clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Choi SJ et al. | The prevalence of vaginal microorganisms in pregnant women with preterm labor and preterm birth. | 2012 | Ann Lab Med | pmid:22563554 |
Bowers JR et al. | Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona. | 2012 | BMC Microbiol. | pmid:22251616 |
Sharma H et al. | Fortuitous vasculitis. | 2012 | Ren Fail | pmid:22250755 |
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Barberán J et al. | Update on the clinical utility and optimal use of cefditoren. | 2012 | Int J Gen Med | pmid:22675264 |
Cuadrado-LavÃn A et al. | Levofloxacin versus clarithromycin in a 10 day triple therapy regimen for first-line Helicobacter pylori eradication: a single-blind randomized clinical trial. | 2012 | J. Antimicrob. Chemother. | pmid:22687889 |
Nseir W et al. | Randomised clinical trial: simvastatin as adjuvant therapy improves significantly the Helicobacter pylori eradication rate--a placebo-controlled study. | 2012 | Aliment. Pharmacol. Ther. | pmid:22646167 |
Zaater MF et al. | Determination and stability assessment of clarithromycin in human plasma using RP-LC with electrochemical detection. | 2012 | J Chromatogr Sci | pmid:22647394 |
Matsueda K et al. | A placebo-controlled trial of acotiamide for meal-related symptoms of functional dyspepsia. | 2012 | Gut | pmid:22157329 |
Chan A et al. | A case of wrist tenosynovitis caused by Mycobacterium kansasii in a renal transplant recipient. | 2012 | Transpl Infect Dis | pmid:22822725 |
Koh WJ et al. | Therapeutic drug monitoring in the treatment of Mycobacterium avium complex lung disease. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:22878282 |
Maurer FP et al. | Acquisition of clarithromycin resistance mutations in the 23S rRNA gene of Mycobacterium abscessus in the presence of inducible erm(41). | 2012 | J. Antimicrob. Chemother. | pmid:22833642 |
Patel N and Miller CD | New option for management of HIV-1 infection in treatment-naive patients: once-daily, fixed-dose combination of rilpivirine-emtricitabine-tenofovir. | 2012 | HIV AIDS (Auckl) | pmid:22570576 |
Alzolibani AA and Zedan K | Macrolides in chronic inflammatory skin disorders. | 2012 | Mediators Inflamm. | pmid:22685371 |
Masekela R and Green RJ | The role of macrolides in childhood non-cystic fibrosis-related bronchiectasis. | 2012 | Mediators Inflamm. | pmid:22570510 |
Lee MR et al. | CNS infections caused by Mycobacterium abscessus complex: clinical features and antimicrobial susceptibilities of isolates. | 2012 | J. Antimicrob. Chemother. | pmid:21980068 |
Cuadrado-LavÃn A et al. | Antimicrobial susceptibility of Helicobacter pylori to six antibiotics currently used in Spain. | 2012 | J. Antimicrob. Chemother. | pmid:21965436 |
Zullo A et al. | Role of gastritis pattern on Helicobacter pylori eradication. | 2012 | Intern Emerg Med | pmid:22105372 |
Ivetic Tkalcevic V et al. | Cantharidin-induced inflammation in mouse ear model for translational research of novel anti-inflammatories. | 2012 | Transl Res | pmid:22677362 |
Fujioka T et al. | A large-scale nationwide multicenter prospective observational study of triple therapy using rabeprazole, amoxicillin, and clarithromycin for Helicobacter pylori eradication in Japan. | 2012 | J. Gastroenterol. | pmid:22065160 |
Park HG et al. | Randomised clinical trial: a comparative study of 10-day sequential therapy with 7-day standard triple therapy for Helicobacter pylori infection in naïve patients. | 2012 | Aliment. Pharmacol. Ther. | pmid:22066530 |
Cetin M et al. | Clarithromycin-Induced Long QT Syndrome: A Case Report. | 2012 | Case Rep Med | pmid:22489247 |
Saracino IM et al. | High prevalence of primary antibiotic resistance in Helicobacter pylori isolates in Italy. | 2012 | J Gastrointestin Liver Dis | pmid:23256118 |
Ikegame S et al. | Congenital cystic adenomatoid malformation in adulthood complicated by Mycobacterium celatum infection. | 2012 | Intern. Med. | pmid:22892504 |
Tsay FW et al. | Sequential therapy achieves a higher eradication rate than standard triple therapy in Taiwan. | 2012 | J. Gastroenterol. Hepatol. | pmid:21871025 |
Spyridaki A et al. | Effect of clarithromycin in inflammatory markers of patients with ventilator-associated pneumonia and sepsis caused by Gram-negative bacteria: results from a randomized clinical study. | 2012 | Antimicrob. Agents Chemother. | pmid:22564837 |
Ngan LT et al. | Growth-inhibiting, bactericidal, and urease inhibitory effects of Paeonia lactiflora root constituents and related compounds on antibiotic-susceptible and -resistant strains of Helicobacter pylori. | 2012 | J. Agric. Food Chem. | pmid:22891951 |
McCallum GB et al. | Antibiotics for persistent cough or wheeze following acute bronchiolitis in children. | 2012 | Cochrane Database Syst Rev | pmid:23235681 |
Kao SS et al. | 7-Day Nonbismuth-Containing Concomitant Therapy Achieves a High Eradication Rate for Helicobacter pylori in Taiwan. | 2012 | Gastroenterol Res Pract | pmid:22888337 |
Boyanova L et al. | Numerous risk factors for Helicobacter pylori antibiotic resistance revealed by extended anamnesis: a Bulgarian study. | 2012 | J. Med. Microbiol. | pmid:21873378 |
Shah M et al. | Transient Psychotic Episode Induced by Helicobacter pylori Triple Therapy Treatment. | 2012 | Case Rep Gastroenterol | pmid:22855656 |
Heeb F et al. | Organic micropollutants in rivers downstream of the megacity Beijing: sources and mass fluxes in a large-scale wastewater irrigation system. | 2012 | Environ. Sci. Technol. | pmid:22845779 |
Wu W et al. | Recent Insights into Antibiotic Resistance in Helicobacter pylori Eradication. | 2012 | Gastroenterol Res Pract | pmid:22829809 |
Choi GE et al. | Macrolide treatment for Mycobacterium abscessus and Mycobacterium massiliense infection and inducible resistance. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:22878281 |
Uno K et al. | Rupture of renal mycotic aneurysm that developed during the treatment of streptococcal infective endocarditis and vertebral osteomyelitis. | 2012 | Intern. Med. | pmid:22687800 |
Sano N et al. | Comprehensive Analysis of Bacterial Flora in Postoperative Maxillary Cyst Fluid by 16S rRNA Gene and Culture Methods. | 2012 | ISRN Dent | pmid:22685668 |
Lambiase A et al. | In vitro resistance to macrolides and clindamycin by Group B Streptococcus isolated from pregnant and nonpregnant women. | 2012 | Infect Dis Obstet Gynecol | pmid:22675244 |
Tatar EÇ et al. | Prevalence of biofilms and their response to medical treatment in chronic rhinosinusitis without polyps. | 2012 | Otolaryngol Head Neck Surg | pmid:22241786 |
Chang WJ et al. | Successful salvage treatment of steroid-refractory bronchiolar COP with low-dose macrolides. | 2012 | Pathol. Int. | pmid:22243785 |
Lismond A et al. | Antimicrobial susceptibility of Streptococcus pneumoniae isolates from vaccinated and non-vaccinated patients with a clinically confirmed diagnosis of community-acquired pneumonia in Belgium. | 2012 | Int. J. Antimicrob. Agents | pmid:22245497 |
Agarwal E et al. | Efficacy of local drug delivery of 0.5% clarithromycin gel as an adjunct to non-surgical periodontal therapy in the treatment of current smokers with chronic periodontitis: a randomized controlled clinical trial. | 2012 | J. Periodontol. | pmid:22248223 |
Szałek E et al. | Sunitinib in combination with clarithromycin or azithromycin - is there a risk of interaction or not? | 2012 | Pharmacol Rep | pmid:23406766 |
Takeshima F et al. | Successful management of cap polyposis with eradication of Helicobacter pylori relapsing 15 years after remission on steroid therapy. | 2012 | Intern. Med. | pmid:22333383 |
Lawal TO et al. | Combination studies of Eucalyptus torelliana F. Muell. leaf extracts and clarithromycin on Helicobacter pylori. | 2012 | Phytother Res | pmid:22318891 |
Slater CM and Ford AC | Treatment of Helicobacter pylori in Latin America. | 2012 | Lancet | pmid:22305216 |
Choi GE et al. | Activities of moxifloxacin in combination with macrolides against clinical isolates of Mycobacterium abscessus and Mycobacterium massiliense. | 2012 | Antimicrob. Agents Chemother. | pmid:22564831 |
Lu ZM et al. | Nucleosomes correlate with in vivo progression pattern of de novo methylation of p16 CpG islands in human gastric carcinogenesis. | 2012 | PLoS ONE | pmid:22558275 |
Raithatha AH and Bryden DC | Use of intravenous immunoglobulin therapy in the treatment of septic shock, in particular severe invasive group A streptococcal disease. | 2012 | Indian J Crit Care Med | pmid:22557832 |
Ivetić TkalÄević V et al. | Topical azithromycin and clarithromycin inhibit acute and chronic skin inflammation in sensitized mice, with apparent selectivity for Th2-mediated processes in delayed-type hypersensitivity. | 2012 | Inflammation | pmid:21336676 |
Yang YH et al. | Anti-Helicobacter pylori effects of IgY from egg york of immunized hens. | 2012 | Lab Anim Res | pmid:22474475 |
Grosso F et al. | A comprehensive safety analysis confirms rhabdomyolysis as an uncommon adverse reaction in patients treated with trabectedin. | 2012 | Cancer Chemother. Pharmacol. | pmid:22484722 |
Federico A et al. | Efficacy of 5-day levofloxacin-containing concomitant therapy in eradication of Helicobacter pylori infection. | 2012 | Gastroenterology | pmid:22484118 |
Monno R et al. | Helicobacter pylori clarithromycin resistance detected by Etest and TaqMan real-time polymerase chain reaction: a comparative study. | 2012 | APMIS | pmid:22882260 |
Pandya GJ et al. | Unilateral lobar pulmonary edema. | 2012 | J Assoc Physicians India | pmid:23547417 |
Ablanedo-Terrazas Y et al. | Palatal Actinomycosis and Kaposi Sarcoma in an HIV-Infected Subject with Disseminated Mycobacterium avium-intracellulare Infection. | 2012 | Case Rep Med | pmid:22481952 |
Fakheri H et al. | A comparison between sequential therapy and a modified bismuth-based quadruple therapy for Helicobacter pylori eradication in Iran: a randomized clinical trial. | 2012 | Helicobacter | pmid:22221615 |
Georgopoulos S et al. | Evaluation of a four-drug, three-antibiotic, nonbismuth-containing "concomitant" therapy as first-line Helicobacter pylori eradication regimen in Greece. | 2012 | Helicobacter | pmid:22221616 |
Humphrey B et al. | Fitness of Escherichia coli strains carrying expressed and partially silent IncN and IncP1 plasmids. | 2012 | BMC Microbiol. | pmid:22475035 |
Komatsu S et al. | Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells. | 2012 | Int. J. Oncol. | pmid:22200786 |
Matsuzaki J et al. | Efficacy of sitafloxacin-based rescue therapy for Helicobacter pylori after failures of first- and second-line therapies. | 2012 | Antimicrob. Agents Chemother. | pmid:22203601 |
Kobashi Y et al. | Relationship between clinical efficacy for pulmonary MAC and drug-sensitivity test for isolated MAC in a recent 6-year period. | 2012 | J. Infect. Chemother. | pmid:22205543 |
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Yeboah J and Sharma OP | Co-existence of Crohn's disease, sarcoidosis and malignant lymphomas. | 2012 | JRSM Short Rep | pmid:22393471 |
Martins TG et al. | Local and regional re-establishment of cellular immunity during curative antibiotherapy of murine Mycobacterium ulcerans infection. | 2012 | PLoS ONE | pmid:22393444 |
Legendre DP et al. | Hansen's disease (Leprosy): current and future pharmacotherapy and treatment of disease-related immunologic reactions. | 2012 | Pharmacotherapy | pmid:22392826 |
Li Y et al. | A data-driven predictive approach for drug delivery using machine learning techniques. | 2012 | PLoS ONE | pmid:22384063 |
Hong SJ | The Role of Mycoplasma pneumoniae Infection in Asthma. | 2012 | Allergy Asthma Immunol Res | pmid:22379599 |
Cavusoglu C et al. | Evaluation of antimicrobial susceptibilities of rapidly growing mycobacteria by Sensititre RAPMYCO panel. | 2012 | New Microbiol. | pmid:22378556 |
Sezikli M et al. | Efficacy of the Combination of Tetracycline, Amoxicillin, and Lansoprazole in the Eradication of Helicobacter pylori in Treatment-Naïve Patients and in Patients Who Are Not Responsive to Clarithromycin-Based Regimens: A Pilot Study. | 2012 | Gut Liver | pmid:22375169 |
Molina-Infante J et al. | Nonbismuth quadruple (concomitant) therapy: empirical and tailored efficacy versus standard triple therapy for clarithromycin-susceptible Helicobacter pylori and versus sequential therapy for clarithromycin-resistant strains. | 2012 | Helicobacter | pmid:22759326 |
Kongchayanun C et al. | Pilot studies to identify the optimum duration of concomitant Helicobacter pylori eradication therapy in Thailand. | 2012 | Helicobacter | pmid:22759328 |
Nguyen TV et al. | Eradication of Helicobacter pylori in children in Vietnam in relation to antibiotic resistance. | 2012 | Helicobacter | pmid:22759333 |
NiziÄ T et al. | Solitary erythema migrans in children: comparison of treatment with clarithromycin and amoxicillin. | 2012 | Wien. Klin. Wochenschr. | pmid:22760494 |
Yokota S et al. | Clarithromycin suppresses human respiratory syncytial virus infection-induced Streptococcus pneumoniae adhesion and cytokine production in a pulmonary epithelial cell line. | 2012 | Mediators Inflamm. | pmid:22761540 |
Brown-Elliott BA et al. | Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria. | 2012 | Clin. Microbiol. Rev. | pmid:22763637 |
Lopes R et al. | [Antibiomania: a case of a manic episode induced by clarithromycin]. | 2011 Sep-Oct | Acta Med Port | pmid:22525636 |
Yasar KK et al. | Successfully treated Mycobacterium abscessus mastitis: a rare cause of breast masses. | 2011 Oct-Dec | Indian J Med Microbiol | pmid:22120809 |
Eisig JN et al. | Helicobacter pylori antibiotic resistance in Brazil: clarithromycin is still a good option. | 2011 Oct-Dec | Arq Gastroenterol | pmid:22147131 |
Abadi AT et al. | High frequency of A2143G mutation in clarithromycin-resistant Helicobacter pylori isolates recovered from dyspeptic patients in Iran. | 2011 Nov-Dec | Saudi J Gastroenterol | pmid:22064338 |
Bilgili SG et al. | Phototoxic dermatitis due to Chenopodium album in a child. | 2011 Nov-Dec | Pediatr Dermatol | pmid:21854411 |
Lee CY et al. | Digoxin toxicity precipitated by clarithromycin use: case presentation and concise review of the literature. | 2011 Nov-Dec | Can J Cardiol | pmid:21907534 |
Zeng M et al. | Comparison of efficacy of mometasone furoate versus clarithromycin in the treatment of chronic rhinosinusitis without nasal polyps in Chinese adults. | 2011 Nov-Dec | Am J Rhinol Allergy | pmid:22185725 |
Mello CF and Negra MD | Impact of macrolide therapy on mortality of HIV-infected patients with community-acquired pneumonia in a tertiary teaching hospital. | 2011 May-Jun | Braz J Infect Dis | pmid:21670928 |
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Steyaert S et al. | Soft tissue infections with atypical mycobacteria in two patients with inflammatory rheumatic diseases using TNF-inhibitors and/or leflunomide. | 2011 Mar-Apr | Acta Clin Belg | pmid:21630616 |
Söderberg KC and Böttiger Y | [Difficult choice between clarithromycin and metronidazole in polyneuropathy]. | 2011 Mar 9-15 | Lakartidningen | pmid:21744557 |
Chung JW et al. | The trends of one-week first-line and second-line eradication therapy for Helicobacter pylori infection in Korea. | 2011 Jan-Feb | Hepatogastroenterology | pmid:21510323 |
Galmés-Truyols A et al. | An outbreak of cutaneous infection due to Mycobacterium abscessus associated to mesotherapy. | 2011 Aug-Sep | Enferm. Infecc. Microbiol. Clin. | pmid:21684045 |
Chen XZ et al. | Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. | 2011 | Eur J Med Chem | pmid:21130543 |
Ohe M and Hashino S | A case of follicular B-cell lymphoma treated using clarithromycin. | 2011 | Korean J Hematol | pmid:22065978 |
Mitchell CB et al. | Infection with Mycobacterium immunogenum following a tattoo. | 2011 | J. Am. Acad. Dermatol. | pmid:21496684 |
Gitti Z et al. | Clinical significance and antibiotic susceptibilities of nontuberculous mycobacteria from patients in Crete, Greece. | 2011 | Future Microbiol | pmid:21958147 |
Mencacci A et al. | Legionella pneumophila serogroup 3 pneumonia in a patient with low-grade 4 non-Hodgkin lymphoma: a case report. | 2011 | J Med Case Rep | pmid:21849075 |
Bohnert JA et al. | Efflux inhibition by selective serotonin reuptake inhibitors in Escherichia coli. | 2011 | J. Antimicrob. Chemother. | pmid:21700628 |
Hajiioannou JK et al. | Clarithromycin induced reversible sensorineural hearing loss. | 2011 | B-ENT | pmid:21838098 |
Rathi SK | Acne vulgaris treatment : the current scenario. | 2011 | Indian J Dermatol | pmid:21572783 |
Chin BS et al. | The characteristics of metallo-β-lactamase-producing gram-negative bacilli isolated from sputum and urine: a single center experience in Korea. | 2011 | Yonsei Med. J. | pmid:21319358 |