| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abortion, Spontaneous | D000022 | 12 associated lipids |
| Abnormalities, Drug-Induced | D000014 | 10 associated lipids |
clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with clarithromycin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (5)
- Drug Metab. Dispos. (1)
- FEMS Immunol. Med. Microbiol. (1)
- Others (5)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kunin M et al. | Mycobacterium chelonae peritonitis in peritoneal dialysis. Literature review. | 2014 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:24569948 |
| Fan Y et al. | High and low doses of clarithromycin treatment are associated with different clinical efficacies and immunomodulatory properties in chronic rhinosinusitis. | 2014 | J Laryngol Otol | pmid:24555753 |
| Hanson KE et al. | Rapid molecular detection of inducible macrolide resistance in Mycobacterium chelonae and M. abscessus strains: a replacement for 14-day susceptibility testing? | 2014 | J. Clin. Microbiol. | pmid:24554745 |
| Almeida N et al. | Triple therapy with high-dose proton-pump inhibitor, amoxicillin, and doxycycline is useless for Helicobacter pylori eradication: a proof-of-concept study. | 2014 | Helicobacter | pmid:24506175 |
| Yakoob J et al. | Comparison of antimicrobial activity of zinc chloride and bismuth subsalicylate against clinical isolates of Helicobacter pylori. | 2014 | Microb. Drug Resist. | pmid:23844851 |
| Markert C et al. | Clarithromycin substantially increases steady-state bosentan exposure in healthy volunteers. | 2014 | Br J Clin Pharmacol | pmid:23738582 |
| Khoshnood A et al. | Replacement of clarithromycin with azithromycin in triple therapy regimens for the eradication of Helicobacter pylori: A randomized clinical trial. | 2014 | J Med Life | pmid:25408735 |
| Ueda Y et al. | [Obstructive pneumonia and brain abscess due to Nocardia elegans in a patient with systemic lupus erythematosus]. | 2014 | Kansenshogaku Zasshi | pmid:24974451 |
| NegrÃn-González J et al. | Psychiatric adverse reaction induced by clarithromycin. | 2014 | Eur Ann Allergy Clin Immunol | pmid:24853570 |
| Kurosaki Y et al. | [Two cases of pulmonary Mycobacterium avium complex disease with resistance to clarithromycin]. | 2014 | Kekkaku | pmid:24979948 |
| Iwanaga K and Carter ER | Mycobacterium abscessus complex lung infection in a toddler with a tracheostomy. | 2014 | Pediatr. Pulmonol. | pmid:23460506 |
| Tümgör G et al. | Comparison of standard and standard plus vitamin E therapy for Helicobacter pylori eradications in children. | 2014 | Turk J Gastroenterol | pmid:25910378 |
| Çiftci İH et al. | Comparison of FISH, RFLP and agar dilution methods for testing clarithromycin resistance of Helicobacter pylori. | 2014 | Turk J Gastroenterol | pmid:25910373 |
| Heo J and Jeon SW | [Changes in the eradication rate of conventional triple therapy for Helicobacter pylori infection in Korea]. | 2014 | Korean J Gastroenterol | pmid:24651586 |
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| Patsche CB et al. | Disseminated Mycobacterium celatum disease with prolonged pulmonary involvement. | 2014 | Int. J. Infect. Dis. | pmid:25008771 |
| Pathak V et al. | Macrolide use leads to clinical and radiological improvement in patients with cryptogenic organizing pneumonia. | 2014 | Ann Am Thorac Soc | pmid:24460438 |
| Jesus FP et al. | In vitro synergism observed with azithromycin, clarithromycin, minocycline, or tigecycline in association with antifungal agents against Pythium insidiosum. | 2014 | Antimicrob. Agents Chemother. | pmid:25001300 |
| Wu JY et al. | Evidence-based recommendations for successful Helicobacter pylori treatment. | 2014 | Expert Rev Gastroenterol Hepatol | pmid:24410470 |
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| Phillips RO et al. | Clinical and bacteriological efficacy of rifampin-streptomycin combination for two weeks followed by rifampin and clarithromycin for six weeks for treatment of Mycobacterium ulcerans disease. | 2014 | Antimicrob. Agents Chemother. | pmid:24323473 |
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| Wang B et al. | Standard triple therapy for Helicobacter pylori infection in China: a meta-analysis. | 2014 | World J. Gastroenterol. | pmid:25356059 |
| Morakul B et al. | Dissolution enhancement and in vitro performance of clarithromycin nanocrystals produced by precipitation-lyophilization-homogenization method. | 2014 | Eur J Pharm Biopharm | pmid:25201298 |
| Parekh TM et al. | Hypoglycemia after antimicrobial drug prescription for older patients using sulfonylureas. | 2014 | JAMA Intern Med | pmid:25179404 |
| Kutluk G et al. | Sequential therapy versus standard triple therapy for Helicobacter pylori eradication in children: any advantage in clarithromycin-resistant strains? | 2014 | Eur J Gastroenterol Hepatol | pmid:25171023 |
| Higashi F et al. | Additional treatment with clarithromycin reduces fever duration in patients with influenza. | 2014 | Respir Investig | pmid:25169846 |
| de Boer EM et al. | [Antibiotic resistance of Helicobacter pylori: prevalence in one region in the southern Netherlands and implications for treatment]. | 2014 | Ned Tijdschr Geneeskd | pmid:25159698 |
| Lambert D et al. | Gastritis due to Helicobacter pylori, an unusual cause of chronic diarrhoea in HIV infected patients. | 2014 | Med Mal Infect | pmid:25015308 |
| Teh X et al. | Functional and molecular surveillance of Helicobacter pylori antibiotic resistance in Kuala Lumpur. | 2014 | PLoS ONE | pmid:25003707 |
| Lyons J et al. | An unusual lung mass post stem cell transplantation. | 2014 | Transpl Infect Dis | pmid:24995624 |
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| Pan-In P et al. | Ethyl cellulose nanoparticles: clarithomycin encapsulation and eradication of H. pylori. | 2014 | Carbohydr Polym | pmid:24815396 |
| Ichihara A et al. | Case of disseminated cutaneous Mycobacterium chelonae infection mimicking cutaneous vasculitis. | 2014 | J. Dermatol. | pmid:24801916 |
| Togami K et al. | Involvement of intestinal permeability in the oral absorption of clarithromycin and telithromycin. | 2014 | Biopharm Drug Dispos | pmid:24801141 |
| Bernut A et al. | In vivo assessment of drug efficacy against Mycobacterium abscessus using the embryonic zebrafish test system. | 2014 | Antimicrob. Agents Chemother. | pmid:24798271 |
| Adebisi AO and Conway BR | Lectin-conjugated microspheres for eradication of Helicobacter pylori infection and interaction with mucus. | 2014 | Int J Pharm | pmid:24792977 |
| Bolhuis MS et al. | In vitro synergy between linezolid and clarithromycin against Mycobacterium tuberculosis. | 2014 | Eur. Respir. J. | pmid:24791826 |
| Takazono T et al. | Paradoxical response to disseminated non-tuberculosis mycobacteriosis treatment in a patient receiving tumor necrosis factor-α inhibitor: a case report. | 2014 | BMC Infect. Dis. | pmid:24576098 |
| Skvarc M et al. | Multi locus sequence typing (MLST) used as a tool to confirm the ability of susceptible Helicobacter pylori strains to gain resistance to clarithromycin during eradication therapy. | 2014 Jan-Feb | Hepatogastroenterology | pmid:24895826 |
| UÄŸurlu T et al. | Optimization and evaluation of clarithromycin floating tablets using experimental mixture design. | 2014 Mar-Apr | Acta Pol Pharm | pmid:25272652 |
| Picoli SU et al. | Resistance to amoxicillin, clarithromycin and ciprofloxacin of Helicobacter pylori isolated from Southern Brazil patients. | 2014 May-Jun | Rev. Inst. Med. Trop. Sao Paulo | pmid:24878996 |
| Takagi M et al. | Underlying mechanism of drug-drug interaction between pioglitazone and gemfibrozil: Gemfibrozil acyl-glucuronide is a mechanism-based inhibitor of CYP2C8. | 2015 | Drug Metab. Pharmacokinet. | pmid:26195223 |
| Li Y et al. | Liposomal co-delivery of daptomycin and clarithromycin at an optimized ratio for treatment of methicillin-resistant Staphylococcus aureus infection. | 2015 | Drug Deliv | pmid:24471983 |
| Jung IY et al. | A case of bronchiolitis obliterans organizing pneumonia in an HIV-infected Korean patient successfully treated with clarithromycin. | 2015 | BMC Infect. Dis. | pmid:26201392 |
| Sobajima T et al. | A Case of Pulmonary Actinomycosis Associated With Aspiration of Cedar Leaves. | 2015 | J Bronchology Interv Pulmonol | pmid:26165898 |
| Gunjan S et al. | Clarithromycin enhances the antimalarial efficacy of mefloquine via its increased bioavailability and disrupting P. falciparum apicoplast. | 2015 | Life Sci. | pmid:26164186 |
| Tongtawee T et al. | Effect of Pretreatment with Lactobacillus delbrueckii and Streptococcus thermophillus on Tailored Triple Therapy for Helicobacter pylori Eradication: A Prospective Randomized Controlled Clinical Trial. | 2015 | Asian Pac. J. Cancer Prev. | pmid:26163609 |
| Fujimura S et al. | Antimicrobial efficacy of combined clarithromycin plus daptomycin against biofilms-formed methicillin-resistant Staphylococcus aureus on titanium medical devices. | 2015 | J. Infect. Chemother. | pmid:26162777 |
| Cavkaytar S et al. | Clarithromycin regresses endometriotic implants in rat endometriosis model. | 2015 | J Obstet Gynaecol | pmid:26156575 |
| Bai P et al. | Susceptibility of Helicobacter pylori to antibiotics in Chinese patients. | 2015 | J Dig Dis | pmid:26147515 |
| Zeng M et al. | Clarithromycin and dexamethasone show similar anti-inflammatory effects on distinct phenotypic chronic rhinosinusitis: an explant model study. | 2015 | BMC Immunol. | pmid:26047816 |
| Converse PJ et al. | Efficacy of Rifampin Plus Clofazimine in a Murine Model of Mycobacterium ulcerans Disease. | 2015 | PLoS Negl Trop Dis | pmid:26042792 |
| Klain V and Timmerman L | Comment on The dangers of gastritis: a case of clarithromycin-associated brief psychotic episode. | 2015 | J. Nerv. Ment. Dis. | pmid:26034875 |
| Prapitpaiboon H et al. | High Efficacy of Levofloxacin-Dexlansoprazole-Based Quadruple Therapy as a First Line Treatment for Helicobacter pylori Eradication in Thailand. | 2015 | Asian Pac. J. Cancer Prev. | pmid:26028098 |
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| Sugita S et al. | EGFR-independent autophagy induction with gefitinib and enhancement of its cytotoxic effect by targeting autophagy with clarithromycin in non-small cell lung cancer cells. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25858318 |
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| Kiesewetter B et al. | Clarithromycin Leading to Complete Remission in the First-Line Treatment of Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma. | 2015 | J. Clin. Oncol. | pmid:24778391 |
| Yin SM et al. | Disseminated Mycobacterium kansasii disease in complete DiGeorge syndrome. | 2015 | J. Clin. Immunol. | pmid:26048260 |
| Nakamura M et al. | Clarithromycin ameliorates pulmonary inflammation induced by short term cigarette smoke exposure in mice. | 2015 | Pulm Pharmacol Ther | pmid:26363279 |
| Zhang W et al. | Bismuth, lansoprazole, amoxicillin and metronidazole or clarithromycin as first-line Helicobacter pylori therapy. | 2015 | Gut | pmid:26338726 |
| Fasciana T et al. | Resistance to clarithromycin and genotypes in Helicobacter pylori strains isolated in Sicily. | 2015 | J. Med. Microbiol. | pmid:26338221 |
| Brusselle GG | Are the antimicrobial properties of macrolides required for their therapeutic efficacy in chronic neutrophilic airway diseases? | 2015 | Thorax | pmid:25870311 |