clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

Cross Reference

Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Myxoma D009232 1 associated lipids
Kleine-Levin Syndrome D017593 1 associated lipids
Per page 10 20 50 100 | Total 242

PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with clarithromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with clarithromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with clarithromycin

Download all related citations
Per page 10 20 50 100 | Total 7636
Authors Title Published Journal PubMed Link
Ives DV et al. Impact of clarithromycin and azithromycin on patterns of treatment and survival among AIDS patients with disseminated Mycobacterium avium complex. 1995 AIDS pmid:7755914
Chaisson RE et al. Clarithromycin and ethambutol with or without clofazimine for the treatment of bacteremic Mycobacterium avium complex disease in patients with HIV infection. 1997 AIDS pmid:9147422
Johnson RC et al. Disseminated Mycobacterium ulcerans disease in an HIV-positive patient: a case study. 2002 AIDS pmid:12172103
Heald AE et al. Taste and smell complaints in HIV-infected patients. 1998 AIDS pmid:9764787
Macías J et al. Rhodococcus or mycobacterium? An example of misdiagnosis in HIV infection. 1997 AIDS pmid:9030376
Preston SL et al. Drug interactions in HIV-positive patients initiated on protease inhibitor therapy. 1998 AIDS pmid:9468380
Bayoumi AM and Redelmeier DA Preventing Mycobacterium avium complex in patients who are using protease inhibitors: a cost-effectiveness analysis. 1998 AIDS pmid:9727572
Burman WJ et al. Long-term outcomes of treatment of Mycobacterium avium complex bacteremia using a clarithromycin-containing regimen. 1998 AIDS pmid:9708410
High-dose clarithromycin should be avoided. 1996 AIDS Alert pmid:11363723
Physician's aggressive preventive therapy differs. 1995 AIDS Alert pmid:11362774
New drug applications sought. 1995 AIDS Alert pmid:11362777
Researchers find new drugs to fight MAC. 1995 AIDS Alert pmid:11362925
Clarithromycin for MAC. 1995 AIDS Patient Care pmid:11361361
Rosales CM et al. AIDS presenting with cutaneous Kaposi's sarcoma and bacillary angiomatosis in the bone marrow mimicking Kaposi's sarcoma. 2002 AIDS Patient Care STDS pmid:12542930
Mah Ming JB and Gill MJ Drug-induced rhabdomyolysis after concomitant use of clarithromycin, atorvastatin, and lopinavir/ritonavir in a patient with HIV. 2003 AIDS Patient Care STDS pmid:12816614
Monno R et al. Chlamydia trachomatis and Mycobacterium tuberculosis lung infection in an HIV-positive homosexual man. 2001 AIDS Patient Care STDS pmid:11788074
Yangco BG et al. Is primary mycobacterium avium complex prophylaxis necessary in patients with CD4 <50 cells/μL who are virologically suppressed on cART? 2014 AIDS Patient Care STDS pmid:24833016
Desimone JA et al. Treatment of Mycobacterium avium complex immune reconstitution disease in HIV-1-infected individuals. 2003 AIDS Patient Care STDS pmid:14746655
NIAID study rules out high-dose clarithromycin for AIDS-related MAC. 1996 AIDS Patient Care STDS pmid:11361534
New data suggest antibiotic clarithromycin is effective in prolonging life of AIDS patients. 1996 AIDS Patient Care STDS pmid:11361575
Clarithromycin and MAC. 1996 AIDS Patient Care STDS pmid:11361673
Different clarithromycin doses affect mortality. 1997 AIDS Patient Care STDS pmid:11361754
Aboulafia DM Thalidomide-based treatment for HIV-associated multiple myeloma: a case report. 2003 AIDS Read pmid:14524324
Kahlon SS et al. Mycobacterium-avium-intracellulare complex immune reconstitution inflammatory syndrome in HIV/AIDS presenting as osteomyelitis. 2008 AIDS Read pmid:18975441
Chu J et al. Drug efficacy by direct and adjusted indirect comparison to placebo: An illustration by Mycobacterium avium complex prophylaxis in HIV. 2011 AIDS Res Ther pmid:21388558
Smibert OC et al. Short Communication: Mycobacterium avium Complex Infection and Immune Reconstitution Inflammatory Syndrome Remain a Challenge in the Era of Effective Antiretroviral Therapy. 2017 AIDS Res. Hum. Retroviruses pmid:28791872
Zullo A et al. A new highly effective short-term therapy schedule for Helicobacter pylori eradication. 2000 Aliment. Pharmacol. Ther. pmid:10848654
Ikeda S et al. Evaluation of the cost-effectiveness of Helicobacter pylori eradication triple therapy vs. conventional therapy for ulcers in Japan. 2001 Aliment. Pharmacol. Ther. pmid:11683692
Moayyedi P et al. The effectiveness of omeprazole, clarithromycin and tinidazole in eradicating Helicobacter pylori in a community screen and treat programme. Leeds Help Study Group. 2000 Aliment. Pharmacol. Ther. pmid:10848655
Katelaris PH et al. Randomized trial of omeprazole and metronidazole with amoxycillin or clarithromycin for Helicobacter pylori eradication, in a region of high primary metronidazole resistance: the HERO study. 2000 Aliment. Pharmacol. Ther. pmid:10848659
Ammon S et al. Influence of age on the steady state disposition of drugs commonly used for the eradication of Helicobacter pylori. 2000 Aliment. Pharmacol. Ther. pmid:10848660
Leiper K et al. Open label trial of oral clarithromycin in active Crohn's disease. 2000 Aliment. Pharmacol. Ther. pmid:10848665
Wong WM et al. Randomized controlled study of rabeprazole, levofloxacin and rifabutin triple therapy vs. quadruple therapy as second-line treatment for Helicobacter pylori infection. 2003 Aliment. Pharmacol. Ther. pmid:12622764
Fischbach L and Evans EL Meta-analysis: the effect of antibiotic resistance status on the efficacy of triple and quadruple first-line therapies for Helicobacter pylori. 2007 Aliment. Pharmacol. Ther. pmid:17635369
Huang J et al. Randomised controlled trial: sequential vs. standard triple therapy for Helicobacter pylori infection in Chinese children-a multicentre, open-labelled study. 2013 Aliment. Pharmacol. Ther. pmid:24117692
Molina-Infante J et al. Clinical trial: clarithromycin vs. levofloxacin in first-line triple and sequential regimens for Helicobacter pylori eradication. 2010 Aliment. Pharmacol. Ther. pmid:20180787
Chacko Y and Holtmann GJ Helicobacter pylori eradication and weight gain: has it opened a Pandora's box? 2011 Aliment. Pharmacol. Ther. pmid:21679208
Murakami K et al. Eradication rates of clarithromycin-resistant Helicobacter pylori using either rabeprazole or lansoprazole plus amoxicillin and clarithromycin. 2002 Aliment. Pharmacol. Ther. pmid:12390102
Zullo A et al. High rate of Helicobacter pylori eradication with sequential therapy in elderly patients with peptic ulcer: a prospective controlled study. 2005 Aliment. Pharmacol. Ther. pmid:15948808
Gisbert JP et al. 7-day rescue therapy with ranitidine bismuth citrate after Helicobacter pylori treatment failure. 2005 Aliment. Pharmacol. Ther. pmid:15882246
Nista EC et al. Moxifloxacin-based strategies for first-line treatment of Helicobacter pylori infection. 2005 Aliment. Pharmacol. Ther. pmid:15882245
Bühling A et al. Influence of anti-Helicobacter triple-therapy with metronidazole, omeprazole and clarithromycin on intestinal microflora. 2001 Aliment. Pharmacol. Ther. pmid:11552917
Logan RP et al. Eradication of Helicobacter pylori and prevention of recurrence of duodenal ulcer: a randomized, double-blind, multi-centre trial of omeprazole with or without clarithromycin. 1995 Aliment. Pharmacol. Ther. pmid:8527618
Dani R et al. Omeprazole, clarithromycin and furazolidone for the eradication of Helicobacter pylori in patients with duodenal ulcer. 1999 Aliment. Pharmacol. Ther. pmid:10594400
Miehlke S et al. Randomized trial of rifabutin-based triple therapy and high-dose dual therapy for rescue treatment of Helicobacter pylori resistant to both metronidazole and clarithromycin. 2006 Aliment. Pharmacol. Ther. pmid:16842467
Boixeda D et al. Efficacy of quadruple therapy with pantoprazole, bismuth, tetracycline and metronidazole as rescue treatment for Helicobacter pylori infection. 2002 Aliment. Pharmacol. Ther. pmid:12182745
Lehmann FS et al. Effect of ornidazole and clarithromycin resistance on eradication of Helicobacter pylori in peptic ulcer disease. 2000 Aliment. Pharmacol. Ther. pmid:10735923
Miwa H et al. Cure of Helicobacter pylori infection does not improve symptoms in non-ulcer dyspepsia patients-a double-blind placebo-controlled study. 2000 Aliment. Pharmacol. Ther. pmid:10735925
Spinzi GC et al. Seven-day triple therapy with ranitidine bismuth citrate or omeprazole and two antibiotics for eradication of Helicobacter pylori in duodenal ulcer: a multicentre, randomized, single-blind study. 2000 Aliment. Pharmacol. Ther. pmid:10735926
Graham DY et al. Furazolidone combination therapies for Helicobacter pylori infection in the United States. 2000 Aliment. Pharmacol. Ther. pmid:10651662
Laine L Review article: esomeprazole in the treatment of Helicobacter pylori. 2002 Aliment. Pharmacol. Ther. pmid:12047270
Gu Q et al. Effect of cyclo-oxygenase inhibitors on Helicobacter pylori susceptibility to metronidazole and clarithromycin. 2004 Aliment. Pharmacol. Ther. pmid:15352916
Harris AW et al. Eradication of Helicobacter pylori with lansoprazole and clarithromycin. 1995 Aliment. Pharmacol. Ther. pmid:7605863
Malfertheiner P et al. Helicobacter pylori eradication is beneficial in the treatment of functional dyspepsia. 2003 Aliment. Pharmacol. Ther. pmid:12969088
Hassan C et al. Sequential treatment for Helicobacter pylori eradication in duodenal ulcer patients: improving the cost of pharmacotherapy. 2003 Aliment. Pharmacol. Ther. pmid:12969091
Sheu BS et al. Impact of intravenous omeprazole on Helicobacter pylori eradication by triple therapy in patients with peptic ulcer bleeding. 2002 Aliment. Pharmacol. Ther. pmid:11856088
Ahuja V et al. Lansoprazole and secnidazole with clarithromycin, amoxycillin or pefloxacin in the eradication of Helicobacter pylori in a developing country. 1998 Aliment. Pharmacol. Ther. pmid:9678815
Grübel P and Cave DR Factors affecting solubility and penetration of clarithromycin through gastric mucus. 1998 Aliment. Pharmacol. Ther. pmid:9678818
Huang J and Hunt RH The importance of clarithromycin dose in the management of Helicobacter pylori infection: a meta-analysis of triple therapies with a proton pump inhibitor, clarithromycin and amoxycillin or metronidazole. 1999 Aliment. Pharmacol. Ther. pmid:10383500
Miwa H et al. Impact of rabeprazole, a new proton pump inhibitor, in triple therapy for Helicobacter pylori infection-comparison with omeprazole and lansoprazole. 1999 Aliment. Pharmacol. Ther. pmid:10383502
Ducóns JA et al. Impact of clarithromycin resistance on the effectiveness of a regimen for Helicobacter pylori: a prospective study of 1-week lansoprazole, amoxycillin and clarithromycin in active peptic ulcer. 1999 Aliment. Pharmacol. Ther. pmid:10383507
Calvet X et al. Two-week dual vs. one-week triple therapy for cure of Helicobacter pylori infection in primary care: a multicentre, randomized trial. 1999 Aliment. Pharmacol. Ther. pmid:10383508
Wong BC et al. Rabeprazole-based 3-day and 7-day triple therapy vs. omeprazole-based 7-day triple therapy for the treatment of Helicobacter pylori infection. 2001 Aliment. Pharmacol. Ther. pmid:11736727
Iijima K et al. Long-term effect of Helicobacter pylori eradication on the reversibility of acid secretion in profound hypochlorhydria. 2004 Aliment. Pharmacol. Ther. pmid:15153171
Hoffman JS et al. Efficacy of a 1-week regimen of ranitidine bismuth citrate in combination with metronidazole and clarithromycin for Helicobacter pylori eradication. 1999 Aliment. Pharmacol. Ther. pmid:10215735
De Francesco V et al. Effectiveness and pharmaceutical cost of sequential treatment for Helicobacter pylori in patients with non-ulcer dyspepsia. 2004 Aliment. Pharmacol. Ther. pmid:15113366
Koivisto TT et al. Primary Helicobacter pylori resistance to metronidazole and clarithromycin in the Finnish population. 2004 Aliment. Pharmacol. Ther. pmid:15113368
Gisbert JP and Calvet X Review article: the effectiveness of standard triple therapy for Helicobacter pylori has not changed over the last decade, but it is not good enough. 2011 Aliment. Pharmacol. Ther. pmid:22017749
Pellegrini M et al. Is a long-term ranitidine-based triple therapy against Helicobacter pylori only a heritage of the past? A prospective, randomized clinicopharmacological study. 2005 Aliment. Pharmacol. Ther. pmid:16098001
Spadaccini A et al. Omeprazole versus ranitidine: short-term triple-therapy in patients with Helicobacter pylori-positive duodenal ulcers. 1996 Aliment. Pharmacol. Ther. pmid:8899094
Gisbert JP et al. Helicobacter pylori eradication: proton pump inhibitor vs. ranitidine bismuth citrate plus two antibiotics for 1 week-a meta-analysis of efficacy. 2000 Aliment. Pharmacol. Ther. pmid:10971230
Frevel M et al. Eradication of Helicobacter pylori with pantoprazole and two antibiotics: a comparison of two short-term regimens. 2000 Aliment. Pharmacol. Ther. pmid:10971231
Bigard MA et al. One-week triple therapy using omeprazole, amoxycillin and clarithromycin for the eradication of Helicobacter pylori in patients with non-ulcer dyspepsia: influence of dosage of omeprazole and clarithromycin. 1998 Aliment. Pharmacol. Ther. pmid:9690730
Bardhan KD et al. Pantoprazole-based 10-day triple therapy is effective in Helicobacter pylori eradication. 1998 Aliment. Pharmacol. Ther. pmid:9692693
Catalano F et al. Ranitidine bismuth citrate versus omeprazole triple therapy for the eradication of Helicobacter pylori and healing of duodenal ulcer. 1998 Aliment. Pharmacol. Ther. pmid:9692702
Dobrilla G et al. Ranitidine bismuth citrate with either clarithromycin 1 g/day or 1.5 g/day is equally effective in the eradication of H. pylori and healing of duodenal ulcer. 1998 Aliment. Pharmacol. Ther. pmid:9692703
Perri F et al. Randomized study of different 'second-line' therapies for Helicobacter pylori infection after failure of the standard 'Maastricht triple therapy'. 2003 Aliment. Pharmacol. Ther. pmid:14535875
Xiao SD et al. High cure rate of Helicobacter pylori infection using tripotassium dicitrato bismuthate, furazolidone and clarithromycin triple therapy for 1 week. 1999 Aliment. Pharmacol. Ther. pmid:10102963
Liu WZ et al. Furazolidone-containing short-term triple therapies are effective in the treatment of Helicobacter pylori infection. 1999 Aliment. Pharmacol. Ther. pmid:10102964
Huang J and Hunt RH Clarithromycin-based triple therapies. 1999 Aliment. Pharmacol. Ther. pmid:10102978
Harris A H. pylori eradication by LAC. 1997 Aliment. Pharmacol. Ther. pmid:9354216
Sheu BS et al. Esomeprazole 40 mg twice daily in triple therapy and the efficacy of Helicobacter pylori eradication related to CYP2C19 metabolism. 2005 Aliment. Pharmacol. Ther. pmid:15691303
Savarino V et al. A new 1-week therapy for Helicobacter pylori eradication: ranitidine bismuth citrate plus two antibiotics. 1997 Aliment. Pharmacol. Ther. pmid:9305478
Yousfi MM et al. Metronidazole, ranitidine and clarithromycin combination for treatment of Helicobacter pylori infection (modified Bazzoli's triple therapy). 1996 Aliment. Pharmacol. Ther. pmid:8871452
Williams MP et al. Seven-day treatment for Helicobacter pylori infection: ranitidine bismuth citrate plus clarithromycin and tetracycline hydrochloride. 1997 Aliment. Pharmacol. Ther. pmid:9305479
Janssen MJ et al. A systematic comparison of triple therapies for treatment of Helicobacter pylori infection with proton pump inhibitor/ ranitidine bismuth citrate plus clarithromycin and either amoxicillin or a nitroimidazole. 2001 Aliment. Pharmacol. Ther. pmid:11328254
Broutet N et al. Risk factors for failure of Helicobacter pylori therapy--results of an individual data analysis of 2751 patients. 2003 Aliment. Pharmacol. Ther. pmid:12492738
Chi CH et al. Quadruple therapy containing amoxicillin and tetracycline is an effective regimen to rescue failed triple therapy by overcoming the antimicrobial resistance of Helicobacter pylori. 2003 Aliment. Pharmacol. Ther. pmid:12895220
Higuchi K et al. Is eradication sufficient to heal gastric ulcers in patients infected with Helicobacter pylori? A randomized, controlled, prospective study. 2003 Aliment. Pharmacol. Ther. pmid:12492739
Peterson WL et al. Ranitidine bismuth citrate plus clarithromycin is effective for healing duodenal ulcers, eradicating H. pylori and reducing ulcer recurrence. RBC H. pylori Study Group. 1996 Aliment. Pharmacol. Ther. pmid:8791947
Delchier JC et al. Omeprazole-amoxycillin versus omeprazole-amoxycillin-clarithromycin in the eradication of Helicobacter pylori. 1996 Aliment. Pharmacol. Ther. pmid:8791948
Jaup BH and Norrby A Comparison of two low-dose one-week triple therapy regimens with and without metronidazole for cure of H. pylori infection. 1996 Aliment. Pharmacol. Ther. pmid:8791950
Weldon MJ et al. A seven-day Helicobacter pylori treatment regimen using clarithromycin, omeprazole and tripotassium dicitrato bismuthate. 1996 Aliment. Pharmacol. Ther. pmid:8791951
Gisbert JP et al. Fourth-line rescue therapy with rifabutin in patients with three Helicobacter pylori eradication failures. 2012 Aliment. Pharmacol. Ther. pmid:22372560
Zullo A et al. Clarithromycin or levofloxacin in the sequential therapy for H. pylori eradication? 2010 Aliment. Pharmacol. Ther. pmid:20518756
Graham DY et al. Meta-analysis: proton pump inhibitor or H2-receptor antagonist for Helicobacter pylori eradication. 2003 Aliment. Pharmacol. Ther. pmid:12755836
Gisbert JP and Pajares JM Review article: Helicobacter pylori "rescue" regimen when proton pump inhibitor-based triple therapies fail. 2002 Aliment. Pharmacol. Ther. pmid:12030945
Laine L and Dhir V Helicobacter pylori eradication does not worsen quality of life related to reflux symptoms: a prospective trial. 2002 Aliment. Pharmacol. Ther. pmid:12030957
Vallve M et al. Single vs. double dose of a proton pump inhibitor in triple therapy for Helicobacter pylori eradication: a meta-analysis. 2002 Aliment. Pharmacol. Ther. pmid:12030958
Colin R Duodenal ulcer healing with 1-week eradication triple therapy followed, or not, by anti-secretory treatment: a multicentre double-blind placebo-controlled trial. 2002 Aliment. Pharmacol. Ther. pmid:12030959