clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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VanderHeyden TR et al. | Granulomatous hepatitis due to Bartonella henselae infection in an immunocompetent patient. | 2012 | BMC Infect. Dis. | pmid:22269175 |
Shojaei H et al. | Chronic pulmonary disease due to Mycobacterium monacense infection: the first case from Iran. | 2012 | Ann Lab Med | pmid:22259785 |
Kim SY et al. | Pulmonary infection caused by Mycobacterium conceptionense. | 2012 | Emerging Infect. Dis. | pmid:22257692 |
[Experience with treatment of chronic polypoid rhinosinusitis using low doses of clarithromycin in the postoperative period]. | 2012 | Vestn. Otorinolaringol. | pmid:22678641 | |
Kim SY et al. | Effectiveness of three times daily lansoprazole/amoxicillin dual therapy for Helicobacter pylori infection in Korea. | 2012 | Br J Clin Pharmacol | pmid:21689141 |
Lotfy HM and Abdel-Monem Hagazy M | Comparative study of novel spectrophotometric methods manipulating ratio spectra: an application on pharmaceutical ternary mixture of omeprazole, tinidazole and clarithromycin. | 2012 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:22683662 |
Rajper S et al. | Macrolide and fluoroquinolone resistance in Helicobacter pylori isolates: an experience at a tertiary care centre in Pakistan. | 2012 | J Pak Med Assoc | pmid:23866399 |
Goswami S et al. | Anti-Helicobacter pylori potential of artemisinin and its derivatives. | 2012 | Antimicrob. Agents Chemother. | pmid:22687518 |
Cuadrado-LavÃn A et al. | Levofloxacin versus clarithromycin in a 10 day triple therapy regimen for first-line Helicobacter pylori eradication: a single-blind randomized clinical trial. | 2012 | J. Antimicrob. Chemother. | pmid:22687889 |
Nseir W et al. | Randomised clinical trial: simvastatin as adjuvant therapy improves significantly the Helicobacter pylori eradication rate--a placebo-controlled study. | 2012 | Aliment. Pharmacol. Ther. | pmid:22646167 |
Zaater MF et al. | Determination and stability assessment of clarithromycin in human plasma using RP-LC with electrochemical detection. | 2012 | J Chromatogr Sci | pmid:22647394 |
Bobacheva TIu | [The treatment of chronic polypous rhinosinusitis in the postoperative period with low doses of clarithromycin]. | 2012 | Vestn. Otorinolaringol. | pmid:23011378 |
Omoruyi OJ et al. | Metachronous Mycobacterium terrae complex tenosynovitis of the hand. | 2012 | J Hand Surg Eur Vol | pmid:22415428 |
Ohe M and Hashino S | Successful treatment of eosinophilic gastroenteritis with clarithromycin. | 2012 | Korean J. Intern. Med. | pmid:23269887 |
Breda R et al. | [Mycobacterium massiliense bone infection]. | 2012 | Med Mal Infect | pmid:22154522 |
Takahashi E et al. | Oral clarithromycin enhances airway immunoglobulin A (IgA) immunity through induction of IgA class switching recombination and B-cell-activating factor of the tumor necrosis factor family molecule on mucosal dendritic cells in mice infected with influenza A virus. | 2012 | J. Virol. | pmid:22896605 |
Chung JW et al. | Ten-day sequential versus triple therapy for Helicobacter pylori eradication: a prospective, open-label, randomized trial. | 2012 | J. Gastroenterol. Hepatol. | pmid:22849546 |
van Ingen J et al. | Drug susceptibility testing and pharmacokinetics question current treatment regimens in Mycobacterium simiae complex disease. | 2012 | Int. J. Antimicrob. Agents | pmid:22099521 |
Chan A et al. | A case of wrist tenosynovitis caused by Mycobacterium kansasii in a renal transplant recipient. | 2012 | Transpl Infect Dis | pmid:22822725 |
Patel N and Miller CD | New option for management of HIV-1 infection in treatment-naive patients: once-daily, fixed-dose combination of rilpivirine-emtricitabine-tenofovir. | 2012 | HIV AIDS (Auckl) | pmid:22570576 |
Alzolibani AA and Zedan K | Macrolides in chronic inflammatory skin disorders. | 2012 | Mediators Inflamm. | pmid:22685371 |
Masekela R and Green RJ | The role of macrolides in childhood non-cystic fibrosis-related bronchiectasis. | 2012 | Mediators Inflamm. | pmid:22570510 |
Vazquez-Lago JM et al. | Attitudes of primary care physicians to the prescribing of antibiotics and antimicrobial resistance: a qualitative study from Spain. | 2012 | Fam Pract | pmid:22016323 |
Lee MR et al. | CNS infections caused by Mycobacterium abscessus complex: clinical features and antimicrobial susceptibilities of isolates. | 2012 | J. Antimicrob. Chemother. | pmid:21980068 |
Deguchi R et al. | Effect of pretreatment with Lactobacillus gasseri OLL2716 on first-line Helicobacter pylori eradication therapy. | 2012 | J. Gastroenterol. Hepatol. | pmid:22098133 |
Gao M et al. | The effects of transrectal radiofrequency hyperthermia on patients with chronic prostatitis and the changes of MDA, NO, SOD, and Zn levels in pretreatment and posttreatment. | 2012 | Urology | pmid:22100490 |
Fujita J and Cash HL | Long-term combination treatment of azithromycin with other macrolides: a new era. | 2012 | Intern. Med. | pmid:22687831 |
Zullo A et al. | Role of gastritis pattern on Helicobacter pylori eradication. | 2012 | Intern Emerg Med | pmid:22105372 |
Yamamoto Y et al. | A case of refractory chronic respiratory tract infection due to Pseudomonas aeruginosa successfully controlled by combination of clarithromycin and azithromycin. | 2012 | Intern. Med. | pmid:22687847 |
Ivetic Tkalcevic V et al. | Cantharidin-induced inflammation in mouse ear model for translational research of novel anti-inflammatories. | 2012 | Transl Res | pmid:22677362 |
Espinal DA et al. | [Human metapneumovirus in children: first cases in Colombia]. | 2012 | Biomedica | pmid:23242289 |
Cetin M et al. | Clarithromycin-Induced Long QT Syndrome: A Case Report. | 2012 | Case Rep Med | pmid:22489247 |
Saracino IM et al. | High prevalence of primary antibiotic resistance in Helicobacter pylori isolates in Italy. | 2012 | J Gastrointestin Liver Dis | pmid:23256118 |
Kwan BY and Rabheru K | Manic episode associated with clarithromycin in a patient with medically treated depression. | 2012 | Prim Care Companion CNS Disord | pmid:22943025 |
Cheung JP et al. | Mycobacterium marinum infection of the hand and wrist. | 2012 | J Orthop Surg (Hong Kong) | pmid:22933682 |
Zong W et al. | The first case of cutaneous infection with Mycobacterium parascrofulaceum. | 2012 | Ther Clin Risk Manag | pmid:22930638 |
D'Elios MM et al. | Helicobacter pylori: usefulness of an empirical fourth-line rifabutin-based regimen. | 2012 | Expert Rev Gastroenterol Hepatol | pmid:22928895 |
Wu TS et al. | Fish tank granuloma caused by Mycobacterium marinum. | 2012 | PLoS ONE | pmid:22911774 |
Ikegame S et al. | Congenital cystic adenomatoid malformation in adulthood complicated by Mycobacterium celatum infection. | 2012 | Intern. Med. | pmid:22892504 |
Tsay FW et al. | Sequential therapy achieves a higher eradication rate than standard triple therapy in Taiwan. | 2012 | J. Gastroenterol. Hepatol. | pmid:21871025 |
Ngan LT et al. | Growth-inhibiting, bactericidal, and urease inhibitory effects of Paeonia lactiflora root constituents and related compounds on antibiotic-susceptible and -resistant strains of Helicobacter pylori. | 2012 | J. Agric. Food Chem. | pmid:22891951 |
Kao SS et al. | 7-Day Nonbismuth-Containing Concomitant Therapy Achieves a High Eradication Rate for Helicobacter pylori in Taiwan. | 2012 | Gastroenterol Res Pract | pmid:22888337 |
Boyanova L et al. | Numerous risk factors for Helicobacter pylori antibiotic resistance revealed by extended anamnesis: a Bulgarian study. | 2012 | J. Med. Microbiol. | pmid:21873378 |
Choi GE et al. | Macrolide treatment for Mycobacterium abscessus and Mycobacterium massiliense infection and inducible resistance. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:22878281 |
Karczewska E et al. | Variability in Prevalence of Helicobacter pylori Strains Resistant to Clarithromycin and Levofloxacin in Southern Poland. | 2012 | Gastroenterol Res Pract | pmid:22693490 |
Tuchman SA et al. | Lenalidomide before and after Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma. | 2012 | Adv Hematol | pmid:22690220 |
Ojetti V et al. | Impact of Lactobacillus reuteri Supplementation on Anti-Helicobacter pylori Levofloxacin-Based Second-Line Therapy. | 2012 | Gastroenterol Res Pract | pmid:22690211 |
Uno K et al. | Rupture of renal mycotic aneurysm that developed during the treatment of streptococcal infective endocarditis and vertebral osteomyelitis. | 2012 | Intern. Med. | pmid:22687800 |
Sano N et al. | Comprehensive Analysis of Bacterial Flora in Postoperative Maxillary Cyst Fluid by 16S rRNA Gene and Culture Methods. | 2012 | ISRN Dent | pmid:22685668 |
Sakinc T et al. | Influence of a 23S ribosomal RNA mutation in Helicobacter pylori strains on the in vitro synergistic effect of clarithromycin and amoxicillin. | 2012 | BMC Res Notes | pmid:23110798 |
Robinson P et al. | Clarithromycin therapy for patients with cystic fibrosis: a randomized controlled trial. | 2012 | Pediatr. Pulmonol. | pmid:22266895 |
Korownyk C and Kolber MR | Is quadruple therapy the new triple therapy for H pylori? | 2012 | Can Fam Physician | pmid:22267623 |
Huang J et al. | [A 10-day sequential therapy for eradication of Helicobacter pylori infection in children]. | 2012 | Zhonghua Er Ke Za Zhi | pmid:23158730 |
Mumoli N and Cei M | Clinical images: community-acquired pneumonia. | 2012 | CMAJ | pmid:22271912 |
English ML et al. | Cethromycin versus clarithromycin for community-acquired pneumonia: comparative efficacy and safety outcomes from two double-blinded, randomized, parallel-group, multicenter, multinational noninferiority studies. | 2012 | Antimicrob. Agents Chemother. | pmid:22290969 |
Tatar EÇ et al. | Prevalence of biofilms and their response to medical treatment in chronic rhinosinusitis without polyps. | 2012 | Otolaryngol Head Neck Surg | pmid:22241786 |
Chang WJ et al. | Successful salvage treatment of steroid-refractory bronchiolar COP with low-dose macrolides. | 2012 | Pathol. Int. | pmid:22243785 |
Lismond A et al. | Antimicrobial susceptibility of Streptococcus pneumoniae isolates from vaccinated and non-vaccinated patients with a clinically confirmed diagnosis of community-acquired pneumonia in Belgium. | 2012 | Int. J. Antimicrob. Agents | pmid:22245497 |
Agarwal E et al. | Efficacy of local drug delivery of 0.5% clarithromycin gel as an adjunct to non-surgical periodontal therapy in the treatment of current smokers with chronic periodontitis: a randomized controlled clinical trial. | 2012 | J. Periodontol. | pmid:22248223 |
Szałek E et al. | Sunitinib in combination with clarithromycin or azithromycin - is there a risk of interaction or not? | 2012 | Pharmacol Rep | pmid:23406766 |
Ogoshi T et al. | A case of Good syndrome with pulmonary lesions similar to diffuse panbronchiolitis. | 2012 | Intern. Med. | pmid:22576393 |
Tseng CH | Diabetes, insulin use and Helicobacter pylori eradication: a retrospective cohort study. | 2012 | BMC Gastroenterol | pmid:22571603 |
Park SK et al. | Regression of Advanced Gastric MALT Lymphoma after the Eradication of Helicobacter pylori. | 2012 | Gut Liver | pmid:22570759 |
Choi GE et al. | Activities of moxifloxacin in combination with macrolides against clinical isolates of Mycobacterium abscessus and Mycobacterium massiliense. | 2012 | Antimicrob. Agents Chemother. | pmid:22564831 |
Ivetić TkalÄević V et al. | Topical azithromycin and clarithromycin inhibit acute and chronic skin inflammation in sensitized mice, with apparent selectivity for Th2-mediated processes in delayed-type hypersensitivity. | 2012 | Inflammation | pmid:21336676 |
Godreuil S et al. | Mycobacterium riyadhense pulmonary infection, France and Bahrain. | 2012 | Emerging Infect. Dis. | pmid:22261434 |
Nakajima S et al. | Multiple-antibiotic-resistant Helicobacter pylori infection eradicated with a tailor-made quadruple therapy. | 2012 | J. Gastroenterol. Hepatol. | pmid:22486882 |
Sereni G et al. | Efficacy of a therapeutic strategy for eradication of Helicobacter pylori infection. | 2012 | World J. Gastroenterol. | pmid:22969227 |
Bajaj P et al. | Locally delivered 0.5% clarithromycin, as an adjunct to nonsurgical treatment in chronic periodontitis with well-controlled type 2 diabetes: a randomized controlled clinical trial. | 2012 | J Investig Clin Dent | pmid:22976782 |
Pasqualetti G et al. | Clarithromycin-induced rhabdomyolysis: a case report. | 2012 | Int J Gen Med | pmid:22505827 |
Akelma AZ et al. | Clarithromycin in treatment of acute asthma exacerbations: principles of appropriate antibiotic use. | 2012 | Pediatr Allergy Immunol | pmid:22984834 |
Sachs G and Scott DR | Helicobacter pylori: Eradication or Preservation. | 2012 | F1000 Med Rep | pmid:22500191 |
Bataille S et al. | Vancomycin-induced Henoch-Schönlein purpura: a case report. | 2012 | J Med Case Rep | pmid:22490390 |
Grosso F et al. | A comprehensive safety analysis confirms rhabdomyolysis as an uncommon adverse reaction in patients treated with trabectedin. | 2012 | Cancer Chemother. Pharmacol. | pmid:22484722 |
Federico A et al. | Efficacy of 5-day levofloxacin-containing concomitant therapy in eradication of Helicobacter pylori infection. | 2012 | Gastroenterology | pmid:22484118 |
Monno R et al. | Helicobacter pylori clarithromycin resistance detected by Etest and TaqMan real-time polymerase chain reaction: a comparative study. | 2012 | APMIS | pmid:22882260 |
Pandya GJ et al. | Unilateral lobar pulmonary edema. | 2012 | J Assoc Physicians India | pmid:23547417 |
Ablanedo-Terrazas Y et al. | Palatal Actinomycosis and Kaposi Sarcoma in an HIV-Infected Subject with Disseminated Mycobacterium avium-intracellulare Infection. | 2012 | Case Rep Med | pmid:22481952 |
Fakheri H et al. | A comparison between sequential therapy and a modified bismuth-based quadruple therapy for Helicobacter pylori eradication in Iran: a randomized clinical trial. | 2012 | Helicobacter | pmid:22221615 |
Georgopoulos S et al. | Evaluation of a four-drug, three-antibiotic, nonbismuth-containing "concomitant" therapy as first-line Helicobacter pylori eradication regimen in Greece. | 2012 | Helicobacter | pmid:22221616 |
Komatsu S et al. | Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells. | 2012 | Int. J. Oncol. | pmid:22200786 |
Buyck JM et al. | Increased susceptibility of Pseudomonas aeruginosa to macrolides and ketolides in eukaryotic cell culture media and biological fluids due to decreased expression of oprM and increased outer-membrane permeability. | 2012 | Clin. Infect. Dis. | pmid:22573850 |
Scheel AH et al. | Talcum induced pneumoconiosis following inhalation of adulterated marijuana, a case report. | 2012 | Diagn Pathol | pmid:22420484 |
Brüning J et al. | Erythromycin A dimethyl sulfoxide disolvate 1.43-hydrate. | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22412590 |
Noguchi S et al. | Clarithromycin monohydrate: a synchrotron X-ray powder study. | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22412567 |
Karne SS et al. | Mycobacterium avium-intracellulare brain abscess in HIV-positive patient. | 2012 | Ann Indian Acad Neurol | pmid:22412276 |
Yanai A et al. | Non-bismuth quadruple therapy for first-line Helicobacter pylori eradication: A randomized study in Japan. | 2012 | World J Gastrointest Pharmacol Ther | pmid:22408744 |
Yeboah J and Sharma OP | Co-existence of Crohn's disease, sarcoidosis and malignant lymphomas. | 2012 | JRSM Short Rep | pmid:22393471 |
Martins TG et al. | Local and regional re-establishment of cellular immunity during curative antibiotherapy of murine Mycobacterium ulcerans infection. | 2012 | PLoS ONE | pmid:22393444 |
Legendre DP et al. | Hansen's disease (Leprosy): current and future pharmacotherapy and treatment of disease-related immunologic reactions. | 2012 | Pharmacotherapy | pmid:22392826 |
Li Y et al. | A data-driven predictive approach for drug delivery using machine learning techniques. | 2012 | PLoS ONE | pmid:22384063 |
Hong SJ | The Role of Mycoplasma pneumoniae Infection in Asthma. | 2012 | Allergy Asthma Immunol Res | pmid:22379599 |
Cronnolly B and Pegrum H | Fentanyl-clarithromycin interaction. | 2012 | BMJ Case Rep | pmid:22778456 |
Berti AD et al. | Altering the proclivity towards daptomycin resistance in methicillin-resistant Staphylococcus aureus using combinations with other antibiotics. | 2012 | Antimicrob. Agents Chemother. | pmid:22802248 |
Khavinson VKh et al. | Peptidergic regulation of expression of genes encoding antioxidant and anti-inflammatory proteins. | 2012 | Bull. Exp. Biol. Med. | pmid:22803148 |
Molina-Infante J et al. | Nonbismuth quadruple (concomitant) therapy: empirical and tailored efficacy versus standard triple therapy for clarithromycin-susceptible Helicobacter pylori and versus sequential therapy for clarithromycin-resistant strains. | 2012 | Helicobacter | pmid:22759326 |
Kongchayanun C et al. | Pilot studies to identify the optimum duration of concomitant Helicobacter pylori eradication therapy in Thailand. | 2012 | Helicobacter | pmid:22759328 |
Nguyen TV et al. | Eradication of Helicobacter pylori in children in Vietnam in relation to antibiotic resistance. | 2012 | Helicobacter | pmid:22759333 |
Siqueira JF et al. | Pyrosequencing as a tool for better understanding of human microbiomes. | 2012 | J Oral Microbiol | pmid:22279602 |
O'Brien DP et al. | Successful outcomes with oral fluoroquinolones combined with rifampicin in the treatment of Mycobacterium ulcerans: an observational cohort study. | 2012 | PLoS Negl Trop Dis | pmid:22272368 |