clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Highleyman L | FDA issues Hismanal warning. Food and Drug Administration. | 1998 | BETA | pmid:11365263 |
Bartnof HS | OIs and cancers. | 1999 | BETA | pmid:11367262 |
Lüth S et al. | 4-day triple therapy with rabeprazole, amoxicillin and clarithromycin in the eradication of Helicobacter pylori in patients with peptic ulcer disease--A pilot study. | 2001 | Z Gastroenterol | pmid:11367976 |
Jover-DÃaz F et al. | Q fever during pregnancy: an emerging cause of prematurity and abortion. | 2001 | Infect Dis Obstet Gynecol | pmid:11368259 |
Sontag SJ et al. | Reduced symptoms and need for antisecretory therapy in veterans 3 years after Helicobacter pylori eradication with ranitidine bismuth citrate/amoxicillin/clarithromycin. | 2001 | Am. J. Gastroenterol. | pmid:11374672 |
Fischer H et al. | Effect of Helicobacter pylori eradication on cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) expression during gastric adaptation to aspirin (ASA) in humans. | 2001 | Microsc. Res. Tech. | pmid:11376494 |
Della Libera E et al. | Eradication of Helicobacter pylori infection in patients with duodenal ulcer and non-ulcer dyspepsia and analysis of one-year reinfection rates. | 2001 | Braz. J. Med. Biol. Res. | pmid:11378663 |
Silva FM et al. | Factors affecting Helicobacter pylori eradication using a seven-day triple therapy with a proton pump inhibitor, tinidazole and clarithromycin, in Brazilian patients with peptic ulcer. | 2001 Jan-Feb | Rev Hosp Clin Fac Med Sao Paulo | pmid:11378678 |
Wong BC et al. | Three-day lansoprazole quadruple therapy for Helicobacter pylori-positive duodenal ulcers: a randomized controlled study. | 2001 | Aliment. Pharmacol. Ther. | pmid:11380322 |
Meier R et al. | Fish oil (Eicosapen) is less effective than metronidazole, in combination with pantoprazole and clarithromycin, for Helicobacter pylori eradication. | 2001 | Aliment. Pharmacol. Ther. | pmid:11380323 |
Kurdowska A et al. | The effect of azithromycin and clarithromycin on ex vivo interleukin-8 (IL-8) release from whole blood and IL-8 production by human alveolar macrophages. | 2001 | J. Antimicrob. Chemother. | pmid:11389120 |
Britschgi M et al. | T-cell involvement in drug-induced acute generalized exanthematous pustulosis. | 2001 | J. Clin. Invest. | pmid:11390425 |
Maggi Solcà N et al. | Population genetics of Helicobacter pylori in the southern part of Switzerland analysed by sequencing of four housekeeping genes (atpD, glnA, scoB and recA), and by vacA, cagA, iceA and IS605 genotyping. | 2001 | Microbiology (Reading, Engl.) | pmid:11390701 |
Namiot Z et al. | [The effect of cigarette smoking and alcohol consumption on efficacy of Helicobacter pylori eradication]. | 2000 | Pol. Arch. Med. Wewn. | pmid:11392163 |
Lorenz J et al. | Treatment outcomes in acute exacerbations of chronic bronchitis: comparison of macrolides and moxifloxacin from the patient perspective. | 2001 Mar-Apr | J. Int. Med. Res. | pmid:11393351 |
Araujo MV et al. | Determination of minocycline in human plasma by high-performance liquid chromatography coupled to tandem mass spectrometry: application to bioequivalence study. | 2001 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:11393692 |
Pappa-Louisi A et al. | Study on the electrochemical detection of the macrolide antibiotics clarithromycin and roxithromycin in reversed-phase high-performance liquid chromatography. | 2001 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:11393733 |
Luzza F et al. | Lansoprazole-based triple therapy versus ranitidine bismuth citrate-based dual therapy in the eradication of Helicobacter pylori in patients with duodenal ulcer: a multicenter, randomized, double-dummy study. | 2001 | Clin Ther | pmid:11394734 |
Marchi S et al. | Ranitidine bismuth citrate-based triple therapy for seven days, with or without further anti-secretory therapy, is highly effective in patients with duodenal ulcer and Helicobacter pylori infection. | 2001 | Eur J Gastroenterol Hepatol | pmid:11396535 |
Dan M et al. | Crossover assessment of serum bactericidal activity of grepafloxacin, ofloxacin and clarithromycin against respiratory pathogens after oral administration to healthy volunteers. | 2001 | Int. J. Antimicrob. Agents | pmid:11397620 |
Balfour JA and Figgitt DP | Telithromycin. | 2001 | Drugs | pmid:11398913 |
Ling TK et al. | In vitro activity and post-antibiotic effect of quinupristin/dalfopristin (Synercid). | Chemotherapy | pmid:11399860 | |
Nguyen HN | [Eradication therapy of Helicobacter pylori in antibiotic resistance]. | 2001 | Dtsch. Med. Wochenschr. | pmid:11402917 |
Schwizer W et al. | Helicobacter pylori and symptomatic relapse of gastro-oesophageal reflux disease: a randomised controlled trial. | 2001 | Lancet | pmid:11403809 |
Kalach N et al. | Clarithromycin resistance and eradication of Helicobacter pylori in children. | 2001 | Antimicrob. Agents Chemother. | pmid:11408237 |
Nilius AM et al. | Comparative in vitro activity of ABT-773, a novel antibacterial ketolide. | 2001 | Antimicrob. Agents Chemother. | pmid:11408246 |
Bruce MA et al. | In vivo effect of clarithromycin on multiple cytochrome P450s. | 2001 | Drug Metab. Dispos. | pmid:11408369 |
Tsurita M et al. | Early augmentation of interleukin (IL)-12 level in the airway of mice administered orally with clarithromycin or intranasally with IL-12 results in alleviation of influenza infection. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11408563 |
Nakamura H et al. | Effect of levofloxacin on theophylline clearance during theophylline and clarithromycin combination therapy. | 2001 | Ann Pharmacother | pmid:11408986 |
Yuen KY et al. | Effects of clarithromycin on oral mucositis in bone marrow transplant recipients. | 2001 | Haematologica | pmid:11410428 |
Ordoñez CL et al. | Effect of clarithromycin on airway obstruction and inflammatory markers in induced sputum in cystic fibrosis: a pilot study. | 2001 | Pediatr. Pulmonol. | pmid:11416873 |
You JH et al. | Economic analysis of four triple regimens for the treatment of Helicobacter pylori-related peptic ulcer disease in in-patient and out-patient settings in Hong Kong. | 2001 | Aliment. Pharmacol. Ther. | pmid:11421876 |
Perri F et al. | Ranitidine bismuth citrate-based triple therapies after failure of the standard 'Maastricht triple therapy': a promising alternative to the quadruple therapy? | 2001 | Aliment. Pharmacol. Ther. | pmid:11421877 |
Perri F et al. | Predictors of failure of Helicobacter pylori eradication with the standard 'Maastricht triple therapy'. | 2001 | Aliment. Pharmacol. Ther. | pmid:11421878 |
Pilotto A et al. | Cure of Helicobacter pylori infection in elderly patients: comparison of low versus high doses of clarithromycin in combination with amoxicillin and pantoprazole. | 2001 | Aliment. Pharmacol. Ther. | pmid:11421879 |
Tepes B et al. | Is a one-week course of triple anti-Helicobacter pylori therapy sufficient to control active duodenal ulcer? | 2001 | Aliment. Pharmacol. Ther. | pmid:11421880 |
Calvet X et al. | What is the optimal length of proton pump inhibitor-based triple therapies for H. pylori? A cost-effectiveness analysis. | 2001 | Aliment. Pharmacol. Ther. | pmid:11421884 |
Patel GK and Anstey AV | Rifampicin-induced lupus erythematosus. | 2001 | Clin. Exp. Dermatol. | pmid:11422169 |
Gonçalves AS and Appelberg R | Effects of recombinant granulocyte-colony stimulating factor administration during Mycobacterium avium infection in mice. | 2001 | Clin. Exp. Immunol. | pmid:11422200 |
Yakoob J et al. | Polycolonization of Helicobacter pylori among Chinese subjects. | 2001 | Clin. Microbiol. Infect. | pmid:11422240 |
Hopkins RJ | In search of the Holy Grail of Heliocobacter pylori remedies. | 2001 | Helicobacter | pmid:11422461 |
Ohara T et al. | Inhibitory action of a novel proton pump inhibitor, rabeprazole, and its thioether derivative against the growth and motility of clarithromycin-resistant Helicobacter pylori. | 2001 | Helicobacter | pmid:11422467 |
Gisbert JP et al. | High efficacy of ranitidine bismuth citrate, amoxicillin, clarithromycin and metronidazole twice daily for only five days in Helicobacter pylori Eradication. | 2001 | Helicobacter | pmid:11422472 |
Moayyedi P and Murphy B | Helicobacter pylori: a clinical update. | 2001 | Symp Ser Soc Appl Microbiol | pmid:11422568 |
Kusters JG and Kuipers EJ | Antibiotic resistance of Helicobacter pylori. | 2001 | Symp Ser Soc Appl Microbiol | pmid:11422569 |
Nagahara A et al. | Strategy for retreatment of therapeutic failure of eradication of Helicobacter pylori infection. | 2001 | J. Gastroenterol. Hepatol. | pmid:11422612 |
Hatters DM et al. | Sedimentation analysis of novel DNA structures formed by homo-oligonucleotides. | 2001 | Biophys. J. | pmid:11423421 |
Bateson MC | Quadruple therapy for symptomatic spontaneous duodenal ulcer disease. | 2001 | Postgrad Med J | pmid:11423595 |
Ogura K et al. | Clarithromycin-based triple therapy for non-resistant Helicobacter pylori infection. How long should it be given? | 2001 | Scand. J. Gastroenterol. | pmid:11424316 |
van der Ende A et al. | Clarithromycin-susceptible and -resistant Helicobacter pylori isolates with identical randomly amplified polymorphic DNA-PCR genotypes cultured from single gastric biopsy specimens prior to antibiotic therapy. | 2001 | J. Clin. Microbiol. | pmid:11427586 |
Toyoda H et al. | Regression of primary lymphoma of the ampulla of Vater after eradication of Helicobacter pylori. | 2001 | Gastrointest. Endosc. | pmid:11427853 |
Chiba N et al. | Ranitidine bismuth citrate. | 2001 | Can. J. Gastroenterol. | pmid:11429668 |
Wang YL et al. | Noninvasive stool antigen assay can effectively screen Helicobacter pylori Infection and assess success of eradication therapy in hemodialysis patients. | 2001 | Am. J. Kidney Dis. | pmid:11431188 |
Chan KL et al. | A prospective study of a one-week nonbismuth quadruple therapy for childhood Helicobacter pylori infection. | 2001 | J. Pediatr. Surg. | pmid:11431766 |
Harsch IA et al. | Pseudomembranous colitis after eradication of Helicobacter pylori infection with a triple therapy. | 2001 Jul-Aug | Med. Sci. Monit. | pmid:11433206 |
Iino Y et al. | [Changes in bacterial flora of nasopharynx in children treated with long-term administration of macrolides]. | 2001 | Jpn J Antibiot | pmid:11436829 |
Matsuda H et al. | [Roxithromycin therapy of patients with mycobacterium avium complex lung infection]. | 2001 | Jpn J Antibiot | pmid:11436830 |
Kikuchi T et al. | [Effect of clarithromycin on monocyte-derived inflammatory cytokine production in bacterial infections with special reference to Mycobacterium avium infection]. | 2001 | Jpn J Antibiot | pmid:11436831 |
Kondo K et al. | [Changes in bacterial flora after long-term administration of clarithromycin]. | 2001 | Jpn J Antibiot | pmid:11436834 |
Jervis PN et al. | Management of non-tuberculous mycobacterial peri-sialadenitis in children: the Sheffield otolaryngology experience. | 2001 | Clin Otolaryngol Allied Sci | pmid:11437850 |
Cascio A et al. | Efficacy and safety of clarithromycin as treatment for Mediterranean spotted fever in children: a randomized controlled trial. | 2001 | Clin. Infect. Dis. | pmid:11438914 |
Komiya N and Tamaoki K | [Calcium dependent effect of clarithromycin on IL-8 production in cultured human epidermal cells]. | 2001 | Jpn J Antibiot | pmid:11439889 |
Tagaya E et al. | [Effect and action mechanism of short-term administration of clarithromycin for airway hypersecretion]. | 2001 | Jpn J Antibiot | pmid:11439901 |
Majima Y et al. | [Effect of macrolides on rat models of airway hypersecretion]. | 2001 | Jpn J Antibiot | pmid:11439902 |
Sakamoto M et al. | [Suppression of non-small-cell lung carcinoma metastasis with clarithromycin]. | 2001 | Jpn J Antibiot | pmid:11439903 |
Yoshida S et al. | [Suppression of biological response to surgical stress of lung cancer resection by administration of 14-cyclol linkage macrolides]. | 2001 | Jpn J Antibiot | pmid:11439904 |
Murakawa Y et al. | [Suppressive efffects of clarithromycin and cyclooxygenase-2 inhibitor, etodolac on N-nitrosobis(2-hydroxypropyl)amine(BHP)- induced experimental lung neoplasm in rats]. | 2001 | Jpn J Antibiot | pmid:11439906 |
Lee Y et al. | [Suppressive effect of 14-cyclol linkage macrolides on bleomycin-induced pulmonary fibrosis]. | 2001 | Jpn J Antibiot | pmid:11439908 |
Hojo M et al. | Pooled analysis on the efficacy of the second-line treatment regimens for Helicobacter pylori infection. | 2001 | Scand. J. Gastroenterol. | pmid:11444467 |
Ashorn M et al. | Helicobacter pylori and iron deficiency anaemia in children. | 2001 | Scand. J. Gastroenterol. | pmid:11444468 |
MacLeod CM et al. | Anti-inflammatory activity of clarithromycin in adults with chronically inflamed sinus mucosa. | 2001 Mar-Apr | Adv Ther | pmid:11446271 |
Brown-Elliott BA and Wallace RJ | Clarithromycin resistance to Mycobacterium abscessus. | 2001 | J. Clin. Microbiol. | pmid:11446360 |
Dubois J and St -Pierre C | In vitro activity of ABT-773 versus macrolides and quinolones against resistant respiratory tract pathogens. | 2001 May-Jun | Diagn. Microbiol. Infect. Dis. | pmid:11448561 |
Gangemi S et al. | Immediate reaction to clarithromycin. | 2001 Jan-Feb | Allergol Immunopathol (Madr) | pmid:11449533 |
Schreiber J et al. | [Non-tubercular mycobacterial infection of the lungs due to Mycobacterium smegmatis]. | 2001 | Pneumologie | pmid:11449609 |
Niemi M et al. | The cytochrome P4503A4 inhibitor clarithromycin increases the plasma concentrations and effects of repaglinide. | 2001 | Clin. Pharmacol. Ther. | pmid:11452245 |
Hoeffken G et al. | The efficacy and safety of two oral moxifloxacin regimens compared to oral clarithromycin in the treatment of community-acquired pneumonia. | 2001 | Respir Med | pmid:11453311 |
Ikejima H et al. | Comparison of in-vitro activities of SCH27899 and other antibiotics against Mycoplasma pneumoniae. | 2001 | J. Infect. Chemother. | pmid:11455504 |
Rondini G et al. | Bacteriological and clinical efficacy of various antibiotics used in the treatment of streptococcal pharyngitis in Italy. An epidemiological study. | 2001 | Int. J. Antimicrob. Agents | pmid:11463521 |
Johnson AP et al. | Activity of the ketolide telithromycin (HMR-3647) against erythromycin-susceptible and -resistant pneumococci isolated in the UK. | 2001 | Int. J. Antimicrob. Agents | pmid:11463530 |
Prime K and French P | Neuropsychiatric reaction induced by clarithromycin in a patient on highly active antiretroviral therapy (HAART). | 2001 | Sex Transm Infect | pmid:11463936 |
Guarner J and Mohar A | [The association between Helicobacter pylori and gastric neoplasia. Epidemiologic evidence]. | 2000 Oct-Dec | Rev Gastroenterol Mex | pmid:11464618 |
Kita T et al. | CYP2C19 genotype related effect of omeprazole on intragastric pH and antimicrobial stability. | 2001 | Pharm. Res. | pmid:11465416 |
Yang YJ et al. | Prevalence and rapid identification of clarithromycin-resistant Helicobacter pylori isolates in children. | 2001 | Pediatr. Infect. Dis. J. | pmid:11465837 |
Oncel M et al. | The effectiveness of one-week triple eradication therapy for perforated duodenal ulcer patients treated with simple closure. | 2001 | J. Clin. Gastroenterol. | pmid:11468454 |
Rojas Feria M et al. | Resistance of Helicobacter pylori to antimicrobial treatment in a Seville hospital catchment area. | 2000 | Rev Esp Enferm Dig | pmid:11468787 |
Onuk MD et al. | Effects of eradication therapy on gastric emptying in patients with Helicobacter pylori-positive duodenal ulcers. | 2001 May-Jun | J. Int. Med. Res. | pmid:11471854 |
Bruley Des Varannes S et al. | There are some benefits for eradicating Helicobacter pylori in patients with non-ulcer dyspepsia. | 2001 | Aliment. Pharmacol. Ther. | pmid:11472320 |
Adachi K et al. | Efficacy of ecabet sodium for Helicobacter pylori eradication triple therapy in comparison with a lansoprazole-based regimen. | 2001 | Aliment. Pharmacol. Ther. | pmid:11472321 |
Bardhan KD et al. | Ranitidine bismuth citrate with clarithromycin alone or with metronidazole for the eradication of Helicobacter pylori. | 2001 | Aliment. Pharmacol. Ther. | pmid:11472323 |
Adamek RJ et al. | Relapse prevention in reflux oesophagitis with regard to Helicobacter pylori status: a double-blind, randomized, multicentre trial to compare the efficacy of pantoprazole versus ranitidine. | 2001 | Eur J Gastroenterol Hepatol | pmid:11474311 |
Shimoyama Y et al. | Clinical and endoscopic improvement of lymphocytic gastritis with eradication of Helicobacter pylori. | 2001 | Gastrointest. Endosc. | pmid:11474405 |
Verhelst D et al. | Purple-blue subcutaneous nodules after renal transplantation: not always Kaposi sarcoma. | 2001 | Nephrol. Dial. Transplant. | pmid:11477184 |
Miehlke S et al. | Treatment of Helicobacter pylori infection. | 2001 | Semin. Gastrointest. Dis. | pmid:11478749 |
Lau CF et al. | Pseudomembranous colitis without diarrhoea following Helicobacter pylori eradication therapy. | 2001 | Hosp Med | pmid:11480134 |
Weber P et al. | Genetic and phenotypic characterization of macrolide resistance in group A streptococci isolated from adults with pharyngo-tonsillitis in France. | 2001 | J. Antimicrob. Chemother. | pmid:11481304 |
López-Brea M et al. | A 9 year study of clarithromycin and metronidazole resistance in Helicobacter pylori from Spanish children. | 2001 | J. Antimicrob. Chemother. | pmid:11481305 |
Pilotto A | Helicobacter pylori-associated peptic ulcer disease in older patients: current management strategies. | 2001 | Drugs Aging | pmid:11482742 |
Maniu CV et al. | Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid. | 2001 | Clin. Infect. Dis. | pmid:11486298 |
Nicodemo AC et al. | In vitro activity of fluoroquinolones (gatifloxacin, levofloxacin and trovafloxacin) and seven other antibiotics against Streptococcus pneumoniae. | 2001 | Braz J Infect Dis | pmid:11493408 |