MeSH term | MeSH ID | Detail |
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Abortion, Spontaneous | D000022 | 12 associated lipids |
Abnormalities, Drug-Induced | D000014 | 10 associated lipids |
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Struillou L et al. | Activities of roxithromycin against Mycobacterium avium infections in human macrophages and C57BL/6 mice. | 1995 | Antimicrob. Agents Chemother. | pmid:7785988 |
Fong IW et al. | Clarithromycin versus cefaclor in lower respiratory tract infections. The Canadian Bronchitis Study Group. | 1995 | Clin Invest Med | pmid:7788958 |
Goddard A and Logan R | One-week low-dose triple therapy: new standards for Helicobacter pylori treatment. | 1995 | Eur J Gastroenterol Hepatol | pmid:7866804 |
RamÃrez Ramos A | [Treatment of Helicobacter pylori infection: current status]. | 1995 | Rev Gastroenterol Peru | pmid:8520021 |
Lee D et al. | Localized Mycobacterium avium-intracellulare mastitis in an immunocompetent woman with silicone breast implants. | 1995 | Plast. Reconstr. Surg. | pmid:7809228 |
Forslund T et al. | Disseminated cutaneous infection due to Mycobacterium chelonae in a patient with rheumatoid arthritis, amyloidosis, and renal failure. | 1995 | Nephrol. Dial. Transplant. | pmid:7478131 |
Cavalieri SJ et al. | Synergistic activities of clarithromycin and antituberculous drugs against multidrug-resistant Mycobacterium tuberculosis. | 1995 | Antimicrob. Agents Chemother. | pmid:7492101 |
Reppun JI | From prontolyn to biaxin: the half-century of antibiotics. | 1995 | Hawaii Med J | pmid:7628918 |
Chin DP and Hopewell PC | How to treat bacteraemic Mycobacterium avium complex disease. | 1995 | Lancet | pmid:7564723 |
Kuhn SM et al. | Treatment of Mycobacterium marinum facial abscess using clarithromycin. | 1995 | Pediatr. Infect. Dis. J. | pmid:7567299 |
Uemura N et al. | Effect of Helicobacter pylori eradication on the healing and recurrence of peptic ulcer: combination therapy with low-dose omeprazole and clarithromycin. | 1995 | Eur J Gastroenterol Hepatol | pmid:8574740 |
Ishii K et al. | In vitro dissolution tests corresponding to the in vivo dissolution of clarithromycin tablets in the stomach and intestine. | 1995 | Chem. Pharm. Bull. | pmid:8575034 |
Diehl HG | [One week triple therapy for eradication of Helicobacter pylori infection: simple and effective]. | 1995 | Leber Magen Darm | pmid:8577220 |
Götz JM et al. | Triple therapy with ranitidine, clarithromycin, and metronidazole in the treatment of Helicobacter pylori. | 1995 | Scand. J. Gastroenterol. Suppl. | pmid:8578230 |
Nishi K et al. | [Effect of clarithromycin on symptoms and mucociliary transport in patients with sino-bronchial syndrome]. | 1995 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8821993 |
Parasakthi N and Goh KL | Primary and acquired resistance to clarithromycin among Helicobacter pylori strains in Malaysia. | 1995 | Am. J. Gastroenterol. | pmid:7872306 |
Cama VA et al. | Treatment of acute and chronic Cryptosporidium parvum infections in mice using clarithromycin and 14-OH clarithromycin. | 1994 Sep-Oct | J. Eukaryot. Microbiol. | pmid:7804227 |
O'Connor NK and Fris J | Clarithromycin-carbamazepine interaction in a clinical setting. | 1994 Nov-Dec | J Am Board Fam Pract | pmid:7847111 |
Scaglione F et al. | Effect of antibiotics on Bordetella pertussis adhering activity: hypothesis regarding mechanism of action. | 1994 May-Jun | Chemotherapy | pmid:7515782 |
Gersema LM et al. | Suspected drug interaction between cyclosporine and clarithromycin. | 1994 Mar-Apr | J. Heart Lung Transplant. | pmid:8031821 |
Heifets LB | Quantitative cultures and drug susceptibility testing of Mycobacterium avium clinical isolates before and during the antimicrobial therapy. | 1994 Mar-Apr | Res. Microbiol. | pmid:7809471 |
Dautzenberg B | Clinical trials in Mycobacterium avium therapy: lessons to take home. | 1994 Mar-Apr | Res. Microbiol. | pmid:7809472 |
Winter J | Intravenous clarithromycin. | 1994 Mar 16-Apr 5 | Br J Hosp Med | pmid:8032567 |
Mor N et al. | Accumulation of clarithromycin in macrophages infected with Mycobacterium avium. | 1994 Jan-Feb | Pharmacotherapy | pmid:8159593 |
Tessier MH et al. | Clarithromycin for atypical mycobacterial lymphadenitis in non-immunocompromised children. | 1994 Dec 24-31 | Lancet | pmid:7997032 |
Ploy MC et al. | [Antibacterial activity of clarithromycin and its hydroxylated derivative and two other macrolides against thirty strains of Streptococcus pneumoniae]. | 1994 | Pathol. Biol. | pmid:7824300 |
Darling TN et al. | Treatment of Mycobacterium haemophilum infection with an antibiotic regimen including clarithromycin. | 1994 | Br. J. Dermatol. | pmid:7918014 |
Gevaudan MJ et al. | [Evaluation of the extra- and intracellular activity of clarithromycin against Mycobacterium chelonae]. | 1994 | Pathol. Biol. | pmid:7824305 |
Domschke W | Omeprazole, Helicobacter pylori, and gastritis. | 1994 | J. Gastroenterol. | pmid:7921141 |
Geraci AJ | Empiric antibiotics in sinusitis. | 1994 | Arch Fam Med | pmid:7921288 |
Rust GS | Multicenter comparison of clarithromycin and amoxicillin. | 1994 | Arch Fam Med | pmid:7921290 |
Rolinson GN | A clarithromycin sensitivity survey. | 1994 | J. Antimicrob. Chemother. | pmid:7829420 |
Sieber CC et al. | [Helicobacter pylori resistance against metronidazole in Switzerland: implications for eradication therapy?]. | 1994 | Schweiz Med Wochenschr | pmid:8091165 |
Dorrell L et al. | Toxicity of clarithromycin in the treatment of Mycobacterium avium complex infection in a patient with AIDS. | 1994 | J. Antimicrob. Chemother. | pmid:7868416 |
Funke G et al. | Development of resistance to macrolide antibiotics in an AIDS patient treated with clarithromycin for Campylobacter jejuni diarrhea. | 1994 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:7805694 |
Fujii R et al. | [Clinical studies on clarithromycin dry syrup in the pediatric field. Pediatric Study Group of TE-031 Dry Syrup]. | 1994 | Jpn J Antibiot | pmid:7807690 |
Bonnet E et al. | Clarithromycin: a potent agent against infections due to Mycobacterium marinum. | 1994 | Clin. Infect. Dis. | pmid:8038339 |
Lemmen SW et al. | Bactericidal activity of clarithromycin and cefaclor against Streptococcus pneumoniae and Moraxella catarrhalis in healthy volunteers. | 1994 | J. Antimicrob. Chemother. | pmid:8040139 |
Dautzenberg B et al. | [Treatment with clarithromycin of 173 HIV+ patients with disseminated Mycobacterium avium intracellulare infection]. | 1994 | Rev Mal Respir | pmid:8041990 |
Böttger EC | Resistance to drugs targeting protein synthesis in mycobacteria. | 1994 | Trends Microbiol. | pmid:7850212 |
al-Assi MT et al. | Clarithromycin, tetracycline, and bismuth: a new non-metronidazole therapy for Helicobacter pylori infection. | 1994 | Am. J. Gastroenterol. | pmid:8053435 |
Guelar A et al. | [Therapeutic alternatives for cases of cerebral toxoplasmosis in patients with AIDS: clarithromycin and atovaquone]. | 1994 | Enferm. Infecc. Microbiol. Clin. | pmid:8011719 |
Aspin MM et al. | Comparative study of the safety and efficacy of clarithromycin and amoxicillin-clavulanate in the treatment of acute otitis media in children. | 1994 | J. Pediatr. | pmid:8021763 |
Chaisson RE et al. | Clarithromycin therapy for bacteremic Mycobacterium avium complex disease. A randomized, double-blind, dose-ranging study in patients with AIDS. AIDS Clinical Trials Group Protocol 157 Study Team. | 1994 | Ann. Intern. Med. | pmid:7978715 |
Goldberger M and Masur H | Clarithromycin therapy for Mycobacterium avium complex disease in patients with AIDS: potential and problems. | 1994 | Ann. Intern. Med. | pmid:7978725 |
Thijs JC et al. | Short report: clarithromycin, an alternative to metronidazole in the triple therapy of Helicobacter pylori infection. | 1994 | Aliment. Pharmacol. Ther. | pmid:8186339 |
Gelber RH et al. | Minimal bactericidal concentration of clarithromycin against M. leprae. | 1994 | Int. J. Lepr. Other Mycobact. Dis. | pmid:8189083 |
Xiong JH et al. | Further study of the effectiveness of single doses of clarithromycin and minocycline against Mycobacterium leprae in mice. | 1994 | Int. J. Lepr. Other Mycobact. Dis. | pmid:8189087 |
Paffetti A et al. | [Clarithromycin in pediatric age. Personal experience]. | 1994 | Minerva Pediatr. | pmid:8084327 |
Saran BR et al. | Hypopyon uveitis in patients with acquired immunodeficiency syndrome treated for systemic Mycobacterium avium complex infection with rifabutin. | 1994 | Arch. Ophthalmol. | pmid:8085960 |
Ohgaki N | Bacterial biofilm in chronic airway infection. | 1994 | Kansenshogaku Zasshi | pmid:8138670 |
Yew WW et al. | Cholestatic hepatitis in a patient who received clarithromycin therapy for a Mycobacterium chelonae lung infection. | 1994 | Clin. Infect. Dis. | pmid:8086541 |
Yasuda H et al. | Interaction between clarithromycin and biofilms formed by Staphylococcus epidermidis. | 1994 | Antimicrob. Agents Chemother. | pmid:8141568 |
Zahid MA et al. | Mycobacterium chelonae (M. chelonae subspecies chelonae): report of a patient with a sporotrichoid presentation who was successfully treated with clarithromycin and ciprofloxacin. | 1994 | Clin. Infect. Dis. | pmid:8086568 |
Uveitis associated with rifabutin therapy. | 1994 | MMWR Morb. Mortal. Wkly. Rep. | pmid:8072478 | |
Sano M et al. | [Adaptation study for biofilm of the urinary tract via highly complicated bladder model (biofilm model of the urinary tract)--experimental study using automatic simulator of the urinary antimicrobial agent concentration]. | 1994 | Kansenshogaku Zasshi | pmid:8089557 |
AIDS patients have a new weapon against MAC infection. | 1994 | RN | pmid:8128150 | |
Labenz J and Stolte M | [Current therapy of Helicobacter pylori infection]. | 1994 | Leber Magen Darm | pmid:8145628 |
Logan RP et al. | Eradication of Helicobacter pylori with clarithromycin and omeprazole. | 1994 | Gut | pmid:8150340 |
Honeybourne D et al. | The levels of clarithromycin and its 14-hydroxy metabolite in the lung. | 1994 | Eur. Respir. J. | pmid:7925906 |
Gad A and Unge P | Antibacterial therapy of Helicobacter pylori-associated peptic ulcer disease: a new strategy. The Swedes go for it. | 1994 | J. Clin. Gastroenterol. | pmid:7930437 |
Braegger CP and Nadal D | Clarithromycin and pseudomembranous enterocolitis. | 1994 | Lancet | pmid:7904702 |
Nishimura M et al. | [Therapeutic study on biofilm of the urinary tract using a severely complicated bladder model (biofilm model of the urinary tract)--experimental study using an automatic simulator of urinary antimicrobial agent concentration, and clinical study]. | 1994 | Kansenshogaku Zasshi | pmid:7909830 |
Morikawa K et al. | Immunomodulatory effects of three macrolides, midecamycin acetate, josamycin, and clarithromycin, on human T-lymphocyte function in vitro. | 1994 | Antimicrob. Agents Chemother. | pmid:7532933 |
Labenz J | [Helicobacter pylori therapy with omeprazole and clarithromycin: current status]. | 1994 | Leber Magen Darm | pmid:7968179 |
Oteo JA et al. | Clarithromycin-induced thrombocytopenic purpura. | 1994 | Clin. Infect. Dis. | pmid:7888564 |
Lazard T et al. | Chloroquine does not enhance the activity of clarithromycin against multiplication of Mycobacterium avium within human macrophages. | 1994 | Tuber. Lung Dis. | pmid:7949074 |
Roblin PM et al. | Susceptibilities to clarithromycin and erythromycin of isolates of Chlamydia pneumoniae from children with pneumonia. | 1994 | Antimicrob. Agents Chemother. | pmid:7979292 |
Inderlied CB et al. | Activities of the benzoxazinorifamycin KRM 1648 and ethambutol against Mycobacterium avium complex in vitro and in macrophages. | 1994 | Antimicrob. Agents Chemother. | pmid:7986017 |
Bermudez LE et al. | Activity of KRM 1648 alone or in combination with ethambutol or clarithromycin against Mycobacterium avium in beige mouse model of disseminated infection. | 1994 | Antimicrob. Agents Chemother. | pmid:7986018 |
Onyeji CO et al. | Efficacies of liposome-encapsulated clarithromycin and ofloxacin against Mycobacterium avium-M. intracellulare complex in human macrophages. | 1994 | Antimicrob. Agents Chemother. | pmid:8203849 |
Wallace RJ et al. | Initial clarithromycin monotherapy for Mycobacterium avium-intracellulare complex lung disease. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8173775 |
Husson RN et al. | Orally administered clarithromycin for the treatment of systemic Mycobacterium avium complex infection in children with acquired immunodeficiency syndrome. | 1994 | J. Pediatr. | pmid:8176574 |
Alder J et al. | Treatment of experimental Pneumocystis carinii infection by combination of clarithromycin and sulphamethoxazole. | 1994 | J. Antimicrob. Chemother. | pmid:8182006 |
Tsang KW et al. | The concentrations of clarithromycin and its 14-hydroxy metabolite in sputum of patients with bronchiectasis following single dose oral administration. | 1994 | J. Antimicrob. Chemother. | pmid:8182010 |
Sundberg L and Cederberg A | Penetration of clarithromycin and its 14-hydroxy metabolite into middle ear effusion in children with secretory otitis media. | 1994 | J. Antimicrob. Chemother. | pmid:8182011 |
Bermudez LE et al. | Clarithromycin, dapsone, and a combination of both used to treat or prevent disseminated Mycobacterium avium infection in beige mice. | 1994 | Antimicrob. Agents Chemother. | pmid:7695252 |
Mor N et al. | Effects of clarithromycin and rifabutin alone and in combination on intracellular and extracellular replication of Mycobacterium avium. | 1994 | Antimicrob. Agents Chemother. | pmid:7695255 |
Calì G et al. | [Clarithromycin in the treatment of oral infections]. | 1994 | Minerva Stomatol | pmid:7700226 |
Reed PI | The ECP-IM intervention study. | 1994 | Eur. J. Cancer Prev. | pmid:7735056 |
Kodama R et al. | Combination therapy with clarithromycin and sofalcone for eradication of Helicobacter pylori. | 1994 | Eur J Gastroenterol Hepatol | pmid:7735929 |
Klemens SP and Cynamon MH | Intermittent azithromycin for treatment of Mycobacterium avium infection in beige mice. | 1994 | Antimicrob. Agents Chemother. | pmid:7986001 |
[Zeclar, a new antibiotic (clarithromycin 250 mg from Abbott laboratories]. | 1994 | Rev Infirm | pmid:7652424 | |
Olliaro P et al. | In-vitro and in-vivo activity of rifabutin against Toxoplasma gondii. | 1994 | J. Antimicrob. Chemother. | pmid:7706160 |
Cynamon MH et al. | Comparative activities of azithromycin and clarithromycin against Mycobacterium avium infection in beige mice. | 1994 | Antimicrob. Agents Chemother. | pmid:7979270 |
Marco ML et al. | [Rhodococcus equi pneumonia in patients with AIDS]. | 1994 | Arch. Bronconeumol. | pmid:7827773 |
Antibiotic gets FDA nod for MAC treatment. | 1994 | Am J Nurs | pmid:8304386 | |
Yoshida K et al. | Chlamydia trachomatis infection in the semen of asymptomatic infertile men: detection of the antigen by in situ hybridization. | 1994 | Urol. Int. | pmid:7855940 |
Laing RB et al. | New antimicrobials against Mycobacterium marinum infection. | 1994 | Br. J. Dermatol. | pmid:7857853 |
Spiegl PV and Feiner CM | Mycobacterium phlei infection of the foot: a case report. | 1994 | Foot Ankle Int | pmid:7894643 |
Rapp RP et al. | New macrolide antibiotics: usefulness in infections caused by mycobacteria other than Mycobacterium tuberculosis. | 1994 | Ann Pharmacother | pmid:7849341 |
Walker KJ et al. | Evaluation of antimicrobial activities of clarithromycin and 14-hydroxyclarithromycin against three strains of Haemophilus influenzae by using an in vitro pharmacodynamic model. | 1994 | Antimicrob. Agents Chemother. | pmid:7811010 |
Price DA et al. | Clinical response to the addition of clarithromycin in Pneumocystis carinii pneumonia refractory to high dose co-trimoxazole. | 1994 | J. Antimicrob. Chemother. | pmid:7814298 |
Tahara RW et al. | The question of clarithromycin: a first-line drug for sinusitis? | 1994 | Arch Fam Med | pmid:7818657 |
Pustorino S et al. | [Effects of intravenous administration of clarithromycin on plasma levels of gastrin and group I pepsinogen]. | 1994 | Clin Ter | pmid:7820984 |
Alder J et al. | Treatment of experimental Toxoplasma gondii infection by clarithromycin-based combination therapy with minocycline or pyrimethamine. | 1994 | J. Acquir. Immune Defic. Syndr. | pmid:7932081 |
Ji B et al. | Effectiveness of various antimicrobial agents against Mycobacterium avium complex in the beige mouse model. | 1994 | Antimicrob. Agents Chemother. | pmid:7872741 |
Skinner PS et al. | A bone marrow-derived murine macrophage model for evaluating efficacy of antimycobacterial drugs under relevant physiological conditions. | 1994 | Antimicrob. Agents Chemother. | pmid:7872747 |
Valero G et al. | Activities of clarithromycin, ofloxacin, and clarithromycin plus ethambutol against Mycobacterium simiae in murine model of disseminated infection. | 1994 | Antimicrob. Agents Chemother. | pmid:7872769 |
Yamada S et al. | [A child with iritis due to Chlamydia pneumoniae infection]. | 1994 | Kansenshogaku Zasshi | pmid:7876679 |