancreatic malignancy: case report. | 1997 | Clin. Infect. Dis. | pmid:8994767 |
Greco S et al. | Glossitis, stomatitis, and black tongue with lansoprazole plus clarithromycin and other antibiotics. | 1997 | Ann Pharmacother | pmid:9416400 |
Sugihara J et al. | [Efficacy of clarithromycin on chronic paranasal sinusitis--a comparison between children and adult]. | 1997 | Jpn J Antibiot | pmid:9597431 |
Hamada K et al. | [Evaluation of antineoplastic effect of CAM (clarithromycin) in a mouse model inoculated with lung cancer cells]. | 1997 | Jpn J Antibiot | pmid:9597434 |
Kokubo Y et al. | [Effects of clarithromycin on experimental pulmonary metastasis]. | 1997 | Jpn J Antibiot | pmid:9597436 |
Sakamoto M et al. | [Efficacy of clarithromycin on cancer cachexia in patients with primary non-small cell lung cancer]. | 1997 | Jpn J Antibiot | pmid:9597437 |
Teramoto S et al. | [Fluctuation in the cytokine m-RNA content in primary non-small cell lung cancer caused by clarithromycin (CAM) administration]. | 1997 | Jpn J Antibiot | pmid:9597438 |
Mikasa K et al. | [Effect of clarithromycin on prolonging the life expectancy of patients with primary lung cancer]. | 1997 | Jpn J Antibiot | pmid:9597439 |
Takeda H et al. | [Macrolide antibiotic actions on bacteria and cultured airway cells]. | 1997 | Jpn J Antibiot | pmid:9597448 |
Mita Y et al. | [Vitamin D3 induction of differentiation of HL-60 cells to monocyte- like cells and their aggregation--a dynamic culture method and clarithromycin]. | 1997 | Jpn J Antibiot | pmid:9597462 |
McLaren A et al. | The role of ranitidine bismuth citrate in significantly reducing the emergence of Helicobacter pylori strains resistant to antibiotics. | 1997 | Helicobacter | pmid:9432317 |
Nilius AM et al. | Variability in susceptibilities of Haemophilus influenzae to clarithromycin and azithromycin due to medium pH. | 1997 | J. Clin. Microbiol. | pmid:9163435 |
Bardhan KD et al. | Effects of smoking on cure of Helicobacter pylori infection and duodenal ulcer recurrence in patients treated with clarithromycin and omeprazole. | 1997 | Helicobacter | pmid:9432318 |
Takimoto T et al. | The efficacy and safety of one-week triple therapy with lansoprazole, clarithromycin, and metronidazole for the treatment of Helicobacter pylori infection in Japanese patients. | 1997 | Helicobacter | pmid:9432334 |
Moayyedi P | Amoxycillin dual therapy against Helicobacter pylori--the final nail in the coffin? | 1997 | Ital J Gastroenterol Hepatol | pmid:9513823 |
Pieramico O et al. | Omeprazole-based dual and triple therapy for the treatment of Helicobacter pylori infection in peptic ulcer disease: a randomized trial. | 1997 | Helicobacter | pmid:9432335 |
Pounder RE et al. | Ranitidine bismuth citrate with clarithromycin for the eradication of Helicobacter pylori and for ulcer healing. | 1997 | Helicobacter | pmid:9432341 |
Reisner BS et al. | Electron microscopic analysis of Mycobacterium avium complex isolates exposed to ciprofloxacin, rifabutin, ethambutol and clarithromycin. | 1997 | Int. J. Tuberc. Lung Dis. | pmid:9432376 |
Lerang F et al. | Highly effective second-line anti-Helicobacter pylori therapy in patients with previously failed metronidazole-based therapy. | 1997 | Scand. J. Gastroenterol. | pmid:9438318 |
Akiyama H et al. | Biofilm formation of Staphylococcus aureus strains isolated from impetigo and furuncle: role of fibrinogen and fibrin. | 1997 | J. Dermatol. Sci. | pmid:9438901 |
Bazzoli F and Pozzato P | Therapy of H. pylori infection. | 1997 | J. Physiol. Pharmacol. | pmid:9440054 |
Dixon JS et al. | Ranitidine bismuth citrate plus clarithromycin for the eradication of H. pylori. | 1997 | J. Physiol. Pharmacol. | pmid:9440055 |
Yatsunami J et al. | Clarithromycin is a potent inhibitor of tumor-induced angiogenesis. | 1997 | Res Exp Med (Berl) | pmid:9440137 |
Boixeda de Miquel D | [Efficacy of the triple therapy in the eradication of H. pylori in peptic ulcer]. | 1997 | Rev Esp Enferm Dig | pmid:9494374 |
Pérez Mota A et al. | Helicobacter pylori, efficacy of the new triple therapy in six and twelve-day schedules. | 1997 | Rev Esp Enferm Dig | pmid:9494375 |
Payen MC et al. | [Manifestations, diagnosis and treatment of non-tuberculous mycobacterial infections in patients with HIV infection]. | 1997 | Rev Mal Respir | pmid:9496599 |
Bordet AL et al. | [Mycobacterium chelonae cutaneous infection: efficacy of prolonged treatment by clarithromycin]. | 1997 | Ann Dermatol Venereol | pmid:9686059 |
Klein JO | History of macrolide use in pediatrics. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109154 |
McCracken GH | Microbiologic activity of the newer macrolide antibiotics. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109155 |
Tarlow MJ | Macrolides in the management of streptococcal pharyngitis/tonsillitis. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109157 |
Lévy M et al. | Endoscopic ultrasonography for the initial staging and follow-up in patients with low-grade gastric lymphoma of mucosa-associated lymphoid tissue treated medically. | 1997 | Gastrointest. Endosc. | pmid:9351036 |
Laine L et al. | A United States multicentre trial of dual and proton pump inhibitor-based triple therapies for Helicobacter pylori. | 1997 | Aliment. Pharmacol. Ther. | pmid:9354200 |
Rinaldi V et al. | The management of failed dual or triple therapy for Helicobacter pylori eradication. | 1997 | Aliment. Pharmacol. Ther. | pmid:9354202 |
Breuer T et al. | Clarithromycin, amoxycillin and H2-receptor antagonist therapy for Helicobacter pylori peptic ulcer disease in Korea. | 1997 | Aliment. Pharmacol. Ther. | pmid:9354204 |
Wurzer H et al. | Short-course therapy with amoxycillin-clarithromycin triple therapy for 10 days (ACT-10) eradicates Helicobacter pylori and heals duodenal ulcer. ACT-10 Study Group. | 1997 | Aliment. Pharmacol. Ther. | pmid:9354205 |
Harris A | H. pylori eradication by LAC. | 1997 | Aliment. Pharmacol. Ther. | pmid:9354216 |
Jablonowski H et al. | Ancillary benefits of Mycobacterium avium-intracellulare complex prophylaxis with clarithromycin in HIV-infected patients. | 1997 | Drugs | pmid:9358196 |
Grosset J and Ji B | Prevention of the selection of clarithromycin-resistant Mycobacterium avium-intracellulare complex. | 1997 | Drugs | pmid:9358197 |
Dubé MP et al. | A randomized evaluation of ethambutol for prevention of relapse and drug resistance during treatment of Mycobacterium avium complex bacteremia with clarithromycin-based combination therapy. California Collaborative Treatment Group. | 1997 | J. Infect. Dis. | pmid:9359722 |
Uemura N et al. | Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer. | 1997 | Cancer Epidemiol. Biomarkers Prev. | pmid:9264278 |
Mor N and Esfandiari A | Synergistic activities of clarithromycin and pyrazinamide against Mycobacterium tuberculosis in human macrophages. | 1997 | Antimicrob. Agents Chemother. | pmid:9303411 |
Savarino V et al. | A new 1-week therapy for Helicobacter pylori eradication: ranitidine bismuth citrate plus two antibiotics. | 1997 | Aliment. Pharmacol. Ther. | pmid:9305478 |
Polis MA et al. | Clarithromycin lowers plasma zidovudine levels in persons with human immunodeficiency virus infection. | 1997 | Antimicrob. Agents Chemother. | pmid:9257746 |
Shibata K et al. | Bactericidal effect of ecabet sodium on clarithromycin- and metronidazole-resistant clinical isolates of Helicobacter pylori. | 1997 | Jpn J Antibiot | pmid:9258741 |
Kato A | [Effect of erythromycin and clarithromycin on ion transport across dissected canine tracheal epithelium]. | 1997 | Nippon Jibiinkoka Gakkai Kaiho | pmid:9103848 |
Fietta A et al. | Requirements for intracellular accumulation and release of clarithromycin and azithromycin by human phagocytes. | 1997 | J Chemother | pmid:9106014 |
Srinivasan R and Minocha A | Cure of Helicobacter pylori: a hidden curse? | 1997 | Am. J. Gastroenterol. | pmid:9399784 |
Different clarithromycin doses affect mortality. | 1997 | AIDS Patient Care STDS | pmid:11361754 | |
Akaki T et al. | [In vivo activities of benzoxazinorifamycin KRM-1648, clarithromycin, and levofloxacin, or combination of KRM-1648 with diclofenac sodium against Mycobacterium avium infection induced in mice]. | 1997 | Kekkaku | pmid:9293712 |
Recker MW and Kier KL | Potential interaction between clarithromycin and warfarin. | 1997 | Ann Pharmacother | pmid:9296238 |
Laberge P and Martineau P | Clarithromycin-induced digoxin intoxication. | 1997 | Ann Pharmacother | pmid:9296239 |
Matsukura N | [Two step therapy for education of Helicobacter pylori]. | 1997 | Nihon Shokakibyo Gakkai Zasshi | pmid:9284449 |
Bardhan KD et al. | Ranitidine bismuth citrate with clarithromycin for the treatment of duodenal ulcer. | 1997 | Gut | pmid:9301496 |
Tan WC et al. | Helicobacter pylori eradication--comparison of three drug regimens and symptomatic assessment in duodenitis and antral gastritis. | 1997 | Int. J. Clin. Pract. | pmid:9287260 |
Kobler E et al. | [Effectiveness of short-term triple therapy for healing Helicobacter pylori infection in ulcer disease]. | 1997 | Schweiz Med Wochenschr Suppl | pmid:9289833 |