| MeSH term | MeSH ID | Detail |
|---|---|---|
| Gram-Negative Bacterial Infections | D016905 | 16 associated lipids |
| Angiomatosis, Bacillary | D016917 | 2 associated lipids |
| Meningitis, Bacterial | D016920 | 6 associated lipids |
| Common Variable Immunodeficiency | D017074 | 4 associated lipids |
| AIDS-Related Opportunistic Infections | D017088 | 9 associated lipids |
| IgA Deficiency | D017098 | 2 associated lipids |
| Liver Failure, Acute | D017114 | 11 associated lipids |
| Skin Diseases, Bacterial | D017192 | 8 associated lipids |
| Dermatitis, Phototoxic | D017484 | 4 associated lipids |
| Pityriasis Rosea | D017515 | 3 associated lipids |
| Cutaneous Fistula | D017577 | 1 associated lipids |
| Kleine-Levin Syndrome | D017593 | 1 associated lipids |
| Periodontal Attachment Loss | D017622 | 7 associated lipids |
| Soft Tissue Injuries | D017695 | 2 associated lipids |
| Community-Acquired Infections | D017714 | 8 associated lipids |
| Cytomegalovirus Retinitis | D017726 | 2 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Cardiovascular Abnormalities | D018376 | 2 associated lipids |
| Pneumonia, Bacterial | D018410 | 16 associated lipids |
| Soft Tissue Infections | D018461 | 2 associated lipids |
| Ventricular Dysfunction, Left | D018487 | 33 associated lipids |
| Cryptogenic Organizing Pneumonia | D018549 | 3 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Gingival Overgrowth | D019214 | 7 associated lipids |
| Tooth, Nonvital | D019553 | 2 associated lipids |
| alpha 1-Antitrypsin Deficiency | D019896 | 3 associated lipids |
| Genetic Predisposition to Disease | D020022 | 24 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Central Nervous System Protozoal Infections | D020808 | 3 associated lipids |
| Epilepsy, Partial, Motor | D020938 | 1 associated lipids |
| Chlamydophila Infections | D023521 | 4 associated lipids |
| Desulfovibrionaceae Infections | D045824 | 5 associated lipids |
| Renal Insufficiency | D051437 | 8 associated lipids |
| Immune Reconstitution Inflammatory Syndrome | D054019 | 1 associated lipids |
| Buruli Ulcer | D054312 | 1 associated lipids |
| Extensively Drug-Resistant Tuberculosis | D054908 | 1 associated lipids |
| Leprosy, Paucibacillary | D056005 | 2 associated lipids |
| Upper Extremity Deep Vein Thrombosis | D056824 | 1 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
| Plaque, Atherosclerotic | D058226 | 7 associated lipids |
| Sacroiliitis | D058566 | 1 associated lipids |
| Chlamydial Pneumonia | D061387 | 2 associated lipids |
clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with clarithromycin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu KS et al. | Ten day sequential versus 10 day modified bismuth quadruple therapy as empirical firstline and secondline treatment for Helicobacter pylori in Chinese patients: an open label, randomised, crossover trial. | 2014 | Gut | pmid:24295850 |
| Katayama M et al. | Preliminary study of effects of multiple oral dosing of clarithromycin on the pharmacokinetics of cyclosporine in dogs. | 2014 | J. Vet. Med. Sci. | pmid:24189617 |
| Papastergiou V et al. | Current and future insights in H. pylori eradication regimens: the need of tailoring therapy. | 2014 | Curr. Pharm. Des. | pmid:24180408 |
| Tan X and Song Z | Human saliva-based quantitative monitoring of clarithromycin by flow injection chemiluminescence analysis: a pharmacokinetic study. | 2014 | Appl. Biochem. Biotechnol. | pmid:24166104 |
| Kakuda TN et al. | Pharmacokinetic evaluation of the interaction between etravirine and rifabutin or clarithromycin in HIV-negative, healthy volunteers: results from two Phase 1 studies. | 2014 | J. Antimicrob. Chemother. | pmid:24155058 |
| Seung KJ et al. | Salvage therapy for multidrug-resistant tuberculosis. | 2014 | Clin. Microbiol. Infect. | pmid:23991934 |
| Kathariya R et al. | Evaluation of subgingivally delivered 0.5% clarithromycin as an adjunct to nonsurgical mechanotherapy in the management of chronic periodontitis: a short-term double blinded randomized control trial. | 2014 | J Investig Clin Dent | pmid:23097216 |
| Shahbazi Niaz M et al. | Investigation into physical-chemical variables affecting the manufacture and dissolution of wet-milled clarithromycin nanoparticles. | 2014 | Pharm Dev Technol | pmid:24093825 |
| Maev IV et al. | [Eradication therapy for Helicobacter pylori infection: review of world trends]. | 2014 | Ter. Arkh. | pmid:24779078 |
| Katagiri S et al. | [Case report; Disseminated Mycobacterium abscessus infection with hemophagocytic syndrome during treatment of chronic lymphocytic leukemia]. | 2014 | Nippon Naika Gakkai Zasshi | pmid:24796145 |
| Kato M | [Expanded indication of National Health Insurance for H. pylori associated gastritis]. | 2014 | Nippon Rinsho | pmid:24912302 |
| Bjerre M et al. | Osteoprotegerin independently predicts mortality in patients with stable coronary artery disease: the CLARICOR trial. | 2014 | Scand. J. Clin. Lab. Invest. | pmid:25026506 |
| Loreto ES et al. | New insights into the in vitro susceptibility of Pythium insidiosum. | 2014 | Antimicrob. Agents Chemother. | pmid:25223997 |
| Tsovolou EC et al. | Effect of clarithromycin in experimental empyema by multidrug-resistant Pseudomonas aeruginosa. | 2014 | APMIS | pmid:23656439 |
| Altman E et al. | Lipopolysaccharide glycotyping of clarithromycin-resistant and clarithromycin-susceptible Canadian isolates of Helicobacter pylori. | 2014 | Can. J. Microbiol. | pmid:24392924 |
| Kim SY et al. | Changes in serum immunomolecules during antibiotic therapy for Mycobacterium avium complex lung disease. | 2014 | Clin. Exp. Immunol. | pmid:24354934 |
| Yamada K et al. | Azithromycin inhibits MUC5AC induction via multidrug-resistant Acinetobacter baumannii in human airway epithelial cells. | 2014 | Pulm Pharmacol Ther | pmid:24910464 |
| Page SR and Yee KC | Rhabdomyolysis in association with simvastatin and dosage increment in clarithromycin. | 2014 | Intern Med J | pmid:25041770 |
| Methaneethorn J et al. | A pharmacokinetic drug-drug interaction model of simvastatin and clarithromycin in humans. | 2014 | Conf Proc IEEE Eng Med Biol Soc | pmid:25571290 |
| El-Garem Y et al. | Seminal Helicobacter pylori treatment improves sperm motility in infertile asthenozoospermic men. | 2014 | Urology | pmid:25432826 |
| Kim SY et al. | [Ten day concomitant therapy is superior to ten day sequential therapy for Helicobacter pylori eradication]. | 2014 | Korean J Gastroenterol | pmid:25420735 |
| Mustafa G and Necati B | Clarithromycin-associated rhabdomyolysis in an infant. | 2014 | J Clin Rheumatol | pmid:25417692 |
| Matongo F and Nwodo UU | In vitro assessment of Helicobacter pylori ureases inhibition by honey fractions. | 2014 | Arch. Med. Res. | pmid:25240315 |
| Martos M et al. | Clarithromycin for first-line treatment of Helicobacter pylori infection after culture in high-resistance regions. | 2014 | Eur J Gastroenterol Hepatol | pmid:25229983 |
| Veraldi S et al. | Treatment of sporotrichoid fish tank granuloma with pulsed clarithromycin. | 2014 | Dermatology (Basel) | pmid:25228273 |
| Phillips RO et al. | Reply to "compliance with antimicrobial therapy for buruli ulcer". | 2014 | Antimicrob. Agents Chemother. | pmid:25225343 |
| Klis S et al. | Compliance with antimicrobial therapy for buruli ulcer. | 2014 | Antimicrob. Agents Chemother. | pmid:25225342 |
| Bilgin M et al. | Acute coronary syndrome secondary to clarithromycin: the first case and review of the literature. | 2014 | Turk Kardiyol Dern Ars | pmid:25080953 |
| Hsu PI et al. | Randomized controlled trial comparing 7-day triple, 10-day sequential, and 7-day concomitant therapies for Helicobacter pylori infection. | 2014 | Antimicrob. Agents Chemother. | pmid:25070099 |
| Patel SK et al. | Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study. | 2014 | Biomed Res Int | pmid:25054141 |
| Elkhatib W and Noreddin A | Efficacy of ciprofloxacin-clarithromycin combination against drug-resistant Pseudomonas aeruginosa mature biofilm using in vitro experimental model. | 2014 | Microb. Drug Resist. | pmid:25050970 |
| Ohe M and Bohgaki T | Successful treatment with clarithromycin for patients with polymyalgia rheumatica. | 2014 | Korean J. Intern. Med. | pmid:25045305 |
| Martin JH and Coombes I | Mortality from common drug interactions systems, knowledge and clinical reasoning to optimise prescribing. | 2014 | Intern Med J | pmid:25041768 |
| Dalbøge CS et al. | Pharmacokinetic variability of clarithromycin and differences in CYP3A4 activity in patients with cystic fibrosis. | 2014 | J. Cyst. Fibros. | pmid:24035278 |
| Sugimoto M and Furuta T | Efficacy of tailored Helicobacter pylori eradication therapy based on antibiotic susceptibility and CYP2C19 genotype. | 2014 | World J. Gastroenterol. | pmid:24914361 |
| Heo J and Jeon SW | Optimal treatment strategy for Helicobacter pylori: era of antibiotic resistance. | 2014 | World J. Gastroenterol. | pmid:24914324 |
| Glatz M and Muellegger RR | Drug-associated aquagenic wrinkling of the palms in an atopic male patient. | 2014 | BMJ Case Rep | pmid:24903725 |
| DiCicco M et al. | In vitro synergism of fosfomycin and clarithromycin antimicrobials against methicillin-resistant Staphylococcus pseudintermedius. | 2014 | BMC Microbiol. | pmid:24886369 |
| Noonan KA et al. | Targeting immune suppression with PDE5 inhibition in end-stage multiple myeloma. | 2014 | Cancer Immunol Res | pmid:24878583 |
| Gong EJ et al. | Meta-analysis of first-line triple therapy for helicobacter pylori eradication in Korea: is it time to change? | 2014 | J. Korean Med. Sci. | pmid:24851029 |
| Jeon HK and Kim GH | Does standard triple therapy still have a role in first-line Helicobacter pylori eradication in Korea? | 2014 | J. Korean Med. Sci. | pmid:24851014 |
| Ikawa K et al. | Pharmacokinetic modelling of serum and bronchial concentrations for clarithromycin and telithromycin, and site-specific pharmacodynamic simulation for their dosages. | 2014 | J Clin Pharm Ther | pmid:24661290 |
| Varvyanskaya A and Lopatin A | Efficacy of long-term low-dose macrolide therapy in preventing early recurrence of nasal polyps after endoscopic sinus surgery. | 2014 | Int Forum Allergy Rhinol | pmid:24659566 |
| Lee SH et al. | Detection and assessment of clarithromycin inducible resistant strains among Korean Mycobacterium abscessus clinical strains: PCR methods. | 2014 | J. Clin. Lab. Anal. | pmid:24652818 |
| Binh TT et al. | Discovery of novel mutations for clarithromycin resistance in Helicobacter pylori by using next-generation sequencing. | 2014 | J. Antimicrob. Chemother. | pmid:24648504 |
| Tursi A et al. | Decreasing efficacy of the standard seven-day triple therapy containing amoxycillin and clarithromycin in curing Helicobacter pylori infection in clinical setting in Italy: a 10-year follow-up study. | 2014 | Panminerva Med | pmid:24637473 |
| Wei Z et al. | Rome III criteria cannot distinguish patients with chronic gastritis from those functional dyspepsia patients. | 2014 | Helicobacter | pmid:24617669 |
| Rizzo A et al. | Antimicrobial effect of natural polyphenols with or without antibiotics on Chlamydia pneumoniae infection in vitro. | 2014 | Microb. Drug Resist. | pmid:23952319 |
| Wu JY et al. | Feasibility of shortening 14-day hybrid therapy while maintaining an excellent Helicobacter pylori eradication rate. | 2014 | Helicobacter | pmid:24612093 |
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| Zhang J et al. | Ocular penetration and pharmacokinetics of topical clarithromycin eye drops to rabbits. | 2014 | J Ocul Pharmacol Ther | pmid:24199739 |
| Skvarc M et al. | Multi locus sequence typing (MLST) used as a tool to confirm the ability of susceptible Helicobacter pylori strains to gain resistance to clarithromycin during eradication therapy. | 2014 Jan-Feb | Hepatogastroenterology | pmid:24895826 |
| UÄŸurlu T et al. | Optimization and evaluation of clarithromycin floating tablets using experimental mixture design. | 2014 Mar-Apr | Acta Pol Pharm | pmid:25272652 |
| Picoli SU et al. | Resistance to amoxicillin, clarithromycin and ciprofloxacin of Helicobacter pylori isolated from Southern Brazil patients. | 2014 May-Jun | Rev. Inst. Med. Trop. Sao Paulo | pmid:24878996 |
| Sprague J et al. | Cutaneous infection with Mycobacterium kansasii in a patient with myelodysplastic syndrome and Sweet syndrome. | 2015 | Cutis | pmid:26244358 |
| Sharara AI et al. | Letter: clarithromycin dose for H. pylori therapy remains unresolved--authors' reply. | 2015 | Aliment. Pharmacol. Ther. | pmid:26238584 |
| Graham DY and Gisbert JP | Letter: clarithromycin dose for H. pylori therapy remains unresolved. | 2015 | Aliment. Pharmacol. Ther. | pmid:26238583 |
| Navarro-Jarabo JM et al. | Prevalence of Primary Resistance of Helicobacter pylori to Clarithromycin and Levofloxacin in Southern Spain. | 2015 | Digestion | pmid:26227669 |
| Ufuk A et al. | In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383. | 2015 | Pharm. Res. | pmid:26224396 |
| Cohen O et al. | Colchicine-clarithromycin-induced rhabdomyolysis in Familial Mediterranean Fever patients under treatment for Helicobacter pylori. | 2015 | Rheumatol. Int. | pmid:26210999 |
| Chou HW et al. | Risks of cardiac arrhythmia and mortality among patients using new-generation macrolides, fluoroquinolones, and β-lactam/β-lactamase inhibitors: a Taiwanese nationwide study. | 2015 | Clin. Infect. Dis. | pmid:25409476 |
| Jeong BH et al. | Intermittent antibiotic therapy for nodular bronchiectatic Mycobacterium avium complex lung disease. | 2015 | Am. J. Respir. Crit. Care Med. | pmid:25393520 |
| Hill FJ et al. | From a fish tank injury to hospital haemodialysis: the serious consequences of drug interactions. | 2015 | BMJ Case Rep | pmid:26106178 |
| Yu T et al. | Study on clarithromycin lactobionate based dual selector systems for the enantioseparation of basic drugs in capillary electrophoresis. | 2015 | J Sep Sci | pmid:26097042 |
| Trotti LM et al. | Clarithromycin in γ-aminobutyric acid-Related hypersomnolence: A randomized, crossover trial. | 2015 | Ann. Neurol. | pmid:26094838 |
| Tai WC et al. | Seven-Day Nonbismuth Containing Quadruple Therapy Could Achieve a Grade "A" Success Rate for First-Line Helicobacter pylori Eradication. | 2015 | Biomed Res Int | pmid:26090428 |
| Nguyen AT et al. | Use of Topical Besifloxacin in the Treatment of Mycobacterium chelonae Ocular Surface Infections. | 2015 | Cornea | pmid:26075451 |
| AktaÅŸ B et al. | The impact of amalgam dental fillings on the frequency of Helicobacter pylori infection and H. pylori eradication rates in patients treated with concomitant, quadruple, and levofloxacin-based therapies. | 2015 | Eur J Gastroenterol Hepatol | pmid:25919773 |
| Lam A et al. | Itraconazole and clarithromycin inhibit P-glycoprotein activity in primary human sinonasal epithelial cells. | 2015 | Int Forum Allergy Rhinol | pmid:25907295 |
| Luo RF et al. | Rapid Detection of Acquired and Inducible Clarithromycin Resistance in Mycobacterium abscessus Group by a Simple Real-Time PCR Assay. | 2015 | J. Clin. Microbiol. | pmid:25903572 |
| Mitsui Y et al. | Gastric inflammatory fibroid polyp morphologically changed by Helicobacter pylori eradication. | 2015 | Clin J Gastroenterol | pmid:25733031 |
| Ben Chaabane N and Al-Adhba HS | Ciprofloxacin-containing versus clarithromycin-containing sequential therapy for Helicobacter pylori eradication: A randomized trial. | 2015 | Indian J Gastroenterol | pmid:25721770 |
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| Aoki H et al. | Clarithromycin highly-loaded gastro-floating fine granules prepared by high-shear melt granulation can enhance the efficacy of Helicobacter pylori eradication. | 2015 | Eur J Pharm Biopharm | pmid:25703356 |
| Baysal B et al. | Effect of pantoprazole and Helicobacter pylori therapy on uninvestigated dyspeptic patients. | 2015 | Turk J Gastroenterol | pmid:25698264 |
| Blix HS et al. | Antibiotic prescriptions and cycles of Mycoplasma pneumoniae infections in Norway: can a nationwide prescription register be used for surveillance? | 2015 | Epidemiol. Infect. | pmid:25388750 |
| Brown-Elliott BA et al. | Absence of a functional erm gene in isolates of Mycobacterium immunogenum and the Mycobacterium mucogenicum group, based on in vitro clarithromycin susceptibility. | 2015 | J. Clin. Microbiol. | pmid:25568437 |
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| Li DQ et al. | Risk of adverse events among older adults following co-prescription of clarithromycin and statins not metabolized by cytochrome P450 3A4. | 2015 | CMAJ | pmid:25534598 |
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| Park JB et al. | Modulation of microenvironmental pH and utilization of alkalizers in crystalline solid dispersion for enhanced solubility and stability of clarithromicin. | 2015 | Arch. Pharm. Res. | pmid:25213008 |
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| John A et al. | Does emerging Clarithromycin resistance signal an obituary to empirical standard triple therapy for Helicobacter pylori infection? | 2015 | Indian J Gastroenterol | pmid:26541342 |
| Mel-Hennawi D and Ahmed MR | Outcome evaluation of clarithromycin, metronidazole and lansoprazole regimens in Helicobacter pylori positive or negative children with resistant otitis media with effusion. | 2015 | J Laryngol Otol | pmid:26521817 |
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| Xing J et al. | The application of high-resolution mass spectrometry-based data-mining tools in tandem to metabolite profiling of a triple drug combination in humans. | 2015 | Anal. Chim. Acta | pmid:26515003 |
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| Bérard A et al. | Use of macrolides during pregnancy and the risk of birth defects: a population-based study. | 2015 | Pharmacoepidemiol Drug Saf | pmid:26513406 |
| Weiss S et al. | Efficacy of Single and Combined Antibiotic Treatments of Anthrax in Rabbits. | 2015 | Antimicrob. Agents Chemother. | pmid:26392505 |
| Agrawal V et al. | A Case of Hypotension and Bradycardia Precipitated by Drug Interaction of Clarithromycin and Calcium-Channel Blocker. | 2015 | J Am Geriatr Soc | pmid:26389998 |
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| Glocker EO | The Need for Resistance Surveillance and Antimicrobial Susceptibility Testing of Helicobacter pylori. | 2015 | Digestion | pmid:26372776 |
| Bruhn DF et al. | In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics. | 2015 | Sci Rep | pmid:26365087 |
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