clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Auw-Hädrich C et al. | [Clarithromycin for monotherapy of B-cell MALT lymphoma?]. | 2013 | Ophthalmologe | pmid:24231914 |
Formanoy E et al. | Tenosynovitis of the right hand. Mycobacterium kansasii. | 2013 | Neth J Med | pmid:24394739 |
Lee YC et al. | The benefit of mass eradication of Helicobacter pylori infection: a community-based study of gastric cancer prevention. | 2013 | Gut | pmid:22698649 |
Amado-RodrÃguez L et al. | Anti-inflammatory effects of clarithromycin in ventilator-induced lung injury. | 2013 | Respir. Res. | pmid:23663489 |
Pereira JM et al. | Interplay of degradation, dissolution and stabilization of clarithromycin and its amorphous solid dispersions. | 2013 | Mol. Pharm. | pmid:24116899 |
Huang J et al. | Randomised controlled trial: sequential vs. standard triple therapy for Helicobacter pylori infection in Chinese children-a multicentre, open-labelled study. | 2013 | Aliment. Pharmacol. Ther. | pmid:24117692 |
Yoon H et al. | Meta-analysis: is sequential therapy superior to standard triple therapy for Helicobacter pylori infection in Asian adults? | 2013 | J. Gastroenterol. Hepatol. | pmid:24118110 |
Chen K et al. | Low dose macrolide administration for long term is effective for otitis media with effusion in children. | 2013 | Auris Nasus Larynx | pmid:22673738 |
Drago F et al. | Acute autoimmune thrombocytopenia and worsening of dermatomyositis after administration of clarithromycin. | 2013 | J. Am. Acad. Dermatol. | pmid:24124859 |
Zhu D et al. | Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities. | 2013 | Bioorg. Med. Chem. Lett. | pmid:24139585 |
Nasa M et al. | Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication: a randomized study. | 2013 | Indian J Gastroenterol | pmid:24158898 |
Kim SY et al. | Comparative study of Helicobacter pylori eradication rates with 5-day quadruple "concomitant" therapy and 7-day standard triple therapy. | 2013 | J. Clin. Gastroenterol. | pmid:22647826 |
Fagoonee S et al. | Efficacy of cefixime-based triple therapy for Helicobacter pylori eradication: a retrospective study. | 2013 | Panminerva Med | pmid:24088806 |
Gisbert JP et al. | Second-line therapy with levofloxacin after failure of treatment to eradicate helicobacter pylori infection: time trends in a Spanish Multicenter Study of 1000 patients. | 2013 | J. Clin. Gastroenterol. | pmid:22647827 |
Piso RJ et al. | Coverage of atypical pathogens for hospitalised patients with community-acquired pneumonia is not guided by clinical parameters. | 2013 | Swiss Med Wkly | pmid:24089030 |
Schafranek L et al. | Clarithromycin enhances dasatinib-induced cell death in chronic myeloid leukemia cells, by inhibition of late stage autophagy. | 2013 | Leuk. Lymphoma | pmid:22656271 |
Yonezawa H et al. | Impact of Helicobacter pylori biofilm formation on clarithromycin susceptibility and generation of resistance mutations. | 2013 | PLoS ONE | pmid:24039906 |
Gysel M et al. | Torsades de pointes following clarithromycin treatment. | 2013 | Expert Rev Cardiovasc Ther | pmid:24147515 |
Megraud F et al. | Helicobacter pylori resistance to antibiotics in Europe and its relationship to antibiotic consumption. | 2013 | Gut | pmid:22580412 |
Wang S et al. | A supra-monolayer nanopattern for organic nanoparticle array deposition. | 2013 | ACS Appl Mater Interfaces | pmid:23480527 |
Raghunatha K and George JP | Periodontal tissue and serum concentration of clarithromycin after systemic administration in patients affected by chronic periodontitis. | 2013 | J. Periodontol. | pmid:23451987 |
Liang X et al. | Efficacy of bismuth-containing quadruple therapies for clarithromycin-, metronidazole-, and fluoroquinolone-resistant Helicobacter pylori infections in a prospective study. | 2013 | Clin. Gastroenterol. Hepatol. | pmid:23376004 |
Calza P et al. | Fate of selected pharmaceuticals in river waters. | 2013 | Environ Sci Pollut Res Int | pmid:22851223 |
Morse AL et al. | A randomized controlled trial comparing sequential with triple therapy for Helicobacter pylori in an Aboriginal community in the Canadian North. | 2013 | Can. J. Gastroenterol. | pmid:24340314 |
Pan W et al. | Effects of clopidogrel and clarithromycin on the disposition of sibutramine and its active metabolites M1 and M2 in relation to CYP2B6*6 polymorphism. | 2013 | Xenobiotica | pmid:22830954 |
Schmidt BJ and Hermansen MN | [Late debut of neonatal pneumonia caused by Chlamydia trachomatis]. | 2013 | Ugeskr. Laeg. | pmid:23428270 |
Tsukanov VV et al. | [Helicobacter pylori eradication: current status]. | 2013 | Ter. Arkh. | pmid:23653944 |
Sierra F et al. | Pilot study: miscellaneous therapy is highly successful for Helicobacter pylori eradication. | 2013 | Aliment. Pharmacol. Ther. | pmid:23656465 |
Radouane N et al. | [Generalized chromomycosis caused by Phialophora verrucosa]. | 2013 | Ann Dermatol Venereol | pmid:23466152 |
Otsuka SH | Severe hypoglycemia from Helicobacter pylori triple-drug therapy and insulin detemir drug interaction. | 2013 | Pharmacotherapy | pmid:23471710 |
Jiang JW et al. | Synthesis and antibacterial evaluation of a novel series of 10-hydroxyl ketolide derivatives. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23591116 |
Odagiri T et al. | Design, synthesis, and biological evaluations of novel 7-[7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-8-methoxyquinolines with potent antibacterial activity against respiratory pathogens. | 2013 | J. Med. Chem. | pmid:23409972 |
Trifan A et al. | Pseudomembranous colitis associated with a triple therapy for Helicobacter pylori eradication. | 2013 | World J. Gastroenterol. | pmid:24259981 |
Laving A et al. | Effectiveness of sequential v. standard triple therapy for treatment of Helicobacter pylori infection in children in Nairobi, Kenya. | 2013 | S. Afr. Med. J. | pmid:24300630 |
Cecchini MP et al. | Might Helicobacter pylori infection be associated with distortion on taste perception? | 2013 | Med. Hypotheses | pmid:23845559 |
Delgado JS et al. | Granulomatous gastritis and Helicobacter pylori infection. | 2013 | Isr. Med. Assoc. J. | pmid:23882902 |
Lee HJ et al. | Eradication of Helicobacter pylori according to 23S ribosomal RNA point mutations associated with clarithromycin resistance. | 2013 | J. Infect. Dis. | pmid:23801607 |
Bustamante-Rengifo JA et al. | In vitro effect of amoxicillin and clarithromycin on the 3' region of cagA gene in Helicobacter pylori isolates. | 2013 | World J. Gastroenterol. | pmid:24106405 |
Shallom SJ et al. | New rapid scheme for distinguishing the subspecies of the Mycobacterium abscessus group and identifying Mycobacterium massiliense isolates with inducible clarithromycin resistance. | 2013 | J. Clin. Microbiol. | pmid:23804391 |
Greupink R et al. | Semi-mechanistic physiologically-based pharmacokinetic modeling of clinical glibenclamide pharmacokinetics and drug-drug-interactions. | 2013 | Eur J Pharm Sci | pmid:23806476 |
Kim SG et al. | [Guidelines for the diagnosis and treatment of Helicobacter pylori infection in Korea, 2013 revised edition]. | 2013 | Korean J Gastroenterol | pmid:23954956 |
Park CW et al. | Advanced spray-dried design, physicochemical characterization, and aerosol dispersion performance of vancomycin and clarithromycin multifunctional controlled release particles for targeted respiratory delivery as dry powder inhalation aerosols. | 2013 | Int J Pharm | pmid:23820131 |
Yoshida S et al. | Further isolation of Mycobacterium abscessus subsp. abscessus and subsp. bolletii in different regions of Japan and susceptibility of these isolates to antimicrobial agents. | 2013 | Int. J. Antimicrob. Agents | pmid:23850022 |
Yu Q et al. | Treatment of pulmonary mucosa-associated lymphoid tissue lymphoma with clarithromycin. | 2013 | Chin. Med. J. | pmid:23786961 |
Dabirmoghaddam P et al. | The efficacy of clarithromycin in patients with severe nasal polyposis. | 2013 | Acta Med Iran | pmid:23852839 |
Chen PR and Tan SY | [The treatment outcomes of 21 cases of rapidly growing mycobacteria related pulmonary disease]. | 2013 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:23856140 |
Seyedmajidi S et al. | Penbactam for Helicobacter pylori eradication: a randomised comparison of quadruple and triple treatment schedules in an Iranian population. | 2013 | Arab J Gastroenterol | pmid:23622801 |
Andersen JT et al. | Clarithromycin in early pregnancy and the risk of miscarriage and malformation: a register based nationwide cohort study. | 2013 | PLoS ONE | pmid:23301061 |
Kwak HM et al. | The efficacy of cefazolin plus macrolide (erythromycin or clarithromycin) versus cefazolin alone in neonatal morbidity and placental inflammation for women with preterm premature rupture of membranes. | 2013 | Placenta | pmid:23465535 |
Huang HC et al. | Primary central nervous system diffuse large B cell lymphoma transformed from orbital mucosa-associated lymphoid tissue lymphoma: complete response to combined intrathecal and systemic rituximab. | 2013 | Ann. Hematol. | pmid:23242476 |
Ang TL et al. | Is there still a role for empiric first-line triple therapy using proton pump inhibitor, amoxicillin and clarithromycin for Helicobacter pylori infection in Singapore? Results of a time trend analysis. | 2013 | J Dig Dis | pmid:23253473 |
Danilko L et al. | [Clarithromycin therapy of a B cell MALT lymphoma]. | 2013 | Ophthalmologe | pmid:23224128 |
Liang JH et al. | Synthesis, antibacterial activity and docking of 14-membered 9-O-(3-arylalkyl) oxime 11,12-cyclic carbonate ketolides. | 2013 | Eur J Med Chem | pmid:23202851 |
Delavenne X et al. | A semi-mechanistic absorption model to evaluate drug-drug interaction with dabigatran: application with clarithromycin. | 2013 | Br J Clin Pharmacol | pmid:23210726 |
Duman DG et al. | Saccharomyces boulardii ameliorates clarithromycin- and methotrexate-induced intestinal and hepatic injury in rats. | 2013 | Br. J. Nutr. | pmid:23279717 |
Bessa LJ et al. | Helicobacter pylori free-living and biofilm modes of growth: behavior in response to different culture media. | 2013 | APMIS | pmid:23237527 |
Qvist T et al. | First report of lung transplantation in a patient with active pulmonary Mycobacterium simiae infection. | 2013 | Transplant. Proc. | pmid:23267789 |
Fiorini G et al. | Culture-based selection therapy for patients who did not respond to previous treatment for Helicobacter pylori infection. | 2013 | Clin. Gastroenterol. Hepatol. | pmid:23267869 |
Kazama I and Maruyama Y | Differential effects of clarithromycin and azithromycin on delayed rectifier K(+)-channel currents in murine thymocytes. | 2013 | Pharm Biol | pmid:23527897 |
Kawai Y et al. | Therapeutic efficacy of macrolides, minocycline, and tosufloxacin against macrolide-resistant Mycoplasma pneumoniae pneumonia in pediatric patients. | 2013 | Antimicrob. Agents Chemother. | pmid:23459497 |
Sardarian H et al. | Comparison of hybrid and sequential therapies for Helicobacter pylori eradication in Iran: a prospective randomized trial. | 2013 | Helicobacter | pmid:23121338 |
Liou JM et al. | Sequential versus triple therapy for the first-line treatment of Helicobacter pylori: a multicentre, open-label, randomised trial. | 2013 | Lancet | pmid:23158886 |
Thomas M et al. | Periprosthetic atypical mycobacterial infection in breast implants: a new kid on the block! | 2013 | J Plast Reconstr Aesthet Surg | pmid:23122691 |
Pandey SK et al. | Antimalarial interaction of quinine and quinidine with clarithromycin. | 2013 | Parasitology | pmid:23137860 |
Lahbabi M et al. | Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication: result of the HPFEZ randomised study. | 2013 | Clin Res Hepatol Gastroenterol | pmid:23168228 |
Darwish KM et al. | RP-HPLC/pre-column derivatization for analysis of omeprazole, tinidazole, doxycycline and clarithromycin. | 2013 | J Chromatogr Sci | pmid:23081968 |
Uthman MM et al. | Interventions for the prevention of mycobacterium avium complex in adults and children with HIV. | 2013 | Cochrane Database Syst Rev | pmid:23633339 |
Secka O et al. | Antimicrobial susceptibility and resistance patterns among Helicobacter pylori strains from The Gambia, West Africa. | 2013 | Antimicrob. Agents Chemother. | pmid:23263004 |
Simoens S et al. | Preventing COPD exacerbations with macrolides: a review and budget impact analysis. | 2013 | Respir Med | pmid:23352223 |
Phunpruch S et al. | A role for 16S rRNA dimethyltransferase (ksgA) in intrinsic clarithromycin resistance in Mycobacterium tuberculosis. | 2013 | Int. J. Antimicrob. Agents | pmid:23541074 |
Mueck W et al. | Co-administration of rivaroxaban with drugs that share its elimination pathways: pharmacokinetic effects in healthy subjects. | 2013 | Br J Clin Pharmacol | pmid:23305158 |
Alhajlan M et al. | Efficacy and safety of liposomal clarithromycin and its effect on Pseudomonas aeruginosa virulence factors. | 2013 | Antimicrob. Agents Chemother. | pmid:23545534 |
Goh IX et al. | Cytochrome P450 drug interactions with statin therapy. | 2013 | Singapore Med J | pmid:23546024 |
Georgopoulos S et al. | Nonbismuth quadruple "concomitant" therapy versus standard triple therapy, both of the duration of 10 days, for first-line H. pylori eradication: a randomized trial. | 2013 | J. Clin. Gastroenterol. | pmid:22858517 |
Malfertheiner P | [Is sequential eradication of Helicobacter pylori effective? Sequential treatment more effective than triple therapy in patients with clarithromycin resistance]. | 2013 | Dtsch. Med. Wochenschr. | pmid:23512360 |
Seneviratne K and Herieka E | A rifampicin-resistant Mycobacterium marinum infection in a newly diagnosed HIV-1 individual. | 2013 | Int J STD AIDS | pmid:23512514 |
Ogawa K | Genetic research about Mycobacterium avium complex. | 2013 | Kekkaku | pmid:23513564 |
Liang JH et al. | Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23375796 |
Karmakar S et al. | Hypokalemia: a potent risk for QTc prolongation in clarithromycin treated rats. | 2013 | Eur. J. Pharmacol. | pmid:23567068 |
Benajah DA et al. | Prevalence of Helicobacter pylori and its recurrence after successful eradication in a developing nation (Morocco). | 2013 | Clin Res Hepatol Gastroenterol | pmid:23567104 |
Bolhuis MS et al. | Clarithromycin increases linezolid exposure in multidrug-resistant tuberculosis patients. | 2013 | Eur. Respir. J. | pmid:23520311 |
Schembri S et al. | Cardiovascular events after clarithromycin use in lower respiratory tract infections: analysis of two prospective cohort studies. | 2013 | BMJ | pmid:23525864 |
Matsumoto T et al. | Education and imaging. Gastrointestinal: colonic mucosa-associated lymphoid tissue lymphoma regressed by levofloxacin. | 2013 | J. Gastroenterol. Hepatol. | pmid:23527757 |
Joosten M et al. | Case report: Helicobacter suis infection in a pig veterinarian. | 2013 | Helicobacter | pmid:23551953 |
Howard ST | Recent progress towards understanding genetic variation in the Mycobacterium abscessus complex. | 2013 | Tuberculosis (Edinb) | pmid:24388643 |
Zendedel A et al. | Antibiotic resistance of Helicobacter pylori in Mashhad, Iran. | 2013 | J Pak Med Assoc | pmid:23914633 |
Maggi P et al. | Fatal fulminant hepatitis following administration of clarithromycin in a patient chronically treated with antipsycotic drugs. | 2013 | Immunopharmacol Immunotoxicol | pmid:22804484 |
Haider M et al. | Post-operative sinus formation due to Mycobacterium abscessus: a case report. | 2013 | Indian J Tuberc | pmid:24000496 |
Hong SK et al. | First case of Mycobacterium longobardum infection. | 2013 | Ann Lab Med | pmid:24003427 |
Labenz J | [Fewer stomach cancers after Helicobacter pylori eradication]. | 2013 | MMW Fortschr Med | pmid:24006589 |
Miyauchi R et al. | Clarithromycin-induced haemorrhagic colitis. | 2013 | BMJ Case Rep | pmid:23964038 |
Ergül B et al. | The efficacy of two-week quadruple first-line therapy with bismuth, lansoprazole, amoxicillin, clarithromycin on Helicobacter pylori eradication: a prospective study. | 2013 | Helicobacter | pmid:24011287 |
Gandhi S et al. | Calcium-channel blocker-clarithromycin drug interactions and acute kidney injury. | 2013 | JAMA | pmid:24346990 |
Yu RX et al. | Köebner phenomenon induced by cupping therapy in a psoriasis patient. | 2013 | Dermatol. Online J. | pmid:24011324 |
Abenavoli L et al. | Association between non-alcoholic fatty liver disease, insulin resistance and Helicobacter pylori. | 2013 | Med. Hypotheses | pmid:24011768 |
Nagaoka K et al. | Macrolides inhibit Fusobacterium nucleatum-induced MUC5AC production in human airway epithelial cells. | 2013 | Antimicrob. Agents Chemother. | pmid:23380724 |
Moriya S et al. | Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells. | 2013 | Int. J. Oncol. | pmid:23546223 |
Akiyoshi T et al. | Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants. | 2013 | Drug Metab. Pharmacokinet. | pmid:23514827 |
Makobongo MO et al. | In vitro characterization of the anti-bacterial activity of SQ109 against Helicobacter pylori. | 2013 | PLoS ONE | pmid:23935905 |
Unai S et al. | Sternal wound infection caused by Mycobacterium chelonae. | 2013 | J Card Surg | pmid:23941599 |