clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

Cross Reference

Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Sinusitis D012852 9 associated lipids
Bacteremia D016470 9 associated lipids
AIDS-Related Opportunistic Infections D017088 9 associated lipids
Periodontal Pocket D010514 9 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Dyspnea D004417 10 associated lipids
Hearing Disorders D006311 10 associated lipids
Neuromuscular Diseases D009468 10 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Abnormalities, Drug-Induced D000014 10 associated lipids
Lung Diseases, Obstructive D008173 10 associated lipids
Osteomyelitis D010019 10 associated lipids
Dermatitis, Exfoliative D003873 10 associated lipids
Pancreatitis D010195 10 associated lipids
Hemophilia A D006467 10 associated lipids
Uveitis, Anterior D014606 11 associated lipids
Urinary Tract Infections D014552 11 associated lipids
Exanthema D005076 11 associated lipids
Liver Failure, Acute D017114 11 associated lipids
Shock, Septic D012772 11 associated lipids
Influenza, Human D007251 11 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Endophthalmitis D009877 12 associated lipids
Wound Infection D014946 12 associated lipids
Otitis Media D010033 12 associated lipids
Skin Neoplasms D012878 12 associated lipids
Rosacea D012393 13 associated lipids
Abscess D000038 13 associated lipids
Leishmaniasis, Visceral D007898 13 associated lipids
Bradycardia D001919 13 associated lipids
Urticaria D014581 13 associated lipids
Radiation Injuries D011832 14 associated lipids
Encephalitis D004660 15 associated lipids
HIV Seropositivity D006679 15 associated lipids
Synovitis D013585 15 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Dermatomycoses D003881 17 associated lipids
Ischemia D007511 18 associated lipids
Tuberculosis, Pulmonary D014397 18 associated lipids
Bronchial Spasm D001986 18 associated lipids
Peptic Ulcer D010437 19 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Tuberculosis D014376 20 associated lipids
Bacterial Infections D001424 21 associated lipids
Myocardial Infarction D009203 21 associated lipids
Helicobacter Infections D016481 21 associated lipids
Periodontitis D010518 22 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Per page 10 20 50 100 | Total 7636
Authors Title Published Journal PubMed Link
Raderer M et al. Regression of colonic low grade B cell lymphoma of the mucosa associated lymphoid tissue type after eradication of Helicobacter pylori. 2000 Gut pmid:10601069
Sainz R et al. [Helicobacter pylori infection. The Spanish consensus report. The Spanish Consensus Conference Group]. 1999 Rev Esp Enferm Dig pmid:10601771
Tanaka G et al. Effect of clarithromycin on Pseudomonas aeruginosa biofilms. 2000 Jan-Feb Chemotherapy pmid:10601796
Hamada K et al. Adjuvant effect of clarithromycin on chemotherapy for murine lung cancer. 2000 Jan-Feb Chemotherapy pmid:10601798
Fernández-Roblas R et al. In vitro susceptibilities of rapidly growing mycobacteria to telithromycin (HMR 3647) and seven other antimicrobials. 2000 Antimicrob. Agents Chemother. pmid:10602744
Ku YY et al. Synthesis and antibacterial activities of novel 12-O-methylerythromycin A derivatives. 1999 J. Antibiot. pmid:10604761
Ianaro A et al. Anti-inflammatory activity of macrolide antibiotics. 2000 J. Pharmacol. Exp. Ther. pmid:10604943
Suzuki K et al. Effect of proton pump inhibitor alone or in combination with clarithromycin on mycobacterial growth in human alveolar macrophages. 2000 FEMS Microbiol. Lett. pmid:10612733
Giacometti A et al. In vitro anticryptosporidial activity of ranalexin alone and in combination with other peptides and with hydrophobic antibiotics. 1999 Eur. J. Clin. Microbiol. Infect. Dis. pmid:10614961
Midolo PD et al. In vitro synergy between ranitidine bismuth citrate and tetracycline or clarithromycin against resistant strains of Helicobacter pylori. 1999 Eur. J. Clin. Microbiol. Infect. Dis. pmid:10614963
Abe S et al. Interleukin-8 gene repression by clarithromycin is mediated by the activator protein-1 binding site in human bronchial epithelial cells. 2000 Am. J. Respir. Cell Mol. Biol. pmid:10615065
Kiyota K et al. Comparison of 1-week and 2-week triple therapy with omeprazole, amoxicillin, and clarithromycin in peptic ulcer patients with Helicobacter pylori infection: results of a randomized controlled trial. 1999 J. Gastroenterol. pmid:10616771
Aoyama N et al. Sufficient effect of 1-week omeprazole and amoxicillin dual treatment for Helicobacter pylori eradication in cytochrome P450 2C19 poor metabolizers. 1999 J. Gastroenterol. pmid:10616772
Gotoda T et al. Endoscopic and histological reversibility of gastric adenoma after eradication of Helicobacter pylori. 1999 J. Gastroenterol. pmid:10616774
Maeda S et al. Detection of clarithromycin-resistant helicobacter pylori strains by a preferential homoduplex formation assay. 2000 J. Clin. Microbiol. pmid:10618089
Rocha RT et al. Comparison of spiramycin and clarithromycin for community-acquired lower respiratory tract infections. 1999 Int. J. Clin. Pract. pmid:10622070
Lugannani C and Strickland C Empiric eradication therapy or endoscopy in Helicobacter pylori-positive patients? 1999 J Fam Pract pmid:10628582
Bui KQ et al. In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa. 2000 J. Antimicrob. Chemother. pmid:10629013
Blondon H [Eradication of Helicobacter pylori: what is the effect on symptoms of non-ulcerous dyspepsia?]. 1999 Presse Med pmid:10629694
Cammarota G et al. Six-day or seven-day regimens with ranitidine bismuth citrate plus high-dose clarithromycin and tinidazole are both effective against Helicobacter pylori infection. 1999 Dig. Dis. Sci. pmid:10630486