clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Carcinoma, Hepatocellular D006528 140 associated lipids
Hernia, Hiatal D006551 3 associated lipids
HIV Seropositivity D006679 15 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperemesis Gravidarum D006939 2 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hypoproteinemia D007019 1 associated lipids
Immunoproliferative Small Intestinal Disease D007161 2 associated lipids
Infant, Premature, Diseases D007235 7 associated lipids
Influenza, Human D007251 11 associated lipids
Insulin Resistance D007333 99 associated lipids
Iris Diseases D007499 2 associated lipids
Iritis D007500 2 associated lipids
Ischemia D007511 18 associated lipids
Keratoconjunctivitis D007637 3 associated lipids
Klebsiella Infections D007710 7 associated lipids
Obstetric Labor, Premature D007752 9 associated lipids
Legionnaires' Disease D007877 4 associated lipids
Leishmaniasis, Visceral D007898 13 associated lipids
Leprosy D007918 8 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


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Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Authors Title Published Journal PubMed Link
Sano M et al. [Inhibition of biofilm formation by clarithromycin (CAM) in an experimental model of complicated bladder infection--in vitro study using automated simulation of urinary antimicrobial concentration]. 1994 Kansenshogaku Zasshi pmid:7829898
Sieber CC et al. [Helicobacter pylori resistance against metronidazole in Switzerland: implications for eradication therapy?]. 1994 Schweiz Med Wochenschr pmid:8091165
Terashima T et al. Pulmonary infection due to Mycobacterium xenopi. 1994 Intern. Med. pmid:8000103
Dorrell L et al. Toxicity of clarithromycin in the treatment of Mycobacterium avium complex infection in a patient with AIDS. 1994 J. Antimicrob. Chemother. pmid:7868416
Fish DN et al. Penetration of clarithromycin into lung tissues from patients undergoing lung resection. 1994 Antimicrob. Agents Chemother. pmid:8031063
Funke G et al. Development of resistance to macrolide antibiotics in an AIDS patient treated with clarithromycin for Campylobacter jejuni diarrhea. 1994 Eur. J. Clin. Microbiol. Infect. Dis. pmid:7805694
Ishida K et al. In vitro and in vivo activities of macrolides against Mycoplasma pneumoniae. 1994 Antimicrob. Agents Chemother. pmid:8031048
Shafran SD et al. Uveitis and pseudojaundice during a regimen of clarithromycin, rifabutin, and ethambutol. MAC Study Group of the Canadian HIV Trials Network. 1994 N. Engl. J. Med. pmid:8284019
Meier A et al. Identification of mutations in 23S rRNA gene of clarithromycin-resistant Mycobacterium intracellulare. 1994 Antimicrob. Agents Chemother. pmid:8192472
Labenz J et al. [Omeprazole modified antibiotic therapy of Helicobacter pylori infection: can clarithromycin be replaced by roxithromycin?]. 1994 Leber Magen Darm pmid:8196468
Chan GP et al. Clinical trial of clarithromycin for lepromatous leprosy. 1994 Antimicrob. Agents Chemother. pmid:8203847
Spangler SK et al. Effect of CO2 on susceptibilities of anaerobes to erythromycin, azithromycin, clarithromycin, and roxithromycin. 1994 Antimicrob. Agents Chemother. pmid:8192445
Jones RN et al. Validation of NCCLS macrolide (azithromycin, clarithromycin, and erythromycin) interpretive criteria for Haemophilus influenzae tested with the Haemophilus test medium. National Committee for Clinical Laboratory Standards. 1994 Diagn. Microbiol. Infect. Dis. pmid:7924221
Wolinsky E Mycobacterium avium strains resistant to clarithromycin and azithromycin. 1994 Antimicrob. Agents Chemother. pmid:8031406
Klemens SP and Cynamon MH Activities of azithromycin and clarithromycin against nontuberculous mycobacteria in beige mice. 1994 Antimicrob. Agents Chemother. pmid:7979271
Kanatani MS and Guglielmo BJ The new macrolides. Azithromycin and clarithromycin. 1994 West. J. Med. pmid:8128699
Tahara RW et al. The question of clarithromycin: a first-line drug for sinusitis? 1994 Arch Fam Med pmid:7818657
Pustorino S et al. [Effects of intravenous administration of clarithromycin on plasma levels of gastrin and group I pepsinogen]. 1994 Clin Ter pmid:7820984
Alder J et al. Treatment of experimental Toxoplasma gondii infection by clarithromycin-based combination therapy with minocycline or pyrimethamine. 1994 J. Acquir. Immune Defic. Syndr. pmid:7932081
Ferrari SL et al. The interaction between clarithromycin and cyclosporine in kidney transplant recipients. 1994 Transplantation pmid:7940695
Tomono K [Therapeutic efficacy of macrolide in pulmonary nontuberculous mycobacteriosis]. 1994 Kekkaku pmid:7837727
Sanchez T et al. Quantitation of mycobacteria in blood specimens from patients with AIDS. 1994 Tuber. Lung Dis. pmid:7841433
Sungur C Acute rheumatic fever despite clarithromycin treatment of beta-hemolytic streptococcal tonsillitis. 1994 Ann Pharmacother pmid:7841580
Maass M and Dalhoff K [Isolation of Chlamydia pneumoniae in atypical pneumonia]. 1994 Dtsch. Med. Wochenschr. pmid:7956770
Verbist L and Dhoore F In vitro susceptibility of recently isolated respiratory tract pathogens to minocycline and comparable antibiotics. A multicentre study. 1994 Acta Clin Belg pmid:7871933
Wüst J and Hardegger U Penetration of clarithromycin into human saliva. 1993 Sep-Oct Chemotherapy pmid:8370320
Scaglione F et al. A new model examining intracellular and extracellular activity of amoxicillin, azithromycin, and clarithromycin in infected cells. 1993 Nov-Dec Chemotherapy pmid:8222870
Ohmori S et al. Effects of clarithromycin and its metabolites on the mixed function oxidase system in hepatic microsomes of rats. 1993 Mar-Apr Drug Metab. Dispos. pmid:8097709
Wallace RJ et al. Drug intolerance to high-dose clarithromycin among elderly patients. 1993 Mar-Apr Diagn. Microbiol. Infect. Dis. pmid:8477575
Adam D Clarithromycin 250 mg b.i.d. for 5 or 10 days in the treatment of adult patients with purulent bronchitis. 1993 Jul-Aug Infection pmid:8225636
Coles SJ et al. A comparative study of clarithromycin and amoxycillin suspensions in the treatment of pediatric patients with acute otitis media. 1993 Jul-Aug Infection pmid:8225637
Miller CA Infections, resistant microbes, and older adults. 1993 Jan-Feb Geriatr Nurs pmid:8383085
Ritchie DJ et al. In vitro activity of clarithromycin, cefprozil, and other common oral antimicrobial agents against gram-positive and gram-negative pathogens. 1993 Jan-Feb Clin Ther pmid:8458040
Albani F et al. Clarithromycin-carbamazepine interaction: a case report. 1993 Jan-Feb Epilepsia pmid:8422851
Sader HS et al. In vitro activity of cefpodoxime compared with other oral cephalosporins tested against 5556 recent clinical isolates from five medical centers. 1993 Aug-Sep Diagn. Microbiol. Infect. Dis. pmid:8243035
Parish LC Clarithromycin in the treatment of skin and skin structure infections: two multicenter clinical studies. Clarithromycin Study Group. 1993 Int. J. Dermatol. pmid:8340194
Vaara M Outer membrane permeability barrier to azithromycin, clarithromycin, and roxithromycin in gram-negative enteric bacteria. 1993 Antimicrob. Agents Chemother. pmid:8383945
Dautzenberg B et al. Clarithromycin and other antimicrobial agents in the treatment of disseminated Mycobacterium avium infections in patients with acquired immunodeficiency syndrome. 1993 Arch. Intern. Med. pmid:8427539
Chien SM et al. Treatment of community-acquired pneumonia. A multicenter, double-blind, randomized study comparing clarithromycin with erythromycin. Canada-Sweden Clarithromycin-Pneumonia Study Group. 1993 Chest pmid:8449054
Ji B et al. Powerful bactericidal activities of clarithromycin and minocycline against Mycobacterium leprae in lepromatous leprosy. 1993 J. Infect. Dis. pmid:8257487
Scaglione F et al. The postantibiotic effect of clarithromycin and its major human metabolite, 14-hydroxy clarithromycin. 1993 J. Antimicrob. Chemother. pmid:8262876
Guay DR and Craft JC Overview of the pharmacology of clarithromycin suspension in children and a comparison with that in adults. 1993 Pediatr. Infect. Dis. J. pmid:8295810
Hebert AA et al. Comparative safety and efficacy of clarithromycin and cefadroxil suspensions in the treatment of mild to moderate skin and skin structure infections in children. 1993 Pediatr. Infect. Dis. J. pmid:8295811
Watanabe Y et al. Chemical modification of erythromycins. IX. Selective methylation at the C-6 hydroxyl group of erythromycin A oxime derivatives and preparation of clarithromycin. 1993 J. Antibiot. pmid:8501007
Roig J et al. Treatment of Legionnaires' disease. Current recommendations. 1993 Drugs pmid:7691508
Esvant H et al. [Primary prophylaxis of cerebral toxoplasmosis in AIDS with clarithromycin]. 1993 Presse Med pmid:8337221
Lederer J et al. Clarithromycin treatment of posttraumatic Mycobacterium fortuitum wound infection. 1993 Pediatr. Infect. Dis. J. pmid:8414785
Guay DR et al. Overview of the tolerability profile of clarithromycin in preclinical and clinical trials. 1993 Drug Saf pmid:8504017
de Vega T et al. Clarithromycin-induced leukocytoclastic vasculitis. 1993 Eur. J. Clin. Microbiol. Infect. Dis. pmid:8404922
Dempsey CL et al. Drug usage evaluation: clarithromycin as sequential therapy. 1993 Hosp Formul pmid:10130382