MeSH term | MeSH ID | Detail |
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Abortion, Spontaneous | D000022 | 12 associated lipids |
Abnormalities, Drug-Induced | D000014 | 10 associated lipids |
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Buraczewska A et al. | [Mycobacterial infection caused by Mycobacterium avium in allogenic bone marrow transplant recipient with concomittant bronchiolitis obliterans as a manifestation of graft versus host disease - case report and review of the literature]. | 2008 | Pneumonol Alergol Pol | pmid:18464226 |
Aktan B et al. | Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion. | 2003 Nov-Dec | Pol J Pharmacol | pmid:14730107 |
Namiot Z et al. | [The effect of cigarette smoking and alcohol consumption on efficacy of Helicobacter pylori eradication]. | 2000 | Pol. Arch. Med. Wewn. | pmid:11392163 |
Walicka M et al. | Mycoplasma pneumoniae-induced pneumonia with Stevens-Johnson syndrome of acute atypical course. | Pol. Arch. Med. Wewn. | pmid:18714743 | |
Bartnik W | Clinical aspects of Helicobacter pylori infection. | Pol. Arch. Med. Wewn. | pmid:18714738 | |
Bocheńska-Marciniak M et al. | [Clinical efficacy and safety of spiramycin and clarithromycin in the treatment of outpatients with lower respiratory tract infections]. | 1998 | Pol. Arch. Med. Wewn. | pmid:10335027 |
Andrzejewska E et al. | Antimicrobial resistance of Helicobacter pylori clinical strains in the last 10 years. | 2009 | Pol. J. Microbiol. | pmid:20380140 |
Remer M et al. | [Chronic sinusitis therapy with antibiotics (axetyl cefuroxym, clarithromycin) and steroid (prednisone)]. | 2005 | Pol. Merkur. Lekarski | pmid:16358864 |
Maciorkowska E et al. | [Resistance to antibiotics used in Helicobacter pylori infection in children]. | 2004 | Pol. Merkur. Lekarski | pmid:15510893 |
Prescott LM | Clarithromycin for MAC prevention offers additional benefits. | 1996 May-Jun | Posit Aware | pmid:11363431 |
Laine L and Fendrick AM | Helicobacter pylori and peptic ulcer disease. Bridging the gap between knowledge and treatment. | 1998 | Postgrad Med | pmid:9519040 |
Senatore FJ et al. | Helicobacter pylori treatment: Still a work in progress. | 2016 | Postgrad Med | pmid:26490697 |
Coulston J and Balaratnam N | Irreversible sensorineural hearing loss due to clarithromycin. | 2005 | Postgrad Med J | pmid:15640431 |
Bateson MC | Quadruple therapy for symptomatic spontaneous duodenal ulcer disease. | 2001 | Postgrad Med J | pmid:11423595 |
Laird-Fick HS et al. | Gastric adenocarcinoma: the role of Helicobacter pylori in pathogenesis and prevention efforts. | 2016 | Postgrad Med J | pmid:27222587 |
Arnold Ch et al. | [88 years old woman with acute muscular weakness and diffuse muscular pain: have you thought about the drugs?]. | 2010 | Praxis (Bern 1994) | pmid:21125536 |
Plate A | [Not Available]. | 2016 | Praxis (Bern 1994) | pmid:27606919 |
Naumann UK et al. | [Brochiectasis (in the adult)]. | 2007 | Praxis (Bern 1994) | pmid:17616034 |
Treiber G and Malfertheiner P | [Helicobacter pylori--2002]. | 2002 | Praxis (Bern 1994) | pmid:12071078 |
Steurer J | [Months of antibiotic therapy in persistent symptoms of Lyme disease without effect]. | 2016 | Praxis (Bern 1994) | pmid:27269781 |
Dobrick N et al. | [Legionnaires disease (legionella pneumonia)]. | 2012 | Praxis (Bern 1994) | pmid:23147600 |
Schuster M | [Helicobacter pylori: reasons for eradication]. | 2004 | Praxis (Bern 1994) | pmid:15672764 |
Schuster MJ | [Helicobacter pylori. Update 2002]. | 2002 | Praxis (Bern 1994) | pmid:12508673 |
Landolt M and Heininger U | [Prevalence of perianal streptococcal dermatitis in children and adolescents]. | 2005 | Praxis (Bern 1994) | pmid:16209362 |
Bismuth + metronidazole + tetracycline. Why risk adding bismuth? | 2013 | Prescrire Int | pmid:23662315 | |
Clarithromycin in coronary heart disease: excess mortality in the long term. | 2006 | Prescrire Int | pmid:17167932 | |
Severe colchicine-macrolide interactions. | 2003 | Prescrire Int | pmid:12602385 | |
Sellal A et al. | [Maintenance treatment of cerebral toxoplasmosis in AIDS: role of clarithromycin-minocycline combination]. | 1996 | Presse Med | pmid:8685115 |
Contios S et al. | [Mycobacterium marinum tenosynovitis of the abductors]. | 2005 | Presse Med | pmid:15962499 |
Saint-Marc T et al. | [Mycobacterium avium intracellulare infections. Treatment with a clarithromycin-clofazimine combination. 18 cases]. | 1993 | Presse Med | pmid:8121903 |
Guillemet C et al. | [Clarithromycin-digoxin: an unrecognized interaction in some patients]. | 1997 | Presse Med | pmid:9137381 |
Fonquernie L et al. | [Pseudotumoral abdominal granuloma concomitant with immune reconstitution after antiretroviral treatment]. | 2000 | Presse Med | pmid:10705894 |
Couture G et al. | [Second case of serum sickness-like reaction to claritrhomycin]. | 2016 | Presse Med | pmid:27542759 |
Mégraud F | [Helicobacter pylori infection: Review and practice]. | Presse Med | pmid:20627443 | |
Blondon H | [Eradication of Helicobacter pylori: what is the effect on symptoms of non-ulcerous dyspepsia?]. | 1999 | Presse Med | pmid:10629694 |
Ragnaud JM et al. | [Cerebral toxoplasmosis in AIDS. 73 cases. Clinical Epidemiology Group on AIDS in Aquitania]. | 1993 | Presse Med | pmid:8378280 |
Esvant H et al. | [Primary prophylaxis of cerebral toxoplasmosis in AIDS with clarithromycin]. | 1993 | Presse Med | pmid:8337221 |
de Masson A et al. | Cavitary pulmonary disease in a patient treated with natalizumab. | 2014 | Presse Med | pmid:24742610 |
Mariani-Kurkdjian P et al. | [Current Streptococcus pyogenes sensitivity responsible for acute tonsillopharyngitis in France]. | 2004 | Presse Med | pmid:15257225 |
Bigard MA | [Helicobacter pylori eradication. Therapeutic evolution, value of complementary studies]. | 2001 | Presse Med | pmid:11603094 |
Mégraud F | [Helicobacter pylori: bacteriological aspects, diagnostic methods, and susceptibility to antibiotics]. | 2008 | Presse Med | pmid:18261874 |
Songné B et al. | [Buruli ulcer in Togo: 21 cases]. | 2001 | Presse Med | pmid:11317927 |
Courillon-Mallet A | [Treatment of Helicobacter pylori infection]. | 2008 | Presse Med | pmid:18255253 |
Morlet-Barla N et al. | [Severe hypoglycemia and recurrence caused by disopyramide-clarithromycin interaction]. | 2000 Jul 8-15 | Presse Med | pmid:10938688 |
Khalil T et al. | [Helicobacter pylori infection and eradication are not related to glycosylated hemoglobin levels (HbA1c) in young patients with type 1 diabetes]. | 2007 | Presse Med | pmid:17360147 |
Olivier D | [HIV: a guide on management of seropositive patients]. | 2001 | Presse Med | pmid:11268903 |
Hajjaji N et al. | [Mycobacterium chelonae myositis]. | 2004 | Presse Med | pmid:15614176 |
Kwan BY and Rabheru K | Manic episode associated with clarithromycin in a patient with medically treated depression. | 2012 | Prim Care Companion CNS Disord | pmid:22943025 |
James GD et al. | Use of long-term antibiotic treatment in COPD patients in the UK: a retrospective cohort study. | 2013 | Prim Care Respir J | pmid:23839240 |
Shmelev EI et al. | [Clarythromycin in the treatment of exacerbations of chronic obstructive lung disease]. | 2006 | Probl Tuberk Bolezn Legk | pmid:17002058 |
Björkholm B et al. | Mutation frequency and biological cost of antibiotic resistance in Helicobacter pylori. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11717398 |
Pfister P et al. | 23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15795375 |
Fahey JW et al. | Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12032331 |
Sato Y et al. | Macrolide antibiotics promote the LPS-induced upregulation of prostaglandin E receptor EP2 and thus attenuate macrolide suppression of IL-6 production. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17324565 |
Miyazaki M et al. | Macrolide antibiotics inhibit prostaglandin E2 synthesis and mRNA expression of prostaglandin synthetic enzymes in human leukocytes. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12907132 |
Thorley JA et al. | Mechanisms of viral entry: sneaking in the front door. | 2010 | Protoplasma | pmid:20446005 |
Mach T and Zahradnik-Bilska J | [Reinfection with Helicobacter pylori in patients with duodenal ulcer after successful eradication]. | 1999 | Prz. Lek. | pmid:10575912 |
Hydzik P et al. | [Drug-induced erythrodermia complicated by multiorgan failure--case report]. | 2011 | Prz. Lek. | pmid:22010450 |
Trzebiatowska I et al. | [Psychosis caused by the treatment with clarithromycin--a case report]. | 2011 | Prz. Lek. | pmid:22010468 |
Zwolińska-Wcisło M and Palka M | [Principles of managing Helicobacter pylori infections. Guidelines of the European Society of Gastroenterology in Primary Health Care]. | 2000 | Prz. Lek. | pmid:11293204 |
Mrozińska M | [Legionellosis in three children--cases report]. | 2005 | Przegl Epidemiol | pmid:16729426 |
Härtig G et al. | [Symptomatic psychosis in bland sinus thrombosis and antibiotic therapy]. | 1999 | Psychiatr Prax | pmid:10457975 |
Jiang F et al. | The influences of CYP2D6 genotypes and drug interactions on the pharmacokinetics of venlafaxine: exploring predictive biomarkers for treatment outcomes. | 2015 | Psychopharmacology (Berl.) | pmid:25510856 |
Warner A | Clarithromycin--a precipitant for acute psychotic stress. | 2000 Nov-Dec | Psychosomatics | pmid:11110120 |
Mermelstein HT | Clarithromycin-induced delirium in a general hospital. | 1998 Nov-Dec | Psychosomatics | pmid:9819955 |
Martynova AV et al. | Emergence of Haemophilus influenzae Strains in the Nasopharynx of Children with Tuberculosis. | 2011 | Pulm Med | pmid:21766017 |
Rafii R et al. | Update on pharmaceutical and minimally invasive management strategies for chronic obstructive pulmonary disease. | 2011 | Pulm Med | pmid:21660228 |
Figueiredo Bde C and Ibiapina Cda C | The role of macrolides in noncystic fibrosis bronchiectasis. | 2011 | Pulm Med | pmid:22292118 |
Hasegawa N et al. | Concentrations of clarithromycin and active metabolite in the epithelial lining fluid of patients with Mycobacterium avium complex pulmonary disease. | 2009 | Pulm Pharmacol Ther | pmid:19061965 |
Yamada K et al. | Azithromycin inhibits MUC5AC induction via multidrug-resistant Acinetobacter baumannii in human airway epithelial cells. | 2014 | Pulm Pharmacol Ther | pmid:24910464 |
Morinaga Y et al. | Azithromycin, clarithromycin and telithromycin inhibit MUC5AC induction by Chlamydophila pneumoniae in airway epithelial cells. | 2009 | Pulm Pharmacol Ther | pmid:19716898 |
Gao X et al. | Macrolide antibiotics improve chemotactic and phagocytic capacity as well as reduce inflammation in sulfur mustard-exposed monocytes. | 2010 | Pulm Pharmacol Ther | pmid:19895898 |
Liu CP et al. | NO-releasing xanthine KMUP-1 bonded by simvastatin attenuates bleomycin-induced lung inflammation and delayed fibrosis. | 2014 | Pulm Pharmacol Ther | pmid:23518214 |
Nakamura M et al. | Clarithromycin ameliorates pulmonary inflammation induced by short term cigarette smoke exposure in mice. | 2015 | Pulm Pharmacol Ther | pmid:26363279 |
Burch LH and Picher M | E-NTPDases in human airways: Regulation and relevance for chronic lung diseases. | 2006 | Purinergic Signal. | pmid:18404479 |
Lin YH and Liu TC | Mycobacterium chelonae infection involving the auricle. | 2012 | QJM | pmid:21908384 |
Browne G et al. | A potential role for keratinocyte growth factor and clarithromycin in the treatment of paraquat overdose. | 2010 | QJM | pmid:20154068 |
Harvey E and Varatharaj A | Round pneumonia. | 2014 | QJM | pmid:23708793 |
Lin CM et al. | Is ionizing radiation a risk factor to diffuse panbronchiolitis? | 2017 | QJM | pmid:28069906 |
Ozdemir A et al. | Detection of Helicobacter pylori colonization in dental plaques and tongue scrapings of patients with chronic gastritis. | 2001 | Quintessence Int | pmid:12066673 |
Kim HS et al. | Serial CT findings of Mycobacterium massiliense pulmonary disease compared with Mycobacterium abscessus disease after treatment with antibiotic therapy. | 2012 | Radiology | pmid:22371609 |
Leonard S et al. | Application of liquid chromatography/ion trap mass spectrometry to the characterization of the related substances of clarithromycin. | 2006 | Rapid Commun. Mass Spectrom. | pmid:16991103 |
Calza P et al. | Identification of the unknown transformation products derived from clarithromycin and carbamazepine using liquid chromatography/high-resolution mass spectrometry. | 2012 | Rapid Commun. Mass Spectrom. | pmid:22730089 |
Bergamaschi A et al. | Recent Advances in the Treatment of Helicobacter pylori Infection. | 2007 | Recent Pat Antiinfect Drug Discov | pmid:18221177 |
Campo SM et al. | Antibiotic treatment strategies for Helicobacter pylori infection. | 2007 | Recent Pat Antiinfect Drug Discov | pmid:18221161 |
Zautner AE | Adenotonsillar disease. | 2012 | Recent Pat Inflamm Allergy Drug Discov | pmid:22452646 |
Parola D et al. | [Efficacy and safety of clarithromycin in the treatment of community-acquired pneumonia]. | 2000 | Recenti Prog Med | pmid:10705778 |
Vaira D et al. | [Treatment for Helicobacter pylori: current criteria]. | 2007 | Recenti Prog Med | pmid:18044409 |
Palumbo E et al. | [Mycoplasma pneumoniae encephalitis in immunocompetent child]. | 2008 | Recenti Prog Med | pmid:18710062 |
Sharma H et al. | Fortuitous vasculitis. | 2012 | Ren Fail | pmid:22250755 |
Wen YK and Chen ML | Crescentic glomerulonephritis associated with non-tuberculous mycobacteria infection. | 2008 | Ren Fail | pmid:18350456 |
Itatsu T et al. | Eradication of Helicobacter pylori in hemodialysis patients. | 2007 | Ren Fail | pmid:17365917 |
Yatsunami J et al. | Clarithromycin is a potent inhibitor of tumor-induced angiogenesis. | 1997 | Res Exp Med (Berl) | pmid:9440137 |
Komori T et al. | Effect of clarithromycin on alpha1-acid glycoprotein levels in normal and diabetic rats. | 1998 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9874281 |
Ives TJ et al. | Disposition and functions of clarithromycin in human THP-1 monocytes during stimulated and unstimulated conditions. | 2001 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:12760488 |
Heifets LB | Quantitative cultures and drug susceptibility testing of Mycobacterium avium clinical isolates before and during the antimicrobial therapy. | 1994 Mar-Apr | Res. Microbiol. | pmid:7809471 |
Dautzenberg B | Clinical trials in Mycobacterium avium therapy: lessons to take home. | 1994 Mar-Apr | Res. Microbiol. | pmid:7809472 |
Horgen L et al. | Postantibiotic effect of amikacin, rifampin, sparfloxacin, clofazimine and clarithromycin against Mycobacterium avium. | 1997 | Res. Microbiol. | pmid:9765852 |
Yajko DM | In vitro activity of antimicrobial agents against the Mycobacterium avium complex inside macrophages from HIV1-infected individuals: the link to clinical response to treatment? | 1992 | Res. Microbiol. | pmid:1455069 |
Kargar M et al. | Real-time PCR for Helicobacter pylori quantification and detection of clarithromycin resistance in gastric tissue from patients with gastrointestinal disorders. | 2012 | Res. Microbiol. | pmid:22177975 |