clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Blum AL et al. | Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia. Omeprazole plus Clarithromycin and Amoxicillin Effect One Year after Treatment (OCAY) Study Group. | 1998 | N. Engl. J. Med. | pmid:9862942 |
Adelglass J et al. | A multicenter, investigator-blinded, randomized comparison of oral levofloxacin and oral clarithromycin in the treatment of acute bacterial sinusitis. | 1998 Nov-Dec | Pharmacotherapy | pmid:9855324 |
Shimoyama T et al. | Healing of cimetidine-resistant Ménétrier's disease by eradication of Helicobacter pylori infection. | 1998 | J. Clin. Gastroenterol. | pmid:9855268 |
Cadwgan AM et al. | Neisseria meningitidis W135 pneumonia with sepicaemia in a nonogenarian. | 1998 | Scott Med J | pmid:9854302 |
Coudron PE and Stratton CW | In-vitro evaluation of nitrofurantoin as an alternative agent for metronidazole in combination antimicrobial therapy against Helicobacter pylori. | 1998 | J. Antimicrob. Chemother. | pmid:9848452 |
Gudjonsson H et al. | High Helicobacter pylori eradication rate with a 1-week regimen containing ranitidine bismuth citrate. | 1998 | Aliment. Pharmacol. Ther. | pmid:9845401 |
Gisbert JP et al. | [Role of pantoprazole in the eradicating treatment of Helicobacter pylori]. | 1998 | Rev Clin Esp | pmid:9844458 |
Gisbert JP et al. | [Omeprazole plus 2 antibiotics for the eradication of H. pylori, are 5 days of treatment sufficient?]. | 1998 | Rev Clin Esp | pmid:9844453 |
Kato S et al. | Safety and efficacy of one-week triple therapy for eradicating Helicobacter pylori in children. | 1998 | Helicobacter | pmid:9844069 |
Ohkusa T et al. | Disappearance of hyperplastic polyps in the stomach after eradication of Helicobacter pylori. A randomized, clinical trial. | 1998 | Ann. Intern. Med. | pmid:9841603 |
Moayyedi P et al. | Relevance of antibiotic sensitivities in predicting failure of omeprazole, clarithromycin, and tinidazole to eradicate Helicobacter pylori. | 1998 | J. Gastroenterol. | pmid:9840021 |
Borody TJ et al. | Eradication therapies for Helicobacter pylori. | 1998 | J. Gastroenterol. | pmid:9840019 |
Hogan PA and Sheehan DJ | Macrolide susceptibility and beta-lactamase production among haemophilus influenzae isolates in the United States, 1996-1997. | 1998 | Antimicrob. Agents Chemother. | pmid:9835536 |
Berry V et al. | Bacteriological efficacies of three macrolides compared with those of amoxicillin-clavulanate against Streptococcus pneumoniae and Haemophilus influenzae. | 1998 | Antimicrob. Agents Chemother. | pmid:9835514 |
Xia HH et al. | Metronidazole- and clarithromycin-resistant Helicobacter pylori in dyspeptic patients in western Sydney as determined by testing multiple isolates from different gastric sites. | 1998 | J. Gastroenterol. Hepatol. | pmid:9835322 |
van Haarst AD et al. | The influence of cisapride and clarithromycin on QT intervals in healthy volunteers. | 1998 | Clin. Pharmacol. Ther. | pmid:9834046 |
Sackoff J et al. | Prophylaxis for opportunistic infections among HIV-infected patients receiving medical care. | 1998 | J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. | pmid:9833748 |
Valsecchi R and Pigatto P | Chronic urticaria and Helicobacter pylori. | 1998 | Acta Derm. Venereol. | pmid:9833044 |
Shafran SD | Prevention and treatment of disseminated Mycobacterium avium complex infection in human immunodeficiency virus-infected individuals. | 1998 Jul-Sep | Int. J. Infect. Dis. | pmid:9831675 |
Dhawan VK et al. | Vancomycin-resistant enterococcal colonization in nonhospitalized HIV-infected patients. | 1998 | West. J. Med. | pmid:9830355 |