clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Couturier J et al. | Steroid-induced mania in an adolescent: risk factors and management. | 2001 | Can J Clin Pharmacol | pmid:11493940 |
Cicconi V et al. | Disappearance of antiphospholipid antibodies syndrome after Helicobacter pylori eradication. | 2001 | Am. J. Med. | pmid:11501549 |
Kanamaru T et al. | In vitro and in vivo antibacterial activities of TAK-083, an agent for treatment of Helicobacter pylori infection. | 2001 | Antimicrob. Agents Chemother. | pmid:11502514 |
Chu HW et al. | Evaluation of blood vessels and edema in the airways of asthma patients: regulation with clarithromycin treatment. | 2001 | Chest | pmid:11502638 |
Holmberg SD and Moorman AC | Possible bias of ascertainment in assessing chemoprophylaxis for cryptosporidiosis. | 2001 | AIDS | pmid:11504998 |
Avcu N et al. | The relationship between gastric-oral Helicobacter pylori and oral hygiene in patients with vitamin B12-deficiency anemia. | 2001 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod | pmid:11505263 |
González C et al. | [In vitro antimicrobial susceptibility of Helicobacter pylori strains: isolation of strains resistant to clarithromycin]. | 2001 | Rev Med Chil | pmid:11510204 |
Andersson T et al. | Drug interaction studies with esomeprazole, the (S)-isomer of omeprazole. | 2001 | Clin Pharmacokinet | pmid:11510629 |
Azuma T et al. | Gastric leptin and Helicobacter pylori infection. | 2001 | Gut | pmid:11511551 |
Martinot JB et al. | A comparative study of clarithromycin modified release and amoxicillin/clavulanic acid in the treatment of acute exacerbation of chronic bronchitis. | 2001 Jan-Feb | Adv Ther | pmid:11512528 |
Froehlich F et al. | Helicobacter pylori eradication treatment does not benefit patients with nonulcer dyspepsia. | 2001 | Am. J. Gastroenterol. | pmid:11513170 |
Maconi G et al. | Prolonging proton pump inhibitor-based anti-Helicobacter pylori treatment from one to two weeks in duodenal ulcer: is it worthwhile? | 2000 | Dig Liver Dis | pmid:11515622 |
Kim YG et al. | Bioequivalence of clarithromycin tablet formulations assessed in Korean males. | 2001 | Int J Clin Pharmacol Ther | pmid:11515711 |
Sazhin VP and Fedorov AV | [Current principles of the use of laparoscopic surgery in gastroduodenal ulcer]. | 2001 | Khirurgiia (Mosk) | pmid:11517693 |
Maev IV et al. | [Experience in the use of losek (omeprazole) in gastroenterology]. | 2001 | Ter. Arkh. | pmid:11523419 |
Douthwaite S | Structure-activity relationships of ketolides vs. macrolides. | 2001 | Clin. Microbiol. Infect. | pmid:11523556 |
Wongkusoltham P et al. | Eradication rates of Helicobacter pylori between metronidazole-sensitive and metronidazole-resistant strains with metronidazole containing regimen in Thai patients with peptic ulcer disease. | 2001 | J Med Assoc Thai | pmid:11529378 |
Schlegel L et al. | In vitro activity of midecamycin diacetate, a 16-membered macrolide, against Streptococcus pyogenes isolated in France, 1995-1999. | 2001 | Clin. Microbiol. Infect. | pmid:11531981 |
Miyashita N et al. | In vitro activity of telithromycin, a new ketolide, against Chlamydia pneumoniae. | 2001 | J. Antimicrob. Chemother. | pmid:11533006 |
Weiss K et al. | In vitro activity of a novel ketolide ABT-773 against invasive strains of Streptococcus pneumoniae. | 2001 | J. Antimicrob. Chemother. | pmid:11533007 |
Miyazaki S et al. | Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice. | 2001 | J. Antimicrob. Chemother. | pmid:11533011 |
Bujanda L et al. | [Comparative study of the eradication of Helicobacter pylori: ranitidine bismuth citrate versus omeprazole plus two antibiotics for seven days]. | 2001 | An Med Interna | pmid:11534420 |
Naqvi B et al. | Efficacy of clarithromycin in preventing viridans streptococcal bacteremia following autologous stem cell transplantation. | 2001 | Infection | pmid:11545480 |
Beales IL | Efficacy of Helicobacter pylori eradication therapies: a single centre observational study. | 2001 | BMC Gastroenterol | pmid:11545677 |
Bharani A and Kumar H | Drug points: Diabetes inspidus induced by ofloxacin. | 2001 | BMJ | pmid:11546701 |
Fichtenbaum CJ et al. | Reply to 'Possible bias of ascertainment in assessing chemoprophylaxis for cryptosporidiosis' by Holmberg and Moorman. | 2001 | AIDS | pmid:11546956 |
Yamanaka Y et al. | Gene expression profiles of human small airway epithelial cells treated with low doses of 14- and 16-membered macrolides. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11549274 |
Acar JF | A comparison of side effects of levofloxacin to other agents concerning the ecological and microbiological effects on normal human flora. | 2001 | Chemotherapy | pmid:11549785 |
Gisbert JP and Pajares JM | Helicobacter pylori therapy: first-line options and rescue regimen. | 2001 | Dig Dis | pmid:11549823 |
Magaret N et al. | A randomized trial of lansoprazole, amoxycillin, and clarithromycin versus lansoprazole, bismuth, metronidazole and tetracycline in the retreatment of patients failing initial Helicobacter pylori therapy. | 2001 | Dig Dis | pmid:11549829 |
Di Vita G et al. | Resolution of Ménétrier's disease after Helicobacter pylori eradicating therapy. | 2001 | Dig Dis | pmid:11549830 |
Müller H et al. | Healing of active, non-atrophic autoimmune gastritis by H. pylori eradication. | 2001 | Digestion | pmid:11549834 |
Bühling A et al. | Influence of anti-Helicobacter triple-therapy with metronidazole, omeprazole and clarithromycin on intestinal microflora. | 2001 | Aliment. Pharmacol. Ther. | pmid:11552917 |
Hokari K et al. | Efficacy of triple therapy with rabeprazole for Helicobacter pylori infection and CYP2C19 genetic polymorphism. | 2001 | Aliment. Pharmacol. Ther. | pmid:11552922 |
Kamberoglou D et al. | Comparison of 1-week vs. 2- or 4-week therapy regimens with ranitidine bismuth citrate plus two antibiotics for Helicobacter pylori eradication. | 2001 | Aliment. Pharmacol. Ther. | pmid:11552924 |
Hayashi T et al. | Enhancement of innate immunity against Mycobacterium avium infection by immunostimulatory DNA is mediated by indoleamine 2,3-dioxygenase. | 2001 | Infect. Immun. | pmid:11553555 |
Kroegel C et al. | Chlamydia pneumoniae, clarithromycin, and severe asthma. | 2001 | Chest | pmid:11555549 |
Nishimoto A et al. | Studies on macrolide antibiotics I. Synthesis and antibacterial activity of erythromycin A 9-O-substituted oxime ether derivatives against Mycobacterium avium complex. | 2001 | Chem. Pharm. Bull. | pmid:11558597 |
Scott LJ et al. | Cefuroxime axetil: an updated review of its use in the management of bacterial infections. | 2001 | Drugs | pmid:11558834 |
Yang JC et al. | A multicenter study on eradication of Helicobacter pylori infection in patients with duodenal ulcer by lansoprazole-antibiotics combined therapy. | 1999 | J Microbiol Immunol Infect | pmid:11561564 |
Kume K et al. | Disappearance of both MALT lymphoma and hyperplastic polyps in the stomach after eradication of Helicobacter pylori. | 2001 | Am. J. Gastroenterol. | pmid:11569719 |
Chey WD and Fendrick AM | Noninvasive Helicobacter pylori testing for the "test-and-treat" strategy: a decision analysis to assess the effect of past infection on test choice. | 2001 | Arch. Intern. Med. | pmid:11570943 |
Amsden GW | Advanced-generation macrolides: tissue-directed antibiotics. | 2001 | Int. J. Antimicrob. Agents | pmid:11574189 |
Rubinstein E | Comparative safety of the different macrolides. | 2001 | Int. J. Antimicrob. Agents | pmid:11574199 |
Fukushima K et al. | [A case of post-tuberculosis chronic empyema with effective low-dose, long-term clarithromycin administration]. | 2001 | Nihon Kokyuki Gakkai Zasshi | pmid:11579526 |
Ikeue T et al. | [Pneumonia caused by Nocardia nova]. | 2001 | Nihon Kokyuki Gakkai Zasshi | pmid:11579529 |
Kerr JR and Preston NW | Current pharmacotherapy of pertussis. | 2001 | Expert Opin Pharmacother | pmid:11584995 |
Tse KC et al. | Delusion of worm infestation associated with clarithromycin in a patient on peritoneal dialysis. | 2001 Jul-Aug | Perit Dial Int | pmid:11587409 |
Sillakivi T et al. | An attempt at Helicobacter pylori eradication with intravenous clarithromycin in perforated peptic ulcer patients. | 2001 | Scand. J. Gastroenterol. | pmid:11589389 |
Okazaki N et al. | Characteristics of macrolide-resistant Mycoplasma pneumoniae strains isolated from patients and induced with erythromycin in vitro. | 2001 | Microbiol. Immunol. | pmid:11592636 |
Yakoob J et al. | Antibiotic susceptibility of Helicobacter pylori in the Chinese population. | 2001 | J. Gastroenterol. Hepatol. | pmid:11595061 |
Keto Y et al. | Gastric mucosal changes induced by long term infection with Helicobacter pylori in Mongolian gerbils: effects of bacteria eradication. | 2001 Jan-Dec | J. Physiol. Paris | pmid:11595471 |
Buzás GM et al. | Six regimens for the eradication of Helicobacter pylori (Hp) in duodenal ulcer patients: three consecutive trials (1995-1999). | J. Physiol. Paris | pmid:11595472 | |
Chahine C et al. | Ultrashort regimen of lansoprazole-amoxicillin-azithromycin for eradicating Helicobacter pylori. | 2001 | Am J Health Syst Pharm | pmid:11596697 |
Agro K et al. | Cost effectiveness in Canada of a multidrug prepackaged regimen (Hp-PAC)+ for Helicobacter pylori eradication. | 2001 | Pharmacoeconomics | pmid:11596835 |
Hyde TB et al. | Macrolide resistance among invasive Streptococcus pneumoniae isolates. | 2001 | JAMA | pmid:11597287 |
Ling KL et al. | Efficacy of a nitroimidazole containing tripletherapy regime in Singapore. | 2001 | Singapore Med J | pmid:11599627 |
Lounis N et al. | Efficacies of clarithromycin regimens against Mycobacterium xenopi in mice. | 2001 | Antimicrob. Agents Chemother. | pmid:11600387 |
Nagai K et al. | Activities of a new fluoroketolide, HMR 3787, and its (des)-fluor derivative RU 64399 compared to those of telithromycin, erythromycin A, azithromycin, clarithromycin, and clindamycin against macrolide-susceptible or -resistant Streptococcus pneumoniae and S. pyogenes. | 2001 | Antimicrob. Agents Chemother. | pmid:11600391 |
Gikas A et al. | In vitro susceptibility of Coxiella burnetii to linezolid in comparison with its susceptibilities to quinolones, doxycycline, and clarithromycin. | 2001 | Antimicrob. Agents Chemother. | pmid:11600400 |
Bigard MA | [Helicobacter pylori eradication. Therapeutic evolution, value of complementary studies]. | 2001 | Presse Med | pmid:11603094 |
Tankovic J et al. | Clarithromycin resistance of Helicobacter pylori has a major impact on the efficacy of the omeprazole-amoxicillin-clarithromycin therapy. | 2001 | Pathol. Biol. | pmid:11642014 |
Timm S et al. | First successful treatment of a primary high-grade gastric MALT lymphoma by eradication therapy for Helicobacter pylori. | 2001 | Gastroenterology | pmid:11665693 |
Saruç M et al. | The effect of CagA status on response to Helicobacter pylori eradication therapy in Western Turkey. | 2001 | Braz. J. Med. Biol. Res. | pmid:11668353 |
Kumar D et al. | Randomized trial of a quadruple-drug regimen and a triple-drug regimen for eradication of Helicobacter pylori: long-term follow-up study. | 2001 Sep-Oct | Indian J Gastroenterol | pmid:11676331 |
Moayyedi P et al. | Helicobacter pylori eradication does not exacerbate reflux symptoms in gastroesophageal reflux disease. | 2001 | Gastroenterology | pmid:11677204 |
Schlünzen F et al. | Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. | 2001 | Nature | pmid:11677599 |
Gisbert JP et al. | Are twelve days of omeprazole, amoxicillin and clarithromycin better than six days for treating H. pylori infection in peptic ulcer and in non-ulcer dyspepsia? | 2001 Sep-Oct | Hepatogastroenterology | pmid:11677970 |
Xu H and Rashkow A | Clarithromycin-induced digoxin toxicity: a case report and a review of the literature. | 2001 | Conn Med | pmid:11678058 |
Kanj SS et al. | Campylobacter fetus pericarditis in a patient with beta-thalassemia: case report and review of the literature. | 2001 | Clin. Microbiol. Infect. | pmid:11678937 |
Lascols C et al. | Effect of pH on the susceptibility of Helicobacter pylori to the ketolide telithromycin (HMR 3647) and clarithromycin. | 2001 | J. Antimicrob. Chemother. | pmid:11679568 |
Guyot A and Barrett SP | What is an appropriate control group to identify risk factors for Clostridium difficile-associated diarrhoea? | 2001 | J. Antimicrob. Chemother. | pmid:11679574 |
Keto Y et al. | [Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils]. | 2001 | Nippon Yakurigaku Zasshi | pmid:11680169 |
Rüssmann H et al. | Rapid and accurate determination of genotypic clarithromycin resistance in cultured Helicobacter pylori by fluorescent in situ hybridization. | 2001 | J. Clin. Microbiol. | pmid:11682543 |
Ikeda S et al. | Evaluation of the cost-effectiveness of Helicobacter pylori eradication triple therapy vs. conventional therapy for ulcers in Japan. | 2001 | Aliment. Pharmacol. Ther. | pmid:11683692 |
Laurent J et al. | A randomized comparison of four omeprazole-based triple therapy regimens for the eradication of Helicobacter pylori in patients with non-ulcer dyspepsia. | 2001 | Aliment. Pharmacol. Ther. | pmid:11683693 |
Asaka M et al. | Guidelines in the management of Helicobacter pylori infection in Japan. | 2001 | Helicobacter | pmid:11683920 |
Ozen H et al. | Helicobacter pylori infection and recurrent abdominal pain in Turkish children. | 2001 | Helicobacter | pmid:11683926 |
McNulty CA et al. | A pilot study to determine the effectiveness of garlic oil capsules in the treatment of dyspeptic patients with Helicobacter pylori. | 2001 | Helicobacter | pmid:11683929 |
Asaka M et al. | A multicenter, double-blind study on triple therapy with lansoprazole, amoxicillin and clarithromycin for eradication of Helicobacter pylori in Japanese peptic ulcer patients. | 2001 | Helicobacter | pmid:11683930 |
McCarty JM and Pierce PF | Five days of cefprozil versus 10 days of clarithromycin in the treatment of an acute exacerbation of chronic bronchitis. | 2001 | Ann. Allergy Asthma Immunol. | pmid:11686426 |
Dubois J and St-Pierre C | In vitro susceptibility study of BMS-284756 against Legionella species. | 2001 Sep-Oct | Diagn. Microbiol. Infect. Dis. | pmid:11687318 |
Vichev E et al. | [Gastroduodenitis and ulcers--statistical study for 1998]. | 2000 | Vutr Boles | pmid:11688321 |
Stratchounski LS et al. | Antimicrobial susceptibility of nasopharyngeal isolates of Haemophilus influenzae from healthy children in day-care centres: results of multicentre study in Russia. | 2001 | Int. J. Antimicrob. Agents | pmid:11691567 |
Zheng X et al. | Clinical isolates of Streptococcus pneumoniae resistant to levofloxacin contain mutations in both gyrA and parC genes. | 2001 | Int. J. Antimicrob. Agents | pmid:11691571 |
Dzierzanowska-Fangrat K et al. | Primary resistance to clarithromycin in clinical strains of Helicobacter pylori isolated from children in Poland. | 2001 | Int. J. Antimicrob. Agents | pmid:11691574 |
Dandekar SS and Laidlaw DA | Suprachoroidal haemorrhage after addition of clarithromycin to warfarin. | 2001 | J R Soc Med | pmid:11691898 |
Gisbert JP et al. | Helicobacter pylori eradication therapy is more effective in peptic ulcer than in non-ulcer dyspepsia. | 2001 | Eur J Gastroenterol Hepatol | pmid:11692055 |
Mayr-Kanhäuser S et al. | Resolution of granulomatous rosacea after eradication of Helicobacter pylori with clarithromycin, metronidazole and pantoprazole. | 2001 | Eur J Gastroenterol Hepatol | pmid:11692067 |
Horsburgh CR et al. | Disseminated Mycobacterium avium complex disease among patients infected with human immunodeficiency virus, 1985-2000. | 2001 | Clin. Infect. Dis. | pmid:11692307 |
Heurtin C et al. | [Comparative study of the bacteriostatic and bactericidal activity of levofloxacin against Pasteurella strains isolated from man]. | 2001 | Pathol. Biol. | pmid:11692747 |
Matheson AJ and Jarvis B | Lansoprazole: an update of its place in the management of acid-related disorders. | 2001 | Drugs | pmid:11693467 |
Chai D et al. | [Effect of macrolides on biofilm of mucoid Pseudomonas aeruginosa]. | 2001 | Zhonghua Yi Xue Za Zhi | pmid:11702671 |
Ena P et al. | Rapid identification of cutaneous infections by nontubercular mycobacteria by polymerase chain reaction-restriction analysis length polymorphism of the hsp65 gene. | 2001 | Int. J. Dermatol. | pmid:11703519 |
Carabias ML et al. | [Are the antimicrobials used in community-acquired respiratory infection useful for preventing transmission of meningococcal disease? In vitro study]. | 2001 | Rev Esp Quimioter | pmid:11704772 |
Okano A et al. | Subcutaneous infection with Mycobacterium fortuitum after allogeneic bone marrow transplantation. | 2001 | Bone Marrow Transplant. | pmid:11704796 |
Capitano B et al. | Antibacterials for the prophylaxis and treatment of bacterial endocarditis in children. | 2001 | Paediatr Drugs | pmid:11706922 |
Ramón Maestre J et al. | [Bacteremia caused by Campylobacter jejuni in a 22 year old male with autoimmune haemolytic anaemia]. | 2001 | Enferm. Infecc. Microbiol. Clin. | pmid:11709134 |
Komori T et al. | Up-regulation by clarithromycin of alpha(1)-acid glycoprotein expression in liver and primary cultured hepatocytes. | 2001 | Biochem. Pharmacol. | pmid:11709199 |
Endo H et al. | Effects of lansoprazole and amoxicillin on uptake of [(14)C]clarithromycin into gastric tissue in rats. | 2001 | Antimicrob. Agents Chemother. | pmid:11709323 |