clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Xu Y et al. | Synthesis and antibacterial activity of novel modified 5-O-mycaminose 14-membered ketolides. | 2013 | Eur J Med Chem | pmid:24021890 |
Ranganathan D et al. | Mycobacterium fortuitum peritonitis in a patient receiving continuous ambulatory peritoneal dialysis. | 2013 | Saudi J Kidney Dis Transpl | pmid:24029271 |
de Zeeuw J et al. | Serum levels of neopterin during antimicrobial treatment for Mycobacterium ulcerans infection. | 2013 | Am. J. Trop. Med. Hyg. | pmid:23836576 |
Janković B et al. | Consolidation trend design based on Young's modulus of clarithromycin single crystals. | 2013 | Int J Pharm | pmid:23872226 |
Yoshida S et al. | Further isolation of Mycobacterium abscessus subsp. abscessus and subsp. bolletii in different regions of Japan and susceptibility of these isolates to antimicrobial agents. | 2013 | Int. J. Antimicrob. Agents | pmid:23850022 |
Bismuth + metronidazole + tetracycline. Why risk adding bismuth? | 2013 | Prescrire Int | pmid:23662315 | |
Singh RP et al. | Antimicrobial prophylaxis in open reduction and internal fixation of compound mandibular fractures: a collaborative regional audit of outcome. | 2013 | Br J Oral Maxillofac Surg | pmid:23369782 |
Prasertpetmanee S et al. | Improved efficacy of proton pump inhibitor - amoxicillin - clarithromycin triple therapy for Helicobacter pylori eradication in low clarithromycin resistance areas or for tailored therapy. | 2013 | Helicobacter | pmid:23356886 |
Koh WJ et al. | Reply: drug concentration monitoring in Mycobacterium avium lung disease: problems with methods and conclusions. | 2013 | Am. J. Respir. Crit. Care Med. | pmid:23577353 |
Schmitt BH et al. | PCR detection of clarithromycin-susceptible and -resistant Helicobacter pylori from formalin-fixed, paraffin-embedded gastric biopsies. | 2013 | Mod. Pathol. | pmid:23579617 |
Asaoka D et al. | Trends of second-line eradication therapy for Helicobacter pylori in Japan: a multicenter study in the Tokyo metropolitan area. | 2013 | Helicobacter | pmid:23773231 |
Al-Haj A et al. | Method development, validation and bioequivalence of varenicline in human plasma by liquid chromatography tandem mass spectrometry. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23774248 |
Faraji F et al. | The effect of Helicobacter pylori eradication on migraine: a randomized, double blind, controlled trial. | 2012 Nov-Dec | Pain Physician | pmid:23159967 |
Eremenko AA et al. | [Effect of clarithromycin on the systemic inflammatory response syndrome severity in patients after myocardial revascularization surgery]. | 2012 May-Jun | Anesteziol Reanimatol | pmid:22993930 |
Singh V et al. | Vesicular palmoplantar pityriasis rosea. | 2012 Mar-Apr | Skinmed | pmid:22545332 |
Gutiérrez-Castrellón P et al. | Efficacy and safety of clarithromycin in pediatric patients with upper respiratory infections: a systematic review with meta-analysis. | 2012 Mar-Apr | Rev. Invest. Clin. | pmid:22991774 |
Rajendiran S et al. | Increased protein carbonylation and decreased antioxidant status in anemic H. pylori infected patients: effect of treatment. | 2012 Jul-Aug | Saudi J Gastroenterol | pmid:22824768 |
De Sanctis V et al. | Anti-Helicobacter pylori therapy in primary MALT lymphoma of rectum. | 2012 Jul-Aug | Tumori | pmid:23052174 |
Figueroa M et al. | [Antimicrobial susceptibility of Helicobacter pylori with chronic gastritis]. | 2012 Jan-Mar | Biomedica | pmid:23235785 |
de Lalibera IB et al. | Meningoencephalitis associated with Mycoplasma pneumoniae. | 2012 Jan-Mar | Einstein (Sao Paulo) | pmid:23045836 |
Dhillon GS et al. | Clarithromycin for prevention of bronchiolitis obliterans syndrome in lung allograft recipients. | 2012 Jan-Feb | Clin Transplant | pmid:21352378 |
Onsun N et al. | Impact of Helicobacter pylori infection on severity of psoriasis and response to treatment. | 2012 Jan-Feb | Eur J Dermatol | pmid:22063790 |
Montero-Tinnirello J et al. | [Pulmonary hemorrhage due to leptospirosis]. | 2012 Jan-Feb | Med Intensiva | pmid:21592620 |
Dai WQ et al. | The eradicating Helicobacter pylori infection in duodenal ulcer patients by three short-term triple therapies in China: a multicenter clinical comparative study. | 2012 Jan-Feb | Hepatogastroenterology | pmid:22260837 |
VanderHeyden TR et al. | Granulomatous hepatitis due to Bartonella henselae infection in an immunocompetent patient. | 2012 | BMC Infect. Dis. | pmid:22269175 |
Ji R et al. | Mucosal barrier defects in gastric intestinal metaplasia: in vivo evaluation by confocal endomicroscopy. | 2012 | Gastrointest. Endosc. | pmid:22325805 |
[Experience with treatment of chronic polypoid rhinosinusitis using low doses of clarithromycin in the postoperative period]. | 2012 | Vestn. Otorinolaringol. | pmid:22678641 | |
Kim SY et al. | Effectiveness of three times daily lansoprazole/amoxicillin dual therapy for Helicobacter pylori infection in Korea. | 2012 | Br J Clin Pharmacol | pmid:21689141 |
Lotfy HM and Abdel-Monem Hagazy M | Comparative study of novel spectrophotometric methods manipulating ratio spectra: an application on pharmaceutical ternary mixture of omeprazole, tinidazole and clarithromycin. | 2012 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:22683662 |
Rajper S et al. | Macrolide and fluoroquinolone resistance in Helicobacter pylori isolates: an experience at a tertiary care centre in Pakistan. | 2012 | J Pak Med Assoc | pmid:23866399 |
Salmon JH et al. | Discitis and sacroiliitis diagnosed 15 years after iatrogenic Mycobacterium xenopi inoculation. | 2012 | Joint Bone Spine | pmid:22405857 |
Katayama M et al. | Interaction of clarithromycin with cyclosporine in cats: pharmacokinetic study and case report. | 2012 | J. Feline Med. Surg. | pmid:22412163 |
Bobacheva TIu | [The treatment of chronic polypous rhinosinusitis in the postoperative period with low doses of clarithromycin]. | 2012 | Vestn. Otorinolaringol. | pmid:23011378 |
Omoruyi OJ et al. | Metachronous Mycobacterium terrae complex tenosynovitis of the hand. | 2012 | J Hand Surg Eur Vol | pmid:22415428 |
Ohe M and Hashino S | Successful treatment of eosinophilic gastroenteritis with clarithromycin. | 2012 | Korean J. Intern. Med. | pmid:23269887 |
Breda R et al. | [Mycobacterium massiliense bone infection]. | 2012 | Med Mal Infect | pmid:22154522 |
Zarogoulidis P et al. | Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases. | 2012 | Eur. J. Clin. Pharmacol. | pmid:22105373 |
Takahashi E et al. | Oral clarithromycin enhances airway immunoglobulin A (IgA) immunity through induction of IgA class switching recombination and B-cell-activating factor of the tumor necrosis factor family molecule on mucosal dendritic cells in mice infected with influenza A virus. | 2012 | J. Virol. | pmid:22896605 |
Bruin JP et al. | Wild-type MIC distribution and epidemiological cut-off values in clinical Legionella pneumophila serogroup 1 isolates. | 2012 | Diagn. Microbiol. Infect. Dis. | pmid:22100012 |
Chung JW et al. | Ten-day sequential versus triple therapy for Helicobacter pylori eradication: a prospective, open-label, randomized trial. | 2012 | J. Gastroenterol. Hepatol. | pmid:22849546 |
van Ingen J et al. | Drug susceptibility testing and pharmacokinetics question current treatment regimens in Mycobacterium simiae complex disease. | 2012 | Int. J. Antimicrob. Agents | pmid:22099521 |
Bondon-Guitton E et al. | Drug-induced gingival overgrowth: a study in the French Pharmacovigilance Database. | 2012 | J. Clin. Periodontol. | pmid:22519416 |
Vazquez-Lago JM et al. | Attitudes of primary care physicians to the prescribing of antibiotics and antimicrobial resistance: a qualitative study from Spain. | 2012 | Fam Pract | pmid:22016323 |
Bosnar M et al. | N'-substituted-2'-O,3'-N-carbonimidoyl bridged macrolides: novel anti-inflammatory macrolides without antimicrobial activity. | 2012 | J. Med. Chem. | pmid:22697905 |
Prechtl J et al. | Monitoring of antibiotic resistance rates of Helicobacter pylori in Austrian children, 2002-2009. | 2012 | Pediatr. Infect. Dis. J. | pmid:22094633 |
Deguchi R et al. | Effect of pretreatment with Lactobacillus gasseri OLL2716 on first-line Helicobacter pylori eradication therapy. | 2012 | J. Gastroenterol. Hepatol. | pmid:22098133 |
Gao M et al. | The effects of transrectal radiofrequency hyperthermia on patients with chronic prostatitis and the changes of MDA, NO, SOD, and Zn levels in pretreatment and posttreatment. | 2012 | Urology | pmid:22100490 |
Fujita J and Cash HL | Long-term combination treatment of azithromycin with other macrolides: a new era. | 2012 | Intern. Med. | pmid:22687831 |
Yamamoto Y et al. | A case of refractory chronic respiratory tract infection due to Pseudomonas aeruginosa successfully controlled by combination of clarithromycin and azithromycin. | 2012 | Intern. Med. | pmid:22687847 |
Espinal DA et al. | [Human metapneumovirus in children: first cases in Colombia]. | 2012 | Biomedica | pmid:23242289 |
Nishizawa T et al. | Proton pump inhibitor-amoxicillin-clarithromycin versus proton pump inhibitor-amoxicillin-metronidazole as first-line Helicobacter pylori eradication therapy. | 2012 | J Clin Biochem Nutr | pmid:22962528 |
Amin M et al. | Green synthesis of silver nanoparticles through reduction with Solanum xanthocarpum L. berry extract: characterization, antimicrobial and urease inhibitory activities against Helicobacter pylori. | 2012 | Int J Mol Sci | pmid:22949839 |
Kwan BY and Rabheru K | Manic episode associated with clarithromycin in a patient with medically treated depression. | 2012 | Prim Care Companion CNS Disord | pmid:22943025 |
Cheung JP et al. | Mycobacterium marinum infection of the hand and wrist. | 2012 | J Orthop Surg (Hong Kong) | pmid:22933682 |
Zong W et al. | The first case of cutaneous infection with Mycobacterium parascrofulaceum. | 2012 | Ther Clin Risk Manag | pmid:22930638 |
D'Elios MM et al. | Helicobacter pylori: usefulness of an empirical fourth-line rifabutin-based regimen. | 2012 | Expert Rev Gastroenterol Hepatol | pmid:22928895 |
Wu TS et al. | Fish tank granuloma caused by Mycobacterium marinum. | 2012 | PLoS ONE | pmid:22911774 |
Kim BJ et al. | Discovery of a novel hsp65 genotype within Mycobacterium massiliense associated with the rough colony morphology. | 2012 | PLoS ONE | pmid:22693637 |
Karczewska E et al. | Variability in Prevalence of Helicobacter pylori Strains Resistant to Clarithromycin and Levofloxacin in Southern Poland. | 2012 | Gastroenterol Res Pract | pmid:22693490 |
Tuchman SA et al. | Lenalidomide before and after Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma. | 2012 | Adv Hematol | pmid:22690220 |
Ojetti V et al. | Impact of Lactobacillus reuteri Supplementation on Anti-Helicobacter pylori Levofloxacin-Based Second-Line Therapy. | 2012 | Gastroenterol Res Pract | pmid:22690211 |
Dobrick N et al. | [Legionnaires disease (legionella pneumonia)]. | 2012 | Praxis (Bern 1994) | pmid:23147600 |
Uno K et al. | Rupture of renal mycotic aneurysm that developed during the treatment of streptococcal infective endocarditis and vertebral osteomyelitis. | 2012 | Intern. Med. | pmid:22687800 |
Ratcliffe AT and Ismail KM | Intravenous macrolide use: a reminder of the dangers of rapid infusion rates. | 2012 | J Clin Anesth | pmid:23101782 |
Sakinc T et al. | Influence of a 23S ribosomal RNA mutation in Helicobacter pylori strains on the in vitro synergistic effect of clarithromycin and amoxicillin. | 2012 | BMC Res Notes | pmid:23110798 |
Robinson P et al. | Clarithromycin therapy for patients with cystic fibrosis: a randomized controlled trial. | 2012 | Pediatr. Pulmonol. | pmid:22266895 |
Korownyk C and Kolber MR | Is quadruple therapy the new triple therapy for H pylori? | 2012 | Can Fam Physician | pmid:22267623 |
Mumoli N and Cei M | Clinical images: community-acquired pneumonia. | 2012 | CMAJ | pmid:22271912 |
English ML et al. | Cethromycin versus clarithromycin for community-acquired pneumonia: comparative efficacy and safety outcomes from two double-blinded, randomized, parallel-group, multicenter, multinational noninferiority studies. | 2012 | Antimicrob. Agents Chemother. | pmid:22290969 |
Ogoshi T et al. | A case of Good syndrome with pulmonary lesions similar to diffuse panbronchiolitis. | 2012 | Intern. Med. | pmid:22576393 |
Tseng CH | Diabetes, insulin use and Helicobacter pylori eradication: a retrospective cohort study. | 2012 | BMC Gastroenterol | pmid:22571603 |
Park SK et al. | Regression of Advanced Gastric MALT Lymphoma after the Eradication of Helicobacter pylori. | 2012 | Gut Liver | pmid:22570759 |
Conde-Ãlvarez R et al. | The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition. | 2012 | PLoS Pathog. | pmid:22589715 |
Nakajima S et al. | Multiple-antibiotic-resistant Helicobacter pylori infection eradicated with a tailor-made quadruple therapy. | 2012 | J. Gastroenterol. Hepatol. | pmid:22486882 |
Buzás GM | [Helicobacter pylori - 2012]. | 2012 | Orv Hetil | pmid:22951408 |
Misiewicz JJ | Management of Helicobacter pylori-related disorders. | 2012 | Eur J Gastroenterol Hepatol | pmid:22498902 |
Sereni G et al. | Efficacy of a therapeutic strategy for eradication of Helicobacter pylori infection. | 2012 | World J. Gastroenterol. | pmid:22969227 |
Bajaj P et al. | Locally delivered 0.5% clarithromycin, as an adjunct to nonsurgical treatment in chronic periodontitis with well-controlled type 2 diabetes: a randomized controlled clinical trial. | 2012 | J Investig Clin Dent | pmid:22976782 |
Pasqualetti G et al. | Clarithromycin-induced rhabdomyolysis: a case report. | 2012 | Int J Gen Med | pmid:22505827 |
Akelma AZ et al. | Clarithromycin in treatment of acute asthma exacerbations: principles of appropriate antibiotic use. | 2012 | Pediatr Allergy Immunol | pmid:22984834 |
Sachs G and Scott DR | Helicobacter pylori: Eradication or Preservation. | 2012 | F1000 Med Rep | pmid:22500191 |
Bataille S et al. | Vancomycin-induced Henoch-Schönlein purpura: a case report. | 2012 | J Med Case Rep | pmid:22490390 |
Pandya GJ et al. | Unilateral lobar pulmonary edema. | 2012 | J Assoc Physicians India | pmid:23547417 |
Buyck JM et al. | Increased susceptibility of Pseudomonas aeruginosa to macrolides and ketolides in eukaryotic cell culture media and biological fluids due to decreased expression of oprM and increased outer-membrane permeability. | 2012 | Clin. Infect. Dis. | pmid:22573850 |
Shimizu T and Shimizu S | Azithromycin inhibits mucus hypersecretion from airway epithelial cells. | 2012 | Mediators Inflamm. | pmid:22577246 |
Farfan-Portet MI et al. | Patient socioeconomic determinants of the choice of generic versus brand name drugs in the context of a reference price system: evidence from Belgian prescription data. | 2012 | Eur J Health Econ | pmid:22427042 |
Mégraud F | The challenge of Helicobacter pylori resistance to antibiotics: the comeback of bismuth-based quadruple therapy. | 2012 | Therap Adv Gastroenterol | pmid:22423259 |
Scheel AH et al. | Talcum induced pneumoconiosis following inhalation of adulterated marijuana, a case report. | 2012 | Diagn Pathol | pmid:22420484 |
Brüning J et al. | Erythromycin A dimethyl sulfoxide disolvate 1.43-hydrate. | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22412590 |
Noguchi S et al. | Clarithromycin monohydrate: a synchrotron X-ray powder study. | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22412567 |
Karne SS et al. | Mycobacterium avium-intracellulare brain abscess in HIV-positive patient. | 2012 | Ann Indian Acad Neurol | pmid:22412276 |
Yanai A et al. | Non-bismuth quadruple therapy for first-line Helicobacter pylori eradication: A randomized study in Japan. | 2012 | World J Gastrointest Pharmacol Ther | pmid:22408744 |
Morisset J et al. | A case of difficult-to-treat eosinophilic asthma controlled with clarithromycin. | 2012 | Ann. Allergy Asthma Immunol. | pmid:22727169 |
Calza P et al. | Identification of the unknown transformation products derived from clarithromycin and carbamazepine using liquid chromatography/high-resolution mass spectrometry. | 2012 | Rapid Commun. Mass Spectrom. | pmid:22730089 |
Cronnolly B and Pegrum H | Fentanyl-clarithromycin interaction. | 2012 | BMJ Case Rep | pmid:22778456 |
Berti AD et al. | Altering the proclivity towards daptomycin resistance in methicillin-resistant Staphylococcus aureus using combinations with other antibiotics. | 2012 | Antimicrob. Agents Chemother. | pmid:22802248 |
Khavinson VKh et al. | Peptidergic regulation of expression of genes encoding antioxidant and anti-inflammatory proteins. | 2012 | Bull. Exp. Biol. Med. | pmid:22803148 |
Polat Z et al. | Comparison of levofloxacin-containing sequential and standard triple therapies for the eradication of Helicobacter pylori. | 2012 | Eur. J. Intern. Med. | pmid:22284248 |
Siqueira JF et al. | Pyrosequencing as a tool for better understanding of human microbiomes. | 2012 | J Oral Microbiol | pmid:22279602 |
O'Brien DP et al. | Successful outcomes with oral fluoroquinolones combined with rifampicin in the treatment of Mycobacterium ulcerans: an observational cohort study. | 2012 | PLoS Negl Trop Dis | pmid:22272368 |