clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

Cross Reference

Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Periodontitis D010518 22 associated lipids
Fibrosis D005355 23 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Nasal Polyps D009298 26 associated lipids
Angina Pectoris D000787 27 associated lipids
Gastritis D005756 27 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Endometriosis D004715 29 associated lipids
Proteinuria D011507 30 associated lipids
Drug Eruptions D003875 30 associated lipids
Diarrhea D003967 32 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Fever D005334 35 associated lipids
Heart Failure D006333 36 associated lipids
Lung Diseases D008171 37 associated lipids
Arthritis D001168 41 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Psoriasis D011565 47 associated lipids
Parkinson Disease D010300 53 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Pain D010146 64 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Colitis D003092 69 associated lipids
Hyperlipidemias D006949 73 associated lipids
Stomach Ulcer D013276 75 associated lipids
Arteriosclerosis D001161 86 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Insulin Resistance D007333 99 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Body Weight D001835 333 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Per page 10 20 50 100 | Total 7636
Authors Title Published Journal PubMed Link
Landesman KA et al. Rhabdomyolysis associated with the combined use of hydroxymethylglutaryl-coenzyme A reductase inhibitors with gemfibrozil and macrolide antibiotics. 1999 Conn Med pmid:10500341
Gómez G et al. Acute tacrolimus nephrotoxicity in renal transplant patients treated with clarithromycin. 1999 Transplant. Proc. pmid:10500563
Unge P The OAC and OMC options. 1999 Eur J Gastroenterol Hepatol pmid:10503817
Spiller RC Is there any difference in Helicobacter pylori eradication rates in patients with active peptic ulcer, inactive peptic ulcer and functional dyspepsia? 1999 Eur J Gastroenterol Hepatol pmid:10503819
Mégraud F Resistance of Helicobacter pylori to antibiotics: the main limitation of current proton-pump inhibitor triple therapy. 1999 Eur J Gastroenterol Hepatol pmid:10503821
Bazzoli F et al. What can be learnt from the new data about antibiotic resistance? Are there any practical clinical consequences of Helicobacter pylori antibiotic resistance? 1999 Eur J Gastroenterol Hepatol pmid:10503822
Gisbert JP et al. Re-treatment after Helicobacter pylori eradication failure. 1999 Eur J Gastroenterol Hepatol pmid:10503846
Uygun A et al. Efficacy of omeprazole plus two antimicrobials for the eradication of Helicobacter pylori in a Turkish population. 1999 Clin Ther pmid:10509849
McMullin ST et al. Impact of a Web-based clinical information system on cisapride drug interactions and patient safety. 1999 Arch. Intern. Med. pmid:10510994
Furuta T et al. Effects of clarithromycin on the metabolism of omeprazole in relation to CYP2C19 genotype status in humans. 1999 Clin. Pharmacol. Ther. pmid:10511062
Galil K et al. Abscesses due to mycobacterium abscessus linked to injection of unapproved alternative medication. 1999 Sep-Oct Emerging Infect. Dis. pmid:10511524
Talley NJ et al. Absence of benefit of eradicating Helicobacter pylori in patients with nonulcer dyspepsia. 1999 N. Engl. J. Med. pmid:10511608
Gilljam M et al. Therapeutic drug monitoring in patients with cystic fibrosis and mycobacterial disease. 1999 Eur. Respir. J. pmid:10515412
Rovira E et al. Treatment of community-acquired pneumonia in outpatients: randomized study of clarithromycin alone versus clarithromycin and cefuroxime. 1999 Respiration pmid:10516537
Foster SF et al. Chronic pneumonia caused by Mycobacterium thermoresistibile in a cat. 1999 J Small Anim Pract pmid:10516950
Goldberg EI et al. Henoch-Schönlein purpura induced by clarithromycin. 1999 Int. J. Dermatol. pmid:10517691
Uygun A et al. Low efficacy of ranitidine bismuth citrate plus clarithromycin combination on Helicobacter pylori in a Turkish population. 1999 Am. J. Gastroenterol. pmid:10520880
Gibson JR et al. Novel method for rapid determination of clarithromycin sensitivity in Helicobacter pylori. 1999 J. Clin. Microbiol. pmid:10523591
Baylor P and Williams K Interstitial nephritis, thrombocytopenia, hepatitis, and elevated serum amylase levels in a patient receiving clarithromycin therapy. 1999 Clin. Infect. Dis. pmid:10525003
Yoh M et al. Effect of subinhibitory concentrations of antimicrobial agents (quinolones and macrolide) on the production of verotoxin by enterohemorrhagic Escherichia coli O157:H7. 1999 Can. J. Microbiol. pmid:10526400