MeSH term | MeSH ID | Detail |
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Myxoma | D009232 | 1 associated lipids |
Kleine-Levin Syndrome | D017593 | 1 associated lipids |
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Moayyedi P et al. | The effectiveness of omeprazole, clarithromycin and tinidazole in eradicating Helicobacter pylori in a community screen and treat programme. Leeds Help Study Group. | 2000 | Aliment. Pharmacol. Ther. | pmid:10848655 |
Katelaris PH et al. | Randomized trial of omeprazole and metronidazole with amoxycillin or clarithromycin for Helicobacter pylori eradication, in a region of high primary metronidazole resistance: the HERO study. | 2000 | Aliment. Pharmacol. Ther. | pmid:10848659 |
Ammon S et al. | Influence of age on the steady state disposition of drugs commonly used for the eradication of Helicobacter pylori. | 2000 | Aliment. Pharmacol. Ther. | pmid:10848660 |
Leiper K et al. | Open label trial of oral clarithromycin in active Crohn's disease. | 2000 | Aliment. Pharmacol. Ther. | pmid:10848665 |
Bhasin DK et al. | Comparison of seven and fourteen days of lansoprazole, clarithromycin, and amoxicillin therapy for eradication of Helicobacter pylori: a report from India. | 2000 | Helicobacter | pmid:10849056 |
Nagahara A et al. | Addition of metronidazole to rabeprazole-amoxicillin-clarithromycin regimen for Helicobacter pylori infection provides an excellent cure rate with five-day therapy. | 2000 | Helicobacter | pmid:10849057 |
Frueh BE et al. | Mycobacterium szulgai keratitis. | 2000 | Arch. Ophthalmol. | pmid:10922211 |
Pamuk ON et al. | Are Turkish Helicobacter pylori strains gaining resistance against clarithromycin? | 2000 | Am. J. Gastroenterol. | pmid:10926000 |
Nagaya T et al. | A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndrome. | 2000 | J. Clin. Invest. | pmid:10930442 |
Van Oijen AH et al. | Review article: treatment of Helicobacter pylori infection with ranitidine bismuth citrate- or proton pump inhibitor-based triple therapies. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930892 |
Hurenkamp GJ et al. | Equally high efficacy of 4, 7 and 10-day triple therapies to eradicate Helicobacter pylori infection in patients with ulcer disease. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930901 |
Dore MP et al. | Effect of pretreatment antibiotic resistance to metronidazole and clarithromycin on outcome of Helicobacter pylori therapy: a meta-analytical approach. | 2000 | Dig. Dis. Sci. | pmid:10695616 |
Miwa H et al. | Efficacy of reduced dosage of rabeprazole in PPI/AC therapy for Helicobacter pylori infection: comparison of 20 and 40 mg rabeprazole with 60 mg lansoprazole. | 2000 | Dig. Dis. Sci. | pmid:10695617 |
Shibuya N et al. | [Effect of clarithromycin on adhesion and infiltration of cancer cells]. | 2000 | Jpn J Antibiot | pmid:10756451 |
Majima T et al. | [Administration of clarithromycin (CAM) to non-small cell lung cancer]. | 2000 | Jpn J Antibiot | pmid:10756452 |
Matsunaga Y et al. | [Effect of clarithromycin on KL-8 formation by epidermal keratocytes]. | 2000 | Jpn J Antibiot | pmid:10756455 |
Miyanohara T et al. | [Effects of macrolides on cultured cells derived from the nose]. | 2000 | Jpn J Antibiot | pmid:10756463 |
Sato Y et al. | [Effect of long-term administration of small dosages of clarithromycin for the treatment of uterine pyometra]. | 2000 | Jpn J Antibiot | pmid:10756466 |
Franzin L et al. | Clarithromycin and amoxicillin susceptibility of Helicobacter pylori strains isolated from adult patients with gastric or duodenal ulcer in Italy. | 2000 | Curr. Microbiol. | pmid:10594221 |
Fukushima K et al. | [Outstanding efficacy of a macrolide in a small dosage for the treatment of refractory skin fistula communicating with the thoracic cavity and accompanying pyothorax]. | 2000 | Jpn J Antibiot | pmid:10756469 |
Shamaly H et al. | Efficacy of bismuth-based triple therapy in children with abdominal pain and Helicobacter pylori gastritis. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:10697140 |
Ives TJ et al. | In vitro susceptibilities of Rickettsia and Bartonella spp. to 14-hydroxy-clarithromycin as determined by immunofluorescent antibody analysis of infected vero cell monolayers. | 2000 | J. Antimicrob. Chemother. | pmid:10702548 |
Schweeger I et al. | Successful eradication of Helicobacter pylori as determined by ((13))C-urea breath test does not alter fibrinogen and acute phase response markers. | 2000 | Thromb. Res. | pmid:10704650 |
Raderer M et al. | Regression of colonic low grade B cell lymphoma of the mucosa associated lymphoid tissue type after eradication of Helicobacter pylori. | 2000 | Gut | pmid:10601069 |
Telenti A and Iseman M | Drug-resistant tuberculosis: what do we do now? | 2000 | Drugs | pmid:10730543 |
Namiot Z et al. | [The effect of cigarette smoking and alcohol consumption on efficacy of Helicobacter pylori eradication]. | 2000 | Pol. Arch. Med. Wewn. | pmid:11392163 |
Lehmann FS et al. | Effect of ornidazole and clarithromycin resistance on eradication of Helicobacter pylori in peptic ulcer disease. | 2000 | Aliment. Pharmacol. Ther. | pmid:10735923 |
Miwa H et al. | Cure of Helicobacter pylori infection does not improve symptoms in non-ulcer dyspepsia patients-a double-blind placebo-controlled study. | 2000 | Aliment. Pharmacol. Ther. | pmid:10735925 |
Spinzi GC et al. | Seven-day triple therapy with ranitidine bismuth citrate or omeprazole and two antibiotics for eradication of Helicobacter pylori in duodenal ulcer: a multicentre, randomized, single-blind study. | 2000 | Aliment. Pharmacol. Ther. | pmid:10735926 |
Suzuki K et al. | Effect of proton pump inhibitor alone or in combination with clarithromycin on mycobacterial growth in human alveolar macrophages. | 2000 | FEMS Microbiol. Lett. | pmid:10612733 |
Miyanohara T et al. | Effects of clarithromycin on cultured human nasal epithelial cells and fibroblasts. | 2000 | Laryngoscope | pmid:10646728 |
Bui KQ et al. | In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa. | 2000 | J. Antimicrob. Chemother. | pmid:10629013 |
Graham DY et al. | Furazolidone combination therapies for Helicobacter pylori infection in the United States. | 2000 | Aliment. Pharmacol. Ther. | pmid:10651662 |
Wong BC et al. | Comparison of lansoprazole-based triple and dual therapy for treatment of Helicobacter pylori-related duodenal ulcer: an Asian multicentre double-blind randomized placebo controlled study. | 2000 | Aliment. Pharmacol. Ther. | pmid:10651663 |
Fock KM et al. | Triple therapy in the eradication of Helicobacter pylori in patients with duodenal ulcer disease: results of a multicentre study in South-East Asia. South-East Asia Multicenter Study Group. | 2000 | Aliment. Pharmacol. Ther. | pmid:10651664 |
Bortolotti M et al. | Effect of clarithromycin on esophageal motility. | 2000 | Dis. Esophagus | pmid:11206638 |
McWhinney PH et al. | Failure to produce detectable antibodies to Legionella pneumophila by an immunocompetent adult. | 2000 | J. Infect. | pmid:11041710 |
Westphal JF | Macrolide - induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin. | 2000 | Br J Clin Pharmacol | pmid:11012550 |
Dunne M et al. | A randomized, double-blind trial comparing azithromycin and clarithromycin in the treatment of disseminated Mycobacterium avium infection in patients with human immunodeficiency virus. | 2000 | Clin. Infect. Dis. | pmid:11073759 |
Bojarski C et al. | Patients with dyspepsia benefit from eradication of Helicobacter pylori if other organic causes for dyspepsia were carefully ruled out. | 2000 | Z Gastroenterol | pmid:10768243 |
Adamsson I et al. | Microbial ecology and treatment of Helicobacter pylori infections: review. | 2000 | J Chemother | pmid:10768510 |
Singer J et al. | Symptomatic and health status outcomes in the Canadian randomized MAC treatment trial (CTN010). Canadian HIV Trials Network Protocol 010 Study Group. | 2000 | Int J STD AIDS | pmid:10772083 |
Flockhart DA et al. | Studies on the mechanism of a fatal clarithromycin-pimozide interaction in a patient with Tourette syndrome. | 2000 | J Clin Psychopharmacol | pmid:10831018 |
Spiegel JR et al. | Prolonged ulcerative laryngitis. | 2000 | Ear Nose Throat J | pmid:10832196 |
Gisbert JP et al. | One-week therapy with pantoprazole versus ranitidine bismuth citrate plus two antibiotics for Helicobacter pylori eradication. | 2000 | Eur J Gastroenterol Hepatol | pmid:10833090 |
Kaushik SP and Vu C | Helicobacter pylori eradication with lansoprazole, amoxycillin and clarithromycin: testing an ideal regimen in a multicultural south east Asian population and examining factors potentially influencing eradication. | 2000 | Aust N Z J Med | pmid:10833116 |
Waites K et al. | Use of clindamycin disks To detect macrolide resistance mediated by ermB and mefE in Streptococcus pneumoniae isolates from adults and children. | 2000 | J. Clin. Microbiol. | pmid:10790089 |
Ohtani H et al. | Comparative pharmacodynamic analysis of Q-T interval prolongation induced by the macrolides clarithromycin, roxithromycin, and azithromycin in rats. | 2000 | Antimicrob. Agents Chemother. | pmid:10991836 |
Mushiroda T et al. | The involvement of flavin-containing monooxygenase but not CYP3A4 in metabolism of itopride hydrochloride, a gastroprokinetic agent: comparison with cisapride and mosapride citrate. | 2000 | Drug Metab. Dispos. | pmid:10997945 |
Kuper JI and D'Aprile M | Drug-Drug interactions of clinical significance in the treatment of patients with Mycobacterium avium complex disease. | 2000 | Clin Pharmacokinet | pmid:11020135 |
Aydin A and Isler M | Efficacy of omeprazole plus two antimicrobials for the eradication of Helicobacter pylori in a Turkish population. | 2000 | Clin Ther | pmid:11117661 |
Ferrero M et al. | Factors affecting the variation in antibiotic resistance of Helicobacter pylori over a 3-year period. | 2000 | Int. J. Antimicrob. Agents | pmid:11091043 |
Yoshida H et al. | Reversal of intra-amniotic Chlamydia trachomatis antigen status. | 2000 | Gynecol. Obstet. Invest. | pmid:11093054 |
Knower MT et al. | Clarithromycin for safe and cost-effective reduction of cyclosporine doses in lung allograft recipients. | 2000 | South. Med. J. | pmid:11095559 |
Lucas J et al. | Mycobacterium genavense infection in two aged ferrets with conjunctival lesions. | 2000 | Aust. Vet. J. | pmid:11098383 |
Fujiwara T et al. | Helicobacter pylori infection in renal transplant recipients. | 2000 | Transplant. Proc. | pmid:11120026 |
Okhravi N et al. | Assessment of the effect of oral clarithromycin on visual outcome following presumed bacterial endophthalmitis. | 2000 | Curr. Eye Res. | pmid:11120557 |
Veldhuyzen Van Zanten S et al. | One-week triple therapy with esomeprazole provides effective eradication of Helicobacter pylori in duodenal ulcer disease. | 2000 | Aliment. Pharmacol. Ther. | pmid:11121908 |
Isomoto H et al. | 5-day vs. 7-day triple therapy with rabeprazole, clarithromycin and amoxicillin for Helicobacter pylori eradication. | 2000 | Aliment. Pharmacol. Ther. | pmid:11121910 |
Canducci F et al. | A lyophilized and inactivated culture of Lactobacillus acidophilus increases Helicobacter pylori eradication rates. | 2000 | Aliment. Pharmacol. Ther. | pmid:11121911 |
Kunishima H et al. | Evaluation of the activity of antimicrobial agents against Legionella pneumophila multiplying in a human monocytic cell line, THP-1, and an alveolar epithelial cell line, A549. | 2000 | J. Infect. Chemother. | pmid:11810567 |
Frevel M et al. | Eradication of Helicobacter pylori with pantoprazole and two antibiotics: a comparison of two short-term regimens. | 2000 | Aliment. Pharmacol. Ther. | pmid:10971231 |
Denis A et al. | Beta-keto-ester chemistry and ketolides. Synthesis and antibacterial activity of 2-halogeno, 2-methyl and 2,3 enol-ether ketolides. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10987440 |
Hentschel E | [Treatment of Helicobacter pylori infections]. | 2000 | Acta Med. Austriaca | pmid:10989677 |
Mégraud F et al. | Ranitidine bismuth citrate can help to overcome Helicobacter pylori resistance to clarithromycin in vivo. | 2000 | Helicobacter | pmid:11179987 |
Bermudez LE et al. | Clarithromycin-resistant mycobacterium avium is still susceptible to treatment with clarithromycin and is virulent in mice. | 2000 | Antimicrob. Agents Chemother. | pmid:10991834 |
Esposito S et al. | Bactericidal activity of moxifloxacin compared to grepafloxacin and clarithromycin against Streptococcus pneumoniae and Streptococcus pyogenes investigated using an in vitro pharmacodynamic model. | 2000 | J Chemother | pmid:11154028 |
Feng X et al. | [Interaction between biofilm formed by Pseudomonas aeruginosa and antibacterial agents]. | 2000 | Wei Sheng Wu Xue Bao | pmid:12548947 |
Rastogi N et al. | In vitro activities of the ketolides telithromycin (HMR 3647) and HMR 3004 compared to those of clarithromycin against slowly growing mycobacteria at pHs 6.8 and 7.4. | 2000 | Antimicrob. Agents Chemother. | pmid:10991870 |
Adler JL et al. | Phase III, randomized, double-blind study of clarithromycin extended-release and immediate-release formulations in the treatment of patients with acute exacerbation of chronic bronchitis. | 2000 | Clin Ther | pmid:11192133 |
Murray JJ et al. | Phase III, randomized, double-blind study of clarithromycin extended-release and immediate-release formulations in the treatment of adult patients with acute maxillary sinusitis. | 2000 | Clin Ther | pmid:11192134 |
Howden CW | Treatment of Helicobacter pylori infection: is less more? | 2000 | J. Clin. Gastroenterol. | pmid:10993423 |
Matsuo K et al. | [Pulmonary Nocardia otitidiscaviarum infection in an immunocompetent host]. | 2000 | Nihon Kokyuki Gakkai Zasshi | pmid:11193319 |
Catalano F et al. | Five-day triple therapy in Helicobacter pylori-positive duodenal ulcer: an eighteen-month follow-up. | 2000 | J. Clin. Gastroenterol. | pmid:10993428 |
Katelaris PH | Helicobacter pylori: changing patterns of ulcer disease and antibiotic resistance. | 2000 | Med. J. Aust. | pmid:11194729 |
Testoni PA and Bagnolo F | In dyspeptic patients without gastric phase III of the migrating motor complex, Helicobacter pylori eradication produces no short-term changes in interdigestive motility pattern. | 2000 | Scand. J. Gastroenterol. | pmid:10994618 |
Mollison LC et al. | Antibiotic resistance in Helicobacter pylori. | 2000 | Med. J. Aust. | pmid:11194734 |
Gisbert JP et al. | Proton pump inhibitor, clarithromycin and either amoxycillin or nitroimidazole: a meta-analysis of eradication of Helicobacter pylori. | 2000 | Aliment. Pharmacol. Ther. | pmid:11012477 |
Badyal DK and Garg SK | Effect of clarithromycin on the pharmacokinetics of carbamazepine in rhesus monkeys. | 2000 | Methods Find Exp Clin Pharmacol | pmid:11196346 |
Catalano F et al. | Helicobacter pylori-positive duodenal ulcer: three-day antibiotic eradication regimen. | 2000 | Aliment. Pharmacol. Ther. | pmid:11012478 |
Nomura H et al. | A short-term eradication therapy for Helicobacter pylori acute gastritis. | 2000 | J. Gastroenterol. Hepatol. | pmid:11197046 |
Zwolińska-Wcisło M and Palka M | [Principles of managing Helicobacter pylori infections. Guidelines of the European Society of Gastroenterology in Primary Health Care]. | 2000 | Prz. Lek. | pmid:11293204 |
Shimizu T et al. | Case of intrafamilial Helicobacter pylori reinfection after successful eradication therapy. | 2000 | Pediatr. Infect. Dis. J. | pmid:11001123 |
Bermejo F et al. | [Effects of Helicobacter pylori eradication on the recurrence of gastric ulcer during a 12-month follow up]. | 2000 | Med Clin (Barc) | pmid:11002456 |
Laine L et al. | Esomeprazole-based Helicobacter pylori eradication therapy and the effect of antibiotic resistance: results of three US multicenter, double-blind trials. | 2000 | Am. J. Gastroenterol. | pmid:11151867 |
Saint-Blancard P et al. | [Cutaneous nodular infection with hemopathy]. | 2000 | Ann Pathol | pmid:11015652 |
Fichtenbaum CJ et al. | Rifabutin but not clarithromycin prevents cryptosporidiosis in persons with advanced HIV infection. | 2000 | AIDS | pmid:11153670 |
Lamouliatte H et al. | [Treatment of Helicobacter pylori infection]. | 2000 | Rev Prat | pmid:11019637 |
Fuentes F et al. | In vitro activity of clarithromycin against penicillin-susceptible and penicillin-resistant strains of Streptococcus pneumoniae in a pharmacodynamic simulation model. | 2000 | J Chemother | pmid:11154032 |
Cirioni O et al. | Inhibition of growth of Pneumocystis carinii by lactoferrins alone and in combination with pyrimethamine, clarithromycin and minocycline. | 2000 | J. Antimicrob. Chemother. | pmid:11020255 |
Alarcón T et al. | Clarithromycin resistance stability in Helicobacter pylori: influence of the MIC and type of mutation in the 23S rRNA. | 2000 | J. Antimicrob. Chemother. | pmid:11020260 |
Makristathis A et al. | Two enzyme immunoassays and PCR for detection of Helicobacter pylori in stool specimens from pediatric patients before and after eradication therapy. | 2000 | J. Clin. Microbiol. | pmid:11015388 |
Guyot A et al. | Clarithromycin appears to be linked with Clostridium difficile-associated diarrhoea in the elderly. | 2000 | J. Antimicrob. Chemother. | pmid:11020269 |
Wolfe J et al. | Mycobacterium branderi from both a hand infection and a case of pulmonary disease. | 2000 | J. Clin. Microbiol. | pmid:11015432 |
Umegaki N et al. | Clarithromycin-resistance and point mutations in the 23S rRNA gene in Helicobacter pylori isolates from Japan. | 2000 | J. Gastroenterol. Hepatol. | pmid:11022832 |
Goh K et al. | Efficacy of a 1-week pantoprazole triple therapy in eradicating Helicobacter pylori in Asian patients. | 2000 | J. Gastroenterol. Hepatol. | pmid:11022833 |
Maconi G et al. | Prolonging proton pump inhibitor-based anti-Helicobacter pylori treatment from one to two weeks in duodenal ulcer: is it worthwhile? | 2000 | Dig Liver Dis | pmid:11515622 |
Rathi P et al. | Comparison of two regimens on eradication of Helicobacter pylori. | 2000 | J Assoc Physicians India | pmid:11273492 |
Suzuki K et al. | [Fibrosing alveolitis following Legionella pneumonia]. | 2000 | Nihon Kokyuki Gakkai Zasshi | pmid:10879037 |
Hizawa K et al. | Effect of amoxicillin, clarithromycin, and rabeprazole, a new proton pump inhibitor, in eradication therapy for relapsing peptic ulcer diseases with Helicobacter pylori infection. | 2000 | J. Clin. Gastroenterol. | pmid:11129280 |