clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Gisbert JP et al. | [Previous treatment with omeprazole and H. pylori: does it diminish the eradication efficacy of the "new" triple therapies of one week's duration?]. | 1998 | Med Clin (Barc) | pmid:9887438 |
Tohnai A et al. | Clarithromycin suppresses proliferation of rat nasal epithelium exposed to endotoxin. | 1998 Nov-Dec | Am J Rhinol | pmid:9883303 |
MartÃn Mir ML et al. | [Effectiveness of the eradication of Helicobacter pylori by treatment with omeprazol, amoxicillin, and clarithromycin according to dosage and administration schedule]. | 1998 | Gastroenterol Hepatol | pmid:9882932 |
Komori T et al. | Effects of repeated clarithromycin administration on the pharmacokinetic properties of pindolol in rats. | 1998 | Biol. Pharm. Bull. | pmid:9881659 |
Sakamoto M et al. | [Effect of clarithromycin treatment of natural killer cell activity in patients with advanced non-small cell lung cancer]. | 1998 | Gan To Kagaku Ryoho | pmid:9881083 |
Vorbach H et al. | Endothelial cell compatibility of clarithromycin for intravenous use. | 1998 | Clin. Biochem. | pmid:9876898 |
Matteelli A et al. | Long term treatment with clarithromycin for cryptosporidiosis and emergence of drug resistant disseminated infection due to Mycobacterium avium: case report. | 1998 | J Chemother | pmid:9876056 |
Komori T et al. | Effect of clarithromycin on alpha1-acid glycoprotein levels in normal and diabetic rats. | 1998 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9874281 |
Sakurai N et al. | Synthesis and structure-activity relationships of 7-(2-aminoalkyl)morpholinoquinolones as anti-Helicobacter pylori agents. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9873510 |
Yoshida Y et al. | Discovery of a novel benzyloxyisoquinoline derivative with potent anti-Helicobacter pylori activity. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9873455 |
Sakaki N et al. | Preliminary study on a novel quadruple eradication therapy with a mucoprotective drug, sofalcone, for Helicobacter pylori infection. | 1998 | J. Clin. Gastroenterol. | pmid:9872520 |
Suzuki J et al. | Relationship between the eradication of Helicobacter pylori and the healing pattern of peptic ulcer. | 1998 | J. Clin. Gastroenterol. | pmid:9872515 |
Lee CL et al. | One-week low-dose triple therapy is effective in treating Helicobacter pylori-infected patients with bleeding peptic ulcers. | 1998 | J. Formos. Med. Assoc. | pmid:9872028 |
Waddell ST et al. | Synthesis and antibacterial activity of O-methyl derivatives of azalide antibiotics: II. 6-OME derivatives via clarithromycin. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9871759 |
van Westrhenen R et al. | Pneumonia and glomerulonephritis caused by Mycoplasma pneumoniae. | 1998 | Nephrol. Dial. Transplant. | pmid:9870493 |
Sassa K et al. | Therapeutic effect of clarithromycin on a transplanted tumor in rats. | 1999 | Antimicrob. Agents Chemother. | pmid:9869567 |
Shafran SD et al. | Does in vitro susceptibility to rifabutin and ethambutol predict the response to treatment of Mycobacterium avium complex bacteremia with rifabutin, ethambutol, and clarithromycin? Canadian HIV Trials Network Protocol 010 Study Group. | 1998 | Clin. Infect. Dis. | pmid:9868650 |
Wallace RJ and Brown BA | Catheter sepsis due to Mycobacterium chelonae. | 1998 | J. Clin. Microbiol. | pmid:9867491 |
Al-Sibai MB et al. | Ocular penetration of oral clarithromycin in humans. | 1998 | J Ocul Pharmacol Ther | pmid:9867340 |
Maeda S et al. | Helicobacter pylori specific nested PCR assay for the detection of 23S rRNA mutation associated with clarithromycin resistance. | 1998 | Gut | pmid:9863474 |