| MeSH term | MeSH ID | Detail |
|---|---|---|
| Myxoma | D009232 | 1 associated lipids |
| Kleine-Levin Syndrome | D017593 | 1 associated lipids |
clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with clarithromycin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Irie Y et al. | Antibiotic MICs and short time-killing against Helicobacter pylori: therapeutic potential of kanamycin. | 1997 | J. Antimicrob. Chemother. | pmid:9301989 |
| Stone GG et al. | PCR-RFLP typing of ureC from Helicobacter pylori isolated from gastric biopsies during a European multi-country clinical trial. | 1997 | J. Antimicrob. Chemother. | pmid:9301991 |
| López-Brea M et al. | Evolution of resistance to metronidazole and clarithromycin in Helicobacter pylori clinical isolates from Spain. | 1997 | J. Antimicrob. Chemother. | pmid:9301996 |
| Versalovic J et al. | Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance. | 1997 | J. Antimicrob. Chemother. | pmid:9301997 |
| Hoffman JS | Pharmacological therapy of Helicobacter pylori infection. | 1997 | Semin. Gastrointest. Dis. | pmid:9232728 |
| Sano M et al. | [A clinical study on combination therapy of antimicrobial agents for complicated urinary tract infection--with special reference to combination with clarithromycin]. | 1997 | Nippon Hinyokika Gakkai Zasshi | pmid:9234616 |
| Saluja A et al. | A surgical wound infection due to Mycobacterium chelonae successfully treated with clarithromycin. | 1997 | Dermatol Surg | pmid:9236871 |
| Stephenson GA et al. | Solid-state investigations of erythromycin A dihydrate: structure, NMR spectroscopy, and hygroscopicity. | 1997 | J Pharm Sci | pmid:9383733 |
| Taylor DE et al. | Cloning and sequence analysis of two copies of a 23S rRNA gene from Helicobacter pylori and association of clarithromycin resistance with 23S rRNA mutations. | 1997 | Antimicrob. Agents Chemother. | pmid:9420030 |
| Katari SR et al. | Clinical features of acute reversible tacrolimus (FK 506) nephrotoxicity in kidney transplant recipients. | 1997 | Clin Transplant | pmid:9193849 |
| Kim MJ et al. | Serum 13C-bicarbonate assay for the diagnosis of gastric Helicobacter pylori infection and response to treatment. | 1997 | Gastroenterology | pmid:9207259 |
| Gotoh A et al. | Susceptibility of Helicobacter pylori isolates against agents commonly administered for eradication therapy and the efficacy of chemotherapy. | 1997 | Microbiol. Immunol. | pmid:9087962 |
| Driscoll MS and Tyring SK | Development of resistance to clarithromycin after treatment of cutaneous Mycobacterium chelonae infection. | 1997 | J. Am. Acad. Dermatol. | pmid:9091495 |
| Gui GP et al. | Two-year-outcomes analysis of Crohn's disease treated with rifabutin and macrolide antibiotics. | 1997 | J. Antimicrob. Chemother. | pmid:9096189 |
| Hoogkamp-Korstanje JA et al. | Multicentre in-vitro evaluation of the susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis to ciprofloxacin, clarithromycin, co-amoxiclav and sparfloxacin. | 1997 | J. Antimicrob. Chemother. | pmid:9096192 |
| Fujii K et al. | Multiple primary Mycobacterium avium infection of the skin. | 1997 | Int. J. Dermatol. | pmid:9071619 |
| Stone GG et al. | PCR-RFLP typing of ureC from Helicobacter pylori isolated in Argentina from gastric biopsies before and after treatment with clarithromycin. | 1997 | Epidemiol. Infect. | pmid:9129588 |
| Spicer ST et al. | The mechanism of cyclosporine toxicity induced by clarithromycin. | 1997 | Br J Clin Pharmacol | pmid:9131953 |
| Guillemet C et al. | [Clarithromycin-digoxin: an unrecognized interaction in some patients]. | 1997 | Presse Med | pmid:9137381 |
| Rodrigues AD et al. | Oxidative metabolism of clarithromycin in the presence of human liver microsomes. Major role for the cytochrome P4503A (CYP3A) subfamily. | 1997 | Drug Metab. Dispos. | pmid:9152603 |
| Yanagihara K et al. | Effect of clarithromycin on lymphocytes in chronic respiratory Pseudomonas aeruginosa infection. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9001333 |
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| Pendland SL et al. | Comparison of charcoal- and starch-based media for testing susceptibilities of Legionella species to macrolides, azalides, and fluoroquinolones. | 1997 | J. Clin. Microbiol. | pmid:9350781 |
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| Tonai A et al. | [Clarithromycin suppression of DNA synthesis by rat nasal mucosal cells enhanced by endotoxin instillation]. | 1997 | Jpn J Antibiot | pmid:9678983 |
| Ridgway GL et al. | The in-vitro activity of grepafloxacin against Chlamydia spp., Mycoplasma spp., Ureaplasma urealyticum and Legionella spp. | 1997 | J. Antimicrob. Chemother. | pmid:9484871 |
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| Sander P et al. | The role of ribosomal RNAs in macrolide resistance. | 1997 | Mol. Microbiol. | pmid:9402018 |
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| Jingu K et al. | [A case of fluminant Mycoplasma pneumonia and bronchiolitis managed by artificial respiration]. | 1997 | Nippon Naika Gakkai Zasshi | pmid:9340346 |
| Szántó D et al. | [Could Helicobacter pylori cause reactive arthro-osteitis?]. | 1997 | Orv Hetil | pmid:9340585 |
| Yamamoto M et al. | [The clinical study of clarithromycin for pulmonary Mycobacterium avium-intracellulare complex infection]. | 1997 | Kekkaku | pmid:9038009 |
| Rodrigues AD and Wong SL | Application of human liver microsomes in metabolism-based drug-drug interactions: in vitro-in vivo correlations and the Abbott Laboratories experience. | 1997 | Adv. Pharmacol. | pmid:9342173 |
| Yasui N et al. | Carbamazepine toxicity induced by clarithromycin coadministration in psychiatric patients. | 1997 | Int Clin Psychopharmacol | pmid:9347384 |
| May T et al. | Comparison of combination therapy regimens for treatment of human immunodeficiency virus-infected patients with disseminated bacteremia due to Mycobacterium avium. ANRS Trial 033 Curavium Group. Agence Nationale de Recherche sur le Sida. | 1997 | Clin. Infect. Dis. | pmid:9314450 |
| Dohil R et al. | Effective 2-wk therapy for Helicobacter pylori disease in children. | 1997 | Am. J. Gastroenterol. | pmid:9040199 |
| Wright DH | Regression of mucosa-associated lymphoid-tissue lymphoma after eradication of Helicobacter pylori. | 1997 | Lancet | pmid:9314895 |
| Lerang F et al. | Highly effective twice-daily triple therapies for Helicobacter pylori infection and peptic ulcer disease: does in vitro metronidazole resistance have any clinical relevance? | 1997 | Am. J. Gastroenterol. | pmid:9040200 |
| Visalli MA et al. | Susceptibility of twenty penicillin-susceptible and -resistant pneumococci to levofloxacin, ciprofloxacin, ofloxacin, erythromycin, azithromycin, and clarithromycin by MIC and time-kill. | 1997 | Diagn. Microbiol. Infect. Dis. | pmid:9294703 |
| Brown BA et al. | Clarithromycin-associated digoxin toxicity in the elderly. | 1997 | Clin. Infect. Dis. | pmid:8994761 |
| de'Clari F | Ciprofloxacin was the culprit--not itraconazole. | 1997 | Clin. Infect. Dis. | pmid:8994764 |
| Visalli MA et al. | Susceptibility of penicillin-susceptible and -resistant pneumococci to dirithromycin compared with susceptibilities to erythromycin, azithromycin, clarithromycin, roxithromycin, and clindamycin. | 1997 | Antimicrob. Agents Chemother. | pmid:9303375 |
| Ednie LM et al. | Comparative antianaerobic activities of the ketolides HMR 3647 (RU 66647) and HMR 3004 (RU 64004). | 1997 | Antimicrob. Agents Chemother. | pmid:9303406 |
| Greco S et al. | Glossitis, stomatitis, and black tongue with lansoprazole plus clarithromycin and other antibiotics. | 1997 | Ann Pharmacother | pmid:9416400 |
| Sugihara J et al. | [Efficacy of clarithromycin on chronic paranasal sinusitis--a comparison between children and adult]. | 1997 | Jpn J Antibiot | pmid:9597431 |
| Hamada K et al. | [Evaluation of antineoplastic effect of CAM (clarithromycin) in a mouse model inoculated with lung cancer cells]. | 1997 | Jpn J Antibiot | pmid:9597434 |
| Kokubo Y et al. | [Effects of clarithromycin on experimental pulmonary metastasis]. | 1997 | Jpn J Antibiot | pmid:9597436 |
| Sakamoto M et al. | [Efficacy of clarithromycin on cancer cachexia in patients with primary non-small cell lung cancer]. | 1997 | Jpn J Antibiot | pmid:9597437 |
| Teramoto S et al. | [Fluctuation in the cytokine m-RNA content in primary non-small cell lung cancer caused by clarithromycin (CAM) administration]. | 1997 | Jpn J Antibiot | pmid:9597438 |
| Mikasa K et al. | [Effect of clarithromycin on prolonging the life expectancy of patients with primary lung cancer]. | 1997 | Jpn J Antibiot | pmid:9597439 |
| Tzivras M et al. | One-week therapy with omeprazole, clarithromycin and metronidazole or ornidazole, followed by 3 weeks' treatment with omeprazole, eradicates Helicobacter pylori equally and heals duodenal ulcer. | 1997 | Eur J Gastroenterol Hepatol | pmid:9471024 |
| Kawasaki M et al. | Ménétrièr's disease associated with Helicobacter pylori infection: resolution of enlarged gastric folds and hypoproteinemia after antibacterial treatment. | 1997 | Am. J. Gastroenterol. | pmid:9382064 |
| Adamek RJ et al. | Pantoprazole versus omeprazole in one-week low-dose triple therapy for curve of H. pylori infection. | 1997 | Am. J. Gastroenterol. | pmid:9382084 |
| McLaren A et al. | The role of ranitidine bismuth citrate in significantly reducing the emergence of Helicobacter pylori strains resistant to antibiotics. | 1997 | Helicobacter | pmid:9432317 |
| Bardhan KD et al. | Effects of smoking on cure of Helicobacter pylori infection and duodenal ulcer recurrence in patients treated with clarithromycin and omeprazole. | 1997 | Helicobacter | pmid:9432318 |
| Takimoto T et al. | The efficacy and safety of one-week triple therapy with lansoprazole, clarithromycin, and metronidazole for the treatment of Helicobacter pylori infection in Japanese patients. | 1997 | Helicobacter | pmid:9432334 |
| Moayyedi P | Amoxycillin dual therapy against Helicobacter pylori--the final nail in the coffin? | 1997 | Ital J Gastroenterol Hepatol | pmid:9513823 |
| Pieramico O et al. | Omeprazole-based dual and triple therapy for the treatment of Helicobacter pylori infection in peptic ulcer disease: a randomized trial. | 1997 | Helicobacter | pmid:9432335 |
| Pounder RE et al. | Ranitidine bismuth citrate with clarithromycin for the eradication of Helicobacter pylori and for ulcer healing. | 1997 | Helicobacter | pmid:9432341 |
| Reisner BS et al. | Electron microscopic analysis of Mycobacterium avium complex isolates exposed to ciprofloxacin, rifabutin, ethambutol and clarithromycin. | 1997 | Int. J. Tuberc. Lung Dis. | pmid:9432376 |
| Lerang F et al. | Highly effective second-line anti-Helicobacter pylori therapy in patients with previously failed metronidazole-based therapy. | 1997 | Scand. J. Gastroenterol. | pmid:9438318 |
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| Payen MC et al. | [Manifestations, diagnosis and treatment of non-tuberculous mycobacterial infections in patients with HIV infection]. | 1997 | Rev Mal Respir | pmid:9496599 |
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| Briant C et al. | Pericarditis as a manifestation of Lyme disease. | 1997 | J Emerg Nurs | pmid:9460386 |
| Feldman C et al. | Roxithromycin, clarithromycin, and azithromycin attenuate the injurious effects of bioactive phospholipids on human respiratory epithelium in vitro. | 1997 | Inflammation | pmid:9429912 |
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| Harris A | H. pylori eradication by LAC. | 1997 | Aliment. Pharmacol. Ther. | pmid:9354216 |
| Jablonowski H et al. | Ancillary benefits of Mycobacterium avium-intracellulare complex prophylaxis with clarithromycin in HIV-infected patients. | 1997 | Drugs | pmid:9358196 |
| Grosset J and Ji B | Prevention of the selection of clarithromycin-resistant Mycobacterium avium-intracellulare complex. | 1997 | Drugs | pmid:9358197 |
| Dubé MP et al. | A randomized evaluation of ethambutol for prevention of relapse and drug resistance during treatment of Mycobacterium avium complex bacteremia with clarithromycin-based combination therapy. California Collaborative Treatment Group. | 1997 | J. Infect. Dis. | pmid:9359722 |
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| Hultén K et al. | Macrolide resistance in Helicobacter pylori: mechanism and stability in strains from clarithromycin-treated patients. | 1997 | Antimicrob. Agents Chemother. | pmid:9371366 |
| Barry AL et al. | In vitro activity of the new ketolide HMR 3004 compared to an azalide and macrolides against Streptococcus pneumoniae and Haemophilus influenzae. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9405952 |
| Mitsuyama T et al. | Neutrophil-induced endothelial cell damage: inhibition by a 14-membered ring macrolide through the action of nitric oxide. | 1997 | Int. Arch. Allergy Immunol. | pmid:9338603 |
| Kundu S et al. | Clarithromycin-induced ventricular tachycardia. | 1997 | Ann Emerg Med | pmid:9326871 |
| Laine L et al. | Randomized comparison of ranitidine bismuth citrate-based triple therapies for Helicobacter pylori. | 1997 | Am. J. Gastroenterol. | pmid:9399755 |
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| Different clarithromycin doses affect mortality. | 1997 | AIDS Patient Care STDS | pmid:11361754 | |
| Sekkarie MA | Torsades de pointes in two chronic renal failure patients treated with cisapride and clarithromycin. | 1997 | Am. J. Kidney Dis. | pmid:9292575 |
| Akaki T et al. | [In vivo activities of benzoxazinorifamycin KRM-1648, clarithromycin, and levofloxacin, or combination of KRM-1648 with diclofenac sodium against Mycobacterium avium infection induced in mice]. | 1997 | Kekkaku | pmid:9293712 |
| Recker MW and Kier KL | Potential interaction between clarithromycin and warfarin. | 1997 | Ann Pharmacother | pmid:9296238 |
| Laberge P and Martineau P | Clarithromycin-induced digoxin intoxication. | 1997 | Ann Pharmacother | pmid:9296239 |
| Matsukura N | [Two step therapy for education of Helicobacter pylori]. | 1997 | Nihon Shokakibyo Gakkai Zasshi | pmid:9284449 |
| Bardhan KD et al. | Ranitidine bismuth citrate with clarithromycin for the treatment of duodenal ulcer. | 1997 | Gut | pmid:9301496 |
| Tan WC et al. | Helicobacter pylori eradication--comparison of three drug regimens and symptomatic assessment in duodenitis and antral gastritis. | 1997 | Int. J. Clin. Pract. | pmid:9287260 |
| Kobler E et al. | [Effectiveness of short-term triple therapy for healing Helicobacter pylori infection in ulcer disease]. | 1997 | Schweiz Med Wochenschr Suppl | pmid:9289833 |