MeSH term | MeSH ID | Detail |
---|---|---|
Myxoma | D009232 | 1 associated lipids |
Kleine-Levin Syndrome | D017593 | 1 associated lipids |
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Koh WJ et al. | Mycobacterial Characteristics and Treatment Outcomes in Mycobacterium abscessus Lung Disease. | 2017 | Clin. Infect. Dis. | pmid:28011608 |
Çekin AH et al. | Use of probiotics as an adjuvant to sequential H. pylori eradication therapy: impact on eradication rates, treatment resistance, treatment-related side effects, and patient compliance. | 2017 | Turk J Gastroenterol | pmid:28007678 |
Ikeue T et al. | Pleuritis Caused by Mycobacterium kyorinense without Pulmonary Involvement. | 2017 | Intern. Med. | pmid:28924121 |
Yamamoto S et al. | Mitochondrial proteins NIP-SNAP-1 and -2 are a target for the immunomodulatory activity of clarithromycin, which involves NF-κB-mediated cytokine production. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27998764 |
Panozzo C et al. | Chemicals or mutations that target mitochondrial translation can rescue the respiratory deficiency of yeast bcs1 mutants. | 2017 | Biochim. Biophys. Acta | pmid:28888990 |
Santos MA et al. | Nothing to (S)cough at: Pulmonary Mycobacterium avium Complex Infection. | 2017 | Am. J. Med. | pmid:27984010 |
Smibert OC et al. | Short Communication: Mycobacterium avium Complex Infection and Immune Reconstitution Inflammatory Syndrome Remain a Challenge in the Era of Effective Antiretroviral Therapy. | 2017 | AIDS Res. Hum. Retroviruses | pmid:28791872 |
Hiroi S et al. | Impact of health insurance coverage for gastritis on the trends in eradication therapy in Japan: retrospective observational study and simulation study based on real-world data. | 2017 | BMJ Open | pmid:28760790 |
Jenkins H et al. | Effect of Multiple Oral Doses of the Potent CYP3A4 Inhibitor Clarithromycin on the Pharmacokinetics of a Single Oral Dose of Vonoprazan: A Phase I, Open-Label, Sequential Design Study. | 2017 | Clin Drug Investig | pmid:27928738 |
Takemoto Y et al. | Disseminated Mycobacterium scrofulaceum Infection in an Immunocompetent Host. | 2017 | Intern. Med. | pmid:28717096 |
Alba C et al. | Antibiotic resistance in Helicobacter pylori. | 2017 | Curr. Opin. Infect. Dis. | pmid:28704226 |
Mishima E et al. | Acute Kidney Injury from Excessive Potentiation of Calcium-channel Blocker via Synergistic CYP3A4 Inhibition by Clarithromycin Plus Voriconazole. | 2017 | Intern. Med. | pmid:28674358 |
Shimoyama T et al. | Randomized Trial Comparing Esomeprazole and Rabeprazole in First-line Eradication Therapy for Helicobacter pylori Infection based on the Serum Levels of Pepsinogens. | 2017 | Intern. Med. | pmid:28674348 |
Ustundag GH et al. | The Effects of Synbiotic " B94 plus Inulin" Addition on Standard Triple Therapy of Eradication in Children. | 2017 | Can J Gastroenterol Hepatol | pmid:28656129 |
Peng X et al. | Gastric Juice-Based Real-Time PCR for Tailored Treatment: A Practical Approach. | 2017 | Int J Med Sci | pmid:28638276 |
Stieler Stewart AL et al. | Effects of clarithromycin, azithromycin and rifampicin on terbutaline-induced sweating in foals. | 2017 | Equine Vet. J. | pmid:28238211 |
Emmanuel R et al. | Antimicrobial efficacy of drug blended biosynthesized colloidal gold nanoparticles from Justicia glauca against oral pathogens: A nanoantibiotic approach. | 2017 | Microb. Pathog. | pmid:29101061 |
Bichler EK et al. | Clarithromycin increases neuronal excitability in CA3 pyramidal neurons through a reduction in GABAergic signaling. | 2017 | J. Neurophysiol. | pmid:27733592 |
Tsugawa K et al. | Clarithromycin attenuates the expression of monocyte chemoattractant protein-1 by activating toll-like receptor 4 in human mesangial cells. | 2017 | Clin. Exp. Nephrol. | pmid:27614743 |
Okuda M et al. | Nationwide survey of Helicobacter pylori treatment for children and adolescents in Japan. | 2017 | Pediatr Int | pmid:27223686 |
Bewick J et al. | The value of a feasibility study into long-term macrolide therapy in chronic rhinosinusitis. | 2017 | Clin Otolaryngol | pmid:27223120 |
Legendre T et al. | [Antibiomania: Think of the manic syndrome secondary to antibiotic therapy]. | 2017 | Encephale | pmid:27178256 |
Chang KH et al. | Comparison of antibiotic regimens in preterm premature rupture of membranes: neonatal morbidity and 2-year follow-up of neurologic outcome. | 2017 | J. Matern. Fetal. Neonatal. Med. | pmid:27687157 |
Abadi ATB | Resistance to clarithromycin and gastroenterologist's persistence roles in nomination for Helicobacter pylori as high priority pathogen by World Health Organization. | 2017 | World J. Gastroenterol. | pmid:29085187 |
Pastukh N et al. | GenoType® HelicoDR test in comparison with histology and culture for Helicobacter pylori detection and identification of resistance mutations to clarithromycin and fluoroquinolones. | 2017 | Helicobacter | pmid:29058343 |
Tognetti L et al. | Bullous impetigo during interstitial pneumonitis. | 2017 | G Ital Dermatol Venereol | pmid:29050448 |
Gunnarsdottir AI et al. | Antibiotic susceptibility of Helicobacter pylori in Iceland. | 2017 | Infect Dis (Lond) | pmid:28440099 |
Manniello MD et al. | Clarithromycin and N-acetylcysteine co-spray-dried powders for pulmonary drug delivery: A focus on drug solubility. | 2017 | Int J Pharm | pmid:28377314 |
Van der Paardt AL et al. | Safety and tolerability of clarithromycin in the treatment of multidrug-resistant tuberculosis. | 2017 | Eur. Respir. J. | pmid:28331034 |
Souto Filho JTD et al. | Long-term complete remission of primary gastric plasmacytoma following endoscopic resection. | 2017 | Ann. Hematol. | pmid:28315923 |
Antonakos N et al. | Decreased cytokine production by mononuclear cells after severe gram-negative infections: early clinical signs and association with final outcome. | 2017 | Crit Care | pmid:28274246 |
Koratala A et al. | Exit Site Infection in Peritoneal Dialysis; Need for Follow-Up on Cultures Despite Clinical Improvement. | 2017 | Blood Purif. | pmid:28268216 |
Radzikowska E et al. | Cryptogenic organizing pneumonia-Results of treatment with clarithromycin versus corticosteroids-Observational study. | 2017 | PLoS ONE | pmid:28945804 |
Chew KL et al. | Predominance of clarithromycin-susceptible Mycobacterium massiliense subspecies: Characterization of the Mycobacterium abscessus complex at a tertiary acute care hospital. | 2017 | J. Med. Microbiol. | pmid:28874233 |
Miura S et al. | [Effective BiRd Therapy after the Addition of Clarithromycin for Lenalidomide and Dexamethasone Resistant Multiple Myeloma Ineligible for Stem Cell Transplantation]. | 2017 | Gan To Kagaku Ryoho | pmid:28860442 |
McCallum GB et al. | Antibiotics for persistent cough or wheeze following acute bronchiolitis in children. | 2017 | Cochrane Database Syst Rev | pmid:28828759 |
de Ãvila BE et al. | Micromotor-enabled active drug delivery for in vivo treatment of stomach infection. | 2017 | Nat Commun | pmid:28814725 |
Zhang D et al. | Berberine containing quadruple therapy for initial Helicobacter pylori eradication: An open-label randomized phase IV trial. | 2017 | Medicine (Baltimore) | pmid:28796053 |
Fraser AG | Editorial: replacing standard proton pump inhibitors with vonoprazan may breathe new life into triple therapy for Helicobacter pylori. | 2017 | Aliment. Pharmacol. Ther. | pmid:28776748 |
Jung YS et al. | Editorial: replacing standard proton pump inhibitors with vonoprazan may breathe new life into triple therapy for Helicobacter pylori-authors' reply. | 2017 | Aliment. Pharmacol. Ther. | pmid:28776746 |
Turvey SL et al. | Mycobacterium branderi infection: Case report and literature review of an unusual and difficult-to-treat non-tuberculous mycobacterium. | 2017 | Int. J. Infect. Dis. | pmid:28268125 |
Kadota JI et al. | The clinical efficacy of a clarithromycin-based regimen for Mycobacterium avium complex disease: A nationwide post-marketing study. | 2017 | J. Infect. Chemother. | pmid:28254517 |
Ufuk A et al. | In Vitro and in Silico Tools To Assess Extent of Cellular Uptake and Lysosomal Sequestration of Respiratory Drugs in Human Alveolar Macrophages. | 2017 | Mol. Pharm. | pmid:28252969 |
Iwayama K et al. | Long-term treatment of clarithromycin at a low concentration improves hydrogen peroxide-induced oxidant/antioxidant imbalance in human small airway epithelial cells by increasing Nrf2 mRNA expression. | 2017 | BMC Pharmacol Toxicol | pmid:28235416 |
Komiya K et al. | Clarithromycin attenuates IL-13-induced periostin production in human lung fibroblasts. | 2017 | Respir. Res. | pmid:28219384 |
Sakurai K et al. | Comparative study: Vonoprazan and proton pump inhibitors in eradication therapy. | 2017 | World J. Gastroenterol. | pmid:28216974 |
Awan S et al. | Is clarithromycin a potential treatment for cachexia in people with lung cancer? A feasibility study. | 2017 | Lung Cancer | pmid:28213005 |
Su J et al. | Efficacy of 1st-line bismuth-containing quadruple therapies with levofloxacin or clarithromycin for the eradication of Helicobacter pylori infection: A 1-week, open-label, randomized trial. | 2017 | Medicine (Baltimore) | pmid:28207505 |
Branquinho D et al. | Levofloxacin or Clarithromycin-based quadruple regimens: what is the best alternative as first-line treatment for Helicobacter pylori eradication in a country with high resistance rates for both antibiotics? | 2017 | BMC Gastroenterol | pmid:28202013 |
Quinn KL et al. | Macrolides, Digoxin Toxicity and the Risk of Sudden Death: A Population-Based Study. | 2017 | Drug Saf | pmid:28421551 |