clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

Cross Reference

Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with clarithromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with clarithromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with clarithromycin

Download all related citations
Per page 10 20 50 100 | Total 7636
Authors Title Published Journal PubMed Link
Espinal DA et al. [Human metapneumovirus in children: first cases in Colombia]. 2012 Biomedica pmid:23242289
Figueroa M et al. [Antimicrobial susceptibility of Helicobacter pylori with chronic gastritis]. 2012 Jan-Mar Biomedica pmid:23235785
Reed PI and Johnston BJ Treatment of Helicobacter pylori infection. 1997 Biomed. Pharmacother. pmid:9084725
Li W et al. Liquid chromatographic-electrospray tandem mass spectrometric determination of clarithromycin in human plasma. 2006 Biomed. Chromatogr. pmid:16838265
Niopas I and Daftsios AC Determination of clarithromycin in human plasma by HPLC with electrochemical detection: validation and application in pharmacokinetic study. 2001 Biomed. Chromatogr. pmid:11748684
Kousoulos C et al. Validation of a fully automated high throughput liquid chromatographic/tandem mass spectrometric method for roxithromycin quantification in human plasma. Application to a bioequivalence study. 2008 Biomed. Chromatogr. pmid:18059078
Angol DC et al. from Peptic Ulcer Patients in Uganda Is Highly Resistant to Clarithromycin and Fluoroquinolones: Results of the GenoType HelicoDR Test Directly Applied on Stool. 2017 Biomed Res Int pmid:28555193
Nie W et al. Species Identification and Clarithromycin Susceptibility Testing of 278 Clinical Nontuberculosis Mycobacteria Isolates. 2015 Biomed Res Int pmid:26146620
Tai WC et al. Seven-Day Nonbismuth Containing Quadruple Therapy Could Achieve a Grade "A" Success Rate for First-Line Helicobacter pylori Eradication. 2015 Biomed Res Int pmid:26090428
Patel SK et al. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study. 2014 Biomed Res Int pmid:25054141
Peric A et al. Influence of allergy on the immunomodulatory and clinical effects of long-term low-dose macrolide treatment of nasal polyposis. 2010 Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub pmid:21293544
Dogan Z et al. The effect of Helicobacter pylori eradication on insulin resistance and HbA1c level in people with normal glucose levels: a prospective study. 2015 Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub pmid:24993741
Liang CM et al. Levofloxacin-containing second-line anti-Helicobacter pylori eradication in Taiwanese real-world practice. Biomed J pmid:25163495
Vijayananthan A et al. Mastoiditis secondary to mycobacterium abscessus imaged with gallium-67 scintigraphy. 2008 Biomed Imaging Interv J pmid:21614326
Roccaro AM et al. Advances in the treatment of monoclonal gammopaties: The emerging role of targeted therapy in plasma cell dyscrasias. 2008 Biologics pmid:19707373
Prakash S and Urbanska AM Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells. 2008 Biologics pmid:19707368
Yoneda K et al. In vitro metabolism and inhibitory effects of pranlukast in human liver microsomes. 2009 Biol. Pharm. Bull. pmid:19336906
Matsui E et al. The influence of glycyrrhiza and antibiotics on the purgative action of sennoside a from Daiokanzoto in mice. 2011 Biol. Pharm. Bull. pmid:21881230
Ishii K et al. A new pharmacokinetic model including in vivo dissolution and gastrointestinal transit parameters. 1995 Biol. Pharm. Bull. pmid:7550125
Miyamoto D et al. Clarithromycin inhibits progeny virus production from human influenza virus-infected host cells. 2008 Biol. Pharm. Bull. pmid:18239276
Togami K et al. Subcellular distribution of azithromycin and clarithromycin in rat alveolar macrophages (NR8383) in vitro. 2013 Biol. Pharm. Bull. pmid:23995662
Hanawa T et al. In vitro antibacterial activity of Phx-3 against Helicobacter pylori. 2010 Biol. Pharm. Bull. pmid:20118538
Komori T et al. Effects of repeated clarithromycin administration on the pharmacokinetic properties of pindolol in rats. 1998 Biol. Pharm. Bull. pmid:9881659
Masa K et al. Effect of clarithromycin and other macrolides on the sulfoxidation and 5-hydroxylation of lansoprazole in dogs. 1999 Biol. Pharm. Bull. pmid:10375172
Zaidi SF et al. Potent bactericidal constituents from Mallotus philippinensis against clarithromycin and metronidazole resistant strains of Japanese and Pakistani Helicobacter pylori. 2009 Biol. Pharm. Bull. pmid:19336896
Kido H et al. Secretory leukoprotease inhibitor and pulmonary surfactant serve as principal defenses against influenza A virus infection in the airway and chemical agents up-regulating their levels may have therapeutic potential. 2004 Biol. Chem. pmid:15576322
Mark T et al. Stem cell mobilization with cyclophosphamide overcomes the suppressive effect of lenalidomide therapy on stem cell collection in multiple myeloma. 2008 Biol. Blood Marrow Transplant. pmid:18541199
Panozzo C et al. Chemicals or mutations that target mitochondrial translation can rescue the respiratory deficiency of yeast bcs1 mutants. 2017 Biochim. Biophys. Acta pmid:28888990
Sinan S et al. Amphenicol and macrolide derived antibiotics inhibit paraoxonase enzyme activity in human serum and human hepatoma cells (HepG2) in vitro. 2006 Biochemistry Mosc. pmid:16457617
Burgie ES and Holden HM Molecular architecture of DesI: a key enzyme in the biosynthesis of desosamine. 2007 Biochemistry pmid:17630700
Komori T et al. Up-regulation by clarithromycin of alpha(1)-acid glycoprotein expression in liver and primary cultured hepatocytes. 2001 Biochem. Pharmacol. pmid:11709199
Yamamoto S et al. Mitochondrial proteins NIP-SNAP-1 and -2 are a target for the immunomodulatory activity of clarithromycin, which involves NF-κB-mediated cytokine production. 2017 Biochem. Biophys. Res. Commun. pmid:27998764
Wang EJ et al. Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. 2001 Biochem. Biophys. Res. Commun. pmid:11716514
Yamanaka Y et al. Gene expression profiles of human small airway epithelial cells treated with low doses of 14- and 16-membered macrolides. 2001 Biochem. Biophys. Res. Commun. pmid:11549274
Sugita S et al. EGFR-independent autophagy induction with gefitinib and enhancement of its cytotoxic effect by targeting autophagy with clarithromycin in non-small cell lung cancer cells. 2015 Biochem. Biophys. Res. Commun. pmid:25858318
Komatsu S et al. Combined treatment with SAHA, bortezomib, and clarithromycin for concomitant targeting of aggresome formation and intracellular proteolytic pathways enhances ER stress-mediated cell death in breast cancer cells. 2013 Biochem. Biophys. Res. Commun. pmid:23792097
Highleyman L FDA issues Hismanal warning. Food and Drug Administration. 1998 BETA pmid:11365263
Bartnof HS OIs and cancers. 1999 BETA pmid:11367262
Wolle K and Malfertheiner P Treatment of Helicobacter pylori. 2007 Best Pract Res Clin Gastroenterol pmid:17382279
Pilotto A Aging and upper gastrointestinal disorders. 2004 Best Pract Res Clin Gastroenterol pmid:15588798
Chen SA et al. HLA-A*02:07 Allele Associates with Clarithromycin-Induced Cutaneous Adverse Drug Reactions in Chinese Patients. 2018 Basic Clin. Pharmacol. Toxicol. pmid:29575644
Gao X et al. Suppression of inducible nitric oxide synthase expression and nitric oxide production by macrolide antibiotics in sulfur mustard-exposed airway epithelial cells. 2008 Basic Clin. Pharmacol. Toxicol. pmid:18684233
Hajiioannou JK et al. Clarithromycin induced reversible sensorineural hearing loss. 2011 B-ENT pmid:21838098
Ledwoń A et al. Multidrug therapy of Mycobacterium avium subsp. avium infection in experimentally inoculated budgerigars (Melopsittacus undulatus). 2015 Avian Pathol. pmid:26364975
Simjee S et al. Antimicrobial susceptibility and distribution of antimicrobial-resistance genes among Enterococcus and coagulase-negative Staphylococcus isolates recovered from poultry litter. 2007 Avian Dis. pmid:18251398
Phan TA and Relic J Sporotrichoid Mycobacterium marinum infection of the face following a cat scratch. 2010 Australas. J. Dermatol. pmid:20148843
Orrin E et al. Sporotrichoid Mycobacterium chelonae. 2016 Australas. J. Dermatol. pmid:27469486
Ricciardo B et al. Mycobacterium abscessus infection complicating a professional tattoo. 2010 Australas. J. Dermatol. pmid:21198529
Ozluer SM and De'Ambrosis BJ Mycobacterium abscessus wound infection. 2001 Australas. J. Dermatol. pmid:11233716
Bennie CJ et al. In vitro interaction of some drug combinations to inhibit rapidly growing mycobacteria isolates from cats and dogs and these isolates' susceptibility to cefovecin and clofazimine. Aust. Vet. J. pmid:25622709
Lucas J et al. Mycobacterium genavense infection in two aged ferrets with conjunctival lesions. 2000 Aust. Vet. J. pmid:11098383
Malik R et al. Treatment of canine leproid granuloma syndrome: preliminary findings in seven dogs. 2001 Aust. Vet. J. pmid:11221566
Lunn JA et al. Pneumonia due to Mycobacterium abscessus in two domestic ferrets (Mustelo putorius furo). 2005 Aust. Vet. J. pmid:16164141
Gioulekas J and Hall A Uveitis associated with rifabutin therapy. 1995 Aust N Z J Ophthalmol pmid:11980079
Kaushik SP and Vu C Helicobacter pylori eradication with lansoprazole, amoxycillin and clarithromycin: testing an ideal regimen in a multicultural south east Asian population and examining factors potentially influencing eradication. 2000 Aust N Z J Med pmid:10833116
Fraser AG et al. Helicobacter pylori treatment and antibiotic susceptibility: results of a five-year audit. 1999 Aust N Z J Med pmid:10868529
Bradbeer L et al. Childhood headache and H. pylori--a possible association. 2013 Aust Fam Physician pmid:23529524
Chen K et al. Low dose macrolide administration for long term is effective for otitis media with effusion in children. 2013 Auris Nasus Larynx pmid:22673738
Majima Y et al. Efficacy of combined treatment with S-carboxymethylcysteine (carbocisteine) and clarithromycin in chronic rhinosinusitis patients without nasal polyp or with small nasal polyp. 2012 Auris Nasus Larynx pmid:21636230
Tojima I et al. Anti-inflammatory effects of a novel non-antibiotic macrolide, EM900, on mucus secretion of airway epithelium. 2015 Auris Nasus Larynx pmid:25769240
Enomoto F et al. Effect of new macrolides on the expression of adhesion molecules on neutrophils in chronic sinusitis. 2002 Auris Nasus Larynx pmid:12167449
Sugimoto H et al. A case of chronic otitis media caused by Mycobacterium abscessus. 2010 Auris Nasus Larynx pmid:20206453
Jang YJ et al. Maxillary sinus hypoplasia with a patent ostiomeatal complex: A therapeutic dilemma. 2012 Auris Nasus Larynx pmid:21571467
Nakamura Y et al. Optimal duration of macrolide treatment for chronic sinusitis after endoscopic sinus surgery. 2013 Auris Nasus Larynx pmid:23107100
Shimizu T and Suzaki H Past, present and future of macrolide therapy for chronic rhinosinusitis in Japan. 2016 Auris Nasus Larynx pmid:26441370
Paju S et al. Clarithromycin reduces recurrent cardiovascular events in subjects without periodontitis. 2006 Atherosclerosis pmid:16388809
Gené E et al. [Seven or ten days? Cost-effectiveness study on the duration of H. pylori treatment in primary care]. 2006 Aten Primaria pmid:17198608
Vernet Vernet M et al. [Analysis of indications and diagnosis of the gastroscopies requested by primary care physicians]. 2000 Aten Primaria pmid:10795440
Solé López J et al. [Consumption of antibiotics and their possible relationship with bacterial resistance in the "Costa de Ponent" health region: analysis of evolution through the initial and end periods of the last decade]. Aten Primaria pmid:15274900
Baena Díez JM et al. [Treatment with omeprazole, clarithromycin and amoxicillin for one week. Their efficacy and tolerance in eradicating Helicobacter pylori in primary care]. 1998 Aten Primaria pmid:9887574
Sanfélix Genovés J et al. [Helicobacter pylori: 6-day triple therapy in duodenal ulcer]. 1998 Aten Primaria pmid:9670578
Gené E et al. [Management of dyspepsia, gastroduodenal ulcer and Helicobacter pylori infection in primary care]. 2002 Aten Primaria pmid:12031222
Pandey R et al. Helicobacter pylori and gastric cancer. 2010 Asian Pac. J. Cancer Prev. pmid:21039020
Tongtawee T et al. Effect of Pretreatment with Lactobacillus delbrueckii and Streptococcus thermophillus on Tailored Triple Therapy for Helicobacter pylori Eradication: A Prospective Randomized Controlled Clinical Trial. 2015 Asian Pac. J. Cancer Prev. pmid:26163609
Prapitpaiboon H et al. High Efficacy of Levofloxacin-Dexlansoprazole-Based Quadruple Therapy as a First Line Treatment for Helicobacter pylori Eradication in Thailand. 2015 Asian Pac. J. Cancer Prev. pmid:26028098
Phiphatpatthamaamphan K et al. Effect of IL-1 Polymorphisms, CYP2C19 Genotype and Antibiotic Resistance on Helicobacter pylori Eradication Comparing Between 10-day Sequential Therapy and 14-day Standard Triple Therapy with Four-Times-Daily-Dosing of Amoxicillin in Thailand: a Prospective Randomized Study. 2016 Asian Pac. J. Cancer Prev. pmid:27221874
Srinarong C et al. Improved eradication rate of standard triple therapy by adding bismuth and probiotic supplement for Helicobacter pylori treatment in Thailand. 2014 Asian Pac. J. Cancer Prev. pmid:25520127
Vannarath S et al. Antibiotic Resistant Pattern of Helicobacter Pylori Infection Based on Molecular Tests in Laos. 2016 Asian Pac. J. Cancer Prev. pmid:26838225
Tongtawee T et al. High Prevalence of Helicobacter pylori Resistance to Clarithromycin: a Hospital-Based Cross-Sectional Study in Nakhon Ratchasima Province, Northeast of Thailand. 2015 Asian Pac. J. Cancer Prev. pmid:26745073
Abdul Aziz AF et al. Helicobacter pylori related dyspepsia: prevalence and treatment outcomes at University Kebangsaan Malaysia-Primary Care Centre. 2009 Asia Pac Fam Med pmid:19435494
Klotz U Interaction potential of lercanidipine, a new vasoselective dihydropyridine calcium antagonist. 2002 Arzneimittelforschung pmid:11963641
Koytchev R et al. Studies on the bioequivalence of different strengths of tablets containing clarithromycin. 2004 Arzneimittelforschung pmid:15497665
Koytchev R et al. Clarithromycin suspension: bioequivalence studies on two different strengths. 2004 Arzneimittelforschung pmid:15497666
Frotz H et al. [Ranitidine and clarithromycin for eradication of Helicobacter pylori in patients with duodenal ulcer]. 1995 Arzneimittelforschung pmid:7710445
Zakeri-Milani P et al. Pharmacokinetics and comparative bioavailability study of two clarithromycin suspensions following administration of a single oral dose to healthy volunteers. 2009 Arzneimittelforschung pmid:19813467
Lombardi A et al. Antimicrobial activity of thiamphenicol-glycinate-acetylcysteinate and other drugs against Chlamydia pneumoniae. 2001 Arzneimittelforschung pmid:11304944
Ullah S et al. Hydrophilically modified self-assembling α-tocopherol derivative as niosomal nanocarrier for improving clarithromycin oral bioavailability. 2018 Artif Cells Nanomed Biotechnol pmid:28541761
Terkeltaub RA et al. Novel evidence-based colchicine dose-reduction algorithm to predict and prevent colchicine toxicity in the presence of cytochrome P450 3A4/P-glycoprotein inhibitors. 2011 Arthritis Rheum. pmid:21480191
Anim-Appiah D et al. Mycobacterium avium complex tenosynovitis of the wrist and hand. 2004 Arthritis Rheum. pmid:14872467
Mangat P et al. Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis? 2010 Arthritis Res. Ther. pmid:20553633
Eisig JN et al. The impact of Helicobacter pylori resistance on the efficacy of a short course pantoprazole based triple therapy. 2003 Jan-Mar Arq Gastroenterol pmid:14534667
Araújo-Filho I et al. Prevalence of Helicobacter pylori infection in advanced gastric carcinoma. Arq Gastroenterol pmid:17406757
Martins GM et al. MOLECULAR DETECTION OF CLARITHROMYCIN AND FLUOROQUINOLONES RESISTANCE IN HELICOBACTER PYLORI INFECTION, DIRECTLY APPLIED TO GASTRIC BIOPSIES, IN AN URBAN BRAZILIAN POPULATION. Arq Gastroenterol pmid:27305419
Lins AK et al. Clarithromycin-resistant Helicobacter pylori in Recife, Brazil, directly identified from gastric biopsies by polymerase chain reaction. 2010 Oct-Dec Arq Gastroenterol pmid:21225149
Kawakami E et al. Triple therapy with clarithromycin, amoxicillin and omeprazole for Helicobacter pylori eradication in children and adolescents. 2001 Jul-Sep Arq Gastroenterol pmid:11917721
Batista CA et al. Neither genotype nor the gastric colonization site of Helicobacter pylori are predictive factors for the development of erosive esophagitis in patients with peptic ulcer disease, 1 year after eradication. 2009 Jul-Sep Arq Gastroenterol pmid:19918687
Coelho LG et al. [Efficacy of the dosing regimen of pantoprazole 40 mg, amoxicillin 1000 mg and clarithromycin 500 mg, twice daily for 7 days, in the eradication of Helicobacter pylori in patients with peptic ulcer]. 2004 Jan-Mar Arq Gastroenterol pmid:15499429
Asgari B et al. HONEY-DERIVED LACTOBACILLUS RHAMNOSUS ALLEVIATES HELICOBACTER PYLORI-INDUCED GASTRO-INTESTINAL INFECTION AND GASTRIC INFLAMMATION IN C57BL/6 MICE: AN IMMUNO-HISTOLOGIC STUDY. Arq Gastroenterol pmid:30540092
Eisig JN et al. Helicobacter pylori antibiotic resistance in Brazil: clarithromycin is still a good option. 2011 Oct-Dec Arq Gastroenterol pmid:22147131
Kogan EA et al. [The role of apoptosis and proliferation of epitheliocytes in morphogenesis of Helicobacter pylori-associated gastritis]. 2003 Nov-Dec Arkh. Patol. pmid:14964963