clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Stjepanovic MI et al. | Pulmonary and Vertebral Mycobacterium avium Disease in a HIV-negative 71-year-old Man - A Case Report. | 2016 | Infez Med | pmid:28011973 |
Muñoz-Egea MC et al. | Effect of Antibiotics and Antibiofilm Agents in the Ultrastructure and Development of Biofilms Developed by Nonpigmented Rapidly Growing Mycobacteria. | 2016 | Microb. Drug Resist. | pmid:26208145 |
Salimi A et al. | Toxicity of macrolide antibiotics on isolated heart mitochondria: a justification for their cardiotoxic adverse effect. | 2016 | Xenobiotica | pmid:26068526 |
Losurdo G et al. | Role of concomitant therapy for eradication: A technical note. | 2016 | World J. Gastroenterol. | pmid:27784977 |
Zycinska K et al. | Antibiotic Treatment of Hospitalized Patients with Pneumonia Complicated by Clostridium Difficile Infection. | 2016 | Adv. Exp. Med. Biol. | pmid:27620311 |
Bax HI et al. | Tigecycline Potentiates Clarithromycin Activity against Mycobacterium avium In Vitro. | 2016 | Antimicrob. Agents Chemother. | pmid:26883697 |
Hirata Y et al. | Efficacy of triple therapy with esomeprazole, amoxicillin, and sitafloxacin as a third-line Helicobacter pylori eradication regimen. | 2016 | Int. J. Infect. Dis. | pmid:27590563 |
Liou JM et al. | Concomitant, bismuth quadruple, and 14-day triple therapy in the first-line treatment of Helicobacter pylori: a multicentre, open-label, randomised trial. | 2016 | Lancet | pmid:27769562 |
Campillo A et al. | [10-day triple therapy with esomeprazole 40 mg/12 h vs. quadruple concomitant non-bismuth therapy as first line treatment for Helicobacter pylori infection]. | 2016 | Gastroenterol Hepatol | pmid:27084668 |
Chauffour A et al. | Sterilizing Activity of Fully Oral Intermittent Regimens against Mycobacterium Ulcerans Infection in Mice. | 2016 | PLoS Negl Trop Dis | pmid:27755552 |
Abuhammour A et al. | Standard triple therapy versus sequential therapy for eradication of Helicobacter pylori in treatment naïve and retreat patients. | 2016 | Arab J Gastroenterol | pmid:27665525 |
Matsumoto H et al. | Helicobacter pylori Eradication with Proton Pump Inhibitors or Potassium-Competitive Acid Blockers: The Effect of Clarithromycin Resistance. | 2016 | Dig. Dis. Sci. | pmid:27659671 |
Gisbert JP | Helicobacter pylori-related diseases. | 2016 | Gastroenterol Hepatol | pmid:27888863 |
Zhou L et al. | Tailored versus Triple plus Bismuth or Concomitant Therapy as Initial Helicobacter pylori Treatment: A Randomized Trial. | 2016 | Helicobacter | pmid:26104022 |
Rossi A et al. | Floating modular drug delivery systems with buoyancy independent of release mechanisms to sustain amoxicillin and clarithromycin intra-gastric concentrations. | 2016 | Drug Dev Ind Pharm | pmid:26065531 |
Nagashima A et al. | Clarithromycin Suppresses Chloride Channel Accessory 1 and Inhibits Interleukin-13-Induced Goblet Cell Hyperplasia in Human Bronchial Epithelial Cells. | 2016 | Antimicrob. Agents Chemother. | pmid:27550358 |
Couture G et al. | [Second case of serum sickness-like reaction to claritrhomycin]. | 2016 | Presse Med | pmid:27542759 |
Bugli F et al. | In vitro effect of clarithromycin and alginate lyase against helicobacter pylori biofilm. | 2016 | Biotechnol. Prog. | pmid:27535356 |
Shichijo S et al. | Vonoprazan versus conventional proton pump inhibitor-based triple therapy as first-line treatment against Helicobacter pylori: A multicenter retrospective study in clinical practice. | 2016 | J Dig Dis | pmid:27534444 |
Morimoto K et al. | Macrolide-Resistant Mycobacterium avium Complex Lung Disease: Analysis of 102 Consecutive Cases. | 2016 | Ann Am Thorac Soc | pmid:27513168 |
Christianson S et al. | Time-to-Detection of Inducible Macrolide Resistance in Mycobacterium abscessus Subspecies and Its Association with the Erm(41) Sequevar. | 2016 | PLoS ONE | pmid:27490181 |
Harada T et al. | Premedication with Clarithromycin Is Effective against Secondary Bacterial Pneumonia during Influenza Virus Infection in a Pulmonary Emphysema Mouse Model. | 2016 | J. Pharmacol. Exp. Ther. | pmid:27489022 |
Bonfigli AR et al. | Randomized, double-blind, placebo-controlled trial to evaluate the effect of Helicobacter pylori eradication on glucose homeostasis in type 2 diabetic patients. | 2016 | Nutr Metab Cardiovasc Dis | pmid:27480449 |
Orrin E et al. | Sporotrichoid Mycobacterium chelonae. | 2016 | Australas. J. Dermatol. | pmid:27469486 |
Yamamoto K et al. | Clarithromycin prevents human respiratory syncytial virus-induced airway epithelial responses by modulating activation of interferon regulatory factor-3. | 2016 | Pharmacol. Res. | pmid:27468646 |
Lotfipour F et al. | Study of Antimicrobial Effects of Clarithromycin Loaded PLGA Nanoparticles against Clinical Strains of Helicobacter pylori. | 2016 | Drug Res (Stuttg) | pmid:25919643 |
De Francesco V et al. | Two-week Triple Therapy with either Standard or High-dose Esomeprazole for First-line H. pylori Eradication. | 2016 | J Gastrointestin Liver Dis | pmid:27308644 |
Miyaki A et al. | An assessment of the efficacy of first-line Helicobacter pylori-eradication therapy based on clarithromycin susceptibility. | 2016 | Minerva Gastroenterol Dietol | pmid:27304198 |
Okano Y et al. | Miliary pulmonary nodules due to Mycobacterium xenopi in a steroid-induced immunocompromised patient successfully treated with chemotherapy: a case report. | 2016 | BMC Pulm Med | pmid:27287608 |
Steurer J | [Months of antibiotic therapy in persistent symptoms of Lyme disease without effect]. | 2016 | Praxis (Bern 1994) | pmid:27269781 |
Chung JW et al. | Ten-day empirical sequential or concomitant therapy is more effective than triple therapy for Helicobacter pylori eradication: A multicenter, prospective study. | 2016 | Dig Liver Dis | pmid:27257049 |
Mitchell H and Katelaris P | Epidemiology, clinical impacts and current clinical management of Helicobacter pylori infection. | 2016 | Med. J. Aust. | pmid:27256648 |
Ullah S et al. | Development of a biocompatible creatinine-based niosomal delivery system for enhanced oral bioavailability of clarithromycin. | 2016 | Drug Deliv | pmid:27247018 |
Kuo CH et al. | A Rapid and Accurate Method to Evaluate Helicobacter pylori Infection, Clarithromycin Resistance, and CYP2C19 Genotypes Simultaneously From Gastric Juice. | 2016 | Medicine (Baltimore) | pmid:27227911 |
Sluch IM et al. | Mycobacterium chelonae Scleral Abscess After Intravitreal Ranibizumab Injection. | 2016 | Cornea | pmid:27227391 |
Parize P et al. | Induction therapy with linezolid/clarithromycin combination for Mycobacterium chelonae skin infections in immunocompromised hosts. | 2016 | J Eur Acad Dermatol Venereol | pmid:25677464 |
Akram FE et al. | A combination of silver nanoparticles and visible blue light enhances the antibacterial efficacy of ineffective antibiotics against methicillin-resistant Staphylococcus aureus (MRSA). | 2016 | Ann. Clin. Microbiol. Antimicrob. | pmid:27530257 |
Manniello MD et al. | Aerodynamic properties, solubility and in vitro antibacterial efficacy of dry powders prepared by spray drying: Clarithromycin versus its hydrochloride salt. | 2016 | Eur J Pharm Biopharm | pmid:27106605 |
Fallone CA et al. | The Toronto Consensus for the Treatment of Helicobacter pylori Infection in Adults. | 2016 | Gastroenterology | pmid:27102658 |
Bilgilier C et al. | Prevalence of clarithromycin-resistant Helicobacter pylori strains in gastric mucosa-associated lymphoid tissue lymphoma patients. | 2016 | Ann. Hematol. | pmid:27091350 |
Root AA et al. | Evaluation of the risk of cardiovascular events with clarithromycin using both propensity score and self-controlled study designs. | 2016 | Br J Clin Pharmacol | pmid:27090996 |
Kazama I et al. | Clarithromycin Dose-Dependently Stabilizes Rat Peritoneal Mast Cells. | 2016 | Chemotherapy | pmid:27088971 |
Huynh VA et al. | [Fixed drug eruption to clarithromycin: The importance of challenge tests in diagnosis]. | 2016 | Ann Dermatol Venereol | pmid:27080820 |
EmiralioÄŸlu N et al. | Pulmonary Mycobacterium abscessus Infection in a Patient with Triple A Syndrome. | 2016 | J. Trop. Pediatr. | pmid:27080471 |
Graham DY and Dore MP | Helicobacter pylori therapy: a paradigm shift. | 2016 | Expert Rev Anti Infect Ther | pmid:27077447 |
Song ZQ et al. | Hybrid Therapy Regimen for Helicobacter Pylori Eradication. | 2016 | Chin. Med. J. | pmid:27064046 |
Matsumoto H et al. | Molecular Detection of H. pylori Using Adherent Gastric Mucous to Biopsy Forceps. | 2016 | Helicobacter | pmid:27061611 |
Tsaganos T et al. | Clarithromycin Leads to Long-Term Survival and Cost Benefit in Ventilator-Associated Pneumonia and Sepsis. | 2016 | Antimicrob. Agents Chemother. | pmid:27044546 |
Buchicchio A et al. | Biodegradation of carbamazepine and clarithromycin by Trichoderma harzianum and Pleurotus ostreatus investigated by liquid chromatography - high-resolution tandem mass spectrometry (FTICR MS-IRMPD). | 2016 | Sci. Total Environ. | pmid:27039063 |
Melia MT and Auwaerter PG | Time for a Different Approach to Lyme Disease and Long-Term Symptoms. | 2016 | N. Engl. J. Med. | pmid:27028918 |
Guirao-Arrabal E et al. | Clarithromycin plus linezolid as a sequential therapy for implantable-cardioverter-defibrillator infection caused by coagulase-negative staphylococci. | 2016 | Rev Esp Quimioter | pmid:26888341 |
Friedman ND et al. | Increasing Experience with Primary Oral Medical Therapy for Mycobacterium ulcerans Disease in an Australian Cohort. | 2016 | Antimicrob. Agents Chemother. | pmid:26883709 |
Chua CS et al. | The efficacy of blueberry and grape seed extract combination on triple therapy for Helicobacter pylori eradication: a randomised controlled trial. | 2016 | Int J Food Sci Nutr | pmid:26883189 |
Meng X et al. | [Antibiotic resistance of Helicobacter pylori clinical isolates in Hebei Province]. | 2016 | Zhonghua Yi Xue Za Zhi | pmid:26879786 |
Bakshi SS | Outcome evaluation of clarithromycin, metronidazole and lansoprazole regimens in Helicobacter pylori positive or negative children with resistant otitis media with effusion. | 2016 | J Laryngol Otol | pmid:26878377 |
Franceschi F et al. | High dose amoxicillin-based first line regimen is equivalent to sequential therapy in the eradication of H. pylori infection. | 2016 | Eur Rev Med Pharmacol Sci | pmid:26875899 |
Tepeš B et al. | Randomized clinical trial comparing 10-day sequential, 7-day concomitant and 7-day standard triple therapies for Helicobacter pylori eradication. | 2016 | Eur J Gastroenterol Hepatol | pmid:26862930 |
Lim SG et al. | The relationship between the failure to eradicate Helicobacter pylori and previous antibiotics use. | 2016 | Dig Liver Dis | pmid:26856963 |
Niv Y | Doxycycline in Eradication Therapy of Helicobacter pylori--a Systematic Review and Meta-Analysis. | 2016 | Digestion | pmid:26849820 |
Mukai S et al. | Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines. | 2016 | Int. J. Oncol. | pmid:26718641 |
Radheshi E et al. | Postmortem diagnosis of anaphylaxis in presence of decompositional changes. | 2016 | J Forensic Leg Med | pmid:26735898 |
Hassan ST et al. | In vitro synergistic effect of Hibiscus sabdariffa aqueous extract in combination with standard antibiotics against Helicobacter pylori clinical isolates. | 2016 | Pharm Biol | pmid:26731378 |
Çağan-Appak Y et al. | Clarithromycin resistance and 23S rRNA gene point mutations of Helicobacter pylori infection in children. | 2016 | Turk. J. Pediatr. | pmid:28276208 |
Thung I et al. | Review article: the global emergence of Helicobacter pylori antibiotic resistance. | 2016 | Aliment. Pharmacol. Ther. | pmid:26694080 |
Vermeer LM et al. | Evaluation of Ketoconazole and Its Alternative Clinical CYP3A4/5 Inhibitors as Inhibitors of Drug Transporters: The In Vitro Effects of Ketoconazole, Ritonavir, Clarithromycin, and Itraconazole on 13 Clinically-Relevant Drug Transporters. | 2016 | Drug Metab. Dispos. | pmid:26668209 |
Meng Y et al. | Multi-functional Liposomes Enhancing Target and Antibacterial Immunity for Antimicrobial and Anti-Biofilm Against Methicillin-Resistant Staphylococcus aureus. | 2016 | Pharm. Res. | pmid:26666773 |
Kamiya K et al. | Erythema multiforme caused by triple therapy with amoxicillin, clarithromycin and vonoprazan for Helicobacter pylori. | 2016 | J. Dermatol. | pmid:26508502 |
Mark TM and Coleman M | It's Time to Take Clarithromycin Seriously in Multiple Myeloma. | 2016 | Acta Haematol. | pmid:26505907 |
Qiu XH et al. | Clarithromycin Synergistically Enhances Thalidomide Cytotoxicity in Myeloma Cells. | 2016 | Acta Haematol. | pmid:26505646 |
Oh B et al. | The Effect of Probiotics on Gut Microbiota during the Helicobacter pylori Eradication: Randomized Controlled Trial. | 2016 | Helicobacter | pmid:26395781 |
Lee J et al. | A new anti-microbial combination prolongs the latency period, reduces acute histologic chorioamnionitis as well as funisitis, and improves neonatal outcomes in preterm PROM. | 2016 | J. Matern. Fetal. Neonatal. Med. | pmid:26373262 |
Ghaith D et al. | Mutations affecting domain V of the 23S rRNA gene in Helicobacter pylori from Cairo, Egypt. | 2016 | J Chemother | pmid:26358218 |
Tsujimae M et al. | A Comparative Study of a New Class of Gastric Acid Suppressant Agent Named Vonoparazan versus Esomeprazole for the Eradication of Helicobacter pylori. | 2016 | Digestion | pmid:28030862 |
Li Y et al. | Liposomal co-delivery of daptomycin and clarithromycin at an optimized ratio for treatment of methicillin-resistant Staphylococcus aureus infection. | 2015 | Drug Deliv | pmid:24471983 |
Sobajima T et al. | A Case of Pulmonary Actinomycosis Associated With Aspiration of Cedar Leaves. | 2015 | J Bronchology Interv Pulmonol | pmid:26165898 |
Gunjan S et al. | Clarithromycin enhances the antimalarial efficacy of mefloquine via its increased bioavailability and disrupting P. falciparum apicoplast. | 2015 | Life Sci. | pmid:26164186 |
Tongtawee T et al. | Effect of Pretreatment with Lactobacillus delbrueckii and Streptococcus thermophillus on Tailored Triple Therapy for Helicobacter pylori Eradication: A Prospective Randomized Controlled Clinical Trial. | 2015 | Asian Pac. J. Cancer Prev. | pmid:26163609 |
Fujimura S et al. | Antimicrobial efficacy of combined clarithromycin plus daptomycin against biofilms-formed methicillin-resistant Staphylococcus aureus on titanium medical devices. | 2015 | J. Infect. Chemother. | pmid:26162777 |
Converse PJ et al. | Efficacy of Rifampin Plus Clofazimine in a Murine Model of Mycobacterium ulcerans Disease. | 2015 | PLoS Negl Trop Dis | pmid:26042792 |
Klain V and Timmerman L | Comment on The dangers of gastritis: a case of clarithromycin-associated brief psychotic episode. | 2015 | J. Nerv. Ment. Dis. | pmid:26034875 |
Prapitpaiboon H et al. | High Efficacy of Levofloxacin-Dexlansoprazole-Based Quadruple Therapy as a First Line Treatment for Helicobacter pylori Eradication in Thailand. | 2015 | Asian Pac. J. Cancer Prev. | pmid:26028098 |
Nayyar E and Taimur S | Sporotrichoid lesions: an age-old conundrum. | 2015 | Am. J. Med. | pmid:26021809 |
Harb AH et al. | Systematic review and meta-analysis: full- vs. half-dose anti-microbials in clarithromycin-based regimens for Helicobacter pylori eradication. | 2015 | Aliment. Pharmacol. Ther. | pmid:26011564 |
Heo J et al. | Concomitant and hybrid therapy for Helicobacter pylori infection: A randomized clinical trial. | 2015 | J. Gastroenterol. Hepatol. | pmid:25867608 |
Sugita S et al. | EGFR-independent autophagy induction with gefitinib and enhancement of its cytotoxic effect by targeting autophagy with clarithromycin in non-small cell lung cancer cells. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25858318 |
Kesselheim AS et al. | Reductions in Use of Colchicine after FDA Enforcement of Market Exclusivity in a Commercially Insured Population. | 2015 | J Gen Intern Med | pmid:25855479 |
Gianni C | Treatment and prevention of paronychia using a new combination of topicals: report of 30 cases. | 2015 | G Ital Dermatol Venereol | pmid:25854670 |
Zhang S et al. | Early or late antibiotic intervention prevents Helicobacter pylori-induced gastric cancer in a mouse model. | 2015 | Cancer Lett. | pmid:25853150 |
Iino Y et al. | Clinical effects of clarithromycin on persistent inflammation following Haemophilus influenzae-positive acute otitis media. | 2015 | Acta Otolaryngol. | pmid:25649881 |
Streetman DS and Stout SM | Is there a clinically relevant interaction between clarithromycin and statins not metabolized by cytochrome P450 3A4? | 2015 | CMAJ | pmid:25646282 |
Ang TL et al. | Ten-day triple therapy versus sequential therapy versus concomitant therapy as first-line treatment for Helicobacter pylori infection. | 2015 | J. Gastroenterol. Hepatol. | pmid:25639278 |
Jiang F et al. | The influences of CYP2D6 genotypes and drug interactions on the pharmacokinetics of venlafaxine: exploring predictive biomarkers for treatment outcomes. | 2015 | Psychopharmacology (Berl.) | pmid:25510856 |
Kim H et al. | Efficacy of Helicobacter pylori eradication for the 1st line treatment of immune thrombocytopenia patients with moderate thrombocytopenia. | 2015 | Ann. Hematol. | pmid:25501820 |
Keshavarz Azizi Raftar S et al. | The Helicobacter pylori resistance rate to clarithromycin in Iran. | 2015 | Microb. Drug Resist. | pmid:25144338 |
Chan CC et al. | Comparison of 10-day sequential therapy with 7-day standard triple therapy for Helicobacter pylori eradication in inactive peptic ulcer disease and the efficiency of sequential therapy in inactive peptic ulcer disease and non-ulcer dyspepsia. | 2015 | BMC Gastroenterol | pmid:26635102 |
Hsu PI et al. | A Randomized Controlled Study Comparing Reverse Hybrid Therapy and Standard Triple Therapy for Helicobacter pylori Infection. | 2015 | Medicine (Baltimore) | pmid:26632893 |
Buch T and Andersen SE | [Combination therapy with fluconazole and other QTc-prolonging drugs increase the QTc interval]. | 2015 | Ugeskr. Laeg. | pmid:26471025 |
Kiesewetter B et al. | Clarithromycin Leading to Complete Remission in the First-Line Treatment of Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma. | 2015 | J. Clin. Oncol. | pmid:24778391 |
Zhang W et al. | Bismuth, lansoprazole, amoxicillin and metronidazole or clarithromycin as first-line Helicobacter pylori therapy. | 2015 | Gut | pmid:26338726 |
Fasciana T et al. | Resistance to clarithromycin and genotypes in Helicobacter pylori strains isolated in Sicily. | 2015 | J. Med. Microbiol. | pmid:26338221 |