clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Walkey AJ and Wiener RS | Macrolide antibiotics and survival in patients with acute lung injury. | 2012 | Chest | pmid:22116799 |
Raj JM and Raj SM | Concern about the efficacy of clarithromycin containing standard triple therapy in the eradication of Helicobacter pylori infection in Malaysia. | 2012 | Med. J. Malaysia | pmid:23770883 |
Choi HS et al. | Comparison of sequential and 7-, 10-, 14-d triple therapy for Helicobacter pylori infection. | 2012 | World J. Gastroenterol. | pmid:22654429 |
Majima Y et al. | Efficacy of combined treatment with S-carboxymethylcysteine (carbocisteine) and clarithromycin in chronic rhinosinusitis patients without nasal polyp or with small nasal polyp. | 2012 | Auris Nasus Larynx | pmid:21636230 |
Shakya N et al. | Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2'-'up' fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors. | 2012 | Bioorg. Med. Chem. | pmid:22664188 |
Milani M et al. | The status of antimicrobial resistance of Helicobacter pylori in Eastern Azerbaijan, Iran: comparative study according to demographics. | 2012 | J. Infect. Chemother. | pmid:22581031 |
Perić A et al. | Effect of long-term, low-dose clarithromycin on T helper 2 cytokines, eosinophilic cationic protein and the 'regulated on activation, normal T cell expressed and secreted' chemokine in the nasal secretions of patients with nasal polyposis. | 2012 | J Laryngol Otol | pmid:22559798 |
Yamazaki Y et al. | Antimicrobial and anti-inflammatory effects of clarithromycin on Mycobacterium avium complex replication in cultured human bronchial epithelial cells. | 2012 | J. Infect. Chemother. | pmid:22370922 |
Hiramatsu M et al. | Risk factors that affect the surgical outcome in the management of focal bronchiectasis in a developed country. | 2012 | Ann. Thorac. Surg. | pmid:22119119 |
Zarogoulidis P et al. | Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases. | 2012 | Eur. J. Clin. Pharmacol. | pmid:22105373 |
Bruin JP et al. | Wild-type MIC distribution and epidemiological cut-off values in clinical Legionella pneumophila serogroup 1 isolates. | 2012 | Diagn. Microbiol. Infect. Dis. | pmid:22100012 |
Koh WJ et al. | Therapeutic drug monitoring in the treatment of Mycobacterium avium complex lung disease. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:22878282 |
Maurer FP et al. | Acquisition of clarithromycin resistance mutations in the 23S rRNA gene of Mycobacterium abscessus in the presence of inducible erm(41). | 2012 | J. Antimicrob. Chemother. | pmid:22833642 |
Bondon-Guitton E et al. | Drug-induced gingival overgrowth: a study in the French Pharmacovigilance Database. | 2012 | J. Clin. Periodontol. | pmid:22519416 |
Bosnar M et al. | N'-substituted-2'-O,3'-N-carbonimidoyl bridged macrolides: novel anti-inflammatory macrolides without antimicrobial activity. | 2012 | J. Med. Chem. | pmid:22697905 |
Bai J et al. | Erythromycin enhances CD4+Foxp3+ regulatory T-cell responses in a rat model of smoke-induced lung inflammation. | 2012 | Mediators Inflamm. | pmid:22701274 |
Fujioka T et al. | A large-scale nationwide multicenter prospective observational study of triple therapy using rabeprazole, amoxicillin, and clarithromycin for Helicobacter pylori eradication in Japan. | 2012 | J. Gastroenterol. | pmid:22065160 |
Park HG et al. | Randomised clinical trial: a comparative study of 10-day sequential therapy with 7-day standard triple therapy for Helicobacter pylori infection in naïve patients. | 2012 | Aliment. Pharmacol. Ther. | pmid:22066530 |
Chung JW et al. | Resistance of Helicobacter pylori strains to antibiotics in Korea with a focus on fluoroquinolone resistance. | 2012 | J. Gastroenterol. Hepatol. | pmid:21793912 |
Deng ZH et al. | Influence of Helicobacter pylori infection on ghrelin levels in children. | 2012 | World J. Gastroenterol. | pmid:23049220 |
Malfertheiner P et al. | Helicobacter pylori: clinical management. | 2012 | Curr. Opin. Gastroenterol. | pmid:23010682 |
Tepes B et al. | Treatment of Helicobacter pylori infection 2012. | 2012 | Helicobacter | pmid:22958154 |
Al Aukidy M et al. | Monitoring release of pharmaceutical compounds: occurrence and environmental risk assessment of two WWTP effluents and their receiving bodies in the Po Valley, Italy. | 2012 | Sci. Total Environ. | pmid:22967493 |
Sarker SA et al. | Influence of Helicobacter pylori infection on gastric acid secretion in pre-school Bangladeshi children. | 2012 | Helicobacter | pmid:22967116 |
Nishizawa T et al. | Proton pump inhibitor-amoxicillin-clarithromycin versus proton pump inhibitor-amoxicillin-metronidazole as first-line Helicobacter pylori eradication therapy. | 2012 | J Clin Biochem Nutr | pmid:22962528 |
Amin M et al. | Green synthesis of silver nanoparticles through reduction with Solanum xanthocarpum L. berry extract: characterization, antimicrobial and urease inhibitory activities against Helicobacter pylori. | 2012 | Int J Mol Sci | pmid:22949839 |
Kwan BY and Rabheru K | Manic episode associated with clarithromycin in a patient with medically treated depression. | 2012 | Prim Care Companion CNS Disord | pmid:22943025 |
Spyridaki A et al. | Effect of clarithromycin in inflammatory markers of patients with ventilator-associated pneumonia and sepsis caused by Gram-negative bacteria: results from a randomized clinical study. | 2012 | Antimicrob. Agents Chemother. | pmid:22564837 |
Cajigas-Pezo D et al. | [Swelling of right knee in an immunologically compromised patient]. | 2012 | Enferm. Infecc. Microbiol. Clin. | pmid:22521279 |
McCallum GB et al. | Antibiotics for persistent cough or wheeze following acute bronchiolitis in children. | 2012 | Cochrane Database Syst Rev | pmid:23235681 |
Aguilar JA et al. | Decoupling two-dimensional NMR spectroscopy in both dimensions: pure shift NOESY and COSY. | 2012 | Angew. Chem. Int. Ed. Engl. | pmid:22588724 |
Yoon JH et al. | Trends in the eradication rates of Helicobacter pylori infection for eleven years. | 2012 | World J. Gastroenterol. | pmid:23236238 |
Al-Abri SS et al. | An audit of inpatient management of community-acquired pneumonia in Oman: a comparison with regional clinical guidelines. | 2012 | J Infect Public Health | pmid:22632599 |
Girgis DO et al. | Ocular infections caused by non-tuberculous mycobacteria: update on epidemiology and management. | 2012 | Clin. Experiment. Ophthalmol. | pmid:21902780 |
KurinÄiÄ M et al. | Epigallocatechin gallate as a modulator of Campylobacter resistance to macrolide antibiotics. | 2012 | Int. J. Antimicrob. Agents | pmid:22999765 |
Kudo T et al. | Comparison of lafutidine and rabeprazole in 7-day second-line amoxicillin- and metronidazole-containing triple therapy for Helicobacter pylori: a pilot study. | 2012 | Helicobacter | pmid:22759327 |
Roccarina D et al. | Different Antibiotic No Culture Eradicating (DANCE) strategy: an easy way to manage H. pylori eradication. | 2012 | Dig Liver Dis | pmid:22743557 |
Tursi A et al. | Efficacy and tolerability of a third-line, levofloxacin-based, 10-day sequential therapy in curing resistant Helicobacter pylori infection. | 2012 | J Gastrointestin Liver Dis | pmid:22720300 |
Giguère S et al. | In vitro synergy, pharmacodynamics, and postantibiotic effect of 11 antimicrobial agents against Rhodococcus equi. | 2012 | Vet. Microbiol. | pmid:22704561 |
Kumar KV et al. | Recurrent insulin injection abscesses: Atypical etiology. | 2012 | Indian J Endocrinol Metab | pmid:22701833 |
Kim BJ et al. | Discovery of a novel hsp65 genotype within Mycobacterium massiliense associated with the rough colony morphology. | 2012 | PLoS ONE | pmid:22693637 |
Karczewska E et al. | Variability in Prevalence of Helicobacter pylori Strains Resistant to Clarithromycin and Levofloxacin in Southern Poland. | 2012 | Gastroenterol Res Pract | pmid:22693490 |
Bermudez LE et al. | Identification of (+)-erythro-mefloquine as an active enantiomer with greater efficacy than mefloquine against Mycobacterium avium infection in mice. | 2012 | Antimicrob. Agents Chemother. | pmid:22615290 |
Khan A et al. | Antibiotic resistance and cagA gene correlation: a looming crisis of Helicobacter pylori. | 2012 | World J. Gastroenterol. | pmid:22611319 |
Brereton AS and El Teraifi H | Mycobacterium malmoense: dissemination causes a popliteal aneurysm in a 74-year-old man. | 2012 | BMJ Case Rep | pmid:22602841 |
Lawal TO et al. | Combination studies of Eucalyptus torelliana F. Muell. leaf extracts and clarithromycin on Helicobacter pylori. | 2012 | Phytother Res | pmid:22318891 |
Jigorel E and Houston JB | Utility of drug depletion-time profiles in isolated hepatocytes for accessing hepatic uptake clearance: identifying rate-limiting steps and role of passive processes. | 2012 | Drug Metab. Dispos. | pmid:22593038 |
Slater CM and Ford AC | Treatment of Helicobacter pylori in Latin America. | 2012 | Lancet | pmid:22305216 |
Timour Q et al. | Sudden death of cardiac origin and psychotropic drugs. | 2012 | Front Pharmacol | pmid:22590457 |
Gatta L et al. | Treatment of Helicobacter pylori in Latin America. | 2012 | Lancet | pmid:22305217 |
Dicicco M et al. | Efficacy of clarithromycin on biofilm formation of methicillin-resistant Staphylococcus pseudintermedius. | 2012 | BMC Vet. Res. | pmid:23171620 |
Graham DY and Trespalacios AA | Treatment of Helicobacter pylori in Latin America. | 2012 | Lancet | pmid:22305218 |
Noguchi S et al. | Clarithromycin form I determined by synchrotron X-ray powder diffraction. | 2012 | Acta Crystallogr C | pmid:22307251 |
Soares DN et al. | Cross-sectional microhardness of bovine enamel subjected to three paediatric liquid oral medicines: an in vitro study. | 2012 | Eur Arch Paediatr Dent | pmid:23043884 |
Loghmari H et al. | Clarithromycin versus metronidazole in first-line Helicobacter pylori eradication. Prospective randomized study of 85 Tunisian adults. | 2012 | Tunis Med | pmid:22311445 |
Shiota S et al. | Association of helicobacter pylori dupA with the failure of primary eradication. | 2012 | J. Clin. Gastroenterol. | pmid:22298090 |
Bayles T et al. | Clarithromycin for community-acquired pneumonia: beware drug interactions. | 2012 | Intern Med J | pmid:23046194 |
Liang JH et al. | Structure-activity relationships of novel alkylides: 3-O-arylalkyl clarithromycin derivatives with improved antibacterial activities. | 2012 | Eur J Med Chem | pmid:22301216 |
Ankomah P and Levin BR | Two-drug antimicrobial chemotherapy: a mathematical model and experiments with Mycobacterium marinum. | 2012 | PLoS Pathog. | pmid:22253599 |
Conde-Ãlvarez R et al. | The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition. | 2012 | PLoS Pathog. | pmid:22589715 |
Gisbert JP | Rescue Therapy for Helicobacter pylori Infection 2012. | 2012 | Gastroenterol Res Pract | pmid:22536225 |
Lee RP et al. | Mycobacterium chelonae infection after total knee arthroplasty: a case report. | 2012 | J Orthop Surg (Hong Kong) | pmid:22535831 |
Shaaban HS et al. | Mycobacterium chelonae infection of the parotid gland. | 2012 | J Glob Infect Dis | pmid:22529633 |
Farivar TN et al. | Assessment of helicobacter pylori prevalence by scorpion real-time PCR in chronic tonsillitis patients. | 2012 | J Glob Infect Dis | pmid:22529626 |
Zheng Q et al. | Occurrence and distribution of antibiotics in the Beibu Gulf, China: impacts of river discharge and aquaculture activities. | 2012 | Mar. Environ. Res. | pmid:22525825 |
Misiewicz JJ | Management of Helicobacter pylori-related disorders. | 2012 | Eur J Gastroenterol Hepatol | pmid:22498902 |
Senhorinho GN et al. | Occurrence and antimicrobial susceptibility of Porphyromonas spp. and Fusobacterium spp. in dogs with and without periodontitis. | 2012 | Anaerobe | pmid:22609780 |
Lee HY et al. | Survey of methadone-drug interactions among patients of methadone maintenance treatment program in Taiwan. | 2012 | Subst Abuse Treat Prev Policy | pmid:22429858 |
Kobashi Y et al. | Relationship between clinical efficacy for pulmonary MAC and drug-sensitivity test for isolated MAC in a recent 6-year period. | 2012 | J. Infect. Chemother. | pmid:22205543 |
Lin Z and Will Y | Evaluation of drugs with specific organ toxicities in organ-specific cell lines. | 2012 | Toxicol. Sci. | pmid:22166485 |
Onoe H et al. | Buruli ulcer accompanied by pain in a Japanese patient. | 2012 | J. Dermatol. | pmid:22168180 |
Peters J et al. | Clarithromycin is absorbed by an intestinal uptake mechanism that is sensitive to major inhibition by rifampicin: results of a short-term drug interaction study in foals. | 2012 | Drug Metab. Dispos. | pmid:22170330 |
Liang Y et al. | Epidemiological and molecular characteristics of clinical isolates of Streptococcus pyogenes collected between 2005 and 2008 from Chinese children. | 2012 | J. Med. Microbiol. | pmid:22442290 |
Li Y et al. | Detection of clarithromycin resistance in Helicobacter pylori following noncryogenic storage of rapid urease tests for 30 days. | 2012 | J Dig Dis | pmid:22188917 |
Gomez-Abreo D et al. | [Chronic necrotizing pulmonary aspergillosis following an infection by Mycobacterium malmoense]. | 2012 | Rev Mal Respir | pmid:22440310 |
Mochizuki Y et al. | Chronic mandibular osteomyelitis with suspected underlying synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome: a case report. | 2012 | J Inflamm Res | pmid:22427727 |
Chang CS et al. | Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells. | 2012 | Eur J Med Chem | pmid:22217866 |
Farfan-Portet MI et al. | Patient socioeconomic determinants of the choice of generic versus brand name drugs in the context of a reference price system: evidence from Belgian prescription data. | 2012 | Eur J Health Econ | pmid:22427042 |
Kargar M et al. | Real-time PCR for Helicobacter pylori quantification and detection of clarithromycin resistance in gastric tissue from patients with gastrointestinal disorders. | 2012 | Res. Microbiol. | pmid:22177975 |
Mégraud F | The challenge of Helicobacter pylori resistance to antibiotics: the comeback of bismuth-based quadruple therapy. | 2012 | Therap Adv Gastroenterol | pmid:22423259 |
Srivastav NC et al. | Antimycobacterial activities of 5-alkyl (or halo)-3'-substituted pyrimidine nucleoside analogs. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22178557 |
Scheel AH et al. | Talcum induced pneumoconiosis following inhalation of adulterated marijuana, a case report. | 2012 | Diagn Pathol | pmid:22420484 |
Guillot S et al. | Macrolide-resistant Bordetella pertussis infection in newborn girl, France. | 2012 | Emerging Infect. Dis. | pmid:22608348 |
NiziÄ T et al. | Solitary erythema migrans in children: comparison of treatment with clarithromycin and amoxicillin. | 2012 | Wien. Klin. Wochenschr. | pmid:22760494 |
Yokota S et al. | Clarithromycin suppresses human respiratory syncytial virus infection-induced Streptococcus pneumoniae adhesion and cytokine production in a pulmonary epithelial cell line. | 2012 | Mediators Inflamm. | pmid:22761540 |
Brown-Elliott BA et al. | Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria. | 2012 | Clin. Microbiol. Rev. | pmid:22763637 |
Pereyre S et al. | Clonal spread of Mycoplasma pneumoniae in primary school, Bordeaux, France. | 2012 | Emerging Infect. Dis. | pmid:22305177 |
Butler CC et al. | Effectiveness of multifaceted educational programme to reduce antibiotic dispensing in primary care: practice based randomised controlled trial. | 2012 | BMJ | pmid:22302780 |
Carlos CA et al. | Mycobacterial infection identified with broad-range PCR amplification and suspension array identification. | 2012 | J. Cutan. Pathol. | pmid:22764735 |
Anand TD et al. | Superantigen profiles of emm and emm-like typeable and nontypeable pharyngeal streptococcal isolates of South India. | 2012 | Ann. Clin. Microbiol. Antimicrob. | pmid:22296671 |
Tonkic A et al. | Time trends of primary antibiotic resistance of Helicobacter pylori isolates in Southern Croatia. | 2012 | J Chemother | pmid:22759765 |
Wang YJ et al. | Rapid quantitative analysis of clarithromycin in rat plasma by UPLC-MS/MS after intravenous injection of the clarithromycin-loaded ultrafine PLGA nanoparticles. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22483396 |
Trigo P and Fischer GW | Managing atrial fibrillation in the elderly: critical appraisal of dronedarone. | 2012 | Clin Interv Aging | pmid:22291468 |
Erdur B et al. | Comparison of sequential and standard therapy for Helicobacter pylori eradication in children and investigation of clarithromycin resistance. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22465935 |
Correia M et al. | Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization. | 2012 | PLoS ONE | pmid:22529974 |
Altman JK and Platanias LC | A new purpose for an old drug: inhibiting autophagy with clarithromycin. | 2012 | Leuk. Lymphoma | pmid:22288786 |
McNulty CA et al. | Is Helicobacter pylori antibiotic resistance surveillance needed and how can it be delivered? | 2012 | Aliment. Pharmacol. Ther. | pmid:22469191 |
Polat Z et al. | Comparison of levofloxacin-containing sequential and standard triple therapies for the eradication of Helicobacter pylori. | 2012 | Eur. J. Intern. Med. | pmid:22284248 |
Jakopović IP et al. | Novel desosamine-modified 14- and 15-membered macrolides without antibacterial activity. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22503348 |
Siqueira JF et al. | Pyrosequencing as a tool for better understanding of human microbiomes. | 2012 | J Oral Microbiol | pmid:22279602 |