clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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VanderHeyden TR et al. | Granulomatous hepatitis due to Bartonella henselae infection in an immunocompetent patient. | 2012 | BMC Infect. Dis. | pmid:22269175 |
Huang YK et al. | Lansoprazole-based sequential and concomitant therapy for the first-line Helicobacter pylori eradication. | 2012 | J Dig Dis | pmid:22435509 |
Brož P et al. | Nonirritant intradermal skin test concentrations of ciprofloxacin, clarithromycin, and rifampicin. | 2012 | Allergy | pmid:22435670 |
Hojsak I et al. | Antibiotic resistance of Helicobacter pylori in pediatric patients -- 10 years' experience. | 2012 | Eur. J. Pediatr. | pmid:22430353 |
Koutsoubari I et al. | Effect of clarithromycin on acute asthma exacerbations in children: an open randomized study. | 2012 | Pediatr Allergy Immunol | pmid:22433020 |
Lin YH and Liu TC | Mycobacterium chelonae infection involving the auricle. | 2012 | QJM | pmid:21908384 |
Ji R et al. | Mucosal barrier defects in gastric intestinal metaplasia: in vivo evaluation by confocal endomicroscopy. | 2012 | Gastrointest. Endosc. | pmid:22325805 |
Walkey AJ and Wiener RS | Macrolide antibiotics and survival in patients with acute lung injury. | 2012 | Chest | pmid:22116799 |
Raj JM and Raj SM | Concern about the efficacy of clarithromycin containing standard triple therapy in the eradication of Helicobacter pylori infection in Malaysia. | 2012 | Med. J. Malaysia | pmid:23770883 |
Kim SY et al. | Effectiveness of three times daily lansoprazole/amoxicillin dual therapy for Helicobacter pylori infection in Korea. | 2012 | Br J Clin Pharmacol | pmid:21689141 |
Togami K et al. | Aerosol-based efficient delivery of clarithromycin, a macrolide antimicrobial agent, to lung epithelial lining fluid and alveolar macrophages for treatment of respiratory infections. | 2012 | J Aerosol Med Pulm Drug Deliv | pmid:22360316 |
Shiotani A et al. | H. pylori eradication did not improve dysregulation of specific oncogenic miRNAs in intestinal metaplastic glands. | 2012 | J. Gastroenterol. | pmid:22382634 |
Ding FM et al. | Low-dose clarithromycin therapy modulates CD4(+) T-cell responses in a mouse model of chronic Pseudomonas aeruginosa lung infection. | 2012 | Respirology | pmid:22404374 |
Kadayifci A et al. | Low efficacy of clarithromycin including sequential regimens for Helicobacter pylori infection. | 2012 | Helicobacter | pmid:22404442 |
Gisbert JP and McNicholl AG | Maintenance of Helicobacter pylori eradication rates with triple therapy over 12 years in a Spanish hospital. | 2012 | Helicobacter | pmid:22404448 |
Hiramatsu M et al. | Risk factors that affect the surgical outcome in the management of focal bronchiectasis in a developed country. | 2012 | Ann. Thorac. Surg. | pmid:22119119 |
Salmon JH et al. | Discitis and sacroiliitis diagnosed 15 years after iatrogenic Mycobacterium xenopi inoculation. | 2012 | Joint Bone Spine | pmid:22405857 |
Katayama M et al. | Interaction of clarithromycin with cyclosporine in cats: pharmacokinetic study and case report. | 2012 | J. Feline Med. Surg. | pmid:22412163 |
Bobacheva TIu | [The treatment of chronic polypous rhinosinusitis in the postoperative period with low doses of clarithromycin]. | 2012 | Vestn. Otorinolaringol. | pmid:23011378 |
Omoruyi OJ et al. | Metachronous Mycobacterium terrae complex tenosynovitis of the hand. | 2012 | J Hand Surg Eur Vol | pmid:22415428 |
Ohe M and Hashino S | Successful treatment of eosinophilic gastroenteritis with clarithromycin. | 2012 | Korean J. Intern. Med. | pmid:23269887 |
Breda R et al. | [Mycobacterium massiliense bone infection]. | 2012 | Med Mal Infect | pmid:22154522 |
Zarogoulidis P et al. | Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases. | 2012 | Eur. J. Clin. Pharmacol. | pmid:22105373 |
Takahashi E et al. | Oral clarithromycin enhances airway immunoglobulin A (IgA) immunity through induction of IgA class switching recombination and B-cell-activating factor of the tumor necrosis factor family molecule on mucosal dendritic cells in mice infected with influenza A virus. | 2012 | J. Virol. | pmid:22896605 |
Bruin JP et al. | Wild-type MIC distribution and epidemiological cut-off values in clinical Legionella pneumophila serogroup 1 isolates. | 2012 | Diagn. Microbiol. Infect. Dis. | pmid:22100012 |
van Ingen J et al. | Drug susceptibility testing and pharmacokinetics question current treatment regimens in Mycobacterium simiae complex disease. | 2012 | Int. J. Antimicrob. Agents | pmid:22099521 |
Bondon-Guitton E et al. | Drug-induced gingival overgrowth: a study in the French Pharmacovigilance Database. | 2012 | J. Clin. Periodontol. | pmid:22519416 |
Vazquez-Lago JM et al. | Attitudes of primary care physicians to the prescribing of antibiotics and antimicrobial resistance: a qualitative study from Spain. | 2012 | Fam Pract | pmid:22016323 |
Bosnar M et al. | N'-substituted-2'-O,3'-N-carbonimidoyl bridged macrolides: novel anti-inflammatory macrolides without antimicrobial activity. | 2012 | J. Med. Chem. | pmid:22697905 |
Bai J et al. | Erythromycin enhances CD4+Foxp3+ regulatory T-cell responses in a rat model of smoke-induced lung inflammation. | 2012 | Mediators Inflamm. | pmid:22701274 |
Prechtl J et al. | Monitoring of antibiotic resistance rates of Helicobacter pylori in Austrian children, 2002-2009. | 2012 | Pediatr. Infect. Dis. J. | pmid:22094633 |
Deguchi R et al. | Effect of pretreatment with Lactobacillus gasseri OLL2716 on first-line Helicobacter pylori eradication therapy. | 2012 | J. Gastroenterol. Hepatol. | pmid:22098133 |
Malfertheiner P et al. | Helicobacter pylori: clinical management. | 2012 | Curr. Opin. Gastroenterol. | pmid:23010682 |
Tepes B et al. | Treatment of Helicobacter pylori infection 2012. | 2012 | Helicobacter | pmid:22958154 |
Al Aukidy M et al. | Monitoring release of pharmaceutical compounds: occurrence and environmental risk assessment of two WWTP effluents and their receiving bodies in the Po Valley, Italy. | 2012 | Sci. Total Environ. | pmid:22967493 |
Sarker SA et al. | Influence of Helicobacter pylori infection on gastric acid secretion in pre-school Bangladeshi children. | 2012 | Helicobacter | pmid:22967116 |
Nishizawa T et al. | Proton pump inhibitor-amoxicillin-clarithromycin versus proton pump inhibitor-amoxicillin-metronidazole as first-line Helicobacter pylori eradication therapy. | 2012 | J Clin Biochem Nutr | pmid:22962528 |
Amin M et al. | Green synthesis of silver nanoparticles through reduction with Solanum xanthocarpum L. berry extract: characterization, antimicrobial and urease inhibitory activities against Helicobacter pylori. | 2012 | Int J Mol Sci | pmid:22949839 |
Kwan BY and Rabheru K | Manic episode associated with clarithromycin in a patient with medically treated depression. | 2012 | Prim Care Companion CNS Disord | pmid:22943025 |
Cheung JP et al. | Mycobacterium marinum infection of the hand and wrist. | 2012 | J Orthop Surg (Hong Kong) | pmid:22933682 |
Zong W et al. | The first case of cutaneous infection with Mycobacterium parascrofulaceum. | 2012 | Ther Clin Risk Manag | pmid:22930638 |
KurinÄiÄ M et al. | Epigallocatechin gallate as a modulator of Campylobacter resistance to macrolide antibiotics. | 2012 | Int. J. Antimicrob. Agents | pmid:22999765 |
Roccarina D et al. | Different Antibiotic No Culture Eradicating (DANCE) strategy: an easy way to manage H. pylori eradication. | 2012 | Dig Liver Dis | pmid:22743557 |
Tursi A et al. | Efficacy and tolerability of a third-line, levofloxacin-based, 10-day sequential therapy in curing resistant Helicobacter pylori infection. | 2012 | J Gastrointestin Liver Dis | pmid:22720300 |
Giguère S et al. | In vitro synergy, pharmacodynamics, and postantibiotic effect of 11 antimicrobial agents against Rhodococcus equi. | 2012 | Vet. Microbiol. | pmid:22704561 |
O'Connor MB et al. | Rituximab-induced pulmonary disease. | 2012 | Rheumatol. Int. | pmid:21892654 |
Nakagawa T et al. | [Multicenter study on clinical features and genetic characteristics of Mycobacterium avium strains from patients in Japan with lung disease caused by M. avium]. | 2012 | Kekkaku | pmid:23367826 |
Kumar KV et al. | Recurrent insulin injection abscesses: Atypical etiology. | 2012 | Indian J Endocrinol Metab | pmid:22701833 |
Gochi M et al. | [Mycobacterium xenopi lung infection in a patient with multiple lung cysts that responded well to chemotherapy: a case report]. | 2012 | Kekkaku | pmid:23367833 |
Kim BJ et al. | Discovery of a novel hsp65 genotype within Mycobacterium massiliense associated with the rough colony morphology. | 2012 | PLoS ONE | pmid:22693637 |
Karczewska E et al. | Variability in Prevalence of Helicobacter pylori Strains Resistant to Clarithromycin and Levofloxacin in Southern Poland. | 2012 | Gastroenterol Res Pract | pmid:22693490 |
Tuchman SA et al. | Lenalidomide before and after Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma. | 2012 | Adv Hematol | pmid:22690220 |
Fujita M et al. | The clinical efficacy and safety of a fluoroquinolone-containing regimen for pulmonary MAC disease. | 2012 | J. Infect. Chemother. | pmid:21927844 |
Dobrick N et al. | [Legionnaires disease (legionella pneumonia)]. | 2012 | Praxis (Bern 1994) | pmid:23147600 |
Ratcliffe AT and Ismail KM | Intravenous macrolide use: a reminder of the dangers of rapid infusion rates. | 2012 | J Clin Anesth | pmid:23101782 |
English ML et al. | Cethromycin versus clarithromycin for community-acquired pneumonia: comparative efficacy and safety outcomes from two double-blinded, randomized, parallel-group, multicenter, multinational noninferiority studies. | 2012 | Antimicrob. Agents Chemother. | pmid:22290969 |
Khan A et al. | Antibiotic resistance and cagA gene correlation: a looming crisis of Helicobacter pylori. | 2012 | World J. Gastroenterol. | pmid:22611319 |
Brereton AS and El Teraifi H | Mycobacterium malmoense: dissemination causes a popliteal aneurysm in a 74-year-old man. | 2012 | BMJ Case Rep | pmid:22602841 |
Jigorel E and Houston JB | Utility of drug depletion-time profiles in isolated hepatocytes for accessing hepatic uptake clearance: identifying rate-limiting steps and role of passive processes. | 2012 | Drug Metab. Dispos. | pmid:22593038 |
Timour Q et al. | Sudden death of cardiac origin and psychotropic drugs. | 2012 | Front Pharmacol | pmid:22590457 |
Ogoshi T et al. | A case of Good syndrome with pulmonary lesions similar to diffuse panbronchiolitis. | 2012 | Intern. Med. | pmid:22576393 |
Conde-Ãlvarez R et al. | The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition. | 2012 | PLoS Pathog. | pmid:22589715 |
Ichiki H et al. | [A study of adverse drug reactions in the treatment of pulmonary Mycobacterium avium complex disease]. | 2012 | Kekkaku | pmid:22993889 |
Schluger NW | Treatment of pulmonary Mycobacterium avium complex infections: do drug levels matter? | 2012 | Am. J. Respir. Crit. Care Med. | pmid:23071188 |
Li K and Haber RM | Stevens-Johnson syndrome without skin lesions (Fuchs syndrome): a literature review of adult cases with Mycoplasma cause. | 2012 | Arch Dermatol | pmid:22911206 |
Li H et al. | [Clarithromycin combined with tanshinone for rhinosinusal and laryngeal radiation injury in patients with nasopharyngeal carcinoma after radiotherapy]. | 2012 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:22931614 |
Nakajima S et al. | Multiple-antibiotic-resistant Helicobacter pylori infection eradicated with a tailor-made quadruple therapy. | 2012 | J. Gastroenterol. Hepatol. | pmid:22486882 |
Lee MR et al. | Otitis media and otomastoiditis caused by Mycobacterium massiliense (Mycobacterium abscessus subsp. bolletii). | 2012 | J. Clin. Microbiol. | pmid:22933592 |
Lee RP et al. | Mycobacterium chelonae infection after total knee arthroplasty: a case report. | 2012 | J Orthop Surg (Hong Kong) | pmid:22535831 |
van de Streek J | Reinterpretation of the monohydrate of clarithromycin from X-ray powder diffraction data as a trihydrate. | 2012 | Acta Crystallogr C | pmid:22935507 |
Shaaban HS et al. | Mycobacterium chelonae infection of the parotid gland. | 2012 | J Glob Infect Dis | pmid:22529633 |
Farivar TN et al. | Assessment of helicobacter pylori prevalence by scorpion real-time PCR in chronic tonsillitis patients. | 2012 | J Glob Infect Dis | pmid:22529626 |
Buzás GM | [Helicobacter pylori - 2012]. | 2012 | Orv Hetil | pmid:22951408 |
Zheng Q et al. | Occurrence and distribution of antibiotics in the Beibu Gulf, China: impacts of river discharge and aquaculture activities. | 2012 | Mar. Environ. Res. | pmid:22525825 |
Misiewicz JJ | Management of Helicobacter pylori-related disorders. | 2012 | Eur J Gastroenterol Hepatol | pmid:22498902 |
Sereni G et al. | Efficacy of a therapeutic strategy for eradication of Helicobacter pylori infection. | 2012 | World J. Gastroenterol. | pmid:22969227 |
Senhorinho GN et al. | Occurrence and antimicrobial susceptibility of Porphyromonas spp. and Fusobacterium spp. in dogs with and without periodontitis. | 2012 | Anaerobe | pmid:22609780 |
Lee HY et al. | Survey of methadone-drug interactions among patients of methadone maintenance treatment program in Taiwan. | 2012 | Subst Abuse Treat Prev Policy | pmid:22429858 |
Gomez-Abreo D et al. | [Chronic necrotizing pulmonary aspergillosis following an infection by Mycobacterium malmoense]. | 2012 | Rev Mal Respir | pmid:22440310 |
Shimizu T and Shimizu S | Azithromycin inhibits mucus hypersecretion from airway epithelial cells. | 2012 | Mediators Inflamm. | pmid:22577246 |
Mochizuki Y et al. | Chronic mandibular osteomyelitis with suspected underlying synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome: a case report. | 2012 | J Inflamm Res | pmid:22427727 |
Farfan-Portet MI et al. | Patient socioeconomic determinants of the choice of generic versus brand name drugs in the context of a reference price system: evidence from Belgian prescription data. | 2012 | Eur J Health Econ | pmid:22427042 |
Mégraud F | The challenge of Helicobacter pylori resistance to antibiotics: the comeback of bismuth-based quadruple therapy. | 2012 | Therap Adv Gastroenterol | pmid:22423259 |
Scheel AH et al. | Talcum induced pneumoconiosis following inhalation of adulterated marijuana, a case report. | 2012 | Diagn Pathol | pmid:22420484 |
Brüning J et al. | Erythromycin A dimethyl sulfoxide disolvate 1.43-hydrate. | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22412590 |
Guillot S et al. | Macrolide-resistant Bordetella pertussis infection in newborn girl, France. | 2012 | Emerging Infect. Dis. | pmid:22608348 |
van Ingen J et al. | The pharmacokinetics and pharmacodynamics of pulmonary Mycobacterium avium complex disease treatment. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:22744719 |
Kobashi Y et al. | Pulmonary Mycobacterium kyorinense disease showed clinical improvement following combined therapy with clarithromycin and levofloxacin. | 2012 | Intern. Med. | pmid:22821114 |
Morisset J et al. | A case of difficult-to-treat eosinophilic asthma controlled with clarithromycin. | 2012 | Ann. Allergy Asthma Immunol. | pmid:22727169 |
Calza P et al. | Identification of the unknown transformation products derived from clarithromycin and carbamazepine using liquid chromatography/high-resolution mass spectrometry. | 2012 | Rapid Commun. Mass Spectrom. | pmid:22730089 |
Cronnolly B and Pegrum H | Fentanyl-clarithromycin interaction. | 2012 | BMJ Case Rep | pmid:22778456 |
Pereyre S et al. | Clonal spread of Mycoplasma pneumoniae in primary school, Bordeaux, France. | 2012 | Emerging Infect. Dis. | pmid:22305177 |
Butler CC et al. | Effectiveness of multifaceted educational programme to reduce antibiotic dispensing in primary care: practice based randomised controlled trial. | 2012 | BMJ | pmid:22302780 |
Anand TD et al. | Superantigen profiles of emm and emm-like typeable and nontypeable pharyngeal streptococcal isolates of South India. | 2012 | Ann. Clin. Microbiol. Antimicrob. | pmid:22296671 |
Trigo P and Fischer GW | Managing atrial fibrillation in the elderly: critical appraisal of dronedarone. | 2012 | Clin Interv Aging | pmid:22291468 |
Correia M et al. | Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization. | 2012 | PLoS ONE | pmid:22529974 |
Altman JK and Platanias LC | A new purpose for an old drug: inhibiting autophagy with clarithromycin. | 2012 | Leuk. Lymphoma | pmid:22288786 |
Polat Z et al. | Comparison of levofloxacin-containing sequential and standard triple therapies for the eradication of Helicobacter pylori. | 2012 | Eur. J. Intern. Med. | pmid:22284248 |
Siqueira JF et al. | Pyrosequencing as a tool for better understanding of human microbiomes. | 2012 | J Oral Microbiol | pmid:22279602 |
O'Brien DP et al. | Successful outcomes with oral fluoroquinolones combined with rifampicin in the treatment of Mycobacterium ulcerans: an observational cohort study. | 2012 | PLoS Negl Trop Dis | pmid:22272368 |