clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

Cross Reference

Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Diarrhea D003967 32 associated lipids
Diphtheria D004165 2 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Duodenitis D004382 4 associated lipids
Duodenogastric Reflux D004383 2 associated lipids
Dyspepsia D004415 5 associated lipids
Dyspnea D004417 10 associated lipids
Ecchymosis D004438 3 associated lipids
Empyema D004653 3 associated lipids
Empyema, Tuberculous D004654 1 associated lipids
Encephalitis D004660 15 associated lipids
Encephalomyelitis, Acute Disseminated D004673 1 associated lipids
Endometriosis D004715 29 associated lipids
Enterocolitis, Pseudomembranous D004761 8 associated lipids
Ergotism D004881 4 associated lipids
Erythema Nodosum D004893 5 associated lipids
Esophagitis, Peptic D004942 4 associated lipids
Euthyroid Sick Syndromes D005067 1 associated lipids
Exanthema D005076 11 associated lipids
Fever D005334 35 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


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Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Per page 10 20 50 100 | Total 7636
Authors Title Published Journal PubMed Link
FDA approves Biaxin for MAC prophylaxis. Food and Drug Administration. 1995 J Int Assoc Physicians AIDS Care pmid:11363096
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Gelber RH Successful treatment of a lepromatous patient with clarithromycin. 1995 Int. J. Lepr. Other Mycobact. Dis. pmid:7730711
Midoneck SR and Etingin OR Clarithromycin-related toxic effects of digoxin. 1995 N. Engl. J. Med. pmid:7477159
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Englishby VL Case reports of death associated with pseudomembranous colitis and clarithromycin. 1995 Eur J Gastroenterol Hepatol pmid:7496875
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Chin DP and Hopewell PC How to treat bacteraemic Mycobacterium avium complex disease. 1995 Lancet pmid:7564723
Kuhn SM et al. Treatment of Mycobacterium marinum facial abscess using clarithromycin. 1995 Pediatr. Infect. Dis. J. pmid:7567299
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Saito H et al. Therapeutic effect of KRM-1648 with various antimicrobials against Mycobacterium avium complex infection in mice. 1995 Tuber. Lung Dis. pmid:7718848
Hedenmo M and Eriksson BM Liquid chromatographic determination of the macrolide antibiotics roxithromycin and clarithromycin in plasma by automated solid-phase extraction and electrochemical detection. 1995 J Chromatogr A pmid:7719451
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Fukuda Y et al. Combination therapy with mucosal protective agent for the eradication of Helicobacter pylori. 1995 Eur J Gastroenterol Hepatol pmid:8574735
Graham DY Clarithromycin for treatment of Helicobacter pylori infections. 1995 Eur J Gastroenterol Hepatol pmid:8574737
Takimoto T et al. Dual therapy with lansoprazole and clarithromycin for eradication of Helicobacter pylori. 1995 Eur J Gastroenterol Hepatol pmid:8574739
Uemura N et al. Effect of Helicobacter pylori eradication on the healing and recurrence of peptic ulcer: combination therapy with low-dose omeprazole and clarithromycin. 1995 Eur J Gastroenterol Hepatol pmid:8574740
Ishii K et al. In vitro dissolution tests corresponding to the in vivo dissolution of clarithromycin tablets in the stomach and intestine. 1995 Chem. Pharm. Bull. pmid:8575034
Diehl HG [One week triple therapy for eradication of Helicobacter pylori infection: simple and effective]. 1995 Leber Magen Darm pmid:8577220
Götz JM et al. Triple therapy with ranitidine, clarithromycin, and metronidazole in the treatment of Helicobacter pylori. 1995 Scand. J. Gastroenterol. Suppl. pmid:8578230
Pavlopoulou J et al. Randomized controlled study of clarithromycin versus cefaclor suspensions in the treatment of acute otitis media in children. 1995 J Chemother pmid:8904139
Atkinson BA et al. Treatment of Mycobacterium haemophilum infection in a murine model with clarithromycin, rifabutin, and ciprofloxacin. 1995 Antimicrob. Agents Chemother. pmid:8619588
Nishi K et al. [Effect of clarithromycin on symptoms and mucociliary transport in patients with sino-bronchial syndrome]. 1995 Nihon Kyobu Shikkan Gakkai Zasshi pmid:8821993
Piersimoni C et al. Activity of seven antimicrobial agents, alone and in combination, against AIDS-associated isolates of Mycobacterium avium complex. 1995 J. Antimicrob. Chemother. pmid:8830013
Parasakthi N and Goh KL Primary and acquired resistance to clarithromycin among Helicobacter pylori strains in Malaysia. 1995 Am. J. Gastroenterol. pmid:7872306
Kadayifçi A et al. Low dose clarithromycin plus omeprazole eradicates Helicobacter pylori in duodenal ulcer disease. 1995 Am. J. Gastroenterol. pmid:7872307
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Hashisaki GT Update on macrolide antibiotics. 1995 May-Jun Am J Otolaryngol pmid:7661309
Kees F et al. Serum and cellular pharmacokinetics of clarithromycin 500 mg q.d. and 250 mg b.i.d. in volunteers. 1995 May-Jun Infection pmid:7499006
Sternon J et al. Azithromycin compared with clarithromycin in the treatment of adult patients with acute purulent tracheobronchitis: a cost of illness study. 1995 Nov-Dec J. Int. Med. Res. pmid:8746608
Stein GE et al. A preliminary study of clarithromycin versus doxycycline in the treatment of nongonococcal urethritis and mucopurulent cervicitis. 1995 Nov-Dec Pharmacotherapy pmid:8602379
Dalston MO et al. [Clarithromycin combined with pyrimethamine in cerebral toxoplasmosis--a report of 2 cases]. 1995 Oct-Dec Rev. Soc. Bras. Med. Trop. pmid:8668843
Pinzani V et al. [Occurrence of anterior uveitis in a HIV patient treated with rifabutin, ethambutol, clarithromycin]. 1995 Sep-Oct Therapie pmid:8571297
Shafran SD et al. A comparison of two regimens for the treatment of Mycobacterium avium complex bacteremia in AIDS: rifabutin, ethambutol, and clarithromycin versus rifampin, ethambutol, clofazimine, and ciprofloxacin. Canadian HIV Trials Network Protocol 010 Study Group. 1996 N. Engl. J. Med. pmid:8676931
Shimoyama T et al. Validity of various diagnostic tests to evaluate cure of Helicobacter pylori infection. 1996 J. Gastroenterol. pmid:8680535
MacConnachie AM Clarithromycin (klaricid, Abbott). 1996 Intensive Crit Care Nurs pmid:8696027
Meier A et al. Molecular mechanisms of clarithromycin resistance in Mycobacterium avium: observation of multiple 23S rDNA mutations in a clonal population. 1996 J. Infect. Dis. pmid:8699066
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Schouenborg P [Clarithromycin]. 1996 Ugeskr. Laeg. pmid:8686028
Gisbert JP et al. Response to article by Forné et al. 1996 Am. J. Gastroenterol. pmid:8561132
Steinman MA and Steinman TI Clarithromycin-associated visual hallucinations in a patient with chronic renal failure on continuous ambulatory peritoneal dialysis. 1996 Am. J. Kidney Dis. pmid:8546130
Hultén K et al. New pharmacokinetic in vitro model for studies of antibiotic activity against intracellular microorganisms. 1996 Antimicrob. Agents Chemother. pmid:9124830
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Cone LA et al. Mania due to clarithromycin therapy in a patient who was not infected with human immunodeficiency virus. 1996 Clin. Infect. Dis. pmid:8853002
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Dhaenens L et al. In-vitro activities of clarithromycin and other antimicrobial agents against Helicobacter pylori isolated from children. 1996 J. Antimicrob. Chemother. pmid:8877551
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Ji B et al. Bactericidal activity of single dose of clarithromycin plus minocycline, with or without ofloxacin, against Mycobacterium leprae in patients. 1996 Antimicrob. Agents Chemother. pmid:8878595
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Yamamoto T et al. Activity of KRM-1648 alone or in combination with both ethambutol and kanamycin or clarithromycin against Mycobacterium intracellulare infections in beige mice. 1996 Antimicrob. Agents Chemother. pmid:8834892
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Dattwyler RJ et al. Clarithromycin in treatment of early Lyme disease: a pilot study. 1996 Antimicrob. Agents Chemother. pmid:8834900
Versalovic J et al. Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori. 1996 Antimicrob. Agents Chemother. pmid:8834903
Wallace RJ et al. Genetic basis for clarithromycin resistance among isolates of Mycobacterium chelonae and Mycobacterium abscessus. 1996 Antimicrob. Agents Chemother. pmid:8807061
Jaup BK Duodenal ulcer healing after 7-day treatment: a pilot study with lansoprazole, amoxicillin, and clarithromycin. 1996 Helicobacter pmid:9398878
Moayyedi P et al. Comparison of one or two weeks of lansoprazole, amoxicillin, and clarithromycin in the treatment of Helicobacter pylori. 1996 Helicobacter pmid:9398880
Mégraud F and Malfertheiner P Treatment of Helicobacter pylori infection: summary of a meeting at the Fourth United European Gastroenterology Week, September 20, 1995. 1996 Helicobacter pmid:9398889
O'Morain C et al. Double-blind, multicenter, placebo-controlled evaluation of clarithromycin and omeprazole for Helicobacter pylori-associated duodenal ulcer. 1996 Helicobacter pmid:9398893
Lind T et al. Eradication of Helicobacter pylori using one-week triple therapies combining omeprazole with two antimicrobials: the MACH I Study. 1996 Helicobacter pmid:9398894
van der Hulst RW et al. Treatment of Helicobacter pylori infection: a review of the world literature. 1996 Helicobacter pmid:9398908
Welsh L et al. In vitro activities of azithromycin, clarithromycin, erythromycin, and tetracycline against 13 strains of Chlamydia pneumoniae. 1996 Antimicrob. Agents Chemother. pmid:8787907
NIAID study rules out high-dose clarithromycin for AIDS-related MAC. 1996 AIDS Patient Care STDS pmid:11361534
Brenciaglia MI et al. Inhibitory and bactericidal activity of rokitamycin against Helicobacter pylori and morphological alterations. 1996 J Chemother pmid:8981182