MeSH term | MeSH ID | Detail |
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Sacroiliitis | D058566 | 1 associated lipids |
Chlamydial Pneumonia | D061387 | 2 associated lipids |
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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De Wit S et al. | Acquired resistance to clarithromycin as combined therapy in Mycobacterium avium intracellulare infection. | 1993 | Lancet | pmid:8093299 |
Parish LC | Clarithromycin in the treatment of skin and skin structure infections: two multicenter clinical studies. Clarithromycin Study Group. | 1993 | Int. J. Dermatol. | pmid:8340194 |
Humphreys JE et al. | A clarithromycin sensitivity survey in the United Kingdom using Stokes' method. | 1993 | J. Antimicrob. Chemother. | pmid:8226438 |
Scaglione F et al. | Immunostimulation by clarithromycin in healthy volunteers and chronic bronchitis patients. | 1993 | J Chemother | pmid:8229150 |
Andrews J and Wise R | Disk susceptibility testing for clarithromycin. | 1993 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:8187799 |
Calhoun KH and Hokanson JA | Multicenter comparison of clarithromycin and amoxicillin in the treatment of acute maxillary sinusitis. | 1993 | Arch Fam Med | pmid:8111512 |
Saint-Marc T et al. | [Mycobacterium avium intracellulare infections. Treatment with a clarithromycin-clofazimine combination. 18 cases]. | 1993 | Presse Med | pmid:8121903 |
Hakkarinen WD | Clarithromycin vs penicillin. | 1993 | J Fam Pract | pmid:8482929 |
Akiyama H et al. | Interaction of Staphylococcus aureus cells and silk threads in vitro and in mouse skin. | 1993 | J. Dermatol. Sci. | pmid:8136322 |
Luger SW | Clarithromycin vs penicillin. | 1993 | J Fam Pract | pmid:8482930 |
Granier H et al. | [Mycobacterium chelonei arthritis in an immunosuppressed patient. Efficacy of the treatment with clarithromycin]. | 1993 | Ann Med Interne (Paris) | pmid:8141516 |
MacGowan AR et al. | Synergy testing of macrolide combinations using the chequerboard technique. | 1993 | J. Antimicrob. Chemother. | pmid:8144439 |
Vaara M | Outer membrane permeability barrier to azithromycin, clarithromycin, and roxithromycin in gram-negative enteric bacteria. | 1993 | Antimicrob. Agents Chemother. | pmid:8383945 |
Ximenes E et al. | [Ciprofloxacin, clarithromycin, rifampin: in vitro bactericidal activity of double and triple drug combinations against strains of atypical mycobacteria]. | 1993 | Pathol. Biol. | pmid:8233629 |
Peterson WL et al. | Clarithromycin as monotherapy for eradication of Helicobacter pylori: a randomized, double-blind trial. | 1993 | Am. J. Gastroenterol. | pmid:8237933 |
Romand S et al. | In vitro and in vivo activities of the hydroxynaphthoquinone atovaquone alone or combined with pyrimethamine, sulfadiazine, clarithromycin, or minocycline against Toxoplasma gondii. | 1993 | Antimicrob. Agents Chemother. | pmid:8285620 |
Yasuda H et al. | Interaction between biofilms formed by Pseudomonas aeruginosa and clarithromycin. | 1993 | Antimicrob. Agents Chemother. | pmid:8239580 |
Dautzenberg B et al. | Clarithromycin and other antimicrobial agents in the treatment of disseminated Mycobacterium avium infections in patients with acquired immunodeficiency syndrome. | 1993 | Arch. Intern. Med. | pmid:8427539 |
Lazard T et al. | Clarithromycin, minocycline, and rifabutin treatments before and after infection of C57BL/6 mice with Mycobacterium avium. | 1993 | Antimicrob. Agents Chemother. | pmid:8215285 |
Pialoux G et al. | Combination antibiotic treatment with clarithromycin for human immunodeficiency virus-associated Rhodococcus equi infection. | 1993 | Clin. Infect. Dis. | pmid:8218702 |
Clinical Perspectives on Clarithromycin in Pediatric Infections. Symposium proceedings. February 19-20, 1993. | 1993 | Pediatr. Infect. Dis. J. | pmid:7905199 | |
Chien SM et al. | Treatment of community-acquired pneumonia. A multicenter, double-blind, randomized study comparing clarithromycin with erythromycin. Canada-Sweden Clarithromycin-Pneumonia Study Group. | 1993 | Chest | pmid:8449054 |
Watanabe Y et al. | Chemical modification of erythromycins. IX. Selective methylation at the C-6 hydroxyl group of erythromycin A oxime derivatives and preparation of clarithromycin. | 1993 | J. Antibiot. | pmid:8501007 |
Pukander JS et al. | Clarithromycin vs. amoxicillin suspensions in the treatment of pediatric patients with acute otitis media. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295812 |
McCarty JM et al. | Comparative safety and efficacy of clarithromycin and amoxicillin/clavulanate in the treatment of acute otitis media in children. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295813 |
Gooch WM et al. | Clarithromycin and cefaclor suspensions in the treatment of acute otitis media in children. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295814 |
Roig J et al. | Treatment of Legionnaires' disease. Current recommendations. | 1993 | Drugs | pmid:7691508 |
Still JG et al. | Comparison of clarithromycin and penicillin VK suspensions in the treatment of children with streptococcal pharyngitis and review of currently available alternative antibiotic therapies. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295815 |
Craft JC and Siepman N | Overview of the safety profile of clarithromycin suspension in pediatric patients. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295816 |
Klein JO | Clarithromycin: where do we go from here? | 1993 | Pediatr. Infect. Dis. J. | pmid:8295817 |
Hardy DJ | Extent and spectrum of the antimicrobial activity of clarithromycin. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295818 |
Dubois J et al. | Efficacy of clarithromycin vs. amoxicillin/clavulanate in the treatment of acute maxillary sinusitis. | 1993 | Ear Nose Throat J | pmid:8313865 |
Nasu M | [Helicobacter pylori infections]. | 1993 | Nippon Naika Gakkai Zasshi | pmid:8315343 |
Braga PC and Piatti G | Sub-lethal concentrations of clarithromycin interfere with the expression of Staphylococcus aureus adhesiveness to human cells. | 1993 | J Chemother | pmid:8371124 |
Macklin JL et al. | A single-blind, randomised, comparative study of clarithromycin and amoxycillin suspensions in the treatment of children with lower respiratory tract infections. | 1993 | J Chemother | pmid:8371127 |
Ragnaud JM et al. | [Cerebral toxoplasmosis in AIDS. 73 cases. Clinical Epidemiology Group on AIDS in Aquitania]. | 1993 | Presse Med | pmid:8378280 |
Hoffner SE et al. | Susceptibility of Mycobacterium malmoense to antibacterial drugs and drug combinations. | 1993 | Antimicrob. Agents Chemother. | pmid:8392308 |
Gevaudan MJ et al. | In-vitro evaluation of clarithromycin, temafloxacin, and ethambutol in combination against Mycobacterium avium complex. | 1993 | J. Antimicrob. Chemother. | pmid:8392998 |
Wallace RJ et al. | Clinical trial of clarithromycin for cutaneous (disseminated) infection due to Mycobacterium chelonae. | 1993 | Ann. Intern. Med. | pmid:8357113 |
Guay DR et al. | Overview of the tolerability profile of clarithromycin in preclinical and clinical trials. | 1993 | Drug Saf | pmid:8504017 |
de Vega T et al. | Clarithromycin-induced leukocytoclastic vasculitis. | 1993 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:8404922 |
Chu S et al. | Single- and multiple-dose pharmacokinetics of clarithromycin, a new macrolide antimicrobial. | 1993 | J Clin Pharmacol | pmid:8408732 |
Barradell LB et al. | Clarithromycin. A review of its pharmacological properties and therapeutic use in Mycobacterium avium-intracellulare complex infection in patients with acquired immune deficiency syndrome. | 1993 | Drugs | pmid:7691518 |
Mazzei T et al. | Chemistry and mode of action of macrolides. | 1993 | J. Antimicrob. Chemother. | pmid:7683018 |
Lazard T et al. | Efficacy of granulocyte colony-stimulating factor and RU-40555 in combination with clarithromycin against Mycobacterium avium complex infection in C57BL/6 mice. | 1993 | Antimicrob. Agents Chemother. | pmid:7684213 |
Emori M et al. | Therapeutic efficacy of the benzoxazinorifamycin KRM-1648 against experimental Mycobacterium avium infection induced in rabbits. | 1993 | Antimicrob. Agents Chemother. | pmid:7684214 |
Heifets L et al. | Mycobacterium avium strains resistant to clarithromycin and azithromycin. | 1993 | Antimicrob. Agents Chemother. | pmid:8031351 |
Holdcroft C | Two new macrolide antibiotics: clarithromycin and azithromycin. | 1993 | Nurse Pract | pmid:8380492 |
Dempsey CL et al. | Drug usage evaluation: clarithromycin as sequential therapy. | 1993 | Hosp Formul | pmid:10130382 |
Goldstein EJ and Citron DM | Comparative susceptibilities of 173 aerobic and anaerobic bite wound isolates to sparfloxacin, temafloxacin, clarithromycin, and older agents. | 1993 | Antimicrob. Agents Chemother. | pmid:8390810 |