clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Gram-Negative Bacterial Infections D016905 16 associated lipids
Angiomatosis, Bacillary D016917 2 associated lipids
Meningitis, Bacterial D016920 6 associated lipids
Common Variable Immunodeficiency D017074 4 associated lipids
AIDS-Related Opportunistic Infections D017088 9 associated lipids
IgA Deficiency D017098 2 associated lipids
Liver Failure, Acute D017114 11 associated lipids
Skin Diseases, Bacterial D017192 8 associated lipids
Dermatitis, Phototoxic D017484 4 associated lipids
Pityriasis Rosea D017515 3 associated lipids
Cutaneous Fistula D017577 1 associated lipids
Kleine-Levin Syndrome D017593 1 associated lipids
Periodontal Attachment Loss D017622 7 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Cytomegalovirus Retinitis D017726 2 associated lipids
Tuberculosis, Multidrug-Resistant D018088 6 associated lipids
Cardiovascular Abnormalities D018376 2 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Soft Tissue Infections D018461 2 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Cryptogenic Organizing Pneumonia D018549 3 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Gingival Overgrowth D019214 7 associated lipids
Tooth, Nonvital D019553 2 associated lipids
alpha 1-Antitrypsin Deficiency D019896 3 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Central Nervous System Protozoal Infections D020808 3 associated lipids
Epilepsy, Partial, Motor D020938 1 associated lipids
Chlamydophila Infections D023521 4 associated lipids
Desulfovibrionaceae Infections D045824 5 associated lipids
Renal Insufficiency D051437 8 associated lipids
Immune Reconstitution Inflammatory Syndrome D054019 1 associated lipids
Buruli Ulcer D054312 1 associated lipids
Extensively Drug-Resistant Tuberculosis D054908 1 associated lipids
Leprosy, Paucibacillary D056005 2 associated lipids
Upper Extremity Deep Vein Thrombosis D056824 1 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Sacroiliitis D058566 1 associated lipids
Chlamydial Pneumonia D061387 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Per page 10 20 50 100 | Total 7636
Authors Title Published Journal PubMed Link
Witt A et al. Placental passage of clarithromycin surpasses other macrolide antibiotics. 2003 Am. J. Obstet. Gynecol. pmid:12634663
Gascón A et al. Catheter salvage in a patient on hemodialysis with a catheter-related bacteremia by Pseudomonas aeruginosa. Usefulness of clarithromycin. 2000 Nov-Dec Am. J. Nephrol. pmid:11146320
Gokturk HS et al. Does long-term aspirin use have any effect on Helicobacter pylori eradication? 2011 Am. J. Med. Sci. pmid:21642817
Brener ZZ et al. Rhabdomyolysis following clarithromycin monotherapy. 2009 Am. J. Med. Sci. pmid:19474653
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Butt AA Cervical adenitis due to Mycobacterium fortuitum in patients with acquired immunodeficiency syndrome. 1998 Am. J. Med. Sci. pmid:9427575
Baciewicz AM et al. Update on rifampin and rifabutin drug interactions. 2008 Am. J. Med. Sci. pmid:18277121
Santos MA et al. Nothing to (S)cough at: Pulmonary Mycobacterium avium Complex Infection. 2017 Am. J. Med. pmid:27984010
Curtis LH et al. Prescription of QT-prolonging drugs in a cohort of about 5 million outpatients. 2003 Am. J. Med. pmid:12586234
Nayyar E and Taimur S Sporotrichoid lesions: an age-old conundrum. 2015 Am. J. Med. pmid:26021809
Jaber BL et al. The serotonin syndrome complicating co-prescription of paroxetine and clarithromycin. 2006 Am. J. Med. pmid:16564762
Cicconi V et al. Disappearance of antiphospholipid antibodies syndrome after Helicobacter pylori eradication. 2001 Am. J. Med. pmid:11501549
Siddiqui J Immunomodulatory effects of macrolides: implications for practicing clinicians. 2004 Am. J. Med. pmid:15586561
Tamaoki J et al. Clinical implications of the immunomodulatory effects of macrolides. 2004 Am. J. Med. pmid:15586558
Abisheganaden JA et al. Effect of clarithromycin on experimental rhinovirus-16 colds: a randomized, double-blind, controlled trial. 2000 Am. J. Med. pmid:10781777
Gotfried MH Epidemiology of clinically diagnosed community-acquired pneumonia in the primary care setting: results from the 1999-2000 respiratory surveillance program. 2001 Am. J. Med. pmid:11755440
Sherman PM Appropriate strategies for testing and treating Helicobacter pylori in children: when and how? 2004 Am. J. Med. pmid:15478850
Sokol W Epidemiology of sinusitis in the primary care setting: results from the 1999-2000 respiratory surveillance program. 2001 Am. J. Med. pmid:11755439
Pfaller MA et al. Frequency of pathogen occurrence and antimicrobial susceptibility among community-acquired respiratory tract infections in the respiratory surveillance program study: microbiology from the medical office practice environment. 2001 Am. J. Med. pmid:11755437
Lee KL et al. QT prolongation and Torsades de Pointes associated with clarithromycin. 1998 Am. J. Med. pmid:9576415
Hunt RH Eradication of Helicobacter pylori infection. 1996 Am. J. Med. pmid:8644782
Stasi R et al. Helicobacter pylori eradication in the management of patients with idiopathic thrombocytopenic purpura. 2005 Am. J. Med. pmid:15808140
Steinman MA and Steinman TI Clarithromycin-associated visual hallucinations in a patient with chronic renal failure on continuous ambulatory peritoneal dialysis. 1996 Am. J. Kidney Dis. pmid:8546130
Wang YL et al. Noninvasive stool antigen assay can effectively screen Helicobacter pylori Infection and assess success of eradication therapy in hemodialysis patients. 2001 Am. J. Kidney Dis. pmid:11431188
Mendu ML and Waikar SS Drug-drug interactions and acute kidney injury: caveat prescriptor. 2014 Am. J. Kidney Dis. pmid:24820318
Okada S et al. Angiocentric immunoproliferative lesions of the lung associated with diffuse renal involvement. 2002 Am. J. Kidney Dis. pmid:11877592
Mak SK et al. Efficacy of a 1-week course of proton-pump inhibitor-based triple therapy for eradicating Helicobacter pylori in patients with and without chronic renal failure. 2002 Am. J. Kidney Dis. pmid:12200810
Sekkarie MA Torsades de pointes in two chronic renal failure patients treated with cisapride and clarithromycin. 1997 Am. J. Kidney Dis. pmid:9292575
Keenan N et al. Mycobacterium simiae: a previously undescribed pathogen in peritoneal dialysis peritonitis. 2005 Am. J. Kidney Dis. pmid:15861339
Shaulov A et al. Progressive refractory light chain amyloidosis and multiple myeloma patients are responsive to the addition of clarithromycin to IMiD based therapy. 2017 Am. J. Hematol. pmid:27804150
Gaur S et al. Bronchus-associated lymphoid tissue lymphoma arising in a patient with bronchiectasis and chronic Mycobacterium avium infection. 2004 Am. J. Hematol. pmid:15307101
Rostami N et al. Effect of eradication of Helicobacter pylori on platelet recovery in patients with chronic idiopathic thrombocytopenic purpura: a controlled trial. 2008 Am. J. Hematol. pmid:18183613
Ghosh N et al. Clarithromycin overcomes resistance to lenalidomide and dexamethasone in multiple myeloma. 2014 Am. J. Hematol. pmid:24723438
Gay F et al. Clarithromycin (Biaxin)-lenalidomide-low-dose dexamethasone (BiRd) versus lenalidomide-low-dose dexamethasone (Rd) for newly diagnosed myeloma. 2010 Am. J. Hematol. pmid:20645430
Mirabile A et al. MALT lymphoma and Kaposi sarcoma in an HIV-negative patient. 2010 Am. J. Hematol. pmid:20721890
Adamek RJ et al. Modified short-term triple therapy--ranitidine, clarithromycin, and metronidazole--for cure of Helicobacter pylori infection. 1995 Am. J. Gastroenterol. pmid:7801936
Gisbert JP et al. Esomeprazole-based therapy in Helicobacter pylori eradication: any effect by increasing the dose of esomeprazole or prolonging the treatment? 2005 Am. J. Gastroenterol. pmid:16128936
Pamuk ON et al. Are Turkish Helicobacter pylori strains gaining resistance against clarithromycin? 2000 Am. J. Gastroenterol. pmid:10926000
Sontag SJ et al. Reduced symptoms and need for antisecretory therapy in veterans 3 years after Helicobacter pylori eradication with ranitidine bismuth citrate/amoxicillin/clarithromycin. 2001 Am. J. Gastroenterol. pmid:11374672
Laine L et al. Bismuth-based quadruple therapy using a single capsule of bismuth biskalcitrate, metronidazole, and tetracycline given with omeprazole versus omeprazole, amoxicillin, and clarithromycin for eradication of Helicobacter pylori in duodenal ulcer patients: a prospective, randomized, multicenter, North American trial. 2003 Am. J. Gastroenterol. pmid:12650788
Kume K et al. Disappearance of both MALT lymphoma and hyperplastic polyps in the stomach after eradication of Helicobacter pylori. 2001 Am. J. Gastroenterol. pmid:11569719
al-Assi MT et al. Clarithromycin, tetracycline, and bismuth: a new non-metronidazole therapy for Helicobacter pylori infection. 1994 Am. J. Gastroenterol. pmid:8053435
Savarino V et al. What is the meaning of ranitidine in successful triple-therapy against Helicobacter pylori infection? 1995 Am. J. Gastroenterol. pmid:8540537
Gisbert JP et al. Response to article by Forné et al. 1996 Am. J. Gastroenterol. pmid:8561132
Uygun A et al. Low efficacy of ranitidine bismuth citrate plus clarithromycin combination on Helicobacter pylori in a Turkish population. 1999 Am. J. Gastroenterol. pmid:10520880
Cremonini F et al. Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study. 2002 Am. J. Gastroenterol. pmid:12425542
Peterson WL et al. Clarithromycin as monotherapy for eradication of Helicobacter pylori: a randomized, double-blind trial. 1993 Am. J. Gastroenterol. pmid:8237933
Nista EC et al. Levofloxacin-based triple therapy in first-line treatment for Helicobacter pylori eradication. 2006 Am. J. Gastroenterol. pmid:16968503
van Zanten SV and Thompson K Should the presence of polymorphisms of CYP2C19 enzymes influence the choice of the proton pump inhibitor for treatment of Helicobacter pylori infection? 2006 Am. J. Gastroenterol. pmid:16863548
Froehlich F et al. Helicobacter pylori eradication treatment does not benefit patients with nonulcer dyspepsia. 2001 Am. J. Gastroenterol. pmid:11513170
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Coelho LG et al. Once-daily Helicobacter pylori treatment to family members of gastric cancer patients. 2000 Am. J. Gastroenterol. pmid:10710099
Pilotto A et al. In vitro activity of rifabutin against strains of Helicobacter pylori resistant to metronidazole and clarithromycin. 2000 Am. J. Gastroenterol. pmid:10710100
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Bardhan KD et al. Ranitidine bismuth citrate with clarithromycin given twice daily effectively eradicates Helicobacter pylori and heals duodenal ulcers. 1998 Am. J. Gastroenterol. pmid:9517644
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