clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Gysel M et al. | Torsades de pointes following clarithromycin treatment. | 2013 | Expert Rev Cardiovasc Ther | pmid:24147515 |
Megraud F et al. | Helicobacter pylori resistance to antibiotics in Europe and its relationship to antibiotic consumption. | 2013 | Gut | pmid:22580412 |
Sierra F et al. | Pilot study: miscellaneous therapy is highly successful for Helicobacter pylori eradication. | 2013 | Aliment. Pharmacol. Ther. | pmid:23656465 |
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Odagiri T et al. | Design, synthesis, and biological evaluations of novel 7-[7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-8-methoxyquinolines with potent antibacterial activity against respiratory pathogens. | 2013 | J. Med. Chem. | pmid:23409972 |
Seyedmajidi S et al. | Penbactam for Helicobacter pylori eradication: a randomised comparison of quadruple and triple treatment schedules in an Iranian population. | 2013 | Arab J Gastroenterol | pmid:23622801 |
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Qvist T et al. | First report of lung transplantation in a patient with active pulmonary Mycobacterium simiae infection. | 2013 | Transplant. Proc. | pmid:23267789 |
Secka O et al. | Antimicrobial susceptibility and resistance patterns among Helicobacter pylori strains from The Gambia, West Africa. | 2013 | Antimicrob. Agents Chemother. | pmid:23263004 |
Mueck W et al. | Co-administration of rivaroxaban with drugs that share its elimination pathways: pharmacokinetic effects in healthy subjects. | 2013 | Br J Clin Pharmacol | pmid:23305158 |
Joosten M et al. | Case report: Helicobacter suis infection in a pig veterinarian. | 2013 | Helicobacter | pmid:23551953 |
Unai S et al. | Sternal wound infection caused by Mycobacterium chelonae. | 2013 | J Card Surg | pmid:23941599 |
Faraji F et al. | The effect of Helicobacter pylori eradication on migraine: a randomized, double blind, controlled trial. | 2012 Nov-Dec | Pain Physician | pmid:23159967 |
Eremenko AA et al. | [Effect of clarithromycin on the systemic inflammatory response syndrome severity in patients after myocardial revascularization surgery]. | 2012 May-Jun | Anesteziol Reanimatol | pmid:22993930 |
Singh V et al. | Vesicular palmoplantar pityriasis rosea. | 2012 Mar-Apr | Skinmed | pmid:22545332 |
Gutiérrez-Castrellón P et al. | Efficacy and safety of clarithromycin in pediatric patients with upper respiratory infections: a systematic review with meta-analysis. | 2012 Mar-Apr | Rev. Invest. Clin. | pmid:22991774 |
Rajendiran S et al. | Increased protein carbonylation and decreased antioxidant status in anemic H. pylori infected patients: effect of treatment. | 2012 Jul-Aug | Saudi J Gastroenterol | pmid:22824768 |
De Sanctis V et al. | Anti-Helicobacter pylori therapy in primary MALT lymphoma of rectum. | 2012 Jul-Aug | Tumori | pmid:23052174 |
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de Lalibera IB et al. | Meningoencephalitis associated with Mycoplasma pneumoniae. | 2012 Jan-Mar | Einstein (Sao Paulo) | pmid:23045836 |
Dhillon GS et al. | Clarithromycin for prevention of bronchiolitis obliterans syndrome in lung allograft recipients. | 2012 Jan-Feb | Clin Transplant | pmid:21352378 |
Onsun N et al. | Impact of Helicobacter pylori infection on severity of psoriasis and response to treatment. | 2012 Jan-Feb | Eur J Dermatol | pmid:22063790 |
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Dai WQ et al. | The eradicating Helicobacter pylori infection in duodenal ulcer patients by three short-term triple therapies in China: a multicenter clinical comparative study. | 2012 Jan-Feb | Hepatogastroenterology | pmid:22260837 |
VanderHeyden TR et al. | Granulomatous hepatitis due to Bartonella henselae infection in an immunocompetent patient. | 2012 | BMC Infect. Dis. | pmid:22269175 |
Glatstein M et al. | Lung abscess due to non-tuberculous, non-Mycobacterium fortuitum in a neonate. | 2012 | Pediatr. Pulmonol. | pmid:22451300 |
Matsushima M and Takagi A | "Is it effective?" to "How to use it?": the era has changed in probiotics and functional food products against Helicobacter pylori infection. | 2012 | J. Gastroenterol. Hepatol. | pmid:22515805 |
Fujita Y et al. | Pulmonary Actinomyces graevenitzii infection presenting as organizing pneumonia diagnosed by PCR analysis. | 2012 | J. Med. Microbiol. | pmid:22516132 |
Stout JE and Floto RA | Treatment of Mycobacterium abscessus: all macrolides are equal, but perhaps some are more equal than others. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:23118083 |
Park HS et al. | Placental transfer of clarithromycin in human pregnancies with preterm premature rupture of membranes. | 2012 | J Perinat Med | pmid:23095192 |
Milani M et al. | The status of antimicrobial resistance of Helicobacter pylori in Eastern Azerbaijan, Iran: comparative study according to demographics. | 2012 | J. Infect. Chemother. | pmid:22581031 |
Perić A et al. | Effect of long-term, low-dose clarithromycin on T helper 2 cytokines, eosinophilic cationic protein and the 'regulated on activation, normal T cell expressed and secreted' chemokine in the nasal secretions of patients with nasal polyposis. | 2012 | J Laryngol Otol | pmid:22559798 |
Yamazaki Y et al. | Antimicrobial and anti-inflammatory effects of clarithromycin on Mycobacterium avium complex replication in cultured human bronchial epithelial cells. | 2012 | J. Infect. Chemother. | pmid:22370922 |
Kim HS et al. | Serial CT findings of Mycobacterium massiliense pulmonary disease compared with Mycobacterium abscessus disease after treatment with antibiotic therapy. | 2012 | Radiology | pmid:22371609 |
Hutson JR et al. | Use of clarithromycin and adverse cardiovascular events among older patients receiving donepezil: a population-based, nested case-control study. | 2012 | Drugs Aging | pmid:22372724 |
Hegazy SK et al. | Effect of clarithromycin and fluconazole on the pharmacokinetics of montelukast in human volunteers. | 2012 | Eur. J. Clin. Pharmacol. | pmid:22392555 |
Zarogoulidis P et al. | Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases. | 2012 | Eur. J. Clin. Pharmacol. | pmid:22105373 |
Bruin JP et al. | Wild-type MIC distribution and epidemiological cut-off values in clinical Legionella pneumophila serogroup 1 isolates. | 2012 | Diagn. Microbiol. Infect. Dis. | pmid:22100012 |
van Ingen J et al. | Drug susceptibility testing and pharmacokinetics question current treatment regimens in Mycobacterium simiae complex disease. | 2012 | Int. J. Antimicrob. Agents | pmid:22099521 |
Bondon-Guitton E et al. | Drug-induced gingival overgrowth: a study in the French Pharmacovigilance Database. | 2012 | J. Clin. Periodontol. | pmid:22519416 |
Vazquez-Lago JM et al. | Attitudes of primary care physicians to the prescribing of antibiotics and antimicrobial resistance: a qualitative study from Spain. | 2012 | Fam Pract | pmid:22016323 |
Bosnar M et al. | N'-substituted-2'-O,3'-N-carbonimidoyl bridged macrolides: novel anti-inflammatory macrolides without antimicrobial activity. | 2012 | J. Med. Chem. | pmid:22697905 |
Yamamoto Y et al. | A case of refractory chronic respiratory tract infection due to Pseudomonas aeruginosa successfully controlled by combination of clarithromycin and azithromycin. | 2012 | Intern. Med. | pmid:22687847 |
Sezikli M et al. | Supplementing vitamins C and E to standard triple therapy for the eradication of Helicobacter pylori. | 2012 | J Clin Pharm Ther | pmid:21740452 |
Nishizawa T et al. | Proton pump inhibitor-amoxicillin-clarithromycin versus proton pump inhibitor-amoxicillin-metronidazole as first-line Helicobacter pylori eradication therapy. | 2012 | J Clin Biochem Nutr | pmid:22962528 |
Amin M et al. | Green synthesis of silver nanoparticles through reduction with Solanum xanthocarpum L. berry extract: characterization, antimicrobial and urease inhibitory activities against Helicobacter pylori. | 2012 | Int J Mol Sci | pmid:22949839 |
Kwan BY and Rabheru K | Manic episode associated with clarithromycin in a patient with medically treated depression. | 2012 | Prim Care Companion CNS Disord | pmid:22943025 |
Cheung JP et al. | Mycobacterium marinum infection of the hand and wrist. | 2012 | J Orthop Surg (Hong Kong) | pmid:22933682 |
Zong W et al. | The first case of cutaneous infection with Mycobacterium parascrofulaceum. | 2012 | Ther Clin Risk Manag | pmid:22930638 |
D'Elios MM et al. | Helicobacter pylori: usefulness of an empirical fourth-line rifabutin-based regimen. | 2012 | Expert Rev Gastroenterol Hepatol | pmid:22928895 |
Wu TS et al. | Fish tank granuloma caused by Mycobacterium marinum. | 2012 | PLoS ONE | pmid:22911774 |
Jang YJ et al. | Maxillary sinus hypoplasia with a patent ostiomeatal complex: A therapeutic dilemma. | 2012 | Auris Nasus Larynx | pmid:21571467 |
Kido T et al. | Two cases of primary ciliary dyskinesia with different responses to macrolide treatment. | 2012 | Intern. Med. | pmid:22576394 |
Hansomburana P et al. | Prevalence of single nucleotide mutation in clarithromycin resistant gene of Helicobacter pylori: a 32-months prospective study by using hybridization real time polymerase chain reaction. | 2012 | J Med Assoc Thai | pmid:22619884 |
Rimbara E et al. | Molecular epidemiologic analysis and antimicrobial resistance of Helicobacter cinaedi isolated from seven hospitals in Japan. | 2012 | J. Clin. Microbiol. | pmid:22593597 |
Kant S et al. | Extra-pulmonary primary multidrug-resistant tubercular lymphadenitis in an HIV negative patient. | 2012 | BMJ Case Rep | pmid:22605844 |
Korkmaz S et al. | Unusual manifestations of acute Q fever: autoimmune hemolytic anemia and tubulointerstitial nephritis. | 2012 | Ann. Clin. Microbiol. Antimicrob. | pmid:22607576 |
Oh HS et al. | Ten-day sequential therapy is more effective than proton pump inhibitor-based therapy in Korea: a prospective, randomized study. | 2012 | J. Gastroenterol. Hepatol. | pmid:21916989 |
Wong BC et al. | Effects of selective COX-2 inhibitor and Helicobacter pylori eradication on precancerous gastric lesions. | 2012 | Gut | pmid:21917649 |
Kim BJ et al. | Discovery of a novel hsp65 genotype within Mycobacterium massiliense associated with the rough colony morphology. | 2012 | PLoS ONE | pmid:22693637 |
Karczewska E et al. | Variability in Prevalence of Helicobacter pylori Strains Resistant to Clarithromycin and Levofloxacin in Southern Poland. | 2012 | Gastroenterol Res Pract | pmid:22693490 |
Tuchman SA et al. | Lenalidomide before and after Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma. | 2012 | Adv Hematol | pmid:22690220 |
Ojetti V et al. | Impact of Lactobacillus reuteri Supplementation on Anti-Helicobacter pylori Levofloxacin-Based Second-Line Therapy. | 2012 | Gastroenterol Res Pract | pmid:22690211 |
Ogoshi T et al. | A case of Good syndrome with pulmonary lesions similar to diffuse panbronchiolitis. | 2012 | Intern. Med. | pmid:22576393 |
Tseng CH | Diabetes, insulin use and Helicobacter pylori eradication: a retrospective cohort study. | 2012 | BMC Gastroenterol | pmid:22571603 |
Park SK et al. | Regression of Advanced Gastric MALT Lymphoma after the Eradication of Helicobacter pylori. | 2012 | Gut Liver | pmid:22570759 |
Shiota S et al. | Association of helicobacter pylori dupA with the failure of primary eradication. | 2012 | J. Clin. Gastroenterol. | pmid:22298090 |
Bayles T et al. | Clarithromycin for community-acquired pneumonia: beware drug interactions. | 2012 | Intern Med J | pmid:23046194 |
Liang JH et al. | Structure-activity relationships of novel alkylides: 3-O-arylalkyl clarithromycin derivatives with improved antibacterial activities. | 2012 | Eur J Med Chem | pmid:22301216 |
Ankomah P and Levin BR | Two-drug antimicrobial chemotherapy: a mathematical model and experiments with Mycobacterium marinum. | 2012 | PLoS Pathog. | pmid:22253599 |
Lembo G et al. | Successful treatment of Mycobacterium terrae complex infection of the knee. | 2012 | J Clin Rheumatol | pmid:23047536 |
Melter O et al. | Bartonella quintana transmission from mite to family with high socioeconomic status. | 2012 | Emerging Infect. Dis. | pmid:22257438 |
Kjoller E et al. | Good interobserver agreement was attainable on outcome adjudication in patients with stable coronary heart disease. | 2012 | J Clin Epidemiol | pmid:22257841 |
Conde-Ãlvarez R et al. | The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition. | 2012 | PLoS Pathog. | pmid:22589715 |
Suzuki T | Meibomitis-related keratoconjunctivitis: implications and clinical significance of meibomian gland inflammation. | 2012 | Cornea | pmid:23038034 |
Nakajima S et al. | Multiple-antibiotic-resistant Helicobacter pylori infection eradicated with a tailor-made quadruple therapy. | 2012 | J. Gastroenterol. Hepatol. | pmid:22486882 |
Misiewicz JJ | Management of Helicobacter pylori-related disorders. | 2012 | Eur J Gastroenterol Hepatol | pmid:22498902 |
Pasqualetti G et al. | Clarithromycin-induced rhabdomyolysis: a case report. | 2012 | Int J Gen Med | pmid:22505827 |
Sachs G and Scott DR | Helicobacter pylori: Eradication or Preservation. | 2012 | F1000 Med Rep | pmid:22500191 |
Bataille S et al. | Vancomycin-induced Henoch-Schönlein purpura: a case report. | 2012 | J Med Case Rep | pmid:22490390 |
Buyck JM et al. | Increased susceptibility of Pseudomonas aeruginosa to macrolides and ketolides in eukaryotic cell culture media and biological fluids due to decreased expression of oprM and increased outer-membrane permeability. | 2012 | Clin. Infect. Dis. | pmid:22573850 |
Shimizu T and Shimizu S | Azithromycin inhibits mucus hypersecretion from airway epithelial cells. | 2012 | Mediators Inflamm. | pmid:22577246 |
Chang CS et al. | Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells. | 2012 | Eur J Med Chem | pmid:22217866 |
Farfan-Portet MI et al. | Patient socioeconomic determinants of the choice of generic versus brand name drugs in the context of a reference price system: evidence from Belgian prescription data. | 2012 | Eur J Health Econ | pmid:22427042 |
Kargar M et al. | Real-time PCR for Helicobacter pylori quantification and detection of clarithromycin resistance in gastric tissue from patients with gastrointestinal disorders. | 2012 | Res. Microbiol. | pmid:22177975 |
Mégraud F | The challenge of Helicobacter pylori resistance to antibiotics: the comeback of bismuth-based quadruple therapy. | 2012 | Therap Adv Gastroenterol | pmid:22423259 |
Srivastav NC et al. | Antimycobacterial activities of 5-alkyl (or halo)-3'-substituted pyrimidine nucleoside analogs. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22178557 |
Scheel AH et al. | Talcum induced pneumoconiosis following inhalation of adulterated marijuana, a case report. | 2012 | Diagn Pathol | pmid:22420484 |
Ishii H et al. | Clarithromycin has limited effects in non-elderly, non-severe patients with seasonal influenza virus A infection. | 2012 | J. Infect. | pmid:22178990 |
Brüning J et al. | Erythromycin A dimethyl sulfoxide disolvate 1.43-hydrate. | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22412590 |
Aoyama N et al. | Clarithromycin suppresses the periodontal bacteria-accelerated abdominal aortic aneurysms in mice. | 2012 | J. Periodont. Res. | pmid:22181324 |
Noguchi S et al. | Clarithromycin monohydrate: a synchrotron X-ray powder study. | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22412567 |
Slany M et al. | Mycobacterium marinum infections in humans and tracing of its possible environmental sources. | 2012 | Can. J. Microbiol. | pmid:22182182 |
Karne SS et al. | Mycobacterium avium-intracellulare brain abscess in HIV-positive patient. | 2012 | Ann Indian Acad Neurol | pmid:22412276 |
Yanai A et al. | Non-bismuth quadruple therapy for first-line Helicobacter pylori eradication: A randomized study in Japan. | 2012 | World J Gastrointest Pharmacol Ther | pmid:22408744 |
McNulty CA et al. | Is Helicobacter pylori antibiotic resistance surveillance needed and how can it be delivered? | 2012 | Aliment. Pharmacol. Ther. | pmid:22469191 |
Polat Z et al. | Comparison of levofloxacin-containing sequential and standard triple therapies for the eradication of Helicobacter pylori. | 2012 | Eur. J. Intern. Med. | pmid:22284248 |
Jakopović IP et al. | Novel desosamine-modified 14- and 15-membered macrolides without antibacterial activity. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22503348 |
Siqueira JF et al. | Pyrosequencing as a tool for better understanding of human microbiomes. | 2012 | J Oral Microbiol | pmid:22279602 |
O'Brien DP et al. | Successful outcomes with oral fluoroquinolones combined with rifampicin in the treatment of Mycobacterium ulcerans: an observational cohort study. | 2012 | PLoS Negl Trop Dis | pmid:22272368 |