clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Cerqueira L et al. | Validation of a fluorescence in situ hybridization method using peptide nucleic acid probes for detection of Helicobacter pylori clarithromycin resistance in gastric biopsy specimens. | 2013 | J. Clin. Microbiol. | pmid:23596234 |
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Onsun N et al. | Impact of Helicobacter pylori infection on severity of psoriasis and response to treatment. | 2012 Jan-Feb | Eur J Dermatol | pmid:22063790 |
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Dai WQ et al. | The eradicating Helicobacter pylori infection in duodenal ulcer patients by three short-term triple therapies in China: a multicenter clinical comparative study. | 2012 Jan-Feb | Hepatogastroenterology | pmid:22260837 |
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Choi SJ et al. | The prevalence of vaginal microorganisms in pregnant women with preterm labor and preterm birth. | 2012 | Ann Lab Med | pmid:22563554 |
Bowers JR et al. | Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona. | 2012 | BMC Microbiol. | pmid:22251616 |
Brož P et al. | Nonirritant intradermal skin test concentrations of ciprofloxacin, clarithromycin, and rifampicin. | 2012 | Allergy | pmid:22435670 |
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Koutsoubari I et al. | Effect of clarithromycin on acute asthma exacerbations in children: an open randomized study. | 2012 | Pediatr Allergy Immunol | pmid:22433020 |
Mouktaroudi M and Giamarellos-Bourboulis EJ | Macrolides for the therapy of nosocomial infections. | 2012 | Curr. Opin. Infect. Dis. | pmid:22248975 |
Lin YH and Liu TC | Mycobacterium chelonae infection involving the auricle. | 2012 | QJM | pmid:21908384 |
Ji R et al. | Mucosal barrier defects in gastric intestinal metaplasia: in vivo evaluation by confocal endomicroscopy. | 2012 | Gastrointest. Endosc. | pmid:22325805 |
Raj JM and Raj SM | Concern about the efficacy of clarithromycin containing standard triple therapy in the eradication of Helicobacter pylori infection in Malaysia. | 2012 | Med. J. Malaysia | pmid:23770883 |
Kim SY et al. | Effectiveness of three times daily lansoprazole/amoxicillin dual therapy for Helicobacter pylori infection in Korea. | 2012 | Br J Clin Pharmacol | pmid:21689141 |
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Kumar R et al. | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22153939 |
Matsueda K et al. | A placebo-controlled trial of acotiamide for meal-related symptoms of functional dyspepsia. | 2012 | Gut | pmid:22157329 |
Stepanić V et al. | Physicochemical profile of macrolides and their comparison with small molecules. | 2012 | Eur J Med Chem | pmid:22152985 |
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Ding FM et al. | Low-dose clarithromycin therapy modulates CD4(+) T-cell responses in a mouse model of chronic Pseudomonas aeruginosa lung infection. | 2012 | Respirology | pmid:22404374 |
Kadayifci A et al. | Low efficacy of clarithromycin including sequential regimens for Helicobacter pylori infection. | 2012 | Helicobacter | pmid:22404442 |
Gisbert JP and McNicholl AG | Maintenance of Helicobacter pylori eradication rates with triple therapy over 12 years in a Spanish hospital. | 2012 | Helicobacter | pmid:22404448 |
Salmon JH et al. | Discitis and sacroiliitis diagnosed 15 years after iatrogenic Mycobacterium xenopi inoculation. | 2012 | Joint Bone Spine | pmid:22405857 |
Katayama M et al. | Interaction of clarithromycin with cyclosporine in cats: pharmacokinetic study and case report. | 2012 | J. Feline Med. Surg. | pmid:22412163 |
Bobacheva TIu | [The treatment of chronic polypous rhinosinusitis in the postoperative period with low doses of clarithromycin]. | 2012 | Vestn. Otorinolaringol. | pmid:23011378 |
Omoruyi OJ et al. | Metachronous Mycobacterium terrae complex tenosynovitis of the hand. | 2012 | J Hand Surg Eur Vol | pmid:22415428 |
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Lee MR et al. | CNS infections caused by Mycobacterium abscessus complex: clinical features and antimicrobial susceptibilities of isolates. | 2012 | J. Antimicrob. Chemother. | pmid:21980068 |
Cuadrado-LavÃn A et al. | Antimicrobial susceptibility of Helicobacter pylori to six antibiotics currently used in Spain. | 2012 | J. Antimicrob. Chemother. | pmid:21965436 |
Prechtl J et al. | Monitoring of antibiotic resistance rates of Helicobacter pylori in Austrian children, 2002-2009. | 2012 | Pediatr. Infect. Dis. J. | pmid:22094633 |
Deguchi R et al. | Effect of pretreatment with Lactobacillus gasseri OLL2716 on first-line Helicobacter pylori eradication therapy. | 2012 | J. Gastroenterol. Hepatol. | pmid:22098133 |
Ivetic Tkalcevic V et al. | Cantharidin-induced inflammation in mouse ear model for translational research of novel anti-inflammatories. | 2012 | Transl Res | pmid:22677362 |
Shah M et al. | Transient Psychotic Episode Induced by Helicobacter pylori Triple Therapy Treatment. | 2012 | Case Rep Gastroenterol | pmid:22855656 |
Heeb F et al. | Organic micropollutants in rivers downstream of the megacity Beijing: sources and mass fluxes in a large-scale wastewater irrigation system. | 2012 | Environ. Sci. Technol. | pmid:22845779 |
Wu W et al. | Recent Insights into Antibiotic Resistance in Helicobacter pylori Eradication. | 2012 | Gastroenterol Res Pract | pmid:22829809 |
Shih HY et al. | Comparison between Single-Dose Esomeprazole- and Pantoprazole-Based Triple Therapy on the Effectiveness for Helicobacter pylori Eradication in Taiwanese Population. | 2012 | Gastroenterol Res Pract | pmid:22829808 |
Sanaei Dashti A et al. | Nasopharyngeal carrier rate of Streptococcus pneumoniae in children: serotype distribution and antimicrobial resistance. | 2012 | Arch Iran Med | pmid:22827788 |
Cao S et al. | Pharmacokinetic interactions between ilaprazole and clarithromycin following ilaprazole, clarithromycin and amoxicillin triple therapy. | 2012 | Acta Pharmacol. Sin. | pmid:22820908 |
Choi GE et al. | Macrolide treatment for Mycobacterium abscessus and Mycobacterium massiliense infection and inducible resistance. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:22878281 |
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Ratcliffe AT and Ismail KM | Intravenous macrolide use: a reminder of the dangers of rapid infusion rates. | 2012 | J Clin Anesth | pmid:23101782 |
Lambiase A et al. | In vitro resistance to macrolides and clindamycin by Group B Streptococcus isolated from pregnant and nonpregnant women. | 2012 | Infect Dis Obstet Gynecol | pmid:22675244 |
Dore MP et al. | Efficacy of a "Rescue" Ciprofloxacin-Based Regimen for Eradication of Helicobacter pylori Infection after Treatment Failures. | 2012 | Gastroenterol Res Pract | pmid:22666234 |
Lange JN et al. | Sensitivity of human strains of Oxalobacter formigenes to commonly prescribed antibiotics. | 2012 | Urology | pmid:22656407 |
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Rudramurthy M et al. | Nasal vestibulitis due to Nocardiopsis dassonvillei in a diabetic patient. | 2012 | J. Med. Microbiol. | pmid:22556323 |
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Ivetić TkalÄević V et al. | Topical azithromycin and clarithromycin inhibit acute and chronic skin inflammation in sensitized mice, with apparent selectivity for Th2-mediated processes in delayed-type hypersensitivity. | 2012 | Inflammation | pmid:21336676 |
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Yang YH et al. | Anti-Helicobacter pylori effects of IgY from egg york of immunized hens. | 2012 | Lab Anim Res | pmid:22474475 |
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Humphrey B et al. | Fitness of Escherichia coli strains carrying expressed and partially silent IncN and IncP1 plasmids. | 2012 | BMC Microbiol. | pmid:22475035 |
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Khan GA et al. | The development and application of a system for simultaneously determining anti-infectives and nasal decongestants using on-line solid-phase extraction and liquid chromatography-tandem mass spectrometry. | 2012 | J Pharm Biomed Anal | pmid:22459504 |
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Kobashi Y et al. | Pulmonary Mycobacterium kyorinense disease showed clinical improvement following combined therapy with clarithromycin and levofloxacin. | 2012 | Intern. Med. | pmid:22821114 |
Li Y et al. | A data-driven predictive approach for drug delivery using machine learning techniques. | 2012 | PLoS ONE | pmid:22384063 |
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Morisset J et al. | A case of difficult-to-treat eosinophilic asthma controlled with clarithromycin. | 2012 | Ann. Allergy Asthma Immunol. | pmid:22727169 |
Cavusoglu C et al. | Evaluation of antimicrobial susceptibilities of rapidly growing mycobacteria by Sensititre RAPMYCO panel. | 2012 | New Microbiol. | pmid:22378556 |
Calza P et al. | Identification of the unknown transformation products derived from clarithromycin and carbamazepine using liquid chromatography/high-resolution mass spectrometry. | 2012 | Rapid Commun. Mass Spectrom. | pmid:22730089 |
Sezikli M et al. | Efficacy of the Combination of Tetracycline, Amoxicillin, and Lansoprazole in the Eradication of Helicobacter pylori in Treatment-Naïve Patients and in Patients Who Are Not Responsive to Clarithromycin-Based Regimens: A Pilot Study. | 2012 | Gut Liver | pmid:22375169 |
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Gisbert JP et al. | Fourth-line rescue therapy with rifabutin in patients with three Helicobacter pylori eradication failures. | 2012 | Aliment. Pharmacol. Ther. | pmid:22372560 |
Maselli DJ et al. | Clinical evaluation of the role of ceftaroline in the management of community acquired bacterial pneumonia. | 2012 | Infect Drug Resist | pmid:22355258 |