clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Iris Diseases D007499 2 associated lipids
Insulin Resistance D007333 99 associated lipids
Influenza, Human D007251 11 associated lipids
Infant, Premature, Diseases D007235 7 associated lipids
Immunoproliferative Small Intestinal Disease D007161 2 associated lipids
Hypoproteinemia D007019 1 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hyperemesis Gravidarum D006939 2 associated lipids
Hypercholesterolemia D006937 91 associated lipids
HIV Seropositivity D006679 15 associated lipids
Hernia, Hiatal D006551 3 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Hemophilia A D006467 10 associated lipids
Hemolysis D006461 131 associated lipids
Heart Failure D006333 36 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Hearing Disorders D006311 10 associated lipids
Hand Dermatoses D006229 5 associated lipids
Granuloma, Plasma Cell D006104 1 associated lipids
Glossitis, Benign Migratory D005929 1 associated lipids
Giardiasis D005873 3 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Gastritis, Hypertrophic D005758 1 associated lipids
Gastritis, Atrophic D005757 4 associated lipids
Gastritis D005756 27 associated lipids
Fusobacterium Infections D005674 3 associated lipids
Fractures, Open D005597 3 associated lipids
Foot Diseases D005534 4 associated lipids
Fistula D005402 8 associated lipids
Fibrosis D005355 23 associated lipids
Fever D005334 35 associated lipids
Exanthema D005076 11 associated lipids
Euthyroid Sick Syndromes D005067 1 associated lipids
Esophagitis, Peptic D004942 4 associated lipids
Erythema Nodosum D004893 5 associated lipids
Ergotism D004881 4 associated lipids
Enterocolitis, Pseudomembranous D004761 8 associated lipids
Endometriosis D004715 29 associated lipids
Encephalomyelitis, Acute Disseminated D004673 1 associated lipids
Encephalitis D004660 15 associated lipids
Empyema, Tuberculous D004654 1 associated lipids
Empyema D004653 3 associated lipids
Ecchymosis D004438 3 associated lipids
Dyspnea D004417 10 associated lipids
Dyspepsia D004415 5 associated lipids
Duodenogastric Reflux D004383 2 associated lipids
Duodenitis D004382 4 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Per page 10 20 50 100 | Total 7636
Authors Title Published Journal PubMed Link
Savarino V et al. Optimal duration of therapy combining ranitidine bismuth citrate with clarithromycin and metronidazole in the eradication of Helicobacter pylori infection. 1999 Aliment. Pharmacol. Ther. pmid:9892878
Abe M et al. A case of diffuse panbronchiolitis effectively treated with low-dose macrolide antibiotics and leukotriene D4/E4 receptor antagonist. 1998 Respir Med pmid:9893782
Lacy MK et al. Comparison of bactericidal activity after multidose administration of clarithromycin, azithromycin, and ceruroxime axetil against Streptococcus pneumoniae. 1998 Int. J. Antimicrob. Agents pmid:9916901
Fera MT et al. Bactericidal activity of lansoprazole and three macrolides against Helicobacter pylori strains tested by the time-kill kinetic method. 1998 Int. J. Antimicrob. Agents pmid:9916902
Miglioli PA et al. Antibacterial activity of human pleural fluid: alone and in combination with antibiotics. 1998 Int. J. Antimicrob. Agents pmid:9916908
Garrido A et al. [Eradication of Helicobacter pylori by triple therapy in ulcerous patients: the role of endoscopy and antibiotic sensitivity]. 1998 Enferm. Infecc. Microbiol. Clin. pmid:9918994
Lind T et al. The MACH2 study: role of omeprazole in eradication of Helicobacter pylori with 1-week triple therapies. 1999 Gastroenterology pmid:9922303
Kuipers EJ and Klinkenberg-Knol EC Helicobacter pylori, acid, and omeprazole revisited: bacterial eradication and rebound hypersecretion. 1999 Gastroenterology pmid:9922329
Matsushima T and Miyashita N [Basic and clinical study of Chlamydia pneumoniae infections]. 1998 Nippon Naika Gakkai Zasshi pmid:9922675
Stefansson P et al. Cefuroxime axetil versus clarithromycin in the treatment of acute maxillary sinusitis. 1998 Rhinology pmid:9923060
García-Arata MI et al. Mutations in 23S rRNA in Helicobacter pylori conferring resistance to erythromycin do not always confer resistance to clarithromycin. 1999 Antimicrob. Agents Chemother. pmid:9925537
Lindeboom JA et al. Clarithromycin as a single-modality treatment in mycobacterial avium-intracellular infections. 1999 Oral Surg Oral Med Oral Pathol Oral Radiol Endod pmid:9927080
Principi N and Esposito S Comparative tolerability of erythromycin and newer macrolide antibacterials in paediatric patients. 1999 Drug Saf pmid:9935275
Desta Z et al. Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6). 1999 Clin. Pharmacol. Ther. pmid:9951426
Yonemochi E et al. Physicochemical properties of amorphous clarithromycin obtained by grinding and spray drying. 1999 Eur J Pharm Sci pmid:9971917
Piquette RK Torsade de pointes induced by cisapride/clarithromycin interaction. 1999 Ann Pharmacother pmid:9972380