| MeSH term | MeSH ID | Detail |
|---|---|---|
| Myxoma | D009232 | 1 associated lipids |
| Kleine-Levin Syndrome | D017593 | 1 associated lipids |
clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with clarithromycin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (5)
- Drug Metab. Dispos. (1)
- FEMS Immunol. Med. Microbiol. (1)
- Others (5)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| De Wit S et al. | Acquired resistance to clarithromycin as combined therapy in Mycobacterium avium intracellulare infection. | 1993 | Lancet | pmid:8093299 |
| Humphreys JE et al. | A clarithromycin sensitivity survey in the United Kingdom using Stokes' method. | 1993 | J. Antimicrob. Chemother. | pmid:8226438 |
| Scaglione F et al. | Immunostimulation by clarithromycin in healthy volunteers and chronic bronchitis patients. | 1993 | J Chemother | pmid:8229150 |
| Tomioka H et al. | [In vitro antimycobacterial activity of clarithromycin and its therapeutic efficacy against Mycobacterium intracellulare infection induced in mice]. | 1993 | Kekkaku | pmid:8497119 |
| Monteforte JS and Wood CA | Pneumonia caused by Nocardia nova and Aspergillus fumigatus after cardiac transplantation. | 1993 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:8500477 |
| Andrews J and Wise R | Disk susceptibility testing for clarithromycin. | 1993 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:8187799 |
| Hakkarinen WD | Clarithromycin vs penicillin. | 1993 | J Fam Pract | pmid:8482929 |
| Luger SW | Clarithromycin vs penicillin. | 1993 | J Fam Pract | pmid:8482930 |
| Yasuda H et al. | Interaction between biofilms formed by Pseudomonas aeruginosa and clarithromycin. | 1993 | Antimicrob. Agents Chemother. | pmid:8239580 |
| Lazard T et al. | Clarithromycin, minocycline, and rifabutin treatments before and after infection of C57BL/6 mice with Mycobacterium avium. | 1993 | Antimicrob. Agents Chemother. | pmid:8215285 |
| Pialoux G et al. | Combination antibiotic treatment with clarithromycin for human immunodeficiency virus-associated Rhodococcus equi infection. | 1993 | Clin. Infect. Dis. | pmid:8218702 |
| Fraschini F et al. | Clarithromycin clinical pharmacokinetics. | 1993 | Clin Pharmacokinet | pmid:8222460 |
| Braga PC and Piatti G | Sub-lethal concentrations of clarithromycin interfere with the expression of Staphylococcus aureus adhesiveness to human cells. | 1993 | J Chemother | pmid:8371124 |
| Macklin JL et al. | A single-blind, randomised, comparative study of clarithromycin and amoxycillin suspensions in the treatment of children with lower respiratory tract infections. | 1993 | J Chemother | pmid:8371127 |
| Ragnaud JM et al. | [Cerebral toxoplasmosis in AIDS. 73 cases. Clinical Epidemiology Group on AIDS in Aquitania]. | 1993 | Presse Med | pmid:8378280 |
| Hoffner SE et al. | Susceptibility of Mycobacterium malmoense to antibacterial drugs and drug combinations. | 1993 | Antimicrob. Agents Chemother. | pmid:8392308 |
| Gevaudan MJ et al. | In-vitro evaluation of clarithromycin, temafloxacin, and ethambutol in combination against Mycobacterium avium complex. | 1993 | J. Antimicrob. Chemother. | pmid:8392998 |
| Wallace RJ et al. | Clinical trial of clarithromycin for cutaneous (disseminated) infection due to Mycobacterium chelonae. | 1993 | Ann. Intern. Med. | pmid:8357113 |
| Mazzei T et al. | Chemistry and mode of action of macrolides. | 1993 | J. Antimicrob. Chemother. | pmid:7683018 |
| Lazard T et al. | Efficacy of granulocyte colony-stimulating factor and RU-40555 in combination with clarithromycin against Mycobacterium avium complex infection in C57BL/6 mice. | 1993 | Antimicrob. Agents Chemother. | pmid:7684213 |
| Emori M et al. | Therapeutic efficacy of the benzoxazinorifamycin KRM-1648 against experimental Mycobacterium avium infection induced in rabbits. | 1993 | Antimicrob. Agents Chemother. | pmid:7684214 |
| Ruf B et al. | Effectiveness of the macrolide clarithromycin in the treatment of Mycobacterium avium complex infection in HIV-infected patients. | 1992 Sep-Oct | Infection | pmid:1428183 |
| Friend DR | Polyacrylate resin microcapsules for taste masking of antibiotics. | 1992 Oct-Dec | J Microencapsul | pmid:1403495 |
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| Nilsen OG et al. | Macrolide pharmacokinetics and dose scheduling of roxithromycin. | 1992 May-Jun | Diagn. Microbiol. Infect. Dis. | pmid:1535579 |
| Hoover WW et al. | Clarithromycin in vitro activity enhanced by its major metabolite, 14-hydroxyclarithromycin. | 1992 Mar-Apr | Diagn. Microbiol. Infect. Dis. | pmid:1533827 |
| Chapelsky MC et al. | Renal tubular enzyme effects of clarithromycin in comparison with gentamicin and placebo in volunteers. | 1992 Jul-Aug | Drug Saf | pmid:1355971 |
| Logan RP et al. | Clarithromycin and omeprazole for Helicobacter pylori. | 1992 | Lancet | pmid:1353155 |
| Hammerschlag MR et al. | In vitro activities of azithromycin, clarithromycin, L-ofloxacin, and other antibiotics against Chlamydia pneumoniae. | 1992 | Antimicrob. Agents Chemother. | pmid:1324650 |
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| Hardy DJ et al. | Clarithromycin, a unique macrolide. A pharmacokinetic, microbiological, and clinical overview. | 1992 | Diagn. Microbiol. Infect. Dis. | pmid:1530914 |
| Chu S et al. | Drug-food interaction potential of clarithromycin, a new macrolide antimicrobial. | 1992 | J Clin Pharmacol | pmid:1531484 |
| Heifets LB et al. | Clarithromycin minimal inhibitory and bactericidal concentrations against Mycobacterium avium. | 1992 | Am. Rev. Respir. Dis. | pmid:1532486 |
| Guay DR and Craft JC | Comparative safety and efficacy of clarithromycin and ampicillin in the treatment of out-patients with acute bacterial exacerbation of chronic bronchitis. | 1992 | J. Intern. Med. | pmid:1532615 |
| Ruf B et al. | Failure of clarithromycin in preventing toxoplasmic encephalitis in AIDS patients. | 1992 | J. Acquir. Immune Defic. Syndr. | pmid:1532831 |
| Cynamon MH and Klemens SP | Activity of azithromycin against Mycobacterium avium infection in beige mice. | 1992 | Antimicrob. Agents Chemother. | pmid:1329622 |
| Ruf B et al. | Acquired resistance of MAI to clarithromycin. | 1992 | Am. Rev. Respir. Dis. | pmid:1533999 |
| Chonmaitree T et al. | Effect of viral respiratory tract infection on outcome of acute otitis media. | 1992 | J. Pediatr. | pmid:1534364 |
| Knothe H | [Short-term therapy of acute respiratory and ORL infections with Clarithromycin]. | 1992 | Z Gesamte Inn Med | pmid:9022402 |
| Bale MJ et al. | MIC quality control guidelines for Haemophilus susceptibility tests using cefdinir (FK482), cefepime, cefetamet, cefpirome, ceftibuten, fleroxacin, temafloxacin, clarithromycin, RP59500, and trospectomycin. | 1992 | J. Clin. Microbiol. | pmid:1310329 |
| Neu HC | New macrolide antibiotics: azithromycin and clarithromycin. | 1992 | Ann. Intern. Med. | pmid:1310839 |
| Brown BA et al. | Activities of four macrolides, including clarithromycin, against Mycobacterium fortuitum, Mycobacterium chelonae, and M. chelonae-like organisms. | 1992 | Antimicrob. Agents Chemother. | pmid:1317144 |
| Bahal N and Nahata MC | The new macrolide antibiotics: azithromycin, clarithromycin, dirithromycin, and roxithromycin. | 1992 | Ann Pharmacother | pmid:1318761 |
| Berk SL | New macrolide antibiotics. | 1992 | Ann. Intern. Med. | pmid:1386966 |
| Chu SY et al. | Absolute bioavailability of clarithromycin after oral administration in humans. | 1992 | Antimicrob. Agents Chemother. | pmid:1387301 |
| Yajko DM et al. | Comparison of the intracellular activities of clarithromycin and erythromycin against Mycobacterium avium complex strains in J774 cells and in alveolar macrophages from human immunodeficiency virus type 1-infected individuals. | 1992 | Antimicrob. Agents Chemother. | pmid:1387302 |
| de Lalla F et al. | Clarithromycin-ciprofloxacin-amikacin for therapy of Mycobacterium avium-Mycobacterium intracellulare bacteremia in patients with AIDS. | 1992 | Antimicrob. Agents Chemother. | pmid:1387303 |
| Cohen Y et al. | Activities of WIN-57273, minocycline, clarithromycin, and 14-hydroxy-clarithromycin against Mycobacterium avium complex in human macrophages. | 1992 | Antimicrob. Agents Chemother. | pmid:1332586 |
| Sifrim D et al. | Comparison of the effects of midecamycin acetate and clarithromycin on gastrointestinal motility in man. | 1992 | Drugs Exp Clin Res | pmid:1292916 |
| Dautzenberg B | [Treatment of atypical mycobacterium infections: current state and therapeutic perspectives]. | 1992 | Rev Pneumol Clin | pmid:1296257 |
| Peters DH and Clissold SP | Clarithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic potential. | 1992 | Drugs | pmid:1379907 |
| Calzolari E et al. | The efficacy of clarythromycin (A-56268, TE-031) in the treatment of genital chlamydial infection. | 1992 | Drugs Exp Clin Res | pmid:1306155 |
| Klemens SP et al. | Activity of clarithromycin against Mycobacterium avium complex infection in beige mice. | 1992 | Antimicrob. Agents Chemother. | pmid:1336945 |
| Ji B et al. | Bactericidal activities of single or multiple doses of various combinations of new antileprosy drugs and/or rifampin against M. leprae in mice. | 1992 | Int. J. Lepr. Other Mycobact. Dis. | pmid:1338596 |
| Yajko DM | In vitro activity of antimicrobial agents against the Mycobacterium avium complex inside macrophages from HIV1-infected individuals: the link to clinical response to treatment? | 1992 | Res. Microbiol. | pmid:1455069 |
| Omura S et al. | [Research and development of clarithromycin]. | 1992 | Yakugaku Zasshi | pmid:1469609 |
| Chu SY et al. | Clarithromycin pharmacokinetics in healthy young and elderly volunteers. | 1992 | J Clin Pharmacol | pmid:1474166 |
| Gelber RH et al. | Clarithromycin at very low levels and on intermittent administration inhibits the growth of M. leprae in mice. | 1992 | Int. J. Lepr. Other Mycobact. Dis. | pmid:1474290 |
| Heifets LB et al. | Bacteriostatic and bactericidal activities of gentamicin alone and in combination with clarithromycin against Mycobacterium avium. | 1992 | Antimicrob. Agents Chemother. | pmid:1416852 |
| Brown BA et al. | Activities of clarithromycin against eight slowly growing species of nontuberculous mycobacteria, determined by using a broth microdilution MIC system. | 1992 | Antimicrob. Agents Chemother. | pmid:1416891 |
| Biehle J and Cavalieri SJ | In vitro susceptibility of Mycobacterium kansasii to clarithromycin. | 1992 | Antimicrob. Agents Chemother. | pmid:1416897 |
| Chu SY et al. | Pharmacokinetics of clarithromycin, a new macrolide, after single ascending oral doses. | 1992 | Antimicrob. Agents Chemother. | pmid:1489187 |
| Araujo FG et al. | Activity of clarithromycin alone or in combination with other drugs for treatment of murine toxoplasmosis. | 1992 | Antimicrob. Agents Chemother. | pmid:1489188 |
| Gan VN et al. | Pharmacokinetics of a clarithromycin suspension in infants and children. | 1992 | Antimicrob. Agents Chemother. | pmid:1489191 |
| Sturgill MG and Rapp RP | Clarithromycin: review of a new macrolide antibiotic with improved microbiologic spectrum and favorable pharmacokinetic and adverse effect profiles. | 1992 | Ann Pharmacother | pmid:1421677 |
| Denny FW | Current management of streptococcal pharyngitis. | 1992 | J Fam Pract | pmid:1453145 |
| Schrock CG | Clarithromycin vs penicillin in the treatment of streptococcal pharyngitis. | 1992 | J Fam Pract | pmid:1453146 |
| Chaisson R | Clarithromycin is effective against M. avium complex in AIDS. | 1992 | Am Fam Physician | pmid:1456199 |
| Ji B et al. | Selection of resistant mutants of Mycobacterium avium in beige mice by clarithromycin monotherapy. | 1992 | Antimicrob. Agents Chemother. | pmid:1482155 |
| Rastogi N and Goh KS | Effect of pH on radiometric MICs of clarithromycin against 18 species of mycobacteria. | 1992 | Antimicrob. Agents Chemother. | pmid:1482156 |
| Rastogi N et al. | Activity of clarithromycin compared with those of other drugs against Mycobacterium paratuberculosis and further enhancement of its extracellular and intracellular activities by ethambutol. | 1992 | Antimicrob. Agents Chemother. | pmid:1482157 |
| Derouin F et al. | Synergistic activity of clarithromycin and minocycline in an animal model of acute experimental toxoplasmosis. | 1992 | Antimicrob. Agents Chemother. | pmid:1482160 |
| Takeda H et al. | [A study to clarify the mechanism of the usefulness of the macrolides--the influence of clarithromycin to biofilm with P. aeruginosa]. | 1992 | Kansenshogaku Zasshi | pmid:1363435 |
| Rehg JE | Anti-cryptosporidial activity of macrolides in immunosuppressed rats. | 1991 Nov-Dec | J. Protozool. | pmid:1667930 |
| Hughes WT | Macrolide-antifol synergism in anti-Pneumocystis carinii therapeutics. | 1991 Nov-Dec | J. Protozool. | pmid:1818149 |
| De Punzio C et al. | Isolation of Chlamydia trachomatis during IVF-ET. | 1991 Jul-Aug | Acta Eur. Fertil. | pmid:1844324 |
| Cogo R et al. | [Dynamics of sIgA concentration in bronchial secretions in patients with COBP treated with clarithromycin]. | 1991 Jan-Dec | G Ital Chemioter | pmid:1365564 |
| Anderson G | Clarithromycin in the treatment of community-acquired lower respiratory tract infections. | 1991 | J. Hosp. Infect. | pmid:1684979 |
| Davey PG | The pharmacokinetics of clarithromycin and its 14-OH metabolite. | 1991 | J. Hosp. Infect. | pmid:1684980 |
| King A and Phillips I | A comparison of the in-vitro activity of clarithromycin, a new macrolide antibiotic, with erythromycin and other oral agents. | 1991 | J. Hosp. Infect. | pmid:1684981 |
| Wood MJ | The tolerance and toxicity of clarithromycin. | 1991 | J. Hosp. Infect. | pmid:1684982 |
| Clarithro- and azithromycin--better erythromycins? | 1991 | Drug Ther Bull | pmid:1665125 | |
| Rastogi N et al. | Antimycobacterial spectrum of sparfloxacin and its activities alone and in association with other drugs against Mycobacterium avium complex growing extracellularly and intracellularly in murine and human macrophages. | 1991 | Antimicrob. Agents Chemother. | pmid:1667250 |
| Gu JW et al. | Bactericidal activity of clarithromycin and its 14-hydroxy metabolite against Haemophilus influenzae and streptococcal pathogens. | 1991 | J Clin Pharmacol | pmid:1837032 |
| Hughes WT and Killmar JT | Synergistic anti-Pneumocystis carinii effects of erythromycin and sulfisoxazole. | 1991 | J. Acquir. Immune Defic. Syndr. | pmid:2016690 |
| Rastogi N and Labrousse V | Extracellular and intracellular activities of clarithromycin used alone and in association with ethambutol and rifampin against Mycobacterium avium complex. | 1991 | Antimicrob. Agents Chemother. | pmid:1828135 |
| Ji B et al. | Effectiveness of clarithromycin and minocycline alone and in combination against experimental Mycobacterium leprae infection in mice. | 1991 | Antimicrob. Agents Chemother. | pmid:1828136 |
| Lu MY et al. | A polymer carrier system for taste masking of macrolide antibiotics. | 1991 | Pharm. Res. | pmid:1829521 |
| Perronne C et al. | Activities of sparfloxacin, azithromycin, temafloxacin, and rifapentine compared with that of clarithromycin against multiplication of Mycobacterium avium complex within human macrophages. | 1991 | Antimicrob. Agents Chemother. | pmid:1656860 |
| Morgan DK et al. | A reversed-phase high-performance liquid chromatographic method for the determination and identification of clarithromycin as the drug substance and in various dosage forms. | 1991 | J Pharm Biomed Anal | pmid:1831386 |
| Dautzenberg B et al. | Activity of clarithromycin against Mycobacterium avium infection in patients with the acquired immune deficiency syndrome. A controlled clinical trial. | 1991 | Am. Rev. Respir. Dis. | pmid:1832527 |
| Rotsch TD et al. | Determination of clarithromycin as a contaminant on surfaces by high-performance liquid chromatography using electrochemical detection. | 1991 | Pharm. Res. | pmid:1833731 |
| Jorgensen JH et al. | Activity of clarithromycin and its principal human metabolite against Haemophilus influenzae. | 1991 | Antimicrob. Agents Chemother. | pmid:1834012 |
| Truffot-Pernot C et al. | Effect of pH on the in vitro potency of clarithromycin against Mycobacterium avium complex. | 1991 | Antimicrob. Agents Chemother. | pmid:1834015 |
| Hamedani P et al. | The safety and efficacy of clarithromycin in patients with Legionella pneumonia. | 1991 | Chest | pmid:1835689 |
| Fernandez-Martin J et al. | Pyrimethamine-clarithromycin combination for therapy of acute Toxoplasma encephalitis in patients with AIDS. | 1991 | Antimicrob. Agents Chemother. | pmid:1836943 |
| Gelber RH et al. | Activities of various macrolide antibiotics against Mycobacterium leprae infection in mice. | 1991 | Antimicrob. Agents Chemother. | pmid:1648889 |
| Straneo G and Scarpazza G | Efficacy and safety of clarithromycin versus josamycin in the treatment of hospitalized patients with bacterial pneumonia. | 1990 Mar-Apr | J. Int. Med. Res. | pmid:2140330 |
| Fraschini F | Clinical efficacy and tolerance of two new macrolides, clarithromycin and josamycin, in the treatment of patients with acute exacerbations of chronic bronchitis. | 1990 Mar-Apr | J. Int. Med. Res. | pmid:2140331 |
| Ferrero JL et al. | Metabolism and disposition of clarithromycin in man. | 1990 Jul-Aug | Drug Metab. Dispos. | pmid:1976065 |