clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Gisbert JP et al. | [One-week treatment with omeprazole, clarithromycin and amoxicillin: high efficacy in the eradication of Helicobacter pylori and cicatrization of duodenal ulcer]. | 1997 | Med Clin (Barc) | pmid:9190436 |
Damianos AJ and McGarrity TJ | Treatment strategies for Helicobacter pylori infection. | 1997 | Am Fam Physician | pmid:9191460 |
Stephenson GA et al. | Solid-state investigations of erythromycin A dihydrate: structure, NMR spectroscopy, and hygroscopicity. | 1997 | J Pharm Sci | pmid:9383733 |
Ebell MH et al. | Evaluation of the dyspeptic patient: a cost-utility study. | 1997 | J Fam Pract | pmid:9191627 |
Griffith DE | Nontuberculous mycobacteria. | 1997 | Curr Opin Pulm Med | pmid:9193860 |
Villanueva A et al. | Report on an outbreak of postinjection abscesses due to Mycobacterium abscessus, including management with surgery and clarithromycin therapy and comparison of strains by random amplified polymorphic DNA polymerase chain reaction. | 1997 | Clin. Infect. Dis. | pmid:9195073 |
Gabl M et al. | Flexor tenosynovitis in the hand caused by Mycobacterium malmoense: a case report. | 1997 | J Hand Surg Am | pmid:9195437 |
Rubin BK et al. | Effect of clarithromycin on nasal mucus properties in healthy subjects and in patients with purulent rhinitis. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9196110 |
Lo WC et al. | Clarithromycin in the combination therapy for the eradication of Helicobacter pylori in peptic ulcer disease. | 1997 | Zhonghua Yi Xue Za Zhi (Taipei) | pmid:9198292 |
Fréhel C et al. | The phagosomal environment protects virulent Mycobacterium avium from killing and destruction by clarithromycin. | 1997 | Infect. Immun. | pmid:9199452 |
Marignani M et al. | Reversal of long-standing iron deficiency anaemia after eradication of Helicobacter pylori infection. | 1997 | Scand. J. Gastroenterol. | pmid:9200297 |
Kato S et al. | Omeprazole-based dual and triple regimens for Helicobacter pylori eradication in children. | 1997 | Pediatrics | pmid:9200377 |
Woo MS et al. | Pediatric transplant grand rounds. A case presentation: skin lesions in a post-lung transplant patient. | 1997 | Pediatr Transplant | pmid:10084776 |
Gisbert JP et al. | [What is the current role of clarithromycin in the eradication of Helicobacter pylori?]. | 1997 | Rev Esp Enferm Dig | pmid:9221019 |
Taylor DE et al. | Cloning and sequence analysis of two copies of a 23S rRNA gene from Helicobacter pylori and association of clarithromycin resistance with 23S rRNA mutations. | 1997 | Antimicrob. Agents Chemother. | pmid:9420030 |
Rodrigo Sáez L et al. | [The efficacy of using a short course of 6-day duration (OCA-6) in the treatment to eradicate Helicobacter pylori infection. Omeprazole, clarithromycin, amoxicillin]. | 1997 | Rev Esp Enferm Dig | pmid:9115827 |
Reed PI and Johnston BJ | Treatment of Helicobacter pylori infection. | 1997 | Biomed. Pharmacother. | pmid:9084725 |
Plemmons RM et al. | Osteomyelitis due to Mycobacterium haemophilum in a cardiac transplant patient: case report and analysis of interactions among clarithromycin, rifampin, and cyclosporine. | 1997 | Clin. Infect. Dis. | pmid:9142810 |
Khan AA et al. | Activity of trovafloxacin in combination with other drugs for treatment of acute murine toxoplasmosis. | 1997 | Antimicrob. Agents Chemother. | pmid:9145840 |
Collins L and Franzblau SG | Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium. | 1997 | Antimicrob. Agents Chemother. | pmid:9145860 |
Lounis N et al. | Comparative activities of amikacin against Mycobacterium avium complex in nude and beige mice. | 1997 | Antimicrob. Agents Chemother. | pmid:9145892 |
Spinzi G et al. | Randomized study comparing omeprazole plus amoxycillin versus omeprazole plus clarithromycin for eradication of Helicobacter pylori. | 1997 | Aliment. Pharmacol. Ther. | pmid:9146769 |
Fietta A et al. | Inhibition of intracellular growth of Staphylococcus aureus by exposure of infected human monocytes to clarithromycin and azithromycin. | 1997 | J Chemother | pmid:9106013 |
Peterson WL | The role of antisecretory drugs in the treatment of Helicobacter pylori infection. | 1997 | Aliment. Pharmacol. Ther. | pmid:9146787 |
Chaisson RE et al. | Clarithromycin and ethambutol with or without clofazimine for the treatment of bacteremic Mycobacterium avium complex disease in patients with HIV infection. | 1997 | AIDS | pmid:9147422 |
Lazzaroni M et al. | Triple therapy with ranitidine or lansoprazole in the treatment of Helicobacter pylori-associated duodenal ulcer. | 1997 | Am. J. Gastroenterol. | pmid:9128316 |
Fischbach W et al. | Regression of immunoproliferative small intestinal disease after eradication of Helicobacter pylori. | 1997 | Lancet | pmid:8988128 |
Pendland SL et al. | Comparison of charcoal- and starch-based media for testing susceptibilities of Legionella species to macrolides, azalides, and fluoroquinolones. | 1997 | J. Clin. Microbiol. | pmid:9350781 |
Walzer PD et al. | Clinically used antimicrobial drugs against experimental pneumocystosis, singly and in combination: analysis of drug interactions and efficacies. | 1997 | Antimicrob. Agents Chemother. | pmid:9021174 |
Banerjee DK et al. | Experimental evaluation of possible new short-term drug regimens for treatment of multibacillary leprosy. | 1997 | Antimicrob. Agents Chemother. | pmid:9021187 |
Paar D et al. | Life-threatening interaction between clarithromycin and disopyramide. | 1997 | Lancet | pmid:9024381 |
Wang XM et al. | [Time course of disappearance of Helicobacter pylori after topical therapy and new triple therapy]. | 1997 | Nihon Shokakibyo Gakkai Zasshi | pmid:9028149 |
MacÃas J et al. | Rhodococcus or mycobacterium? An example of misdiagnosis in HIV infection. | 1997 | AIDS | pmid:9030376 |
Burman WJ et al. | A retrospective comparison of clarithromycin versus rifampin in combination treatment for disseminated Mycobacterium avium complex disease in AIDS: clarithromycin decreases transfusion requirements. | 1997 | Int. J. Tuberc. Lung Dis. | pmid:9441082 |
Brady RC et al. | Facial sporotrichoid infection with Mycobacterium marinum. | 1997 | J. Pediatr. | pmid:9042142 |
Suzuki K et al. | Activity of KRM 1648 or rifabutin alone or in combination with clarithromycin against Mycobacterium avium complex in human alveolar macrophages. | 1997 | Int. J. Tuberc. Lung Dis. | pmid:9441102 |
Axon AT et al. | Ranitidine bismuth citrate and clarithromycin twice daily in the eradication of Helicobacter pylori. | 1997 | Aliment. Pharmacol. Ther. | pmid:9042977 |
Picardeau M et al. | Use of different molecular typing techniques for bacteriological follow-up in a clinical trial with AIDS patients with Mycobacterium avium bacteremia. | 1997 | J. Clin. Microbiol. | pmid:9316897 |
Chey WD et al. | Bismuth subsalicylate instead of metronidazole with lansoprazole and clarithromycin for Helicobacter pylori infection: a randomized trial. | 1997 | Am. J. Gastroenterol. | pmid:9317068 |
Raasveld MH et al. | Cat-scratch disease mimicking pancreatic malignancy: case report. | 1997 | Clin. Infect. Dis. | pmid:8994767 |
Pipkin GA et al. | Clarithromycin dual therapy regimens for eradication of Helicobacter pylori: a review. | 1997 | Helicobacter | pmid:9421117 |
Tompkins DS et al. | Failed treatment of Helicobacter pylori infection associated with resistance to clarithromycin. | 1997 | Helicobacter | pmid:9421121 |
Taylor JL et al. | Pharmacoeconomic comparison of treatments for the eradication of Helicobacter pylori. | 1997 | Arch. Intern. Med. | pmid:8996045 |
Hultén K et al. | Combination treatment with ranitidine is highly efficient against Helicobacter pylori despite negative impact of macrolide resistance. | 1997 | Helicobacter | pmid:9421122 |
Drugs for treatment of peptic ulcers. | 1997 | Med Lett Drugs Ther | pmid:8996458 | |
O'Connor HJ et al. | One week triple therapy for Helicobacter pylori: does high-dose clarithromycin confer additional benefit? | 1997 | Helicobacter | pmid:9421124 |
Matsunaga K et al. | [Successful eradication of H. pylori in an elderly patient with gastric cancer after effective UFT-E therapy]. | 1997 | Gan To Kagaku Ryoho | pmid:9422074 |
Stone GG et al. | A PCR-oligonucleotide ligation assay to determine the prevalence of 23S rRNA gene mutations in clarithromycin-resistant Helicobacter pylori. | 1997 | Antimicrob. Agents Chemother. | pmid:9056021 |
Moayyedi P et al. | Patient factors that predict failure of omeprazole, clarithromycin, and tinidazole to eradicate Helicobacter pylori. | 1997 | J. Gastroenterol. | pmid:9058291 |
Zuberi BF et al. | Low dose, short-term, triple therapy for helicobacter pylori associated peptic ulcer. | 1997 | J Pak Med Assoc | pmid:9361485 |
Zullo A et al. | Omeprazole plus clarithromycin and either tinidazole or tetracycline for Helicobacter pylori infection: a randomized prospective study. | 1997 | Am. J. Gastroenterol. | pmid:9362185 |
Dautzenberg B | Rationale for the prevention of disseminated Mycobacterium avium-intracellulare complex disease. | 1997 | Drugs | pmid:9358194 |
Cohn DL | Prevention strategies for Mycobacterium avium-intracellulare complex (MAC) infection. A review of recent studies in patients with AIDS. | 1997 | Drugs | pmid:9358195 |
Marone P et al. | Rapid drug susceptibility of Mycobacterium avium complex using a fluorescence quenching method. | 1997 | J Chemother | pmid:9269603 |
Takeda H et al. | [Macrolide antibiotic actions on bacteria and cultured airway cells]. | 1997 | Jpn J Antibiot | pmid:9597448 |
Mita Y et al. | [Vitamin D3 induction of differentiation of HL-60 cells to monocyte- like cells and their aggregation--a dynamic culture method and clarithromycin]. | 1997 | Jpn J Antibiot | pmid:9597462 |
Yanagihara K et al. | [Analysis of chronic respiratory tract infection by using an intubation model--evaluation based on fluctuations in cytokine content]. | 1997 | Jpn J Antibiot | pmid:9597463 |
Konishi M et al. | [Log-term administration of clarithromycin as a possible adjuvant therapy of HIV infections]. | 1997 | Jpn J Antibiot | pmid:9597467 |
Dixon JS et al. | Ranitidine bismuth citrate plus clarithromycin for the eradication of H. pylori. | 1997 | J. Physiol. Pharmacol. | pmid:9440055 |
Yatsunami J et al. | Clarithromycin is a potent inhibitor of tumor-induced angiogenesis. | 1997 | Res Exp Med (Berl) | pmid:9440137 |
Konishi T and Nakao M | Antibiotic treatment in mice infected with Japanese Borrelia garinii: efficacy of ceftriaxone for eradicating the infection induced by Ixodes persulcatus tick bites. | 1997 | Microbiol. Immunol. | pmid:9087959 |
Payen MC et al. | [Manifestations, diagnosis and treatment of non-tuberculous mycobacterial infections in patients with HIV infection]. | 1997 | Rev Mal Respir | pmid:9496599 |
GarcÃa-de-Lomas J et al. | Antimicrobial susceptibility of Streptococcus pneumoniae isolated from pediatric carriers in Spain. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9063666 |
Weiss I et al. | Serotyping and susceptibility to macrolides and other antimicrobial drugs of Streptococcus pyogenes isolated from patients with invasive diseases in southern Israel. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9063669 |
Price J and Hamilton W | Pragmatic eradication of H. pylori. | 1997 | Br J Gen Pract | pmid:9474836 |
Cammarota G et al. | Regression of a primary gastric MALT lymphoma with extensive antrum lesions by Helicobacter pylori eradication. | 1997 | Ital J Gastroenterol Hepatol | pmid:9476192 |
Hotz J | [Reflux disease of the gastrointestinal tract. Acute therapy and long-term care in daily practice. 2. Therapeutic procedure--diagnosis--therapy-diagram]. | 1997 | Fortschr. Med. | pmid:9480263 |
Feldman C et al. | Roxithromycin, clarithromycin, and azithromycin attenuate the injurious effects of bioactive phospholipids on human respiratory epithelium in vitro. | 1997 | Inflammation | pmid:9429912 |
Sousa C et al. | [Cholestatic hepatitis probably induced by clarithromycin]. | 1997 | Gastroenterol. Clin. Biol. | pmid:9587506 |
Misiewicz JJ | Management of Helicobacter pylori-related disorders. | 1997 | Eur J Gastroenterol Hepatol | pmid:9160212 |
Mor N and Esfandiari A | Synergistic activities of clarithromycin and pyrazinamide against Mycobacterium tuberculosis in human macrophages. | 1997 | Antimicrob. Agents Chemother. | pmid:9303411 |
Savarino V et al. | A new 1-week therapy for Helicobacter pylori eradication: ranitidine bismuth citrate plus two antibiotics. | 1997 | Aliment. Pharmacol. Ther. | pmid:9305478 |
Williams MP et al. | Seven-day treatment for Helicobacter pylori infection: ranitidine bismuth citrate plus clarithromycin and tetracycline hydrochloride. | 1997 | Aliment. Pharmacol. Ther. | pmid:9305479 |
Hultén K et al. | Macrolide resistance in Helicobacter pylori: mechanism and stability in strains from clarithromycin-treated patients. | 1997 | Antimicrob. Agents Chemother. | pmid:9371366 |
Sánchez-Nuñez ML et al. | Clarithromycin in the treatment of cyclosporin-associated gingival hyperplasia. | 1997 | Nephrol. Dial. Transplant. | pmid:9306384 |
Finkenbine R and Gill HS | Case of mania due to prednisone-clarithromycin interaction. | 1997 | Can J Psychiatry | pmid:9307841 |
Gisbert JP et al. | Unhealed duodenal ulcers despite Helicobacter pylori eradication. | 1997 | Scand. J. Gastroenterol. | pmid:9246702 |
Barry AL et al. | In vitro activity of the new ketolide HMR 3004 compared to an azalide and macrolides against Streptococcus pneumoniae and Haemophilus influenzae. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9405952 |
Fuursted K | Evaluation of the post-antibiotic effect of six anti-mycobacterial agents against Mycobacterium avium by the Bactec radiometric method. | 1997 | J. Antimicrob. Chemother. | pmid:9249202 |
Polis MA et al. | Clarithromycin lowers plasma zidovudine levels in persons with human immunodeficiency virus infection. | 1997 | Antimicrob. Agents Chemother. | pmid:9257746 |
Shibata K et al. | Bactericidal effect of ecabet sodium on clarithromycin- and metronidazole-resistant clinical isolates of Helicobacter pylori. | 1997 | Jpn J Antibiot | pmid:9258741 |
Böttger EC et al. | Prophylaxis of mycobacterial infection and acquired drug resistance. | 1997 | J. Antimicrob. Chemother. | pmid:9249224 |
Sato K et al. | [Anti-Mycobacterium avium complex activities of KRM-1648, clarithromycin and levofloxacin in 7HSF medium at peak or average blood concentrations after their oral administration of clinical dosages]. | 1997 | Kekkaku | pmid:9259129 |
Peloquin CA and Berning SE | Advice on treatment of Mycobacterium avium complex infection. | 1997 | Am J Health Syst Pharm | pmid:9161632 |
OÄŸuz O et al. | Conjunctival involvement in familial chronic benign pemphigus (Hailey-Hailey disease). | 1997 | Int. J. Dermatol. | pmid:9169328 |
Alfandari S et al. | Isolated cutaneous Mycobacterium avium complex infection in AIDS. | 1997 | Int. J. Dermatol. | pmid:9169332 |
Walsh D et al. | One week treatment for Helicobacter pylori infection. | 1997 | Arch. Dis. Child. | pmid:9166031 |
Tillenburg B et al. | [Helicobacter pylori: pretherapeutic resistance status in Germany (Ruhr area)]. | 1997 | Z Gastroenterol | pmid:9173687 |
Suzuki Y et al. | [Antimicrobial activities of clarithromycin against recent obtained clinical isolates]. | 1997 | Jpn J Antibiot | pmid:9394238 |
Ando H et al. | [Changes in serum anti-Helicobacter pylori IgG antibody, pepsinogen I, and pepsinogen II after eradication therapy of Helicobacter pylori]. | 1997 | Nihon Shokakibyo Gakkai Zasshi | pmid:9396326 |
Veldhuyzen van Zanten SJ et al. | Helicobacter pylori: new developments and treatments. | 1997 | CMAJ | pmid:9176424 |
Nakao K et al. | Relation of lactoferrin levels in gastric mucosa with Helicobacter pylori infection and with the degree of gastric inflammation. | 1997 | Am. J. Gastroenterol. | pmid:9177520 |
Langtry HD and Brogden RN | Clarithromycin. A review of its efficacy in the treatment of respiratory tract infections in immunocompetent patients. | 1997 | Drugs | pmid:9179528 |
Current European concepts in the management of Helicobacter pylori infection. The Maastricht Consensus Report. European Helicobacter Pylori Study Group. | 1997 | Gut | pmid:9274464 | |
Lam SK et al. | Does treatment of Helicobacter pylori with antibiotics alone heal duodenal ulcer? A randomised double blind placebo controlled study. | 1997 | Gut | pmid:9274470 |
Kundu S et al. | Clarithromycin-induced ventricular tachycardia. | 1997 | Ann Emerg Med | pmid:9326871 |
Kato A | [Effect of erythromycin and clarithromycin on ion transport across dissected canine tracheal epithelium]. | 1997 | Nippon Jibiinkoka Gakkai Kaiho | pmid:9103848 |
Hirakawa T | [Diagnosis and treatment of Helicobacter pylori]. | 1997 | Nippon Ika Daigaku Zasshi | pmid:9283206 |
Fietta A et al. | Requirements for intracellular accumulation and release of clarithromycin and azithromycin by human phagocytes. | 1997 | J Chemother | pmid:9106014 |
Midolo PD et al. | Antimicrobial resistance testing of Helicobacter pylori: a comparison of Etest and disk diffusion methods. | 1997 | Pathology | pmid:9423225 |