clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Splenic Diseases D013158 5 associated lipids
Sexually Transmitted Diseases, Bacterial D015231 5 associated lipids
Ureaplasma Infections D016869 5 associated lipids
Dyspepsia D004415 5 associated lipids
Erythema Nodosum D004893 5 associated lipids
Pyelonephritis D011704 5 associated lipids
Hand Dermatoses D006229 5 associated lipids
Desulfovibrionaceae Infections D045824 5 associated lipids
Meningitis, Bacterial D016920 6 associated lipids
Carcinoma, Basal Cell D002280 6 associated lipids
Syphilis D013587 6 associated lipids
Tuberculosis, Multidrug-Resistant D018088 6 associated lipids
Skin Ulcer D012883 6 associated lipids
Pneumonia, Mycoplasma D011019 6 associated lipids
Bronchiolitis D001988 6 associated lipids
Nocardia Infections D009617 6 associated lipids
Whooping Cough D014917 6 associated lipids
Bronchitis D001991 6 associated lipids
Stomach Diseases D013272 7 associated lipids
Infant, Premature, Diseases D007235 7 associated lipids
Bacteriuria D001437 7 associated lipids
Periodontal Attachment Loss D017622 7 associated lipids
Bronchiectasis D001987 7 associated lipids
Surgical Wound Infection D013530 7 associated lipids
Psychoses, Substance-Induced D011605 7 associated lipids
Chlamydia Infections D002690 7 associated lipids
Prosthesis-Related Infections D016459 7 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Skin Diseases, Infectious D012874 7 associated lipids
Klebsiella Infections D007710 7 associated lipids
Metaplasia D008679 7 associated lipids
Tooth Discoloration D014075 7 associated lipids
Gingival Overgrowth D019214 7 associated lipids
Leprosy D007918 8 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Fistula D005402 8 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Bronchiolitis Obliterans D001989 8 associated lipids
Enterocolitis, Pseudomembranous D004761 8 associated lipids
Renal Insufficiency D051437 8 associated lipids
Lymphadenitis D008199 8 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Arthritis, Infectious D001170 8 associated lipids
Skin Diseases, Bacterial D017192 8 associated lipids
Sinusitis D012852 9 associated lipids
Bacteremia D016470 9 associated lipids
AIDS-Related Opportunistic Infections D017088 9 associated lipids
Periodontal Pocket D010514 9 associated lipids
Obstetric Labor, Premature D007752 9 associated lipids
Otitis Media with Effusion D010034 9 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Authors Title Published Journal PubMed Link
Calvet Calvo X [Treatment of Helicobacter pylori infections]. 1998 Gastroenterol Hepatol pmid:9633184
Burman WJ et al. AIDS-related Mycobacterium kansasii infection with initial resistance to clarithromycin. 1998 Diagn. Microbiol. Infect. Dis. pmid:9635911
Nordt SP et al. Clarithromycin induced digoxin toxicity. 1998 J Accid Emerg Med pmid:9639187
Gray VS Syncopal episodes associated with cisapride and concurrent drugs. 1998 Ann Pharmacother pmid:9640482
Grove DI et al. Comparison of culture, histopathology and urease testing for the diagnosis of Helicobacter pylori gastritis and susceptibility to amoxycillin, clarithromycin, metronidazole and tetracycline. 1998 Pathology pmid:9643503
Makhani S et al. Atypical cervico-facial mycobacterial infections in childhood. 1998 Br J Oral Maxillofac Surg pmid:9643597
Wharton JR et al. Erythrasma treated with single-dose clarithromycin. 1998 Arch Dermatol pmid:9645634
Shimoyama T et al. [Antibiotic therapy in eradicating Helicobacter pylori infections]. 1998 Nippon Naika Gakkai Zasshi pmid:9648426
Kimura K and Sato K [Recent topics on Helicobacter pylori--Historic background and problems caused by bacteria]. 1998 Nippon Naika Gakkai Zasshi pmid:9648427
Aoyama N [Efficacy of antibiotic therapy in eradicating Helicobacter pylori]. 1998 Nippon Naika Gakkai Zasshi pmid:9648439
Sato R et al. [Problems following antibiotic therapy for eradication of Helicobacter pylori]. 1998 Nippon Naika Gakkai Zasshi pmid:9648440
Nakamura T et al. [Topics on Helicobacter pylori (discussion)]. 1998 Nippon Naika Gakkai Zasshi pmid:9648442
Parente F et al. Effects of Helicobacter pylori eradication on gastric function indices in functional dyspepsia. A prospective controlled study. 1998 Scand. J. Gastroenterol. pmid:9648983
Moshkowitz M et al. One-week triple therapy with omeprazole, clarithromycin, and nitroimidazole for Helicobacter pylori infection in children and adolescents. 1998 Pediatrics pmid:9651466
Wiedermann BL Macrolides: clarithromycin and azithromycin. 1998 Pediatr Rev pmid:9654947
Klein JO Clarithromycin and azithromycin. 1998 Pediatr. Infect. Dis. J. pmid:9655546
Amsden GW et al. Oral cimetidine prolongs clarithromycin absorption. 1998 Antimicrob. Agents Chemother. pmid:9660986
Spinzi GC et al. Comparison of omeprazole and lansoprazole in short-term triple therapy for Helicobacter pylori infection. 1998 Aliment. Pharmacol. Ther. pmid:9663722
Bazzoli F et al. Evaluation of short-term low-dose triple therapy for the eradication of Helicobacter pylori by factorial design in a randomized, double-blind, controlled study. 1998 Aliment. Pharmacol. Ther. pmid:9663723
Pozzato P et al. Ranitidine bismuth citrate plus clarithromycin 7-day regimen is effective in eradicating Helicobacter pylori in patients with duodenal ulcer. 1998 Aliment. Pharmacol. Ther. pmid:9663724