clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Buruli Ulcer D054312 1 associated lipids
Gastritis, Hypertrophic D005758 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

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Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


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Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

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What genes are associated with clarithromycin?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Authors Title Published Journal PubMed Link
Savarino V et al. What is the meaning of ranitidine in successful triple-therapy against Helicobacter pylori infection? 1995 Am. J. Gastroenterol. pmid:8540537
Gustavson LE et al. Effect of omeprazole on concentrations of clarithromycin in plasma and gastric tissue at steady state. 1995 Antimicrob. Agents Chemother. pmid:8540719
Gelber RH Successful treatment of a lepromatous patient with clarithromycin. 1995 Int. J. Lepr. Other Mycobact. Dis. pmid:7730711
Schepp W [Omeprazole + clarithromycin + metronidazole--a new standard for eradication of Helicobacter pylori]. 1995 Z Gastroenterol pmid:7502558
Widgerow AD et al. Atypical Mycobacterium and breast surgery. 1995 Ann Plast Surg pmid:7486746
Tamaoki J et al. Effect of clarithromycin on sputum production and its rheological properties in chronic respiratory tract infections. 1995 Antimicrob. Agents Chemother. pmid:7486901
Mushatt DM and Witzig RS Successful treatment of Mycobacterium abscessus infections with multidrug regimens containing clarithromycin. 1995 Clin. Infect. Dis. pmid:7620048
Vance E et al. Pharmacokinetics of clarithromycin and zidovudine in patients with AIDS. 1995 Antimicrob. Agents Chemother. pmid:7574530
Singh N and Yu VL Clarithromycin therapy for Mycobacterium avium complex bacteremia. 1995 Ann. Intern. Med. pmid:7632282
Metz DC and Getz HD Helicobacter pylori gastritis therapy with omeprazole and clarithromycin increases serum carbamazepine levels. 1995 Dig. Dis. Sci. pmid:7720489
Atkinson BA et al. Treatment of Mycobacterium haemophilum infection in a murine model with clarithromycin, rifabutin, and ciprofloxacin. 1995 Antimicrob. Agents Chemother. pmid:8619588
Ford A et al. Clarithromycin-induced digoxin toxicity in a patient with AIDS. 1995 Clin. Infect. Dis. pmid:8645810
Gidoh M and Saito H [Present status of studies on antileprosy drugs]. 1995 Nihon Rai Gakkai Zasshi pmid:8582877
Gioulekas J and Hall A Uveitis associated with rifabutin therapy. 1995 Aust N Z J Ophthalmol pmid:11980079
Parasakthi N and Goh KL Primary and acquired resistance to clarithromycin among Helicobacter pylori strains in Malaysia. 1995 Am. J. Gastroenterol. pmid:7872306
Kadayifçi A et al. Low dose clarithromycin plus omeprazole eradicates Helicobacter pylori in duodenal ulcer disease. 1995 Am. J. Gastroenterol. pmid:7872307
Cama VA et al. Treatment of acute and chronic Cryptosporidium parvum infections in mice using clarithromycin and 14-OH clarithromycin. 1994 Sep-Oct J. Eukaryot. Microbiol. pmid:7804227
O'Connor NK and Fris J Clarithromycin-carbamazepine interaction in a clinical setting. 1994 Nov-Dec J Am Board Fam Pract pmid:7847111
Scaglione F et al. Effect of antibiotics on Bordetella pertussis adhering activity: hypothesis regarding mechanism of action. 1994 May-Jun Chemotherapy pmid:7515782
Gersema LM et al. Suspected drug interaction between cyclosporine and clarithromycin. 1994 Mar-Apr J. Heart Lung Transplant. pmid:8031821
Heifets LB Quantitative cultures and drug susceptibility testing of Mycobacterium avium clinical isolates before and during the antimicrobial therapy. 1994 Mar-Apr Res. Microbiol. pmid:7809471
Dautzenberg B Clinical trials in Mycobacterium avium therapy: lessons to take home. 1994 Mar-Apr Res. Microbiol. pmid:7809472
Winter J Intravenous clarithromycin. 1994 Mar 16-Apr 5 Br J Hosp Med pmid:8032567
Mor N et al. Accumulation of clarithromycin in macrophages infected with Mycobacterium avium. 1994 Jan-Feb Pharmacotherapy pmid:8159593
Tessier MH et al. Clarithromycin for atypical mycobacterial lymphadenitis in non-immunocompromised children. 1994 Dec 24-31 Lancet pmid:7997032
Böttger EC Resistance to drugs targeting protein synthesis in mycobacteria. 1994 Trends Microbiol. pmid:7850212
Guelar A et al. [Therapeutic alternatives for cases of cerebral toxoplasmosis in patients with AIDS: clarithromycin and atovaquone]. 1994 Enferm. Infecc. Microbiol. Clin. pmid:8011719
Aspin MM et al. Comparative study of the safety and efficacy of clarithromycin and amoxicillin-clavulanate in the treatment of acute otitis media in children. 1994 J. Pediatr. pmid:8021763
Chaisson RE et al. Clarithromycin therapy for bacteremic Mycobacterium avium complex disease. A randomized, double-blind, dose-ranging study in patients with AIDS. AIDS Clinical Trials Group Protocol 157 Study Team. 1994 Ann. Intern. Med. pmid:7978715
Goldberger M and Masur H Clarithromycin therapy for Mycobacterium avium complex disease in patients with AIDS: potential and problems. 1994 Ann. Intern. Med. pmid:7978725
Thijs JC et al. Short report: clarithromycin, an alternative to metronidazole in the triple therapy of Helicobacter pylori infection. 1994 Aliment. Pharmacol. Ther. pmid:8186339
Gelber RH et al. Minimal bactericidal concentration of clarithromycin against M. leprae. 1994 Int. J. Lepr. Other Mycobact. Dis. pmid:8189083
Xiong JH et al. Further study of the effectiveness of single doses of clarithromycin and minocycline against Mycobacterium leprae in mice. 1994 Int. J. Lepr. Other Mycobact. Dis. pmid:8189087
Paffetti A et al. [Clarithromycin in pediatric age. Personal experience]. 1994 Minerva Pediatr. pmid:8084327
Ohgaki N Bacterial biofilm in chronic airway infection. 1994 Kansenshogaku Zasshi pmid:8138670
Yasuda H et al. Interaction between clarithromycin and biofilms formed by Staphylococcus epidermidis. 1994 Antimicrob. Agents Chemother. pmid:8141568
Uveitis associated with rifabutin therapy. 1994 MMWR Morb. Mortal. Wkly. Rep. pmid:8072478
Honeybourne D et al. The levels of clarithromycin and its 14-hydroxy metabolite in the lung. 1994 Eur. Respir. J. pmid:7925906
Gad A and Unge P Antibacterial therapy of Helicobacter pylori-associated peptic ulcer disease: a new strategy. The Swedes go for it. 1994 J. Clin. Gastroenterol. pmid:7930437
Braegger CP and Nadal D Clarithromycin and pseudomembranous enterocolitis. 1994 Lancet pmid:7904702
Nishimura M et al. [Therapeutic study on biofilm of the urinary tract using a severely complicated bladder model (biofilm model of the urinary tract)--experimental study using an automatic simulator of urinary antimicrobial agent concentration, and clinical study]. 1994 Kansenshogaku Zasshi pmid:7909830
Wallace RJ et al. Initial clarithromycin monotherapy for Mycobacterium avium-intracellulare complex lung disease. 1994 Am. J. Respir. Crit. Care Med. pmid:8173775
Bermudez LE et al. Clarithromycin, dapsone, and a combination of both used to treat or prevent disseminated Mycobacterium avium infection in beige mice. 1994 Antimicrob. Agents Chemother. pmid:7695252
Mor N et al. Effects of clarithromycin and rifabutin alone and in combination on intracellular and extracellular replication of Mycobacterium avium. 1994 Antimicrob. Agents Chemother. pmid:7695255
Calì G et al. [Clarithromycin in the treatment of oral infections]. 1994 Minerva Stomatol pmid:7700226
Reed PI The ECP-IM intervention study. 1994 Eur. J. Cancer Prev. pmid:7735056
Kodama R et al. Combination therapy with clarithromycin and sofalcone for eradication of Helicobacter pylori. 1994 Eur J Gastroenterol Hepatol pmid:7735929
Olliaro P et al. In-vitro and in-vivo activity of rifabutin against Toxoplasma gondii. 1994 J. Antimicrob. Chemother. pmid:7706160
Marco ML et al. [Rhodococcus equi pneumonia in patients with AIDS]. 1994 Arch. Bronconeumol. pmid:7827773
Yamada S et al. [A child with iritis due to Chlamydia pneumoniae infection]. 1994 Kansenshogaku Zasshi pmid:7876679