clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

Cross Reference

Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Leprosy, Paucibacillary D056005 2 associated lipids
Typhoid Fever D014435 2 associated lipids
Soft Tissue Infections D018461 2 associated lipids
Empyema, Pleural D016724 2 associated lipids
Diphtheria D004165 2 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Mastoiditis D008417 2 associated lipids
Periodontal Abscess D010508 2 associated lipids
Cytomegalovirus Retinitis D017726 2 associated lipids
Duodenogastric Reflux D004383 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Authors Title Published Journal PubMed Link
Lonks JR and Medeiros AA High rate of erythromycin and clarithromycin resistance among Streptococcus pneumoniae isolates from blood cultures from Providence, R.I. 1993 Antimicrob. Agents Chemother. pmid:8239578
Sader HS et al. In vitro activity of cefpodoxime compared with other oral cephalosporins tested against 5556 recent clinical isolates from five medical centers. 1993 Aug-Sep Diagn. Microbiol. Infect. Dis. pmid:8243035
Miller CA Infections, resistant microbes, and older adults. 1993 Jan-Feb Geriatr Nurs pmid:8383085
Ritchie DJ et al. In vitro activity of clarithromycin, cefprozil, and other common oral antimicrobial agents against gram-positive and gram-negative pathogens. 1993 Jan-Feb Clin Ther pmid:8458040
Albani F et al. Clarithromycin-carbamazepine interaction: a case report. 1993 Jan-Feb Epilepsia pmid:8422851
Adam D Clarithromycin 250 mg b.i.d. for 5 or 10 days in the treatment of adult patients with purulent bronchitis. 1993 Jul-Aug Infection pmid:8225636
Coles SJ et al. A comparative study of clarithromycin and amoxycillin suspensions in the treatment of pediatric patients with acute otitis media. 1993 Jul-Aug Infection pmid:8225637
Ohmori S et al. Effects of clarithromycin and its metabolites on the mixed function oxidase system in hepatic microsomes of rats. 1993 Mar-Apr Drug Metab. Dispos. pmid:8097709
Wallace RJ et al. Drug intolerance to high-dose clarithromycin among elderly patients. 1993 Mar-Apr Diagn. Microbiol. Infect. Dis. pmid:8477575
Scaglione F et al. A new model examining intracellular and extracellular activity of amoxicillin, azithromycin, and clarithromycin in infected cells. 1993 Nov-Dec Chemotherapy pmid:8222870
Wüst J and Hardegger U Penetration of clarithromycin into human saliva. 1993 Sep-Oct Chemotherapy pmid:8370320
Darling TN et al. Treatment of Mycobacterium haemophilum infection with an antibiotic regimen including clarithromycin. 1994 Br. J. Dermatol. pmid:7918014
Domschke W Omeprazole, Helicobacter pylori, and gastritis. 1994 J. Gastroenterol. pmid:7921141
Geraci AJ Empiric antibiotics in sinusitis. 1994 Arch Fam Med pmid:7921288
Rust GS Multicenter comparison of clarithromycin and amoxicillin. 1994 Arch Fam Med pmid:7921290
Rolinson GN A clarithromycin sensitivity survey. 1994 J. Antimicrob. Chemother. pmid:7829420
Durodie J and Slocombe B A clarithromycin sensitivity survey. 1994 J. Antimicrob. Chemother. pmid:7829421
Sano M et al. [Inhibition of biofilm formation by clarithromycin (CAM) in an experimental model of complicated bladder infection--in vitro study using automated simulation of urinary antimicrobial concentration]. 1994 Kansenshogaku Zasshi pmid:7829898
Sieber CC et al. [Helicobacter pylori resistance against metronidazole in Switzerland: implications for eradication therapy?]. 1994 Schweiz Med Wochenschr pmid:8091165
Dorrell L et al. Toxicity of clarithromycin in the treatment of Mycobacterium avium complex infection in a patient with AIDS. 1994 J. Antimicrob. Chemother. pmid:7868416
Funke G et al. Development of resistance to macrolide antibiotics in an AIDS patient treated with clarithromycin for Campylobacter jejuni diarrhea. 1994 Eur. J. Clin. Microbiol. Infect. Dis. pmid:7805694
Fujii R et al. [Clinical studies on clarithromycin dry syrup in the pediatric field. Pediatric Study Group of TE-031 Dry Syrup]. 1994 Jpn J Antibiot pmid:7807690
Uveitis associated with rifabutin therapy. 1994 MMWR Morb. Mortal. Wkly. Rep. pmid:8072478
Labenz J and Stolte M [Current therapy of Helicobacter pylori infection]. 1994 Leber Magen Darm pmid:8145628
Logan RP et al. Eradication of Helicobacter pylori with clarithromycin and omeprazole. 1994 Gut pmid:8150340
Fujii K et al. In vitro and in vivo antibacterial activities of KRM-1648 and KRM-1657, new rifamycin derivatives. 1994 Antimicrob. Agents Chemother. pmid:8067748
Bermudez LE et al. Activity of KRM 1648 alone or in combination with ethambutol or clarithromycin against Mycobacterium avium in beige mouse model of disseminated infection. 1994 Antimicrob. Agents Chemother. pmid:7986018
al-Assi MT et al. Clarithromycin-amoxycillin therapy for Helicobacter pylori infection. 1994 Aliment. Pharmacol. Ther. pmid:7986970
Neri M et al. Omeprazole, bismuth and clarithromycin in the sequential treatment of Helicobacter pylori infection. 1994 Aliment. Pharmacol. Ther. pmid:7986974
[Recent advances in macrolide antibiotics: focused on clarithromycin. Discussion]. 1994 Jpn J Antibiot pmid:7990251
Wallace RJ et al. Initial clarithromycin monotherapy for Mycobacterium avium-intracellulare complex lung disease. 1994 Am. J. Respir. Crit. Care Med. pmid:8173775
Husson RN et al. Orally administered clarithromycin for the treatment of systemic Mycobacterium avium complex infection in children with acquired immunodeficiency syndrome. 1994 J. Pediatr. pmid:8176574
Alder J et al. Treatment of experimental Pneumocystis carinii infection by combination of clarithromycin and sulphamethoxazole. 1994 J. Antimicrob. Chemother. pmid:8182006
Tsang KW et al. The concentrations of clarithromycin and its 14-hydroxy metabolite in sputum of patients with bronchiectasis following single dose oral administration. 1994 J. Antimicrob. Chemother. pmid:8182010
Sundberg L and Cederberg A Penetration of clarithromycin and its 14-hydroxy metabolite into middle ear effusion in children with secretory otitis media. 1994 J. Antimicrob. Chemother. pmid:8182011
Kodama R et al. Combination therapy with clarithromycin and sofalcone for eradication of Helicobacter pylori. 1994 Eur J Gastroenterol Hepatol pmid:7735929
Klemens SP and Cynamon MH Intermittent azithromycin for treatment of Mycobacterium avium infection in beige mice. 1994 Antimicrob. Agents Chemother. pmid:7986001
[Zeclar, a new antibiotic (clarithromycin 250 mg from Abbott laboratories]. 1994 Rev Infirm pmid:7652424
Cynamon MH et al. Comparative activities of azithromycin and clarithromycin against Mycobacterium avium infection in beige mice. 1994 Antimicrob. Agents Chemother. pmid:7979270
Antibiotic gets FDA nod for MAC treatment. 1994 Am J Nurs pmid:8304386
Yoshida K et al. Chlamydia trachomatis infection in the semen of asymptomatic infertile men: detection of the antigen by in situ hybridization. 1994 Urol. Int. pmid:7855940
Laing RB et al. New antimicrobials against Mycobacterium marinum infection. 1994 Br. J. Dermatol. pmid:7857853
Spiegl PV and Feiner CM Mycobacterium phlei infection of the foot: a case report. 1994 Foot Ankle Int pmid:7894643
Walker KJ et al. Evaluation of antimicrobial activities of clarithromycin and 14-hydroxyclarithromycin against three strains of Haemophilus influenzae by using an in vitro pharmacodynamic model. 1994 Antimicrob. Agents Chemother. pmid:7811010
Price DA et al. Clinical response to the addition of clarithromycin in Pneumocystis carinii pneumonia refractory to high dose co-trimoxazole. 1994 J. Antimicrob. Chemother. pmid:7814298
Tahara RW et al. The question of clarithromycin: a first-line drug for sinusitis? 1994 Arch Fam Med pmid:7818657
Pustorino S et al. [Effects of intravenous administration of clarithromycin on plasma levels of gastrin and group I pepsinogen]. 1994 Clin Ter pmid:7820984
Alder J et al. Treatment of experimental Toxoplasma gondii infection by clarithromycin-based combination therapy with minocycline or pyrimethamine. 1994 J. Acquir. Immune Defic. Syndr. pmid:7932081
Ferrari SL et al. The interaction between clarithromycin and cyclosporine in kidney transplant recipients. 1994 Transplantation pmid:7940695
Tomono K [Therapeutic efficacy of macrolide in pulmonary nontuberculous mycobacteriosis]. 1994 Kekkaku pmid:7837727