clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

Cross Reference

Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Rhabdomyolysis D012206 9 associated lipids
Otitis Media with Effusion D010034 9 associated lipids
Urethritis D014526 9 associated lipids
Cross Infection D003428 9 associated lipids
Lung Diseases, Obstructive D008173 10 associated lipids
Dermatitis, Exfoliative D003873 10 associated lipids
Hemophilia A D006467 10 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Abnormalities, Drug-Induced D000014 10 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Dyspnea D004417 10 associated lipids
Osteomyelitis D010019 10 associated lipids
Pancreatitis D010195 10 associated lipids
Hearing Disorders D006311 10 associated lipids
Neuromuscular Diseases D009468 10 associated lipids
Influenza, Human D007251 11 associated lipids
Shock, Septic D012772 11 associated lipids
Uveitis, Anterior D014606 11 associated lipids
Exanthema D005076 11 associated lipids
Urinary Tract Infections D014552 11 associated lipids
Liver Failure, Acute D017114 11 associated lipids
Wound Infection D014946 12 associated lipids
Otitis Media D010033 12 associated lipids
Skin Neoplasms D012878 12 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Endophthalmitis D009877 12 associated lipids
Urticaria D014581 13 associated lipids
Rosacea D012393 13 associated lipids
Bradycardia D001919 13 associated lipids
Leishmaniasis, Visceral D007898 13 associated lipids
Abscess D000038 13 associated lipids
Radiation Injuries D011832 14 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Encephalitis D004660 15 associated lipids
HIV Seropositivity D006679 15 associated lipids
Synovitis D013585 15 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Dermatomycoses D003881 17 associated lipids
Tuberculosis, Pulmonary D014397 18 associated lipids
Ischemia D007511 18 associated lipids
Bronchial Spasm D001986 18 associated lipids
Peptic Ulcer D010437 19 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Tuberculosis D014376 20 associated lipids
Helicobacter Infections D016481 21 associated lipids
Myocardial Infarction D009203 21 associated lipids
Bacterial Infections D001424 21 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Per page 10 20 50 100 | Total 7636
Authors Title Published Journal PubMed Link
Fabry W et al. Comparison of the E test and a proportion dilution method for susceptibility testing of Mycobacterium tuberculosis. 1995 Zentralbl. Bakteriol. pmid:9810662
Abouesh A and Hobbs WR Clarithromycin-induced mania. 1998 Am J Psychiatry pmid:9812131
Miehlke S et al. Comparison of omeprazole, metronidazole and clarithromycin with omeprazole/amoxicillin dual-therapy for the cure of Helicobacter pylori infection. 1998 Nov-Dec Digestion pmid:9813387
Clark CL et al. Antipneumococcal activities of levofloxacin and clarithromycin as determined by agar dilution, microdilution, E-test, and disk diffusion methodologies. 1998 J. Clin. Microbiol. pmid:9817876
Björkholm B et al. Rapid PCR detection of Helicobacter pylori-associated virulence and resistance genes directly from gastric biopsy material. 1998 J. Clin. Microbiol. pmid:9817898
Arimori K et al. Characteristic difference in gastrointestinal excretion of clarithromycin and roxithromycin. 1998 Biopharm Drug Dispos pmid:9818709
Cirioni O et al. In-vitro activity of lytic peptides alone and in combination with macrolides and inhibitors of dihydrofolate reductase against Pneumocystis carinii. 1998 J. Antimicrob. Chemother. pmid:9818742
Vrioni G et al. Treatment of disseminated Mycobacterium genavense infection in a murine model with ciprofloxacin, amikacin, ethambutol, clarithromycin and rifabutin. 1998 J. Antimicrob. Chemother. pmid:9818747
Champney WS and Burdine R Macrolide antibiotic inhibition of translation and 50S ribosomal subunit assembly in methicillin-resistant Staphylococcus aureus cells. 1998 Microb. Drug Resist. pmid:9818968
Mermelstein HT Clarithromycin-induced delirium in a general hospital. 1998 Nov-Dec Psychosomatics pmid:9819955
Murata H et al. Evaluation of the PyloriTek test for detection of Helicobacter pylori infection in cases with and without eradication therapy. 1998 Am. J. Gastroenterol. pmid:9820380
Laine L et al. Twice-daily, 10-day triple therapy with omeprazole, amoxicillin, and clarithromycin for Helicobacter pylori eradication in duodenal ulcer disease: results of three multicenter, double-blind, United States trials. 1998 Am. J. Gastroenterol. pmid:9820381
Kaeser YA et al. Severe hypotension and bradycardia associated with verapamil and clarithromycin. 1998 Am J Health Syst Pharm pmid:9825040
Ward TT et al. Randomized, open-label trial of azithromycin plus ethambutol vs. clarithromycin plus ethambutol as therapy for Mycobacterium avium complex bacteremia in patients with human immunodeficiency virus infection. Veterans Affairs HIV Research Consortium. 1998 Clin. Infect. Dis. pmid:9827282
Howden CW and Hunt RH Treating Helicobacter pylori. 1998 Arch. Intern. Med. pmid:9827792
Anzueto A et al. Etiology, susceptibility, and treatment of acute bacterial exacerbations of complicated chronic bronchitis in the primary care setting: ciprofloxacin 750 mg b.i.d. versus clarithromycin 500 mg b.i.d. Bronchitis Study Group. 1998 Sep-Oct Clin Ther pmid:9829441
Dhawan VK et al. Vancomycin-resistant enterococcal colonization in nonhospitalized HIV-infected patients. 1998 West. J. Med. pmid:9830355
Shafran SD Prevention and treatment of disseminated Mycobacterium avium complex infection in human immunodeficiency virus-infected individuals. 1998 Jul-Sep Int. J. Infect. Dis. pmid:9831675
Valsecchi R and Pigatto P Chronic urticaria and Helicobacter pylori. 1998 Acta Derm. Venereol. pmid:9833044
Sackoff J et al. Prophylaxis for opportunistic infections among HIV-infected patients receiving medical care. 1998 J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. pmid:9833748