| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abortion, Spontaneous | D000022 | 12 associated lipids |
| Abnormalities, Drug-Induced | D000014 | 10 associated lipids |
clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with clarithromycin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (5)
- Drug Metab. Dispos. (1)
- FEMS Immunol. Med. Microbiol. (1)
- Others (5)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Knothe H | [Short-term therapy of acute respiratory and ORL infections with Clarithromycin]. | 1992 | Z Gesamte Inn Med | pmid:9022402 |
| Paar D et al. | Life-threatening interaction between clarithromycin and disopyramide. | 1997 | Lancet | pmid:9024381 |
| Berg-Candolfi M and Candolfi E | Depression of the N-demethylation of erythromycin, azithromycin, clarithromycin and clindamycin in murine Toxoplasma infection. | 1996 | Int. J. Parasitol. | pmid:9024879 |
| Flisch CW et al. | [A case of arthritis of the wrist caused by Mycobacterium marinum. Review of the literature]. | 1996 | Ann Chir Main Memb Super | pmid:9026056 |
| Wang XM et al. | [Time course of disappearance of Helicobacter pylori after topical therapy and new triple therapy]. | 1997 | Nihon Shokakibyo Gakkai Zasshi | pmid:9028149 |
| MacÃas J et al. | Rhodococcus or mycobacterium? An example of misdiagnosis in HIV infection. | 1997 | AIDS | pmid:9030376 |
| Alarcón T et al. | In vitro activity of omeprazole in combination with several antimicrobial agents against clinical isolates of Helicobacter pylori. | 1996 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9031877 |
| Burucoa C et al. | Western blot monitoring of disseminated Nocardia nova infection treated with clarithromycin, imipenem, and surgical drainage. | 1996 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9031879 |
| Engelhardt E et al. | [Postoperative infection with Mycobacterium chelonae]. | 1996 | Hautarzt | pmid:9036143 |
| Yamamoto M et al. | [The clinical study of clarithromycin for pulmonary Mycobacterium avium-intracellulare complex infection]. | 1997 | Kekkaku | pmid:9038009 |
| Kelleher P et al. | Uveitis associated with rifabutin and macrolide therapy for Mycobacterium avium intracellulare infection in AIDS patients. | 1996 | Genitourin Med | pmid:9038637 |
| Dautzenberg B et al. | A randomized comparison of two clarithromycin doses for treatment of Mycobacterium avium complex infections. | 1997 Jan-Feb | Infection | pmid:9039532 |
| Dohil R et al. | Effective 2-wk therapy for Helicobacter pylori disease in children. | 1997 | Am. J. Gastroenterol. | pmid:9040199 |
| Lerang F et al. | Highly effective twice-daily triple therapies for Helicobacter pylori infection and peptic ulcer disease: does in vitro metronidazole resistance have any clinical relevance? | 1997 | Am. J. Gastroenterol. | pmid:9040200 |
| Brady RC et al. | Facial sporotrichoid infection with Mycobacterium marinum. | 1997 | J. Pediatr. | pmid:9042142 |
| Axon AT et al. | Ranitidine bismuth citrate and clarithromycin twice daily in the eradication of Helicobacter pylori. | 1997 | Aliment. Pharmacol. Ther. | pmid:9042977 |
| Labenz J et al. | One-week low-dose triple therapy for Helicobacter pylori is sufficient for relief from symptoms and healing of duodenal ulcers. | 1997 | Aliment. Pharmacol. Ther. | pmid:9042978 |
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| Roche B et al. | Efficacy of combined clarithromycin and sparfloxacin therapy in a patient with discitis: due to Mycobacterium xenopi. | 1997 | Rev Rhum Engl Ed | pmid:9051864 |
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| Gui GP et al. | Two-year-outcomes analysis of Crohn's disease treated with rifabutin and macrolide antibiotics. | 1997 | J. Antimicrob. Chemother. | pmid:9096189 |
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| Matsuoka N et al. | Inhibitory effect of clarithromycin on costimulatory molecule expression and cytokine production by synovial fibroblast-like cells. | 1996 | Clin. Exp. Immunol. | pmid:9099936 |
| DÃaz F et al. | [Cat-scratch disease. A report of 4 cases and a review of the literature]. | 1997 | Rev Clin Esp | pmid:9102668 |
| Kato A | [Effect of erythromycin and clarithromycin on ion transport across dissected canine tracheal epithelium]. | 1997 | Nippon Jibiinkoka Gakkai Kaiho | pmid:9103848 |
| Szczebara F et al. | Evaluation of rapid molecular methods for detection of clarithromycin resistance in Helicobacter pylori. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9105846 |
| Fietta A et al. | Inhibition of intracellular growth of Staphylococcus aureus by exposure of infected human monocytes to clarithromycin and azithromycin. | 1997 | J Chemother | pmid:9106013 |
| Fietta A et al. | Requirements for intracellular accumulation and release of clarithromycin and azithromycin by human phagocytes. | 1997 | J Chemother | pmid:9106014 |
| Arguedas A et al. | Comparative trial of 3 days of azithromycin versus 10 days of clarithromycin in the treatment of children with acute otitis media with effusion. | 1997 | J Chemother | pmid:9106017 |
| Klein JO | History of macrolide use in pediatrics. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109154 |
| McCracken GH | Microbiologic activity of the newer macrolide antibiotics. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109155 |
| Nightingale CH | Pharmacokinetics and pharmacodynamics of newer macrolides. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109156 |
| Tarlow MJ | Macrolides in the management of streptococcal pharyngitis/tonsillitis. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109157 |
| Block SL | Causative pathogens, antibiotic resistance and therapeutic considerations in acute otitis media. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109158 |
| Tarlow MJ et al. | Future indications for macrolides. | 1997 | Pediatr. Infect. Dis. J. | pmid:9109159 |
| Rodrigo Sáez L et al. | [The efficacy of using a short course of 6-day duration (OCA-6) in the treatment to eradicate Helicobacter pylori infection. Omeprazole, clarithromycin, amoxicillin]. | 1997 | Rev Esp Enferm Dig | pmid:9115827 |
| Cadranel JF et al. | [Acute symptomatic cytolytic hepatitis probably related to clarithromycin]. | 1996 | Gastroenterol. Clin. Biol. | pmid:9119179 |
| Hultén K et al. | New pharmacokinetic in vitro model for studies of antibiotic activity against intracellular microorganisms. | 1996 | Antimicrob. Agents Chemother. | pmid:9124830 |
| Lazzaroni M et al. | Triple therapy with ranitidine or lansoprazole in the treatment of Helicobacter pylori-associated duodenal ulcer. | 1997 | Am. J. Gastroenterol. | pmid:9128316 |
| Stone GG et al. | PCR-RFLP typing of ureC from Helicobacter pylori isolated in Argentina from gastric biopsies before and after treatment with clarithromycin. | 1997 | Epidemiol. Infect. | pmid:9129588 |
| [Management of atypical Mycobacterium infections in AIDS-patients]. | 1996 | Internist (Berl) | pmid:9131082 | |
| Spicer ST et al. | The mechanism of cyclosporine toxicity induced by clarithromycin. | 1997 | Br J Clin Pharmacol | pmid:9131953 |
| Guillemet C et al. | [Clarithromycin-digoxin: an unrecognized interaction in some patients]. | 1997 | Presse Med | pmid:9137381 |
| Plemmons RM et al. | Osteomyelitis due to Mycobacterium haemophilum in a cardiac transplant patient: case report and analysis of interactions among clarithromycin, rifampin, and cyclosporine. | 1997 | Clin. Infect. Dis. | pmid:9142810 |
| Khan AA et al. | Activity of trovafloxacin in combination with other drugs for treatment of acute murine toxoplasmosis. | 1997 | Antimicrob. Agents Chemother. | pmid:9145840 |
| Collins L and Franzblau SG | Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium. | 1997 | Antimicrob. Agents Chemother. | pmid:9145860 |
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| Spinzi G et al. | Randomized study comparing omeprazole plus amoxycillin versus omeprazole plus clarithromycin for eradication of Helicobacter pylori. | 1997 | Aliment. Pharmacol. Ther. | pmid:9146769 |
| Peterson WL | The role of antisecretory drugs in the treatment of Helicobacter pylori infection. | 1997 | Aliment. Pharmacol. Ther. | pmid:9146787 |
| Chaisson RE et al. | Clarithromycin and ethambutol with or without clofazimine for the treatment of bacteremic Mycobacterium avium complex disease in patients with HIV infection. | 1997 | AIDS | pmid:9147422 |
| Rodrigues AD et al. | Oxidative metabolism of clarithromycin in the presence of human liver microsomes. Major role for the cytochrome P4503A (CYP3A) subfamily. | 1997 | Drug Metab. Dispos. | pmid:9152603 |
| Garrison MW et al. | Influence of pH on the antimicrobial activity of clarithromycin and 14-hydroxyclarithromycin against Haemophilus influenzae using an in vitro pharmacodynamic model. | 1997 | Diagn. Microbiol. Infect. Dis. | pmid:9154410 |
| Misiewicz JJ | Management of Helicobacter pylori-related disorders. | 1997 | Eur J Gastroenterol Hepatol | pmid:9160212 |
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| Walsh D et al. | One week treatment for Helicobacter pylori infection. | 1997 | Arch. Dis. Child. | pmid:9166031 |
| OÄŸuz O et al. | Conjunctival involvement in familial chronic benign pemphigus (Hailey-Hailey disease). | 1997 | Int. J. Dermatol. | pmid:9169328 |
| Alfandari S et al. | Isolated cutaneous Mycobacterium avium complex infection in AIDS. | 1997 | Int. J. Dermatol. | pmid:9169332 |
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| Rodvold KA et al. | Intrapulmonary steady-state concentrations of clarithromycin and azithromycin in healthy adult volunteers. | 1997 | Antimicrob. Agents Chemother. | pmid:9174209 |
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| Lo WC et al. | Clarithromycin in the combination therapy for the eradication of Helicobacter pylori in peptic ulcer disease. | 1997 | Zhonghua Yi Xue Za Zhi (Taipei) | pmid:9198292 |
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| Marignani M et al. | Reversal of long-standing iron deficiency anaemia after eradication of Helicobacter pylori infection. | 1997 | Scand. J. Gastroenterol. | pmid:9200297 |
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| Verhaegen J et al. | Impredictable susceptibility for cephalosporins in penicillin resistant Streptococcus pneumoniae. | 1997 | Acta Clin Belg | pmid:9204588 |
| Kim MJ et al. | Serum 13C-bicarbonate assay for the diagnosis of gastric Helicobacter pylori infection and response to treatment. | 1997 | Gastroenterology | pmid:9207259 |
| Mikasa K et al. | Significant survival benefit to patients with advanced non-small-cell lung cancer from treatment with clarithromycin. | 1997 Jul-Aug | Chemotherapy | pmid:9209786 |
| Meyer JM et al. | In vitro synergy testing of clarithromycin and 14-hydroxyclarithromycin with amoxicillin or bismuth subsalicylate against Helicobacter pylori. | 1997 | Antimicrob. Agents Chemother. | pmid:9210696 |
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| Lim AG et al. | Helicobacter pylori eradication using a 7-day regimen of low-dose clarithromycin, lansoprazole and amoxycillin. | 1997 | Aliment. Pharmacol. Ther. | pmid:9218079 |
| Best LM et al. | Helicobacter pylori: primary susceptibility to clarithromycin in vitro in Nova Scotia. | 1997 May-Jun | Can. J. Gastroenterol. | pmid:9218854 |
| O'Brien B et al. | Cost effectiveness of alternative Helicobacter pylori eradication strategies in the management of duodenal ulcer. | 1997 May-Jun | Can. J. Gastroenterol. | pmid:9218858 |
| Hoppe JE and Tschirner T | Comparison of Etest and agar dilution for testing the activity of three macrolides against Bordetella parapertussis. | 1997 | Diagn. Microbiol. Infect. Dis. | pmid:9218920 |