clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sugihara J et al. | [Efficacy of clarithromycin on chronic paranasal sinusitis--a comparison between children and adult]. | 1997 | Jpn J Antibiot | pmid:9597431 |
Hamada K et al. | [Evaluation of antineoplastic effect of CAM (clarithromycin) in a mouse model inoculated with lung cancer cells]. | 1997 | Jpn J Antibiot | pmid:9597434 |
Kokubo Y et al. | [Effects of clarithromycin on experimental pulmonary metastasis]. | 1997 | Jpn J Antibiot | pmid:9597436 |
Sakamoto M et al. | [Efficacy of clarithromycin on cancer cachexia in patients with primary non-small cell lung cancer]. | 1997 | Jpn J Antibiot | pmid:9597437 |
Teramoto S et al. | [Fluctuation in the cytokine m-RNA content in primary non-small cell lung cancer caused by clarithromycin (CAM) administration]. | 1997 | Jpn J Antibiot | pmid:9597438 |
Mikasa K et al. | [Effect of clarithromycin on prolonging the life expectancy of patients with primary lung cancer]. | 1997 | Jpn J Antibiot | pmid:9597439 |
Takeda H et al. | [Macrolide antibiotic actions on bacteria and cultured airway cells]. | 1997 | Jpn J Antibiot | pmid:9597448 |
Mita Y et al. | [Vitamin D3 induction of differentiation of HL-60 cells to monocyte- like cells and their aggregation--a dynamic culture method and clarithromycin]. | 1997 | Jpn J Antibiot | pmid:9597462 |
Yanagihara K et al. | [Analysis of chronic respiratory tract infection by using an intubation model--evaluation based on fluctuations in cytokine content]. | 1997 | Jpn J Antibiot | pmid:9597463 |
Konishi M et al. | [Log-term administration of clarithromycin as a possible adjuvant therapy of HIV infections]. | 1997 | Jpn J Antibiot | pmid:9597467 |
Iino Y et al. | [Immunohistochemical study of the paranasal sinus mucosa of patients being treated with macrolide antibiotics--effects of antigen-presenting cells on the expression of a costimulator]. | 1998 | Jpn J Antibiot | pmid:9597477 |
Salgado CG et al. | [Study on the effects of macrolide antibiotics on the expression of B7-1, B7-2, and CD40 on epidermal Langerhans cells]. | 1998 | Jpn J Antibiot | pmid:9597478 |
Isono K et al. | [Effects of macrolide antibiotics on neutrophil infiltration into the airway mucosa and ICAM-1 expression]. | 1998 | Jpn J Antibiot | pmid:9597480 |
Enomoto F et al. | [Changes in adhesion molecule expressions in neutrophils caused by new macrolide administration]. | 1998 | Jpn J Antibiot | pmid:9597482 |
Ieshiro R et al. | [Effect of clarithromycin in extending the life expectancy of patients with non-small-cell lung cancer--the second report]. | 1998 | Jpn J Antibiot | pmid:9597484 |
Sakamoto M et al. | [Efficacy of clarithromycin (CAM) in patients with inoperable non-small-cell lung cancer]. | 1998 | Jpn J Antibiot | pmid:9597485 |
Teramoto S et al. | [Effect of clarithromycin administration on interferon-gamma and interleukin 12 mRNA expression in the tumor tissue of non-small-cell lung cancer]. | 1998 | Jpn J Antibiot | pmid:9597486 |
Ueta K et al. | [Evaluation of BRM (biological response modifier) action of clarithromycin (CAM)--effect on cytokine expression in a mouse lung cancer model]. | 1998 | Jpn J Antibiot | pmid:9597487 |
Kokubo Y et al. | [Effect of clarithromycin on experimental pulmonary metastasis]. | 1998 | Jpn J Antibiot | pmid:9597488 |
Yano S et al. | [Significance of therapeutic efficacy of clarithromycin in a model for human lung cancer metastasis and a mouse tumor system]. | 1998 | Jpn J Antibiot | pmid:9597491 |
Sasa K et al. | [Antineoplastic therapeutic effect of clarithromycin in rats]. | 1998 | Jpn J Antibiot | pmid:9597492 |
Miyamoto N et al. | [Test to set dosages for long-term administration of clarithromycin to treat chronic paranasal sinusitis]. | 1998 | Jpn J Antibiot | pmid:9597498 |
Fujita K et al. | [Neutrophil count and IL-8 level of nasal secretion of patients with chronic paranasal sinusitis and the effects of macrolide antibiotics]. | 1998 | Jpn J Antibiot | pmid:9597505 |
Harris A | Current regimens for treatment of Helicobacter pylori infection. | 1998 | Br. Med. Bull. | pmid:9604443 |
Doherty TM and Sher A | IL-12 promotes drug-induced clearance of Mycobacterium avium infection in mice. | 1998 | J. Immunol. | pmid:9605144 |
Moayyedi P et al. | Relevance of antibiotic sensitivities in predicting failure of omeprazole, clarithromycin, and tinidazole to eradicate Helicobacter pylori. | 1998 | J. Gastroenterol. | pmid:9605943 |
Gavura SR and Nusinowitz S | Leukocytoclastic vasculitis associated with clarithromycin. | 1998 | Ann Pharmacother | pmid:9606474 |
Ramon PM et al. | [Uveitis, arthralgia and pseudo-jaundice in a HIV seronegative patient due to rifabutin]. | 1998 | Rev Mal Respir | pmid:9608993 |
Lilley LL and Guanci R | A dangerous combination. | 1998 | Am J Nurs | pmid:9612423 |
Fischer BP et al. | [Tsutsugamushi fever. Rare rickettsiosis after a stay in the Philippines]. | 1998 | Dtsch. Med. Wochenschr. | pmid:9615696 |
Torresani C | Clarithromycin: a new perspective in rosacea treatment. | 1998 | Int. J. Dermatol. | pmid:9620480 |
Kruppa A et al. | Immediate reaction to roxithromycin and prick test cross-sensitization to erythromycin and clarithromycin. | 1998 | Dermatology (Basel) | pmid:9621142 |
Tsuneoka H et al. | [Sensitivity of Helicobacter pylori to amoxicillin and clarythromycin with special reference to eradication therapy]. | 1998 | Kansenshogaku Zasshi | pmid:9621560 |
Roussel G and Igual J | Clarithromycin with minocycline and clofazimine for Mycobacterium avium intracellulare complex lung disease in patients without the acquired immune deficiency syndrome. GETIM. Groupe d'Etude et de Traitement des Infections à Mycobactéries. | 1998 | Int. J. Tuberc. Lung Dis. | pmid:9626603 |
Archimandritis A et al. | Clostridium difficile colitis associated with a 'triple' regimen, containing clarithromycin and metronidazole, to eradicate Helicobacter pylori. | 1998 | J. Intern. Med. | pmid:9627163 |
Petersen AM et al. | [Resistance of Helicobacter pylori to clarithomycin]. | 1998 | Ugeskr. Laeg. | pmid:9627511 |
Domingo D et al. | High frequency of mutations at position 2144 of the 23S rRNA gene in clarithromycin-resistant Helicobacter pylori strains isolated in Spain. | 1998 | J. Antimicrob. Chemother. | pmid:9630414 |
Fireman Z et al. | Helicobacter pylori and peptic ulcer disease therapies: a survey of gastroenterologists in Israel. | 1998 | Helicobacter | pmid:9631306 |
Battaglia G et al. | Optimal PPI-based triple therapy for the cure of Helicobacter pylori infection: a single center comparison of four 14-day schedules. | 1998 | Helicobacter | pmid:9631310 |
Miwa H et al. | Effectiveness of omeprazole-amoxicillin-clarithromycin (OAC) therapy for Helicobacter pylori infection in a Japanese population. | 1998 | Helicobacter | pmid:9631313 |
Calvet Calvo X | [Treatment of Helicobacter pylori infections]. | 1998 | Gastroenterol Hepatol | pmid:9633184 |
Burman WJ et al. | AIDS-related Mycobacterium kansasii infection with initial resistance to clarithromycin. | 1998 | Diagn. Microbiol. Infect. Dis. | pmid:9635911 |
Nordt SP et al. | Clarithromycin induced digoxin toxicity. | 1998 | J Accid Emerg Med | pmid:9639187 |
Gray VS | Syncopal episodes associated with cisapride and concurrent drugs. | 1998 | Ann Pharmacother | pmid:9640482 |
Grove DI et al. | Comparison of culture, histopathology and urease testing for the diagnosis of Helicobacter pylori gastritis and susceptibility to amoxycillin, clarithromycin, metronidazole and tetracycline. | 1998 | Pathology | pmid:9643503 |
Makhani S et al. | Atypical cervico-facial mycobacterial infections in childhood. | 1998 | Br J Oral Maxillofac Surg | pmid:9643597 |
Wharton JR et al. | Erythrasma treated with single-dose clarithromycin. | 1998 | Arch Dermatol | pmid:9645634 |
Shimoyama T et al. | [Antibiotic therapy in eradicating Helicobacter pylori infections]. | 1998 | Nippon Naika Gakkai Zasshi | pmid:9648426 |
Kimura K and Sato K | [Recent topics on Helicobacter pylori--Historic background and problems caused by bacteria]. | 1998 | Nippon Naika Gakkai Zasshi | pmid:9648427 |
Aoyama N | [Efficacy of antibiotic therapy in eradicating Helicobacter pylori]. | 1998 | Nippon Naika Gakkai Zasshi | pmid:9648439 |
Sato R et al. | [Problems following antibiotic therapy for eradication of Helicobacter pylori]. | 1998 | Nippon Naika Gakkai Zasshi | pmid:9648440 |
Nakamura T et al. | [Topics on Helicobacter pylori (discussion)]. | 1998 | Nippon Naika Gakkai Zasshi | pmid:9648442 |
Parente F et al. | Effects of Helicobacter pylori eradication on gastric function indices in functional dyspepsia. A prospective controlled study. | 1998 | Scand. J. Gastroenterol. | pmid:9648983 |
Moshkowitz M et al. | One-week triple therapy with omeprazole, clarithromycin, and nitroimidazole for Helicobacter pylori infection in children and adolescents. | 1998 | Pediatrics | pmid:9651466 |
Wiedermann BL | Macrolides: clarithromycin and azithromycin. | 1998 | Pediatr Rev | pmid:9654947 |
Klein JO | Clarithromycin and azithromycin. | 1998 | Pediatr. Infect. Dis. J. | pmid:9655546 |
Amsden GW et al. | Oral cimetidine prolongs clarithromycin absorption. | 1998 | Antimicrob. Agents Chemother. | pmid:9660986 |
Spinzi GC et al. | Comparison of omeprazole and lansoprazole in short-term triple therapy for Helicobacter pylori infection. | 1998 | Aliment. Pharmacol. Ther. | pmid:9663722 |
Bazzoli F et al. | Evaluation of short-term low-dose triple therapy for the eradication of Helicobacter pylori by factorial design in a randomized, double-blind, controlled study. | 1998 | Aliment. Pharmacol. Ther. | pmid:9663723 |
Pozzato P et al. | Ranitidine bismuth citrate plus clarithromycin 7-day regimen is effective in eradicating Helicobacter pylori in patients with duodenal ulcer. | 1998 | Aliment. Pharmacol. Ther. | pmid:9663724 |
Goh KL et al. | Comparison of two 1-week low-dose omeprazole triple therapies--optimal treatment for Helicobacter pylori infection? | 1997 | Aliment. Pharmacol. Ther. | pmid:9663838 |
Kolkman JJ et al. | Ranitidine bismuth citrate with clarithromycin versus omeprazole with amoxycillin in the cure of Helicobacter pylori infection. | 1997 | Aliment. Pharmacol. Ther. | pmid:9663840 |
Miyaji H et al. | Susceptibility of Helicobacter pylori isolates to metronidazole, clarithromycin and amoxycillin in vitro and in clinical treatment in Japan. | 1997 | Aliment. Pharmacol. Ther. | pmid:9663841 |
Sanfélix Genovés J et al. | [Helicobacter pylori: 6-day triple therapy in duodenal ulcer]. | 1998 | Aten Primaria | pmid:9670578 |
de Boer WA et al. | Optimal treatment of Helicobacter pylori with ranitidine bismuth citrate (RBC): a randomized comparison between two 7-day triple therapies and a 14-day dual therapy. | 1998 | Am. J. Gastroenterol. | pmid:9672338 |
Dore MP et al. | Demonstration of unexpected antibiotic resistance of genotypically identical Helicobacter pylori isolates. | 1998 | Clin. Infect. Dis. | pmid:9675458 |
Dunne EF et al. | Streptomyces pneumonia in a patient with human immunodeficiency virus infection: case report and review of the literature on invasive streptomyces infections. | 1998 | Clin. Infect. Dis. | pmid:9675460 |
Perri F et al. | Relationship between the results of pre-treatment urea breath test and efficacy of eradication of Helicobacter pylori infection. | 1998 | Ital J Gastroenterol Hepatol | pmid:9675647 |
Talley NJ et al. | Nizatidine in combination with amoxycillin and clarithromycin in the treatment of Helicobacter pylori infection. | 1998 | Aliment. Pharmacol. Ther. | pmid:9678811 |
Ricciardiello L et al. | Efficacy and safety of three 7-day Helicobacter pylori eradication regimens containing ranitidine bismuth citrate. | 1998 | Aliment. Pharmacol. Ther. | pmid:9678812 |
Cammarota G et al. | One-week therapy for Helicobacter pylori eradication: ranitidine bismuth citrate plus medium-dose clarithromycin and either tinidazole or amoxycillin. | 1998 | Aliment. Pharmacol. Ther. | pmid:9678813 |
Louw JA et al. | Two-week course of pantoprazole combined with 1 week of amoxycillin and clarithromycin is effective in Helicobacter pylori eradication and duodenal ulcer healing. | 1998 | Aliment. Pharmacol. Ther. | pmid:9678814 |
Ahuja V et al. | Lansoprazole and secnidazole with clarithromycin, amoxycillin or pefloxacin in the eradication of Helicobacter pylori in a developing country. | 1998 | Aliment. Pharmacol. Ther. | pmid:9678815 |
Grübel P and Cave DR | Factors affecting solubility and penetration of clarithromycin through gastric mucus. | 1998 | Aliment. Pharmacol. Ther. | pmid:9678818 |
Tonai A et al. | [Clarithromycin suppression of DNA synthesis by rat nasal mucosal cells enhanced by endotoxin instillation]. | 1997 | Jpn J Antibiot | pmid:9678983 |
Bordet AL et al. | [Mycobacterium chelonae cutaneous infection: efficacy of prolonged treatment by clarithromycin]. | 1997 | Ann Dermatol Venereol | pmid:9686059 |
Martin SJ and Pendland SL | Bactericidal activity and postantibiotic effect of clarithromycin and 14-hydroxyclarithromycin, alone and in combination, against Legionella pneumophila. | 1998 | J. Antimicrob. Chemother. | pmid:9687103 |
Portaels F et al. | In vitro susceptibility of Mycobacterium ulcerans to clarithromycin. | 1998 | Antimicrob. Agents Chemother. | pmid:9687409 |
Bigard MA et al. | One-week triple therapy using omeprazole, amoxycillin and clarithromycin for the eradication of Helicobacter pylori in patients with non-ulcer dyspepsia: influence of dosage of omeprazole and clarithromycin. | 1998 | Aliment. Pharmacol. Ther. | pmid:9690730 |
Soepandi P et al. | The pattern of micro-organisms and the efficacy of new macrolide in acute lower respiratory tract infections. | 1998 | Respirology | pmid:9692520 |
Bardhan KD et al. | Pantoprazole-based 10-day triple therapy is effective in Helicobacter pylori eradication. | 1998 | Aliment. Pharmacol. Ther. | pmid:9692693 |
Catalano F et al. | Ranitidine bismuth citrate versus omeprazole triple therapy for the eradication of Helicobacter pylori and healing of duodenal ulcer. | 1998 | Aliment. Pharmacol. Ther. | pmid:9692702 |
Dobrilla G et al. | Ranitidine bismuth citrate with either clarithromycin 1 g/day or 1.5 g/day is equally effective in the eradication of H. pylori and healing of duodenal ulcer. | 1998 | Aliment. Pharmacol. Ther. | pmid:9692703 |
Habu Y et al. | Triple therapy with omeprazole, amoxicillin and clarithromycin is effective against Helicobacter pylori infection in gastric ulcer patients as well as in duodenal ulcer patients. Results of a randomized controlled trial in Japan. | 1998 Jul-Aug | Digestion | pmid:9693202 |
Hashimoto Y | [Eradication therapies for Helicobacter pylori]. | 1998 | Kansenshogaku Zasshi | pmid:9695480 |
Wakasugi H et al. | Effect of clarithromycin on renal excretion of digoxin: interaction with P-glycoprotein. | 1998 | Clin. Pharmacol. Ther. | pmid:9695727 |
Hsieh PF et al. | Molecular mechanisms of clarithromycin resistance in Helicobacter pylori. | 1998 | J. Formos. Med. Assoc. | pmid:9700240 |
Fennerty MB et al. | A comparison of 10 and 14 days of lansoprazole triple therapy for eradication of Helicobacter pylori. | 1998 Aug 10-24 | Arch. Intern. Med. | pmid:9701099 |
Takizawa H et al. | Erythromycin and clarithromycin attenuate cytokine-induced endothelin-1 expression in human bronchial epithelial cells. | 1998 | Eur. Respir. J. | pmid:9701415 |
Ellenrieder V et al. | Influence of clarithromycin dosage on pantoprazole combined triple therapy for eradication of Helicobacter pylori. | 1998 | Aliment. Pharmacol. Ther. | pmid:9701524 |
Wang G et al. | Genotypic characterization of clarithromycin-resistant and -susceptible Helicobacter pylori strains from the same patient demonstrates existence of two unrelated isolates. | 1998 | J. Clin. Microbiol. | pmid:9705423 |
van der Wouden EJ et al. | One-week triple therapy with ranitidine bismuth citrate, clarithromycin and metronidazole versus two-week dual therapy with ranitidine bismuth citrate and clarithromycin for Helicobacter pylori infection: a randomized, clinical trial. | 1998 | Am. J. Gastroenterol. | pmid:9707042 |
Burman WJ et al. | Long-term outcomes of treatment of Mycobacterium avium complex bacteremia using a clarithromycin-containing regimen. | 1998 | AIDS | pmid:9708410 |
Fernández Bermejo M and GarcÃa Grávalos R | [Ebrotidine in the eradicating treatment of H. pylori]. | 1998 Jun-Jul | Gastroenterol Hepatol | pmid:9711019 |
Bergmann JS and Woods GL | In vitro activity of antimicrobial combinations against clinical isolates of susceptible and resistant Mycobacterium tuberculosis. | 1998 | Int. J. Tuberc. Lung Dis. | pmid:9712275 |
Améndola R et al. | [Is dental plaque a normal Helicobacter pylori reservoir?]. | 1998 | Acta Gastroenterol. Latinoam. | pmid:9713656 |
Cecchi R and Torelli E | Schönlein-Henoch purpura in association with duodenal ulcer and gastric Helicobacter pylori infection. | 1998 | J. Dermatol. | pmid:9714985 |
Tanahashi T et al. | Analysis of the 13C-urea breath test for detection of Helicobacter pylori infection based on the kinetics of delta-13CO2 using laser spectroscopy. | 1998 | J. Gastroenterol. Hepatol. | pmid:9715426 |
Venuta A et al. | Azithromycin compared with clarithromycin for the treatment of streptococcal pharyngitis in children. | 1998 Jun-Jul | J. Int. Med. Res. | pmid:9718470 |
Nelson KG et al. | Results of operation in Mycobacterium avium-intracellulare lung disease. | 1998 | Ann. Thorac. Surg. | pmid:9725364 |