clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sieber CC et al. | [Helicobacter pylori resistance against metronidazole in Switzerland: implications for eradication therapy?]. | 1994 | Schweiz Med Wochenschr | pmid:8091165 |
Thijs JC et al. | Short report: clarithromycin, an alternative to metronidazole in the triple therapy of Helicobacter pylori infection. | 1994 | Aliment. Pharmacol. Ther. | pmid:8186339 |
Morikawa K et al. | Immunomodulatory effects of three macrolides, midecamycin acetate, josamycin, and clarithromycin, on human T-lymphocyte function in vitro. | 1994 | Antimicrob. Agents Chemother. | pmid:7532933 |
Goldman RC et al. | Tight binding of clarithromycin, its 14-(R)-hydroxy metabolite, and erythromycin to Helicobacter pylori ribosomes. | 1994 | Antimicrob. Agents Chemother. | pmid:7979278 |
Roblin PM et al. | Susceptibilities to clarithromycin and erythromycin of isolates of Chlamydia pneumoniae from children with pneumonia. | 1994 | Antimicrob. Agents Chemother. | pmid:7979292 |
Rapp RP et al. | New macrolide antibiotics: usefulness in infections caused by mycobacteria other than Mycobacterium tuberculosis. | 1994 | Ann Pharmacother | pmid:7849341 |
Price DA et al. | Clinical response to the addition of clarithromycin in Pneumocystis carinii pneumonia refractory to high dose co-trimoxazole. | 1994 | J. Antimicrob. Chemother. | pmid:7814298 |
Tahara RW et al. | The question of clarithromycin: a first-line drug for sinusitis? | 1994 | Arch Fam Med | pmid:7818657 |
Pustorino S et al. | [Effects of intravenous administration of clarithromycin on plasma levels of gastrin and group I pepsinogen]. | 1994 | Clin Ter | pmid:7820984 |
Alder J et al. | Treatment of experimental Toxoplasma gondii infection by clarithromycin-based combination therapy with minocycline or pyrimethamine. | 1994 | J. Acquir. Immune Defic. Syndr. | pmid:7932081 |
Ferrari SL et al. | The interaction between clarithromycin and cyclosporine in kidney transplant recipients. | 1994 | Transplantation | pmid:7940695 |
Tessier MH et al. | Clarithromycin for atypical mycobacterial lymphadenitis in non-immunocompromised children. | 1994 Dec 24-31 | Lancet | pmid:7997032 |
Mor N et al. | Accumulation of clarithromycin in macrophages infected with Mycobacterium avium. | 1994 Jan-Feb | Pharmacotherapy | pmid:8159593 |
Winter J | Intravenous clarithromycin. | 1994 Mar 16-Apr 5 | Br J Hosp Med | pmid:8032567 |
Gersema LM et al. | Suspected drug interaction between cyclosporine and clarithromycin. | 1994 Mar-Apr | J. Heart Lung Transplant. | pmid:8031821 |
Heifets LB | Quantitative cultures and drug susceptibility testing of Mycobacterium avium clinical isolates before and during the antimicrobial therapy. | 1994 Mar-Apr | Res. Microbiol. | pmid:7809471 |
Dautzenberg B | Clinical trials in Mycobacterium avium therapy: lessons to take home. | 1994 Mar-Apr | Res. Microbiol. | pmid:7809472 |
Scaglione F et al. | Effect of antibiotics on Bordetella pertussis adhering activity: hypothesis regarding mechanism of action. | 1994 May-Jun | Chemotherapy | pmid:7515782 |
O'Connor NK and Fris J | Clarithromycin-carbamazepine interaction in a clinical setting. | 1994 Nov-Dec | J Am Board Fam Pract | pmid:7847111 |
Cama VA et al. | Treatment of acute and chronic Cryptosporidium parvum infections in mice using clarithromycin and 14-OH clarithromycin. | 1994 Sep-Oct | J. Eukaryot. Microbiol. | pmid:7804227 |
Adamek RJ et al. | Modified short-term triple therapy--ranitidine, clarithromycin, and metronidazole--for cure of Helicobacter pylori infection. | 1995 | Am. J. Gastroenterol. | pmid:7801936 |
FDA approves Biaxin for MAC prophylaxis. Food and Drug Administration. | 1995 | J Int Assoc Physicians AIDS Care | pmid:11363096 | |
Savarino V et al. | Helicobacter pylori eradication and reinfection. | 1995 | Lancet | pmid:7783564 |
Comley JC and Sterling AM | Effect of atovaquone and atovaquone drug combinations on prophylaxis of Pneumocystis carinii pneumonia in SCID mice. | 1995 | Antimicrob. Agents Chemother. | pmid:7785975 |
Struillou L et al. | Activities of roxithromycin against Mycobacterium avium infections in human macrophages and C57BL/6 mice. | 1995 | Antimicrob. Agents Chemother. | pmid:7785988 |
Fong IW et al. | Clarithromycin versus cefaclor in lower respiratory tract infections. The Canadian Bronchitis Study Group. | 1995 | Clin Invest Med | pmid:7788958 |
Goddard A and Logan R | One-week low-dose triple therapy: new standards for Helicobacter pylori treatment. | 1995 | Eur J Gastroenterol Hepatol | pmid:7866804 |
Labenz J et al. | One-week low-dose triple therapy for the eradication of Helicobacter pylori infection. | 1995 | Eur J Gastroenterol Hepatol | pmid:7866820 |
Weits J and Sprenger HG | [Surgical treatment of lymphadenitis caused by non-tuberculous mycobacteria in children]. | 1995 | Ned Tijdschr Geneeskd | pmid:8524431 |
Nash KA and Inderlied CB | Genetic basis of macrolide resistance in Mycobacterium avium isolated from patients with disseminated disease. | 1995 | Antimicrob. Agents Chemother. | pmid:8592991 |
Ostroff SM et al. | Preventing disseminated Mycobacterium avium complex disease in patients infected with human immunodeficiency virus. | 1995 | Clin. Infect. Dis. | pmid:8547516 |
Odagiri S | Levofloxacin in patients with severe respiratory tract infection. | 1995 | Drugs | pmid:8549387 |
Logan RP et al. | Eradication of Helicobacter pylori and prevention of recurrence of duodenal ulcer: a randomized, double-blind, multi-centre trial of omeprazole with or without clarithromycin. | 1995 | Aliment. Pharmacol. Ther. | pmid:8527618 |
Lee D et al. | Localized Mycobacterium avium-intracellulare mastitis in an immunocompetent woman with silicone breast implants. | 1995 | Plast. Reconstr. Surg. | pmid:7809228 |
Gill CJ et al. | In vivo evaluation of three acid-stable azalide compounds, L-701,677, L-708,299 and L-708,365 compared to erythromycin, azithromycin and clarithromycin. | 1995 | J. Antibiot. | pmid:7490222 |
Gelber RH | Successful treatment of a lepromatous patient with clarithromycin. | 1995 | Int. J. Lepr. Other Mycobact. Dis. | pmid:7730711 |
Adamek RJ et al. | [Short-term triple therapy with pantoprazole, clarithromycin and metronidazole for the healing of Helicobacter pylori infection]. | 1995 | Dtsch. Med. Wochenschr. | pmid:7889816 |
Midoneck SR and Etingin OR | Clarithromycin-related toxic effects of digoxin. | 1995 | N. Engl. J. Med. | pmid:7477159 |
Forslund T et al. | Disseminated cutaneous infection due to Mycobacterium chelonae in a patient with rheumatoid arthritis, amyloidosis, and renal failure. | 1995 | Nephrol. Dial. Transplant. | pmid:7478131 |
Fabry W et al. | Comparison of the E test and a proportion dilution method for susceptibility testing of Mycobacterium tuberculosis. | 1995 | Zentralbl. Bakteriol. | pmid:9810662 |
Xu G et al. | [Effect of clarithromycin on macrophage functions]. | 1995 | Kansenshogaku Zasshi | pmid:7594777 |
Gelber RH et al. | Activity of combinations of dapsone, rifampin, minocycline, clarithromycin, and sparfloxacin against M. leprae-infected mice. | 1995 | Int. J. Lepr. Other Mycobact. Dis. | pmid:7602221 |
Milde P et al. | Cutaneous bacillary angiomatosis in a patient with chronic lymphocytic leukemia. | 1995 | Arch Dermatol | pmid:7543264 |
Nightingale SD et al. | Clarithromycin-induced mania in two patients with AIDS. | 1995 | Clin. Infect. Dis. | pmid:7548513 |
Matsiota-Bernard P et al. | Mycobacterium genavense infection in a patient with AIDS who was successfully treated with clarithromycin. | 1995 | Clin. Infect. Dis. | pmid:7548515 |
Citron DM et al. | Activity of ampicillin/sulbactam, ticarcillin/clavulanate, clarithromycin, and eleven other antimicrobial agents against anaerobic bacteria isolated from infections in children. | 1995 | Clin. Infect. Dis. | pmid:7548597 |
Ishii K et al. | A new pharmacokinetic model including in vivo dissolution and gastrointestinal transit parameters. | 1995 | Biol. Pharm. Bull. | pmid:7550125 |
Harris AW et al. | Eradication of Helicobacter pylori with lansoprazole and clarithromycin. | 1995 | Aliment. Pharmacol. Ther. | pmid:7605863 |
Katelaris PH et al. | A randomized prospective comparison of clarithromycin versus amoxycillin in combination with omeprazole for eradication of Helicobacter pylori. | 1995 | Aliment. Pharmacol. Ther. | pmid:7605864 |
Yousfi MM et al. | Metronidazole, omeprazole and clarithromycin: an effective combination therapy for Helicobacter pylori infection. | 1995 | Aliment. Pharmacol. Ther. | pmid:7605865 |
Chevalley GF et al. | [Uveitis associated with rifabutin treatment. Apropos of 3 patients]. | 1995 | Klin Monbl Augenheilkd | pmid:7609395 |
Blum AL et al. | [Functional dyspepsia: approaches to Helicobacter pylori eradication therapy]. | 1995 | Leber Magen Darm | pmid:7609589 |
Labenz J et al. | [Short-term triple therapy with pantoprazole, clarithromycin and metronidazole in eradication of Helicobacter pylori]. | 1995 | Leber Magen Darm | pmid:7609590 |
Reppun JI | From prontolyn to biaxin: the half-century of antibiotics. | 1995 | Hawaii Med J | pmid:7628918 |
Chin DP and Hopewell PC | How to treat bacteraemic Mycobacterium avium complex disease. | 1995 | Lancet | pmid:7564723 |
Kuhn SM et al. | Treatment of Mycobacterium marinum facial abscess using clarithromycin. | 1995 | Pediatr. Infect. Dis. J. | pmid:7567299 |
Lacassin F et al. | Clarithromycin-minocycline combination as salvage therapy for toxoplasmosis in patients infected with human immunodeficiency virus. | 1995 | Antimicrob. Agents Chemother. | pmid:7695324 |
Labenz J and Börsch G | Toward an optimal treatment of Helicobacter pylori-positive peptic ulcers. | 1995 | Am. J. Gastroenterol. | pmid:7733070 |
Forné M et al. | Impact of colloidal bismuth subnitrate in the eradication rates of Helicobacter pylori infection-associated duodenal ulcer using a short treatment regimen with omeprazole and clarithromycin: a randomized study. | 1995 | Am. J. Gastroenterol. | pmid:7733075 |
Cahill RJ et al. | Effect of eradication of Helicobacter pylori infection on gastric epithelial cell proliferation. | 1995 | Dig. Dis. Sci. | pmid:7648960 |
Dautzenberg B et al. | Clarithromycin in the treatment of Mycobacterium avium lung infections in patients without AIDS. Clarithromycin Study Group of France. | 1995 | Chest | pmid:7705112 |
Schlossberg D | Azithromycin and clarithromycin. | 1995 | Med. Clin. North Am. | pmid:7791424 |
Gross RH et al. | Corneal pharmacokinetics of topical clarithromycin. | 1995 | Invest. Ophthalmol. Vis. Sci. | pmid:7706046 |
Frotz H et al. | [Ranitidine and clarithromycin for eradication of Helicobacter pylori in patients with duodenal ulcer]. | 1995 | Arzneimittelforschung | pmid:7710445 |
Luna-Herrera J et al. | Antituberculosis activity of clarithromycin. | 1995 | Antimicrob. Agents Chemother. | pmid:8593004 |
Ellis LC et al. | Postantibiotic effect of clarithromycin alone and combined with ethambutol against Mycobacterium avium complex. | 1995 | Antimicrob. Agents Chemother. | pmid:8593025 |
Truffot-Pernot C et al. | Clarithromycin is inactive against Mycobacterium tuberculosis. | 1995 | Antimicrob. Agents Chemother. | pmid:8593032 |
Schütze K and Hentschel E | Duodenal ulcer healing after 7-day treatment: a pilot study with lansoprazole, amoxicillin and clarithromycin. | 1995 | Z Gastroenterol | pmid:8600661 |
Tseng AL and Walmsley SL | Rifabutin-associated uveitis. | 1995 | Ann Pharmacother | pmid:8573961 |
Moayyedi P et al. | Efficacy and optimum dose of omeprazole in a new 1-week triple therapy regimen to eradicate Helicobacter pylori. | 1995 | Eur J Gastroenterol Hepatol | pmid:8574714 |
Fujioka T et al. | Peptic ulcer recurrence after Helicobacter pylori eradication: a 5-year follow-up study. | 1995 | Eur J Gastroenterol Hepatol | pmid:8574733 |
Deltenre M et al. | Omeprazole-based antimicrobial therapies: results in 198 Helicobacter pylori-positive patients. | 1995 | Eur J Gastroenterol Hepatol | pmid:8574734 |
Fukuda Y et al. | Combination therapy with mucosal protective agent for the eradication of Helicobacter pylori. | 1995 | Eur J Gastroenterol Hepatol | pmid:8574735 |
Graham DY | Clarithromycin for treatment of Helicobacter pylori infections. | 1995 | Eur J Gastroenterol Hepatol | pmid:8574737 |
Takimoto T et al. | Dual therapy with lansoprazole and clarithromycin for eradication of Helicobacter pylori. | 1995 | Eur J Gastroenterol Hepatol | pmid:8574739 |
Uemura N et al. | Effect of Helicobacter pylori eradication on the healing and recurrence of peptic ulcer: combination therapy with low-dose omeprazole and clarithromycin. | 1995 | Eur J Gastroenterol Hepatol | pmid:8574740 |
Pavlopoulou J et al. | Randomized controlled study of clarithromycin versus cefaclor suspensions in the treatment of acute otitis media in children. | 1995 | J Chemother | pmid:8904139 |
Gioulekas J and Hall A | Uveitis associated with rifabutin therapy. | 1995 | Aust N Z J Ophthalmol | pmid:11980079 |
Nishi K et al. | [Effect of clarithromycin on symptoms and mucociliary transport in patients with sino-bronchial syndrome]. | 1995 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8821993 |
Reid R et al. | Pneumococcal meningitis during therapy of otitis media with clarithromycin. | 1995 | Pediatr. Infect. Dis. J. | pmid:8786899 |
Van Asselt GJ et al. | Susceptibility of Streptococcus pyogenes to azithromycin, clarithromycin, erythromycin and roxithromycin in vitro. | 1995 | J. Med. Microbiol. | pmid:7563004 |
Parasakthi N and Goh KL | Primary and acquired resistance to clarithromycin among Helicobacter pylori strains in Malaysia. | 1995 | Am. J. Gastroenterol. | pmid:7872306 |
Kadayifçi A et al. | Low dose clarithromycin plus omeprazole eradicates Helicobacter pylori in duodenal ulcer disease. | 1995 | Am. J. Gastroenterol. | pmid:7872307 |
Wallace RJ et al. | Reduced serum levels of clarithromycin in patients treated with multidrug regimens including rifampin or rifabutin for Mycobacterium avium-M. intracellulare infection. | 1995 | J. Infect. Dis. | pmid:7876634 |
Moorthy RS and Rao NA | Atypical mycobacterial wound infection after blepharoplasty. | 1995 | Br J Ophthalmol | pmid:7880802 |
Yoshizawa A et al. | [Legionella pneumonia diagnosed by urinary antigen detection]. | 1995 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:7791279 |
Lounis N et al. | Selection of clarithromycin-resistant Mycobacterium avium complex during combined therapy using the beige mouse model. | 1995 | Antimicrob. Agents Chemother. | pmid:7793860 |
Fattorini L et al. | In vitro and ex vivo activities of antimicrobial agents used in combination with clarithromycin, with or without amikacin, against Mycobacterium avium. | 1995 | Antimicrob. Agents Chemother. | pmid:7793873 |
Abbott files SNDA for MAC prophylaxis. | 1995 | J Int Assoc Physicians AIDS Care | pmid:11362606 | |
Cohen Y et al. | Use of normal C57BL/6 mice with established Mycobacterium avium infections as an alternative model for evaluation of antibiotic activity. | 1995 | Antimicrob. Agents Chemother. | pmid:7793882 |
Pierce M | Another perspective on MAC prophylaxis. Interview by Gordon Nary. | 1995 | J Int Assoc Physicians AIDS Care | pmid:11362746 |
Furney SK et al. | Activities of rifabutin, clarithromycin, and ethambutol against two virulent strains of Mycobacterium avium in a mouse model. | 1995 | Antimicrob. Agents Chemother. | pmid:7793895 |
Archange YR et al. | Clarithromycin prophylaxis against disseminated Mycobacterium avium complex in patients with AIDS. | 1995 | J Int Assoc Physicians AIDS Care | pmid:11362747 |
Brown BA et al. | Clarithromycin-induced hepatotoxicity. | 1995 | Clin. Infect. Dis. | pmid:7795060 |
Physician's aggressive preventive therapy differs. | 1995 | AIDS Alert | pmid:11362774 | |
Raffi F et al. | Breakthrough cerebral toxoplasmosis in patients with AIDS who are being treated with clarithromycin. | 1995 | Clin. Infect. Dis. | pmid:7795062 |
New drug applications sought. | 1995 | AIDS Alert | pmid:11362777 | |
Smart T | Cryptosporidiosis at ICAAC. | 1995 | GMHC Treat Issues | pmid:11362913 |
Sharma PK and Tami TA | AIDS: lessons from the last decade and prospects for the future. | 1995 | Ear Nose Throat J | pmid:7796740 |
Researchers find new drugs to fight MAC. | 1995 | AIDS Alert | pmid:11362925 |